Research Statement

Diabetes greatly increases the risk of cardiovascular diseases, which accounts for the largest number of deaths among American diabetic patients. Dr. Velayutham’s research aims to determine potential non-pharmacological, lifestyle-oriented strategies to reduce the cardiovascular complications in diabetes. His current research investigates the vascular effects of blueberries and strawberries with special emphasis on the microbial metabolites of berry anthocyanins and the molecular signaling mechanisms involved. These studies will provide key insights toward understanding the causal association between dietary berries, gut microbiome and vascular health.

Research Keywords

  • Diabetes Mellitus
  • Metabolic Syndrome
  • Cardiovascular Diseases
  • Vascular Inflammation
  • Cell Signaling
  • Gut microbiome
  • Dietary Supplements
  • Dietary Flavonoids

Presentations

  • Undergraduate Research Symposium 2019, University of Utah, Apr 9. Effects of Dietary Strawberry on Vascular Complications in High Fat Diet Fed C57BL/6J mice. Presenter: Student Mentee Aubrey O’Farrell. Role: Mentor. Poster, Presented, 04/2019.
  • Undergraduate Research Symposium 2018, University of Utah, Aug 2. Dietary supplementation of blueberry modifies NFκB signaling in the aortic vessels of diabetic mice. Presenter: Student Mentee Samantha Nelson. Role: Mentor. Poster, Presented, 08/02/2018.
  • Undergraduate Research Symposium 2018, University of Utah, Aug 2. Dietary strawberry ameliorates vascular inflammation in diabetic db/db mice possibly through a nuclear factor-kB mediated mechanism. Presenter: Student Mentee Aspen Johnson. Role: Mentor. Poster, Presented, 08/02/2018.
  • Undergraduate Research Symposium 2018, University of Utah, Aug 2. Effect of blueberry supplementation on vascular NADPH oxidases in db/db mice. Presenter: Student Mentee Jessica Bigley. Role: Mentor. Poster, Presented, 08/02/2018.
  • American Society for Nutrition Meeting (Nutrition 2018), Boston. Oral Presentation: A.B.P. Velayutham, U.D. Wankhade, C. Petersen, K. Wong, D. Bharat, S. Gholami, S.V. Chintapalli, B.D. Piccolo, J.D. Symons, K. Shankar. Influence of blueberry supplementation on gut microbiome in diabetic db/db mice. Current Developments in Nutrition, 2: OR03-08 (2018). Presentation, Presented, 06/09/2018.
  • American Society for Nutrition Meeting (Nutrition 2018), Boston. C. Petersen, U.D. Wankhade, K. Wong, S.V. Chintapalli, B.D. Piccolo, T. Jalili, J.D. Symons, K. Shankar, A.B.P. Velayutham*. Strawberry supplementation modifies gut microbiota in obese diabetic db/db mice. Current Developments in Nutrition, 2: P23-083 (2018). Poster, Presented, 06/10/2018.
  • USDA/National Institute of Food and Agriculture NRI/AFRI Project Director Meeting 2018, Boston, MA. Dietary strawberry prevents vascular inflammation. Role: Presenter. Poster, Presented, 06/08/2018.
  • Utah Conference on Undergraduate Research 2018. Oral Presentation: Blueberry metabolites suppress endothelial inflammation in diabetic human vascular endothelial cells without altering the expression of syndecan. Presenter: Student Mentee Samira Gholami received Travel Award. Presentation, Presented, 02/09/2018.
  • Experimental Biology Meeting, Chicago, 2017. Oral Presentation: D. Bharat, C. Petersen, C. Denestso, S. Gholami, B. Cutler, J.S. Kim, J.D. Symons, A.B.P. Velayutham*. Dietary Blueberries Attenuate Vascular Inflammation and Dysfunction in Diabetic db/db Mice. The FASEB Journal, 31:166.2 (2017). Presenter: Anandh Babu Pon Velayutham. Student Mentee Divya was a finalist in American Society for Nutrition’s Emerging Leaders in Nutrition Science Poster Competition. Presentation, Presented, 04/2017.
