JON D RAINIER portrait
  • Adjunct Professor, Ophthalmology & Visual Science
  • Professor, Chemistry


  • Dai, C. & 1. Dai, C.; Zhao, X.; Song, C.; Schwartz, Z. Rainier, J.D. (2021). Biphenyl Cyclobutenone Photoelectrocyclizations. Journal of Organic Chemistry. Vol. 86, 15164-15176. Published, 10/01/2021.
  • Zhou, X. & Zhao, X.; Rainier, J. D. (2021). The Synthesis of Conjugated Bis-Aryl Vinyl Substrates and Their Photoelectrocyclization Reactions Towards Phenanthrene Derivatives. Synthesis. Vol. 53, 1200-1212. Published, 03/01/2021.
  • Yin, Jinya & Rainier, Jon D. (2021). The one-pot synthesis of amidonapthoquinones from aminonaphthoquinones. Tetrahedron Letters. Vol. 61. Published, 02/04/2021.
  • Wade, A. & 2. Wade, A.; Rallabandi, R.; Lucas, S.; Oberg, C.; Gorusupudi, A.; Bernstein, P.S.; Rainier, J.D. (2021). The synthesis of the very long chain polyunsaturated fatty acid (VLC-PUFA) 32:6 n-3. Org. Biomol. Chem. Vol. 19, 5563-5566. Published, 02/01/2021.
  • Gorusupudi, A. & 3. Gorusupudi, A.; Rallabandi, R.; Cheng, V.; Lucas, S.; Rognan, G.; Wade, A.; Rainier, J.D.; Conboy, J.C.; Bernstein, P.W. (2021). Retinal Bioavailability and Membrane Biophysics of a Synthetic Retinal Bioavailability and Membrane Biophysics of a Synthetic VLC-PUFA. Proc. Natl. Acad. Sci. Vol. 118, e2017739118. Published, 02/01/2021.
  • Zhao, Xuchen, Song, Changqing & Rainier, Jon D. (2020). Photoelectrocyclization Reactions of Conjugated Cycloalkenones: Scope and Reactivity. Journal of Organic Chemistry. Vol. 85, 5449-5463. Published, 03/16/2020.
  • Yin, Jinya, Landward, Michael B. & Rainier, Jon D. (2020). Photoelectrocyclization Reactions of Amidonaphthoquinones. Journal of Organic Chemistry. Vol. 85, 4298-4311. Published, 02/19/2020.
  • Zhao, Xuchen, Song, Changqing & Rainier, Jon D. (2019). Stereodivergent Photoelectrocyclization Reactions of Bis-aryl Cycloalkenones: Intercepting Photoelectrocyclization Intermediates with Acid. Organic Letters. Vol. 21, 8611-8614. Published, 10/17/2019.
  • Kumar, Sandeep, Nakashizuka, Hiroyuki, Jones, Alex, Lambert, Alyssia, Zhao, Xuchen, Shen, Megan, Parker, Mackenzie, Wang, Shixian, Berriochoa, Zachary, Fnu, Amrita, VanBeuge, Stephanie, Chevez-Barrios, Patricia, Tso, Mark, Rainier, Jon D. & Fu, Yingbin (2017). Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. The American Journal of Pathology. Vol. 187, 2841-2857. Published, 09/21/2017.
  • Xuchen, Zhang & Rainier, Jon D. (2017). Pyridone photoelectrocyclizations to pyridophenanthrenes. Tetrahedon. Vol. 73, 4786-4789. Published, 08/10/2017.
  • Martinez-Morales, Evelyn, Kopljar, Ivan, Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J. & Labro, Alain, J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon. Vol. 120, 57-60. Published, 09/15/2016.
  • Zhang, Tao, Cao, Li-Hui, Kumar, Sandeep, Enemchukwu, Nduka O., Zhang, Ning, Lambert, Alyssia, Zhao, Xuchen, Jones, Alex, Wang, Shixian, Dennis, Emily M., Fnu, Amrita, Ham, Sam, Rainier, Jon D., Yau, King-Wai & Fu, Yingbin (2016). Dimerization of visual pigments in vivo. PNAS. Vol. 113, 9093-9098. Published, 08/09/2016.
  • Koplijar, Ivan, Grottesi, Alessandro, De Block, Tessa, Rainier, Jon D., Tytgat, Jan, Labro, Alain, J. & Snyders, Dirk J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. Vol. 107, 160-167. Published, 08/01/2016.
  • Zhang, Yuan & Rainier, Jon D. (2016). Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin. The Journal of Antibiotics. Vol. 69, 259-272. Published, 03/09/2016.
  • Rocha, Danilo. D, Espejo, Vinson R. , Rainier, Jon D., La Clair, James J., Costa-Lotufo & Leticia V. (2015). Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging. Life Sciences Magazine. Vol. 136, 163-167. Published, 09/01/2015.
  • Wang, J.; Rainier, J.D. “Reactivity of Vinyl Phosphonate Containing Diazoesters: Formation, Reactivity, and Utility,” Org. Lett. 2015, 17, 266. Published, 01/2015.
  • Cao, Z.; Cui, Y.; Busse, E.; Mehrotra, S.; Rainier, J.D.; Murray, T.F. “Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ Oscillations in cerebrocortical neurons,” J. Pharmacol. Exp. Therap. 2014, 350, 615. Published, 03/2014.
  • Jana, S.; Rainier, J.D. “The Synthesis of Indoline and Benzofuran Scaffolds Using a Suzuki-Miyaura Coupling/Oxidative Cyclization Strategy,” Org. Lett. 2013, 15, 4426. Published, 09/06/2013.
  • Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. “The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state” J. Gen. Physiol. 2013, 141, 359. Published, 02/2013.
  • Gautam, M.; Benson, C.J.; Rainier, J. D.; Light, A.R.; Sluka, K.A. “ASICs do not play a role in maintaining hyperalgesia induced by repeated intramuscular acid injections,” Pain Res. Treat. 2012, 817347, 9 pp. Published, 01/01/2012.
  • Espejo, V.R.; Rainier, J.D. “Total Synthesis of Kapakahine E and F” Isr. J. Chem. 2011, 51, 473-482. Published, 03/01/2011.
  • Wang, J.; Rainier, J.D. “Vinyl Diazophosphonates as Precursors to Highly Substituted Indolines and Cyclopentenes,” Org. Lett. 2011, 13, 700-702. Published, 03/01/2011.
  • Zhang, Y.; Rohanna, J.R.; Zhou, J.; Iyer, K.; Rainier, J.D. “Total Synthesis of Brevenal,” J. Am. Chem. Soc. 2011 133, 3208-3216. Published, 02/01/2011.

