Lars Bjorn Laurentius portrait
  • Research Assistant Professor, Elect & Computer Engineering
801-906-3624

Publications

  • Farhoudi N, Leu HY, Laurentius LB, Magda JJ, Solzbacher F & Reiche CF (2020). Smart Hydrogel Micromechanical Resonators with Ultrasound Readout for Biomedical Sensing. ACS sensors. Vol. 5, 1882-1889. Published, 12/01/2020.
  • Owens NA, Young CC, Laurentius LB, De P, Chatterjee D & Porter MD (2019). Detection of the tuberculosis biomarker mannose-capped lipoarabinomannan in human serum: Impact of sample pretreatment with perchloric acid. Analytica chimica acta. Vol. 1046, 140-147. Published, 01/2019.
  • Amin AG, De P, Spencer JS, Brennan PJ, Daum J, Andre BG, Joe M, Bai Y, Laurentius L, Porter MD, Honnen WJ, Choudhary A, Lowary TL, Pinter A & Chatterjee D (2018). Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography/mass spectrometry. Tuberculosis (Edinburgh, Scotland). Vol. 111, 178-187. Published, 11/01/2018.
  • Owens NA, Laurentius LB, Porter MD, Li Q, Wang S & Chatterjee D (2018). Handheld Raman Spectrometer Instrumentation for Quantitative Tuberculosis Biomarker Detection: A Performance Assessment for Point-of-Need Infectious Disease Diagnostics. Applied spectroscopy. Vol. 72, 1104-1115. Published, 10/01/2018.
  • Laurentius LB, Crawford AC, Mulvihill TS, Granger JH, Robinson R, Spencer JS, Chatterjee D, Hanson KE & Porter MD (2016). Importance of specimen pretreatment for the low-level detection of mycobacterial lipoarabinomannan in human serum. Analyst. Vol. 142, 177-185. Published, 11/28/2016.
  • Crawford AC, Laurentius LB, Mulvihill TS, Granger JH, Spencer JS, Chatterjee D, Hanson KE & Porter MD (2016). Detection of the tuberculosis antigenic marker mannose-capped lipoarabinomannan in pretreated serum by surface-enhanced Raman scattering. Analyst. Vol. 142, 186-196. Published, 11/28/2016.
  • Laurentius LB, Owens NA, Park J, Crawford AC & Porter MD (2016). Advantages and limitations of nanoparticle labeling for early diagnosis of infection. Expert review of molecular diagnostics. Vol. 16, 883-95. Published, 08/2016.
  • Qian, H., Laurentius, L. & Ray F Egerton (2015). Artefacts Induced on Soft Layer of Hybrid Metallic Nanoparticles in TEM. Artefacts Induced on Soft Layer of Hybrid Metallic Nanoparticles in TEM. Microscopy and Microanalysis. Vol. 21(S3), 1551-1552. Published, 08/2015.
  • Laurentius L, Stoyanov SR, Gusarov S, Kovalenko A, Du R, Lopinski GP & McDermott MT (2011). Diazonium-derived aryl films on gold nanoparticles: evidence for a carbon-gold covalent bond. ACS nano. Vol. 5, 4219-27. Published, 09/01/2011.

Research Statement

My expertise provide the necessary background to be successful in designing and implementing disease detection strategies, which include laboratory-based diagnostics, and more importantly, field-deployable tests that are both sensitive and user-friendly. As part of my training at the University of Alberta (UofA) and UofU, I worked on aspects of assay performance that include surface immobilization of biological active recognition elements, micro and nanofabrication procedures, overcoming biocompatibility challenges, and reducing non-specific binding for improving assay operations in respect to analysis time, portability, ease-of-use, specificity, and sensitivity.

My early work in developing and evaluating in vitro tests has sparked my interest in contributing to the paradigm shift in diagnostics. Over the past decade, there have been numerus advancements; however, the majority of tests currently in use continue to rely on established gold standards such as enzyme-linked immunoassays (ELISA). I strongly believe that we have the knowledge and capability to advance these tests to a level that matches our technology we are using on a daily basis – handheld computers. Benefits from such form factors achieved through miniaturization and technological advancements include reduced analysis time, portability, and user-friendly operation.

 

Research Keywords

  • Surface Chemistry
  • Raman spectroscopy
  • Nanotechnology
  • Materials Chemistry
  • Diagnostics Assays
  • Biosensors

Presentations

  • N. Farhoudi, L.B. Laurentius, C.F. Reiche, J.J. Magda, and F. Solzbacher, “Ultrasound Imaging of Stimuli-Responsive Hydrogel Structures for Continuous Monitoring of Biomarkers.” 5th Annual MarketsandMarkets Biomarker and Companion Diagnostics Conference Feb 6-7, 2020, San Diego, CA. Poster. Other, Presented, 02/06/2020.
  • N. Farhoudi, H.-Y. Leu, L. Laurentius, J.J. Magda, F. Solzbacher and F. Solzbacher “Continuous Glucose Monitoring using Smart Hydrogel Micromechanical Resonators with Ultrasound Readout,” Poster, Diabetes and Metabolism Fall Retreat, Salt Lake City, UT, Oct 2019. Other, Presented, 10/2019.
  • S. Boroomand, L. Priess, J. Körner, C.F. Reiche, L. B. Laurentius, H.-Y. Leu, J.J. Magda and F. Solzbacher, “A Smart Hydrogel Sensing Concept Based on Optical Imaging Sensor”, Talk, Active Polymeric Materials and Microsystems Conference (APMM), Dresden, Germany, Sep 2019. Invited Talk/Keynote, Presented, 09/2019.
  • Lars Laurentius, Alexis Crawford, Ryan Robinson, Nicholas Owens, Jennifer Granger, Delphi Chatterjee, and Marc Porter, “Diagnostic challenge in blood tests for tuberculosis: Importance of sample pretreatment in overcoming analyte complexation.” 251st ACS National Meeting & Exposition 2016, San Diego, CA. Talk. Invited Talk/Keynote, Presented, 03/2016.
  • • Lars Laurentius and Marc D. Porter, "Contributions of plasmonic interactions in surface-enhanced Raman scattering immunoassay based on labeled gold nanoparticles and gold capture substrates,” SCIX/FACSS 2014, Reno-Tahoe, NV. Invited talk presented by Lars Laurentius. Invited Talk/Keynote, Presented, 10/2014.
  • Lars Laurentius and Marc D. Porter, "Nanoparticle detection as a tool for early diagnosis of infectious disease,” SCIX/FACSS 2014, Reno-Tahoe, NV. Invited talk presented by Lars Laurentius. Invited Talk/Keynote, Presented, 10/2014.
  • Lars Laurentius, Jane Cao, and Mark T. McDermott, “Localized surface plasmon resonance labels in bioassays,” 85th ACS Colloid and Surface Science Symposium 2011, Montreal, QC. Talk. Other, Presented, 06/2011.
  • Lars Laurentius and Mark McDermott, “UV-vis detection of nanoparticle-labels in biosensing,” 56th ICASS International Conference on Analytical Sciences and Spectroscopy 2010, Edmonton, AB. Invited talk. Invited Talk/Keynote, Presented, 09/2010.

Research Groups

  • Pouya Hadipour, Postdoc. Electrical and Computer Engineering. 03/16/2020 - 02/15/2021.

Research Equipment and Testing Expertise

  • Expertise in Raman Spectroscopy.
  • Expertise in Surface Plasmon Resonance.

Languages

  • Danish, fluent.
  • English, fluent.
  • German, fluent.

Geographical Regions of Interest

  • Canada
  • Denmark
  • Germany