  • Experimental Biology Meeting, Chicago, 2017. Oral presentation: C. Petersen, D. Bharat, B. Cutler, S. Gholami, C. Denestso, J.E. Mueller, J. Cho, J.S. Kim, J.D. Symons, A.B.P. Velayutham*. Strawberry Supplementation Lessens Vascular Inflammation and Dysfunction Displayed by Diabetic db/db Mice. The FASEB Journal, 31:431.5 (2017). Presenter: Student Mentee Chrissa Petersen. Presentation, Presented, 04/2017.
  • Experimental Biology Meeting, Chicago 2017. Blueberry Metabolites Restore Composition of Glycosaminoglycan Structures in Diabetic Human Vascular Endothelial Cells. The FASEB Journal, 31:646.61 (2017). Presenter: Student Mentee Brett Cutler received UROP Travel Grant. Poster, Presented, 04/2017.
  • Experimental Biology Meeting, Chicago, 2017. J.Cho, J.S. Kim, J. Allsop, T.Bean, T.Bonn, G. Hestwood, K. Yang, M. Drummond, P.V.A. Babu, J.D. Symons. Basal Endothelial Cell Autophagy is Elevated in Trained vs. Sedentary Mice. The FASEB Journal, 31:840.25 (2017). Poster, Presented, 04/2017.
  • Undergraduate Research Symposium, University of Utah 2017. Vascular effects of strawberries. Presenter: Student Mentee Kiana Wong. Role: Mentor. Poster, Presented, 04/2017.
  • Society for Advancement of Hispanics/Chicanos and Native Americans in Science (SACNAS) National Diversity in STEM Conference, Long Beach, California 2016. Effect of blueberry anthocyanins on adipose tissue inflammation in diabetic db/db mice. Presenter: Student Mentee Christopher Denetso. Poster, Presented, 10/2016.
  • American Physiological Society Intersociety Meeting: The Integrative Biology of Exercise VII, Pheonix, AZ. Nov 2-4, 2016. Exercise-training increases basal autophagy-related gene expression in murine arterial endothelial cells. JS Kim, LP Bharath, J Allsop, T Bean, T Bonn, G Hestwood, D Nelson, M Drummond, PVA Babu, TE Graham, JD Symons. Presentation, Presented, 09/09/2016.
  • University of Utah Undergraduate Research Poster Session 2017. Effect of blueberry anthocyanins on adipose tissue inflammation in diabetic db/db mice. Presenter: Student Mentee Christopher Denetso. Role: Mentor. Poster, Presented, 08/2016.
  • Experimental Biology 2016. D. Bharat, N. Begaye, R. Ramos, M. Ferreira, Y. Li, B. Cutler, L.P. Bharath, J.D. Symons, T. Jalili, A.B.P. Velayutham*. Lipotoxicity-Evoked Reductions in Nitric Oxide Bioavailability and Exaggerated Oxidant Stress Are Blunted By Blueberry Metabolites in Human Vascular Endothelial Cells. The FASEB Journal, 30:1175.3 (2016). Poster, Presented, 04/2016.
  • Institute of Food Technologists (IFT): Bonneville Section IFT Suppliers Night, Research poster session, 2016. Blueberry metabolites suppress high fat-induced endothelial inflammation and improve vascular dysfunction. Presenter: Student Mentee Divya Bharat. Poster, Presented, 04/2016.
  • University of Utah Diabetes & Metabolism Center Retreat, Mar 17, 2016. Metabolites of blueb erry polyphenols improve nitric oxide production and suppress reactive oxygen species in lipotoxicity induced human aortic endothelial cells. Presenter: Student Mentee Divya Bharat . Role: Mentor. Poster, Presented, 03/17/2016.
  • Experimental Biology 2016. L.P. Bharath, T. Ruan, P.V.A. Babu, S. Boudina, T.E. Graham, J.D. Symons. Intact Autophagy is Requisite to Maintain Shear-Stress-Induced Nitric Oxide Generation by Endothelial Cells via a Novel Glucose-Dependent Purinergic Signaling Pathway. The FASEB Journal, 30:1130.3 (2016). Poster, Presented, 04/2016.
  • Utah Conference on Undergraduate Research 2016, University of Utah, Feb 19, 2016. Blueberry metabolites at physiological relevant concentrations do not affect angiogenesis in human aortic endothelial cells. Presenter: Student Mentee - Brett Cutler. Poster, Presented, 02/2016.
