Publications

• Dai, C. & 1. Dai, C.; Zhao, X.; Song, C.; Schwartz, Z. Rainier, J.D. (2021). Biphenyl Cyclobutenone Photoelectrocyclizations. Journal of Organic Chemistry. Vol. 86, 15164-15176. Published, 10/01/2021.
• Zhou, X. & Zhao, X.; Rainier, J. D. (2021). The Synthesis of Conjugated Bis-Aryl Vinyl Substrates and Their Photoelectrocyclization Reactions Towards Phenanthrene Derivatives. Synthesis. Vol. 53, 1200-1212. Published, 03/01/2021.
• Yin, Jinya & Rainier, Jon D. (2021). The one-pot synthesis of amidonapthoquinones from aminonaphthoquinones. Tetrahedron Letters. Vol. 61. Published, 02/04/2021.
  https://doi.org/10.1016/j.tetlet.2020.151800
• Wade, A. & 2. Wade, A.; Rallabandi, R.; Lucas, S.; Oberg, C.; Gorusupudi, A.; Bernstein, P.S.; Rainier, J.D. (2021). The synthesis of the very long chain polyunsaturated fatty acid (VLC-PUFA) 32:6 n-3. Org. Biomol. Chem. Vol. 19, 5563-5566. Published, 02/01/2021.
• Gorusupudi, A. & 3. Gorusupudi, A.; Rallabandi, R.; Cheng, V.; Lucas, S.; Rognan, G.; Wade, A.; Rainier, J.D.; Conboy, J.C.; Bernstein, P.W. (2021). Retinal Bioavailability and Membrane Biophysics of a Synthetic Retinal Bioavailability and Membrane Biophysics of a Synthetic VLC-PUFA. Proc. Natl. Acad. Sci. Vol. 118, e2017739118. Published, 02/01/2021.
• Zhao, Xuchen, Song, Changqing & Rainier, Jon D. (2020). Photoelectrocyclization Reactions of Conjugated Cycloalkenones: Scope and Reactivity. Journal of Organic Chemistry. Vol. 85, 5449-5463. Published, 03/16/2020.
  https://doi.org/10.1021/acs.joc.0c00197
• Yin, Jinya, Landward, Michael B. & Rainier, Jon D. (2020). Photoelectrocyclization Reactions of Amidonaphthoquinones. Journal of Organic Chemistry. Vol. 85, 4298-4311. Published, 02/19/2020.
  https://doi.org/10.1021/acs.joc.9b03417
• Zhao, Xuchen, Song, Changqing & Rainier, Jon D. (2019). Stereodivergent Photoelectrocyclization Reactions of Bis-aryl Cycloalkenones: Intercepting Photoelectrocyclization Intermediates with Acid. Organic Letters. Vol. 21, 8611-8614. Published, 10/17/2019.
  https://doi.org/10.1021/acs.orglett.9b03214
• Kumar, Sandeep, Nakashizuka, Hiroyuki, Jones, Alex, Lambert, Alyssia, Zhao, Xuchen, Shen, Megan, Parker, Mackenzie, Wang, Shixian, Berriochoa, Zachary, Fnu, Amrita, VanBeuge, Stephanie, Chevez-Barrios, Patricia, Tso, Mark, Rainier, Jon D. & Fu, Yingbin (2017). Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. The American Journal of Pathology. Vol. 187, 2841-2857. Published, 09/21/2017.
  https://doi.org/10.1016/j.ajpath.2017.08.025
• Xuchen, Zhang & Rainier, Jon D. (2017). Pyridone photoelectrocyclizations to pyridophenanthrenes. Tetrahedon. Vol. 73, 4786-4789. Published, 08/10/2017.
  https://doi.org/10.1016/j.tet.2017.06.062
• Martinez-Morales, Evelyn, Kopljar, Ivan, Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J. & Labro, Alain, J. (2016). Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K+ pore. Toxicon. Vol. 120, 57-60. Published, 09/15/2016.
  https://doi.org/10.1016/j.toxicon.2016.07.017
• Zhang, Tao, Cao, Li-Hui, Kumar, Sandeep, Enemchukwu, Nduka O., Zhang, Ning, Lambert, Alyssia, Zhao, Xuchen, Jones, Alex, Wang, Shixian, Dennis, Emily M., Fnu, Amrita, Ham, Sam, Rainier, Jon D., Yau, King-Wai & Fu, Yingbin (2016). Dimerization of visual pigments in vivo. PNAS. Vol. 113, 9093-9098. Published, 08/09/2016.
  https://doi.org/10.1073/pnas.1609018113
• Koplijar, Ivan, Grottesi, Alessandro, De Block, Tessa, Rainier, Jon D., Tytgat, Jan, Labro, Alain, J. & Snyders, Dirk J. (2016). Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. Vol. 107, 160-167. Published, 08/01/2016.
• Zhang, Yuan & Rainier, Jon D. (2016). Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin. The Journal of Antibiotics. Vol. 69, 259-272. Published, 03/09/2016.
  https://doi.org/10.1038/ja.2016.18
• Rocha, Danilo. D, Espejo, Vinson R. , Rainier, Jon D., La Clair, James J., Costa-Lotufo & Leticia V. (2015). Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging. Life Sciences Magazine. Vol. 136, 163-167. Published, 09/01/2015.
  https://doi.org/10.1016/j.lfs.2015.06.014
• Wang, J.; Rainier, J.D. “Reactivity of Vinyl Phosphonate Containing Diazoesters: Formation, Reactivity, and Utility,” Org. Lett. 2015, 17, 266. Published, 01/2015.
• Cao, Z.; Cui, Y.; Busse, E.; Mehrotra, S.; Rainier, J.D.; Murray, T.F. “Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca²⁺ Oscillations in cerebrocortical neurons,” J. Pharmacol. Exp. Therap. 2014, 350, 615. Published, 03/2014.
• Jana, S.; Rainier, J.D. “The Synthesis of Indoline and Benzofuran Scaffolds Using a Suzuki-Miyaura Coupling/Oxidative Cyclization Strategy,” Org. Lett. 2013, 15, 4426. Published, 09/06/2013.
  http://www.pubs.acs.org/doi/abs/10.1021/ol401974v
• Kopljar, I.; Labro, A.J.; de Block, T.; Rainier, J.D.; Tytgat, J.; Snyders, D.J. “The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state” J. Gen. Physiol. 2013, 141, 359. Published, 02/2013.
  http://jgp.rupress.org/content/141/3/359.abstract
• Gautam, M.; Benson, C.J.; Rainier, J. D.; Light, A.R.; Sluka, K.A. “ASICs do not play a role in maintaining hyperalgesia induced by repeated intramuscular acid injections,” Pain Res. Treat. 2012, 817347, 9 pp. Published, 01/01/2012.
• Espejo, V.R.; Rainier, J.D. “Total Synthesis of Kapakahine E and F” Isr. J. Chem. 2011, 51, 473-482. Published, 03/01/2011.
• Wang, J.; Rainier, J.D. “Vinyl Diazophosphonates as Precursors to Highly Substituted Indolines and Cyclopentenes,” Org. Lett. 2011, 13, 700-702. Published, 03/01/2011.
• Zhang, Y.; Rohanna, J.R.; Zhou, J.; Iyer, K.; Rainier, J.D. “Total Synthesis of Brevenal,” J. Am. Chem. Soc. 2011 133, 3208-3216. Published, 02/01/2011.

