Publications

  • Russelburg LP, O'Shea Murray VL, Demir M, Knutsen KR, Sehgal SL, Cao S, David SS, Horvath MP. Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY. ACS Chem Biol. 2020;15(1):93-102. Epub 2019/12/13. doi: 10.1021/acschembio.9b00639. PubMed PMID: 31829624. Published, 12/2019.
  • Yuen PK & Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS. (2018). Targeting Base Excision Repair Glycosylases with DNA containing Transition State Mimics prepared via Click Chemistry. [Website/Blog]. Published, 12/2018.
  • Shyam R, Gorusupudi A, Nelson K, Horvath MP & Bernstein PS (2017). RPE65 has an additional function as the lutein tomeso-zeaxanthin isomerase in the vertebrate eye. Proceedings of the National Academy of Sciences of the United States of America. Vol. 114, 10882-10887. Published, 10/01/2017.
  • Shyam R & Gorusupudi A, Nelson K, Horvath MP, Bernstein PS. (2017). RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc Natl Acad Sci USA. Vol. 114(41), 10882-7. Published, 09/2017.
  • Structure of the lutein-binding domain of human StARD3 at 1.74 Å resolution and model of a complex with lutein (2016). Acta Crystallogr F Struct Biol Commun 72: 609–618. Published, 03/01/2016.
  • Classifying neuronal subclasses of the cerebellum through constellation pharmacology (2016). J. Neurophysiol. 115: 1031–1042. Published, 02/01/2016.
  • Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases (2016). Nucleic Acids Res. 44: 801–810. Published, 01/01/2016.
  • Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Missense Mutations in EphB2. Mol Biol Evol, 32, 2657-2664. Published, 10/2015.
  • Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution. Brain Behav Evol, 86, 58-74. Published, 09/2015.
  • Olivera, B.M., Safavi-Hemami, H., Horvath, M.P. and Teichert, R.W. (2015) In Baker, B. J. (ed.), Marine Biomedicine: From Beach to Bedside. CRC Press, Boca Raton, FL (USA), pp. 461-495. Published, 06/2015.
  • Teichert, R.W., Olivera, B.M., McIntosh, J.M., Bulaj, G. and Horvath, M.P. (2015) In King, G. F. (ed.), Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics. The Royal Society of Chemistry, Cambridge, UK, pp. 163-203. Published, 04/2015.
  • R.W. Teichert, B.M. Olivera, J.M. McIntosh, G. Bulaj and M.P. Horvath, The molecular diversity of conoidean venom peptides and their targets: From basic research to therapeutic applications. In Venoms to Drugs, King, G. F., Ed. RCS publishing: Cambridge UK, 2015. Published, 01/01/2015.
  • R.J. Platt, K.J. Curtice, V.D. Twede, M. Watkins, P. Gruszczynski, G. Bulaj, M.P. Horvath and B.M. Olivera, From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes, Toxicon, 2014, 81, 67-79. Published, 04/01/2014.

Research Statement

X-ray crystallography, isothermal titration calorimetry, spectroscopy, protein engineering, molecular evolution

Presentations

  • Sonia Ling Sehgal, MP Horvath (August 2019) Improving Expression in Lost City MutY DNA Repair Enzymes. Undergraduate Research Scholars, SBS 2019 Science Retreat & Gordon Lark Symposium, University of Utah, Salt Lake City, USA. Poster, Presented, 08/2019.
  • Karina Cedeno, MP Horvath (April 2019) Alpha-9 nicotinic acetylcholine receptor, a non-opioid target for treatment of chronic neuropathic pain. Undergraduate Research Symposium, University of Utah, Salt Lake City, USA. Poster, Presented, 04/2019.
  • Malika Kadirova, MP Horvath Structure determination for lutein-complexed proteins in the human eye. Undergraduate Research Symposium, University of Utah, Salt Lake City, USA. Poster, Presented, 04/2018.
  • Mechanism and evolution of the DNA repair enzyme MutY. Understanding Biology Through Structure Symposium, Santa Fe, New Mexico, 13-16 May 2017. Poster, Presented, 05/13/2017.
  • Cecily T. Bader, Sieburth LE and MP Horvath The response of Arabidopsis mutant bps 1-2 on salt media. Undergraduate Research Symposium, University of Utah, Salt Lake City, USA. Poster, Presented, 04/2017.
  • Kacey A. Davis and MP Horvath Predatory Marine Snail Toxins: a Study of Protein Folds. Utah Conference for Undergraduate Research (UCUR), Utah Valley University, American Fork, Utah, USA. Poster, Presented, 02/2016.
  • Alexander M. Cao and M.P. Horvath (April 2015) Refolding of protein domains derived from the NMDA receptor, National Conference for Undergraduate Research, Eastern Washington University, Spokane Washington, USA. Poster, Presented, 08/2015.
  • Alexander M. Cao and M.P. Horvath (March 2015) Refolding of protein domains derived from the NMDA receptor, University of Utah Undergraduate Symposium, Salt Lake City Utah, USA. Poster, Presented, 06/2015.
  • Alyssa I. Fredbo and M.P. Horvath (April 2015) Bacterial expression of predatory cone snail toxins to identify potential novel therapeutic drugs, National Conference for Undergraduate Research, Eastern Washington University, Spokane Washington, USA. Poster, Presented, 06/2015.
  • Sara Lee, Gabe Zharov & MP Horvath. Modifying StARD3 protein for tagless expression in bacteria. High School Poster Session. Poster, Presented, 07/31/2014.
  • MP Horvath, B Li, H Sharifzadeh and PS Bernstein (June 2014) Electron density difference maps calculated for an ocular carotenoid-binding protein GSTP1. (June 2014) Northwest crystallography workshop, Oregon State University, Corvallis Oregon, USA. Poster, Presented, 06/20/2014.
  • Challenges in Crystallography. Informal seminar discussion presented at the University of Oregon, Department of Biochemistry, Biophysics & Molecular Biology. Contributed Talk, Presented, 06/19/2014.
  • Bianca E. Rich and M.P. Horvath (April 2014) Toward crystallizing proteins from NMDA receptor in complex with toxins from marine snails, National Conference for Undergraduate Research, University of Kentucky, Lexington Kentucky, USA. Poster, Presented, 04/03/2014.
  • Sara L. Mann and M.P. Horvath (April 2014) Purification and characterization of aryl alcohol dehydrogenase, a detoxification enzyme found in the gut of woodrats that eat a poison diet, University of Utah Undergraduate Symposium, Salt Lake City Utah, USA . Poster, Presented, 04/01/2014.

Languages

  • French, functional.
  • Swedish, fluent.