  • Society for Advancement of Hispanics/Chicanos and Native Americans in Science (SACNAS) National Conference 2015, Washington, DC, Metabolites of blueberry polyphenols improve nitric oxide production and suppress reactive oxygen species in lipotoxicity induced human aortic endothelial cells. N Begaye, P.V.A. Babu. Presenter: Student Mentee Nathan Begaye. Poster, Presented, 10/2015.
  • Experimental Biology 2015. Oral Presentation: R. Cavalcanti, N. Begaye, M. Costa, L.P. Bharath, J.D. Symons, T. Jalili, N.S. Rajasekaran, Z. Jia, P.V.A. Babu*. Metabolites of Blueberry Anthocyanins Suppress Lipotoxicity Induced Endothelial Inflammation. The FASEB Journal, 29:118.6 (2015). Student Mentee Rafaela Cavalcanti was a finalist in American Society for Nutrition’s Emerging Leaders in Nutrition Science Poster Competition. Conference Paper, Presented, 03/2015.
  • Experimental Biology 2015. P.V.A. Babu, J. McCormick, Z. Jia. Effects of Caffeine on peroxynitrite-mediated DNA strand breakage. The FASEB Journal, 29:LB279 (2015). Poster, Presented, 03/2015.
  • Experimental Biology 2015. L.P. Bharath, T. Ruan, T. Forostyan, A. Sargsyan, R. Goodrich, Y. Han, R. Mueller, P.V.A. Babu, S. Boudina, T. Graham, J.D. Symons. Cross-talk between autophagy and mitophagy regulates shear-induced nitric oxide production in endothelial cells. The FASEB Journal, 29:896.3 (2015). Poster, Presented, 03/2015.
  • Experimental Biology 2015. Y.Y. Li, L.P. Bharath, Y. Quan, E. Mah, Y. Guo, M. Hawkins, R. Bruno, P.V.A. Babu, T. Jalili, J.D. Symons. y-carboxyethyl hydroxychroman preserves nitric oxide bioavailability by attenuating oxidative stress and inflammation in endothelial cells treated with high glucose. The FASEB Journal, 29:758.1 (2015). Poster, Presented, 03/2015.
  • Society for Advancement of Hispanics/Chicanos and Native Americans in Science - National Conference 2014. N. Begaye, A.B.P. Velayutham. Cardiovascular protective effects of blueberry anthocyanins. Presenter: Student Mentee Nathan Begaye. Poster, Presented, 10/2014.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Scientific sessions 2014. A.B.P. Velayutham, E.M. Kim, L. Panneerseelan, V. Muthuswamy, T. Jalili, N.S. Rajasekaran, J.D. Symons, Z. Jia. Berry anthocyanins and their metabolite ameliorate high glucose-induced adhesion of monocytes to human aortic endothelial cells by modulating the cross-talk between eNOS and NFκB Signaling, Arteriosclerosis, Thrombosis, and Vascular Biology, 34:A376 (2014). Poster, Presented, 05/2014.
  • American Diabetes Association Scientific Session 2014. Panneerseelan-Bharath L, Mueller R, Li Y-Y, Kunz D, Goodrich R, Mills T, Deeter L, Sargsyan A, Babu PVA , Graham TE, Symons JD. Impairment of autophagy in endothelial cells prevents shear-stress induced increases in nitric oxide bioavailability. Conference Paper, Presented, 06/2014.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Scientific sessions 2014. P. Nallasamy, P.V.A. Babu, H. Shah, E.A.S. Brooke, H. Zhu, W. Zhen, D. Liu, Y. Li, Z. Jia. Sulforaphane at physiological concentrations inhibits TNF-α induced monocytes adhesion to human vascular endothelial cells and improves vascular inflammation in mice through a nuclear factor-κB-mediated mechanism, Arteriosclerosis, Thrombosis, and Vascular Biology, in press (2014). Poster, Presented, 05/2014.
  • Keystone Symposia on Molecular and Cellular Biology 2014: Autophagy : Fundamentals to Disease, Austin, TX. Other, Other, 05/2014.Panneerseelan-Bharath L, Mueller R, Li Y-Y, Kunz D, Goodrich R, Mills T, Deeter L, Sargsyan A, Babu PVA, Graham TE, Symons JD. Impairment of autophagy in endothelial cells prevents shear-stress induced increases in nitric oxide bioavailability. Other, Other, 05/2014.