Research Statement

Research Keywords

• organic synthesis
• medicinal chemistry
• ion channels
• Drug Delivery Systems
• Age related macular degeneration

Presentations

• Gordon Research Conference on Stereochemistry, July 29, 2012, RI. Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level,” Rainier, J. D . Invited Talk/Keynote, Accepted, 07/29/2012.
• VIIth U.S.-Japan Seminar on Marine Natural Products: Cross-Disciplinary Expansions in Marine Bioorganic Chemistry; Okinawa, Japan; Dec. 11-16, 2011; Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 12/16/2011.
• EESF-COST High-Level Research Conference on Natural Products Chemistry, Biology and Medicine; Acquafredda di Maratea, Italy; Aug. 28-Sep. 2, 2011; Invited Lecture: “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 09/02/2011.
• Oregon State University, Corvallis, OR; March 10, 2011. “Targeting Heterocyclic Natural Products at 4700 Feet Above Sea Level” . Invited Talk/Keynote, Presented, 03/10/2011.

Research Groups

• Minh Nguyen, Graduate Student. Chemistry. 10/2014 - present.
• Tsz Ho Tsang, Graduate Student. Chemistry. 09/2011 - present.
• Ramesh Rallabandi, Graduate Student. Chemistry. 09/2011 - present.

Research/Scholarship Projects

• Therapies targeting diseases of the eye. PI: Ying Bin Fu. Co-PI(s): Jon Rainier. 06/01/2011 - present.

Research Equipment and Testing Expertise

• Small molecule synthesis, chromatography, NMR. Contact: Jon Rainier , 801-581-4954 .