MICHAEL D VERSHININ portrait
  • Adjunct Assistant Professor, Biology
  • Assistant Professor, Physics And Astronomy

Research Statement

My work is centered on understanding biological processes across many scales, from atomic and molecular scale up to the scale of living systems. More specifically, I am interested in quantitatively elucidating how molecular processes associated with cytoskeletal proteins give rise to related cellular structure and function. It is now possible to map out the cytoskeleton and associated proteins in a given cell with nanoscale precision via either electron microscopy or super-resolution fluorescence-based studies. However a top-down deconstruction of a cell is insufficient to understand the underlying interactions and overall dynamics. My lab has a vision of surmounting the key hurdle to further progress by experimentally modeling increasing level of complexity from the bottom up without sacrificing experimental control and precision.

Research Keywords

  • single molecule assays
  • optical trapping
  • Molecular Motors
  • Cytoskeleton

Research Equipment and Testing Expertise

  • Holographic and ordinary optical trapping. Custom setup. Contact: Michael Vershinin , 801-581-5803 , JFB 307.

Publications

  • Hong W, Takshak A, Osunbayo O, Kunwar A & Vershinin M (2016). The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors. Biophysical journal. Vol. 111, 1287-94. Published, 09/01/2016.
  • Scherer J, Yaffe ZA, Vershinin M & Enquist LW (2016). Dual-color Herpesvirus Capsids Discriminate Inoculum from Progeny and Reveal Axonal Transport Dynamics. Journal of virology. In press, 09/01/2016.
  • Hong W, Takshak A, Osunbayo O, Kunwar A & Vershinin M (2016). The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors. Biophysical journal. Vol. 111, 1287-94. Published, 09/01/2016.
  • Scherer J, Yaffe ZA, Vershinin M & Enquist LW (2016). Dual-color Herpesvirus Capsids Discriminate Inoculum from Progeny and Reveal Axonal Transport Dynamics. Journal of virology. In press, 09/01/2016.
  • DOI: 10.1117/2.1201608.006690. Published, 08/26/2016.
    http://spie.org/newsroom/6690-custom-complex-3d-mi...
  • J. Bergman, O. Osunbayo, M. Vershinin, “Constructing 3D microtubule networks using holographic optical trapping”, Sci Rep. 5:18085 (2015). Published, 12/10/2015.
  • O. Osunbayo, J. Butterfield, J. Bergman, L. Mershon, V. Rodionov, M. Vershinin, “Cargo Transport at Microtubule Crossings: Evidence for Prolonged Tug-of-War between Kinesin Motors”, Biophys J. 108:1480-3 (2015). Published, 03/24/2015.
  • T.E. Smith, W. Hong, M.M. Zachariah, M.K. Harper, T.K. Matainaho, R.M. Van Wagoner, C.M. Ireland, Michael Vershinin, “Single Molecule Inhibition of Human Kinesin 5A by Adociasulfates-13 and -14 from the Sponge Cladocroce aculeate”, Proc Natl Acad Sci USA.110: 18880-5 (2013) Co-primary authors, Co-senior authors. Published, 11/2013.
  • 'Construction of a High Resolution Microscope with Conventional and Holographic Optical Trapping Capabilities', Journal of Visualized Experiments. Published, 04/2013.
  • A. Kunwar†, S.K. Tripathy†, J. Xu, M.K. Mattson, P. Anand, R. Sigua, M. Vershinin, R.J. McKenney, C.C. Yu, A. Mogilner‡, S.P. Gross‡ “Mechanical Stochastic Tug-of-war Models Cannot Explain Bi-directional Lipid droplet Transport”, Proc Natl Acad Sci U S A. 108:18960-5 (2011) †co-primary authors. ‡co-senior authors. Published, 09/15/2011.
  • "Mechanical Stochastic Tug-of-war Models Cannot Explain Bi-directional Lipid droplet Transport", Proc. Natl. Acad. Sci. USA. 108:18960-5 (2011). Published, 01/2011.
  • "High-resolution imaging reveals indirect coordintion of opposite motors and a role for lIS1 in high-load axonal transport", J. Cell Biol. 195:193-201 (2011). Published, 01/2011.
  • "LIS1 and NudE Induce a Persistent Dynein Force-Producing State", Cell 141:304 (2010). Published, 01/2010.