  • Experimental Biology 2014. Y. Qian, L. Panneerseelan, P.V.A. Babu, J. D. Symons, T. Jalili. Metabolites of polyphenols preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions, The FASEB Journal, 28: 372.6 (2014). Poster, Presented, 03/2014.
  • Experimental Biology 2014. L. Panneerseelan, T. Ruan, Y. Li, P.V.A. Babu, X. Wan, D. Kunz, M. Walker, J. Nhan, A. Ravindran, Q. J. Zhang, E.D. Abel, J.D. Symons. PP2A activation in vivo is sufficient to disrupt interactions among vascular Akt-Hsp90-eNOS, The FASEB Journal, 28: 1013.16 (2014). Conference Paper, Presented, 03/2014.
  • School of Medicine, University of Utah - Metabolism Interest Group Seminars 2014. Title: Dietary flavonoids for the prevention of vascular disease, January 9, 2014. Presentation, Presented, 01/2014.
  • Experimental Biology 2013. X. Li, J. Luo, A.B.P. Velayutham, R.McMillan, M.Hulver, W.Zhen, H. Alkhalidy, D. Liu. Dietary supplementation of ginseng prevents obese and metabolic syndromes in high fat diet-fed mice. The FASEB Journal, 27: 224.1 (2013). Poster, Presented, 03/2013.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Scientific sessions 2010. A.B.P. Velayutham, H. Si, Z. Fu, D. Liu. Epigallocatechin gallate improves diabetic vascular inflammation in diabetic db/db mice possibly through suppression of Nuclear Factor-κB. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(11): e119, 74 (2010). Poster, Presented, 04/2010.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Scientific sessions 2010. A.B.P. Velayutham, H. Si, D. Liu. Genistein prevents hyperglycemia-induced monocytes adhesion to human aortic endothelial cells and vascular inflammation in obese diabetic mice, Arteriosclerosis, Thrombosis, and Vascular Biology, 30(11): e283, P536 (2010). Presentation, Presented, 04/2010.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2009. H. Si, Z. Fu, Z. Jia, A.B.P. Velayutham, D. Liu. Cocoa flavonoid prevents atherosclerosis by suppressing inflammatory factors, promoting activities of antioxidants, and reducing LDL cholesterol in Type 2 diabetic mice, Arteriosclerosis, Thrombosis, and Vascular Biology, 29: e41, P173 (2009). Poster, Presented, 04/2009.
  • Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2009. A.B.P. Velayutham, D. Liu. Epigallocatechin gallate inhibits high glucose-induced monocytes adhesion to human vascular endothelial cells through a peroxisome proliferator-activated receptor-mediated mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology, 29: e96, P465 (2009). Poster, Presented, 04/2009.
  • GTC Bio’s 3rd Modern Drug Discovery & Development Summit –2007. New therapeutics for cardiovascular complications in diabetes: AGE attenuators and breakers to target diabetic heart (2007). Invited Talk/Keynote, Presented, 11/2007.
  • Fourth International Scientific Symposium on Tea & Human Health by USDA 2007. Green tea protects cardiovascular system in diabetes. Poster, Presented, 09/2007.
  • Institute of Food Technologists (IFT): Bonneville Section IFT Suppliers Night, Research poster session, Apr 7, 201 6. Blueberry metabolites suppress high fat - induced endothelial inflammation and improve vascular dysfunction. Presenter: Student Mentee Divya Bharat . Role: Mentor . Poster, Presented, 04/07/2016.
  • Indo-Swedish Symposium on Genomics and Proteomics of Diabetes 2006. Hotel Savera, Chennai, India, 1&2nd April. Modulatory effect of Green tea extract on advanced glycation end products and cross-linking of collagen in streptozotocin diabetic rats (2006). Poster, Presented, 04/2006.
  • 4th World Congress on Prevention of Diabetes and its complications 2005. Antiglycating effects of green tea extract: an in vitro study on rat lens. Poster, Presented, 02/2005.
  • Indo-Australian conference on Biotechnology in Medicine 2004. Indian Institute of Science, Bangalore, India, 9-11th Feb. Efficacy of Green Tea Polyphenols on Glycation of Lens Proteins: In vitro studies. Poster, Presented, 02/2004.
  • International conference on Natural Products, Free radicals and Radioprotectors in Health 2004. Annamalai University, Chidambaram, India. 17-19th January. Antioxidant effects of Green Tea Extract. Poster, Presented, 01/2004.