Research Statement

Our primary interest lies in the field of chemical synthesis. Within this discipline, we are particularly facinated by the interplay between structure (biological activity), total synthesis, and reaction development.

Research Keywords

  • organic synthesis
  • medicinal chemistry
  • ion channels
  • Drug Delivery Systems
  • Age related macular degeneration


  • Gordon Research Conference on Stereochemistry, July 29, 2012, RI. Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level,” Rainier, J. D . Invited Talk/Keynote, Accepted, 07/29/2012.
  • VIIth U.S.-Japan Seminar on Marine Natural Products: Cross-Disciplinary Expansions in Marine Bioorganic Chemistry; Okinawa, Japan; Dec. 11-16, 2011; Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 12/16/2011.
  • EESF-COST High-Level Research Conference on Natural Products Chemistry, Biology and Medicine; Acquafredda di Maratea, Italy; Aug. 28-Sep. 2, 2011; Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 09/02/2011.
  • Oregon State University, Corvallis, OR; March 10, 2011. “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 03/10/2011.

Research Groups

  • Minh Nguyen, Graduate Student. Chemistry. 10/2014 - present.
  • Tsz Ho Tsang, Graduate Student. Chemistry. 09/2011 - present.
  • Ramesh Rallabandi, Graduate Student. Chemistry. 09/2011 - present.

Research/Scholarship Projects

  • Therapies targeting diseases of the eye. PI: Ying Bin Fu. Co-PI(s): Jon Rainier. 06/01/2011 - present.

Research Equipment and Testing Expertise

  • Small molecule synthesis, chromatography, NMR. Contact: Jon Rainier , 801-581-4954 .