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Dean Roland Tantin
Professor, University of Utah, Pathology
Research Summary: Dean Tantin is a Professor in the Department of Pathology at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute. Tantin studies the regulation of gene expression and its relationship to immune and stem cell function, and malignancy. He focuses on a class of transcription factors that has been tied to cellular reprogramming and immune function. Examples of these proteins are Oc...
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Mahesh B. Chandrasekharan
Assistant Professor, University of Utah, Radiation Oncology
Research Summary: Dr. Chandrasekharan received his PhD in Biology in 2001 from Texas A&M University, College Station, TX. He was a post-doctoral fellow at Vanderbilt University Medical Center in Nashville, TN in Dr. Zu-Wen Sun's lab until 2011. He is currently an Assistant Professor in the Department of Radiation Oncology, and Investigator at Huntsman Cancer Institute, and a member of the Nuclear Control of Cell Growth and Differentiation program.Dr. Chandrasekharan was awarded MS...
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Bethany Anne Buck
Associate Member, University of Utah, Huntsman Cancer Institute
Adjunct Associate Professor, Department Of Biochemistry
Associate Professor, Chemistry
Director, Biological Chemistry Program, University of Utah
Research Summary: Our research utilizes in vitro biophysical/biochemical and in cell genomics approaches to delineate the mechanisms by which the ZBTB family of methyl-CpG binding proteins (MBPs) recognize their DNA and protein targets to regulate cancer relevant transcription. Mounting evidence indicates that ZBTB MBP transcriptional activities mediate cancer progression, however, detailed mechanistic insight for DNA recognition and subsequent transcription regulated by each protein remains to be examined.
Equipment:
Biomolecular NMR
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MICHAEL STEPHEN WERNER
Assistant Professor, School Of Biological Sciences
Research Summary: My lab is primarily interested in a simple yet poorly understood question: How does the environment affect phenotype? We use a suite of methods ranging from chromatin biochemistry to epigenomics to investigate the mechanisms of phenotypic plasticity, and how it facilitates evolutionary innovation. Our primary study system is the Pristionchus genus of nematodes, which exhibit predatory or bacterivorous morphs depending on the environment, and provide a powerful genetic and phylogenetic toolkit.
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Bradley R. Cairns
Professor, University of Utah, Oncological Sciences
Adjunct Professor, University of Utah, Biochemistry
Research Summary: Biography: Dr. Brad Cairns received his B.S. (Honors) in Chemistry from Lewis and Clark College in Portland, Oregon in 1987. He conducted his graduate work at Stanford with Nobel Laureate Roger Kornberg's Ph.D. on characterizing signal transduction and purifying chromatin remodeling complexes. He received his Ph.D. in Cell Biology from Stanford in 1996, and conducted postdoctoral training in chromatin remodeling at Stanford (Fellowship, American Cancer Society)...
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GARY N DREWS
Professor Emeritus, School Of Biological Sciences
Research Summary: Our lab studies the molecular genetics of seed development. Our current focus is on development of the endosperm. Endosperm is an important component of the seed because it provides nutrients and developmental signals to the embryo during seed development. Furthermore, endosperm is an important source of food, feed, and industrial raw materials. Approximately two-thirds of human calories are derived from endosperm.
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CHAN YUL YOO
Assistant Professor, School Of Biological Sciences
Research Summary: Photobodies are photoreceptors-containing biomolecular condensates that sense light and regulate almost every facet of plant growth and development. Our lab is interested in understanding fundamental functions of photobodies in reprogramming plant growth, development, and chloroplast biogenesis. We particularly focus on the role of photobodies as developmental and environmental sensors in nucleus-chloroplast communication to orchestrate transcriptional regulation in nuclear and plastid genomes.