  • Summer Research Symposium 2019, University of Utah. Effect of dietary blueberry on vascular function in aged C57BL/6J mice. Presenter: Student Mentee Madison Putich. Role: Mentor. Poster, Presented, 08/2019.
  • Summer Research Symposium 2019, University of Utah. Effect of Blueberry Supplementation on Metabolic Milieu in Aged Mice. Presenter: Student Mentee Gem Wilson. Role: Mentor. Poster, Presented, 08/2019.
  • American Society for Nutrition Meeting 2019/ Nutrition 2019, Baltimore MD. Dietary supplementation of strawberry improves vascular inflammation without altering metabolic milieu in high-fat diet fed C57BL/6J mice. Presenter: Student Mentee James Coleman Miller. Role: Mentor. Poster, Presented, 06/2019.
  • Undergraduate Research Symposium 2019, University of Utah. Effects of Strawberry Supplementation on Metabolic Milieu in High Fat Diet Fed C57BL/6J Mice. Presenter: Student Mentee Madison Putich. Role: Mentor. Poster, Presented, 04/2019.

Research Groups

  • Kai Benedict, Graduate Student. 08/2019 - present. Awards/Scholarships/Stipends: Research Assistantship through National Institute of Foods and Agriculture Grant.
  • Miley Nguyen, Graduate Student. 08/2019 - present. Awards/Scholarships/Stipends: Research Assistantship through National Institute of Foods and Agriculture Grant.
  • Sydney Larson , Undergraduate Student. 07/2019 - present.
  • Satheesh Babu Adhini Kuppuswamy, Postdoc. 06/2019 - present.
  • Gem Wilson, Undergraduate Student. 05/2019 - 08/2019. Awards/Scholarships/Stipends: Native American Research Internship.
  • Miguel Saldivar-Gonzalez, Undergraduate Student. 04/2019 - present.
  • Chrissa Petersen, Graduate Student. 01/2019 - present.
  • Aubrey Sarah O’Farrell, Undergraduate Student. 10/2018 - 07/2019.
  • James Coleman Miller, Graduate Student. 05/2018 - present.
  • Jessica Bigley, Visiting Student. Summer Program for Undergraduate Research. 05/2018 - 08/2018.
  • Aspen Johnson, Visiting Student. Native American Research Internship Program. 05/2018 - 08/2018.
  • Samantha Nelson, Visiting Student. Summer Program for Undergraduate Research. 05/2018 - 08/2018.
  • Madison Putich, Undergraduate Student. Undergraduate Research Opportunity Program Awardee. 01/2018 - present.
  • Jennifer Ellen Mueller, Graduate Student. 08/2017 - 12/2019.
  • Kiana Wong, Undergraduate Student. Undergraduate Research Opportunity Program (UROP) Awardee. 10/2016 - 01/2018.
  • Christopher Denetso, Undergraduate Student. Native American Research Internship Program. 05/2016 - 08/2016.
  • Samira Gholami, Undergraduate Student. Undergraduate Research Opportunity Program (UROP) Awardee. 05/2016 - 07/2019.
  • Jennifer Ellen Mueller, Undergraduate Student. Undergraduate Research Opportunity Program (UROP) Awardee. 12/2015 - 05/2017.
  • Renata Kelly Luna Gomes Ramos, Visiting Student. Brazil Scientific Mobility Program. 05/2015 - 08/2015.
  • Marina Ramos Ferreira, Visiting Student. Brazil Scientific Mobility Program. 05/2015 - 08/2015.
  • Divya Bharat, Graduate Student. 12/2014 - 04/2017.
  • Chrissa Petersen Mower, Graduate Student. 08/2014 - 10/2017.
  • Marcella Melo Assis Costa, Undergraduate Student. Brazil Scientific Mobility Program. 08/2014 - 12/2014.
  • Brett Ronald Cutler, Undergraduate Student. Undergraduate Research Opportunity Program (UROP) Awardee. 08/2014 - 04/2017.
  • Rafaela Ramos Mororo Cavalcanti, Visiting Student. Brazil Scientific Mobility Program. 05/2014 - 08/2014.
  • Nathan Begaye, Undergraduate Student. Native American Research Internship Program. 05/2014 - 08/2015.
  • Eui Min Kim, Graduate Student. Nutrition. 08/2013 - 04/2014.
  • Lucie Bertuleit, Undergraduate Student. 03/01/2013 - 06/30/2013.

Languages

  • English, fluent.
  • Tamil, fluent.

Geographical Regions of Interest

  • Canada
    Member, Canadian Nutrition Society.
  • Poland
    Grant Reviewer for National Science Center (Narodow Centrum Nauki, Poland).
  • United States of America

Publications

  • P. Mokhtari, J. Metos, P.V. Anandh Babu. Impact of Type 1 Diabetes on the Composition and Functional Potential of Gut Microbiome in Children and Adolescents: Possible Mechanisms, Current Knowledge and Challenges. Gut Microbes, In press (2021). Accepted, 04/30/2021.
  • J.M. Cho, K. Ly, S. Ly, S.K. Park, P.V. Anandh Babu, B. Kuberan, J.D. Symons. Chapter 40: Procedures to Evaluate the Role of Heparan Sulfate in the Reactivity of Resistance and Conductance Arteries Ex Vivo. In: Methods in Molecular Biology 2303, Glycosaminoglycans – Chemistry and Biology. Edited by Kuberan Balagurunathan, Hiroshi Nakato, Umesh Desai and Yukio Saijoh. Springer Publications (2021). Published, 03/15/2021.
  • B. Cutler, J.S. Chua, B. Kuberan, P.V. Anandh Babu. Chapter 37: Methods to Analyze the Effect of Diet-Derived Metabolites on Endothelial Inflammation and Cell Surface Glycosaminoglycans. In: Methods in Molecular Biology 2303, Glycosaminoglycans – Chemistry and Biology. Edited by Kuberan Balagurunathan, Hiroshi Nakato, Umesh Desai and Yukio Saijoh. Springer Publications (2021). Published, 03/2021.
  • M. Kalita, J.S. Chua, R.S. Boothello, A. Joice, O. Antelope, A. Roy, P.V. Anandh Babu, Y. Saijoh, U.R. Desai, B. Kuberan. Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces. Chem Communications, 59, 14423-14426 (2020). Published, 12/15/2020.
  • C. Petersen, U.D. Wankhade, D. Bharat,K. Wong, J.E. Mueller, S.V. Chintapalli, B.D. Piccolo, T. Jalili, Z. Jia, J.D. Symons, K. Shankar, P.V. Anandh Babu. Dietary supplementation of strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. Journal of Nutritional Biochemistry, 66, 63-69 (2019). Published, 04/2019.
  • C. Petersen, D. Bharat, B.R. Cutler, S. Gholami, C. Denetso, J.E. Mueller, J.M. Cho, J.S. Kim, J.D. Symons, P.V. Anandh Babu. Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice. International Journal of Cardiology, 263, 111-117 (2018). Published, 04/09/2018.
  • B. R. Cutler, S. Gholami, J.S. Chua, K. Balagurunthan, P.V. Anandh Babu. Blueberry metabolites reduce cell surface glycosaminoglycans and improve endothelial dysfunction in diabetic human aortic endothelial cells. International Journal of Cardiology, 261: 155-158 (2018). Published, 03/06/2018.
  • Editorial: Z. Jia, P.V.A. Babu, W. Chen, X. Sun. Editorial: Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment. Oxidative Medicine and Cellular Longevity, Article ID: 6576093 (2018). Published, 01/2018.
  • D. Bharat, R.R.M. Cavalcanti, N. Begaye, C. Petersen, B.R. Cutler, M.M.A. Costa, R.K.L.G. Ramos, M.R. Ferreira, Y.Y. Li, L.P. Bharath, E. Toolson, P. Sebahar, R.E. Looper, T. Jalili, N.S. Rajasekaran, Z. Jia, J.D. Symons, P.V. Anandh Babu. Blueberry metabolites attenuate lipotoxicity-induced endothelial dysfunction. Molecular Nutrition and Food Research, 62, 1700601 (2018). Published, 12/2017.
  • Y. Qian, P.V.A. Babu, J.D. Symons, T. Jalili. Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. Nutrition and Diabetes, 7: e286 (2017). PMC5637105. Published, 09/2017.
  • L. Bharath, J. Cho, S. Park, T. Ruan, Y. Li, R. Mueller, T. Bean, V. Reese, R. Richardson, J. Cai, A. Sargsyan, K. Pires, P.V.A. Babu, S. Boudina, T. Graham, and J.D. Symons. Endothelial cell autophagy maintains shear-stress-induced nitric oxide generation via glycolysis-dependent purinergic signaling to eNOS. Arteriosclerosis, Thrombosis, and Vascular Biology, 37: 1646-1656 (2017). PMC5693355. Published, 07/2017.
  • P.V.A. Babu, C.P. Mower, Z. Jia. Chapter: Sulforaphane and atherosclerosis. In: Reference series in Phytochemistry: Glucosinolates. Edited by Jean-Michel Merillon and Kishan Ramawat. Springer Publications (2016).. Published, 08/2016.
  • Y.Li, L.P. Bharath, Y. Qian, T. Ruan, P.V.A. Babu, R.S. Bruno, J.D.Symons, T. Jalili. Carboxyethyl hydroxychroman, a metabolite of –tocopherol, preserves nitric oxide bioavailability in endothelial cells challenged with high glucose. Experimental Biology and Medicine, 241: 2056-62(2016). Published, 07/31/2016.
  • B.R. Cutler, C.Petersen, P.V.A. Babu*. Review: Mechanistic insights in the vascular effects of blueberries: Evidence from recent studies. Molecular Nutrition and Food Research, 61: 1600271 (2017). Published, 06/2016.
  • Editorial: W. Chen, Z. Jia, M.H. Pan, P.V.A. Babu. Natural Products for the Prevention of Oxidative Stress-Related Diseases: Mechanisms and Strategies. Oxidative Medicine and Cellular Longevity, Article ID: 4628502 (2015). Published, 12/2015.
  • L. P. Bharath, T. Ruan, Y. Li, A. Ravindran, X. Wan, J. Nhan, M. Walker, L. Deeter, R. Goodrich, E. Johnson, D. Munday, R. Mueller, D. Kunz, D. Jones, V. Reese, S. Summers, P.V.A. Babu, W. Holland, AQ.J. Zhang, E. Abel, J.D. Symons. Ceramide initiated protein phosphatase 2A activation contributes to arterial dysfunction in vivo. Diabetes, 64(11): 3914-26 (2015). Published, 09/2015.
  • L. Panneerseelan-Bharath, R. Mueller, Y. Li, D. Kunz, R. Goodrich, T. Mills, L. Deeter, A. Sargsyan, P.V.A. Babu, T. E. Graham, J.D. Symons. Impairment of autophagy in endothelial cells prevents shear stress induced increases in nitric oxide bioavailability. Canadian Journal of Pharmacology and Physiology, 92: 605-612 (2014). Published, 06/2014.
  • X. Li, J. Luo, P.V.A. Babu, W. Zhang, E. Gilbert, M. Clline, R. McMillan, M. Hulver, H. Alkhalidy, W. Zhen, H. Zhang, D. Liu. Dietary supplementation of Chinese Ginseng prevents obesity and metabolic syndrome in high-fat diet-fed mice. Journal of Medicinal Food 17:1287-97 (2014). PMC4259183. Published, 05/2014.
  • P. Nallasamy, H. Si, P.V.A. Babu, D. Pan, Y. Fu, E.A.S. Brooke, H. Shah, W. Zhen, H. Zhu, D. Liu, Y. Li, Z. Jia. Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway. Journal of Nutritional Biochemistry 25: 824-833 (2014). PMC4087147. Published, 05/2014.
  • P.V.A. Babu, D. Liu, E.R. Gilbert. Recent advances in understanding the antidiabetic actions of dietary flavonoids. Journal of Nutritional Biochemistry, 24: 1777-1789 (2013). PMC3821977. Published, 07/2013.
  • Z. Jia, P.V.A. Babu, H. Si, P. Nallasamy, H. Zhu, W. Zhen, H.P. Misra, Y. Li, D. Liu. Genistein inhibits TNF-α-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice. International Journal of Cardiology, 168: 2637-2645 (2013). PMC3758913. Published, 03/2013.
  • Z. Jia, W. Zhen, P.V.A. Babu, D. Liu. Phytoestrogen genistein protects against endothelial barrier dysfunction in vascular endothelial cells through PKA-mediated suppression of RhoA signaling. Endocrinology, 154: 727-737 (2013). PMC3548180. Published, 02/2013.
  • P.V.A. Babu, H. Si, D. Liu. Epigallocatechin gallate reduces vascular inflammation and improves vascular function in db/db mice possibly through NFκB-mediated mechanism. Molecular Nutrition and Food Research 56: 1424-1432 (2012). PMC3816509. Published, 06/2012.
  • P.V.A. Babu, H. Si, Z. Fu, W. Zhen, D. Liu. Genistein prevents hyperglycemia-induced monocytesadhesion to endothelial cells partially through preservation of cAMP signaling pathway. Journal of Nutrition 142: 724–730 (2012). PMC3301991. Published, 01/2012.
  • H. Si, Z. Fu, P.V.A. Babu, W.Zhen, T. LeRoith, M.P. Meaney, K.A. Voelker, Z. Jia, R.W. Grange, D. Liu. Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. Journal of Nutrition, 141:1095-100 (2011). PMC3095141. Published, 04/2011.
  • R. Sivakumar, P.V.A. Babu, C.S.Shyamaladevi. Aspartate and glutamate prevents isoproterenol-induced cardiac toxicity by alleviating oxidative stress in rats. Experimental Toxicology & Pathology, 63: 137-142 (2011). PMID: 19962869. Published, 10/2009.
  • P.V.A. Babu, D. Liu. Chapter 18: Flavonoids and cardiovascular health. In: Complementary and Alternative Therapies and the Aging Population. An Evidence Based Approach. Edited by Ronald Ross Watson, Academic press, 371-393 (2009). Published, 09/2009.
  • P.V.A. Babu, D. Liu. Green tea catechins and cardiovascular health: An update. Current Medicinal Chemistry, 15: 1840-1850 (2008). PMC2748751. Published, 12/2008.
  • P.V.A. Babu, K.E.Sabitha, C.S.Shyamaladevi. Effect of Green tea extract on advanced glycation and cross-linking of tail tendon collagen in streptozotocin induced diabetic rats. Food and Chemical Toxicology, 46: 280-285 (2008). PMID: 17884275. Published, 04/2008.
  • P.Srinivasan, S.Suchalatha, P.V.A. Babu, R.S.Devi, S.Narayan, K.E.Sabitha, C.S. Shyamaladevi. Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer. Chemico Biological Interactions, 172: 224-234 (2008). PMID: 18336807. Published, 03/2008.
  • R. Sivakumar, P.V.A. Babu, C.S.Shyamaladevi. Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats. Chemico Biological Interactions, 176: 227–233 (2008). PMID: 18786522. Published, 01/2008.
  • P.V.A. Babu, A.Gokulakrishnan, R.Dhandayuthapani, D.A.Khan, C.V.P.Kumar, M.I.N.Ahamed. Protective effect of Withania somnifera (Solanaceae) on collagen glycation and cross-linking. Comparative Biochemistry and Physiology - Part B, 147: 308-313 (2007). PMID: 17329138. Published, 01/2007.
  • P.V.A. Babu, K.E.Sabitha, P.Srinivasan, C.S.Shyamaladevi. Modulatory effect of Green tea extract on myocardial collagen characteristics in streptozotocin diabetic rats. Pharmacological Research, 55: 433-440 (2007). PMID: 17329138. Published, 01/2007.
  • P.V.Anandh Babu, K.E.Sabitha, C.S.Shyamaladevi. Green tea extract impedes dyslipidemia and development of cardiac dysfunction in streptozotocin diabetic rats. Clinical & Experimental Pharmacology and Physiology, 33: 1184-9 (2006). PMID: 17184499. Published, 06/2006.
  • P.V.A. Babu, K.E.Sabitha, C.S.Shyamaladevi. Therapeutic effect of Green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chemico Biological Interactions, 162:114-20 (2006). PMID: 16860299. Published, 04/2006.
  • P.V.A. Babu, K.E.Sabitha, C.S.Shyamaladevi. Therapeutic effect of Green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats. Clinical & Experimental Pharmacology and Physiology, 33: 351-7 (2006). PMID: 16620300. Published, 04/2006.
  • P.V.A. Babu, K.E.Sabitha, C.S.Shyamaladevi. Therapeutic effect of Green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chemico Biological Interactions, 162:114-20 (2006). PMID: 16860299. Published, 02/2006.