Publications

• Graff S.M., Nakhe A.Y., Dadi P.K., Dickerson M.T., Dobson J.R., Zaborska K.E., Ibsen C.E., Butterworth R.B., Vierra N.C. & Jacobson D.A. (2024). TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet. Vol. 43. Cell Reports. Published, 01/23/2024.
• Casas M., Murray K.D., Hino K., Vierra N.C., Simó S., Trimmer J.S., Dixon R.E. & Dickson E.J. (2023). NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Vol. 14. Nature Communications. Published, 12/01/2023.
• Vierra N.C., Ribeiro-Silva L., Kirmiz M., van der List D., Bhandari P., Mack O.A., Carroll J., Le Monnier E., Aicher S.A., Shigemoto R. & Trimmer J.S. (2023). Neuronal ER-plasma membrane junctions couple excitation to Ca²⁺-activated PKA signaling. Vol. 14. Nature Communications. Published, 12/01/2023.
• Matsumoto C., O’Dwyer S.C., Manning D., Hernandez-Hernandez G., Rhana P., Fong Z., Sato D., Clancy C.E., Vierra N.C., Trimmer J.S. & Fernando Santana L. (2023). The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Vol. 6. Communications Biology. Published, 12/01/2023.
• Vierra N.C. & Trimmer J.S. (2022). Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function. Vol. 23. International Journal of Molecular Sciences. Published, 02/01/2022.
• Vierra N.C., O'Dwyer S.C., Matsumoto C., Fernando Santana L. & Trimmer J.S. (2021). Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM junctions. Vol. 118. Proceedings of the National Academy of Sciences of the United States of America. Published, 11/16/2021.
• Hawkins N.A., Misra S.N., Jurado M., Kang S.K., Vierra N.C., Nguyen K., Wren L., George A.L., Trimmer J.S. & Kearney J.A. (2021). Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Vol. 147. Neurobiology of Disease. Published, 01/01/2021.
• Vierra N.C., Kirmiz M., van der List D., Santana L.F. & Trimmer J.S. (2019). KV2.1 mediates spatial and functional coupling of l-type calcium channels and ryanodine receptors in mammalian neurons. Vol. 8. eLife. Published, 10/01/2019.
• Dickerson X.M.T., Dadi P.K., Altman M.K., Verlage K.R., Thorson A.S., Jordan X.K.L., Vierra N.C., Amarnath G. & Jacobson D.A. (2019). Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion. (pp. E646-E659). Vol. 316. American Journal of Physiology - Endocrinology and Metabolism. Published, 01/01/2019.
• Kirmiz M., Vierra N.C., Palacio S. & Trimmer J.S. (2018). Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum–plasma membrane junctions in mammalian brain neurons. (pp. 7562-7584). Vol. 38. Journal of Neuroscience. Published, 08/29/2018.
• Vierra N.C., Dickerson M.T., Jordan K.L., Dadi P.K., Kadare K.A., Altman M.K., Milian S.C. & Jacobson D.A. (2018). TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. (pp. 84-97). Vol. 9. Molecular Metabolism. Published, 03/01/2018.
• Fine N.H.F., Doig C.L., Elhassan Y.S., Vierra N.C., Marchetti P., Bugliani M., Nano R., Piemonti L., Rutter G.A., Jacobson D.A., Lavery G.G. & Hodson D.J. (2018). Glucocorticoids reprogram b-cell signaling to preserve insulin secretion. (pp. 278-290). Vol. 67. Diabetes. Published, 02/01/2018.
• Vierra N.C., Dickerson M.T., Philipson L.H. & Jacobson D.A. (2018). Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca²⁺ Influx to Assess the Role of Potassium Channels on β-Cell Function. (pp. 73-84). Vol. 1684, Methods in Molecular Biology. Published, 01/01/2018.
• Vierra N.C., Dadi P.K., Milian S.C., Dickerson M.T., Jordan K.L., Gilon P. & Jacobson D.A. (2017). TALK-1 channels control β cell endoplasmic reticulum Ca²⁺ homeostasis. Vol. 10. Science Signaling. Published, 09/19/2017.
• Dickerson M.T., Vierra N.C., Milian S.C., Dadi P.K. & Jacobson D.A. (2017). Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β- Cells. Vol. 12. PLoS ONE. Published, 04/01/2017.
• Dadi P.K., Vierra N.C., Days E., Dickerson M.T., Vinson P.N., Weaver C.D. & Jacobson D.A. (2017). Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. (pp. 558-568). Vol. 8. ACS Chemical Neuroscience. Published, 03/15/2017.
• Zhu L., Almaça J., Dadi P.K., Hong H., Sakamoto W., Rossi M., Lee R.J., Vierra N.C., Lu H., Cui Y., McMillin S.M., Perry N.A., Gurevich V.V., Lee A., Kuo B., Leapman R.D., Matschinsky F.M., Doliba N.M., Urs N.M., Caron M.G., Jacobson D.A., Caicedo A. & Wess J. (2017). β-Arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Vol. 8. Nature Communications. Published, 02/01/2017.
• Vierra N.C., Dadi P.K., Jeong I., Dickerson M., Powell D.R. & Jacobson D.A. (2015). Type 2 diabetes-associated K⁺ channel TALK-1 modulates β-cell electrical excitability, second-phase insulin secretion, and glucose homeostasis. (pp. 3818-3828). Vol. 64. Diabetes. Published, 11/01/2015.
• Dadi P.K., Luo B., Vierra N.C. & Jacobson D.A. (2015). TASK-1 potassium channels limit pancreatic α-cell calcium influx and glucagon secretion. (pp. 777-787). Vol. 29. Molecular Endocrinology. Published, 01/01/2015.
• Dadi P.K., Vierra N.C. & Jacobson D.A. (2014). Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. (pp. 3757-3768). Vol. 155. Endocrinology (United States). Published, 10/01/2014.
• Dadi P.K., Vierra N.C., Ustione A., Piston D.W., Colbran R.J. & Jacobson D.A. (2014). Inhibition of pancreatic β-cell ca2+/calmodulin-dependent protein kinase ii reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance. (pp. 12435-12445). Vol. 289. Journal of Biological Chemistry. Published, 01/01/2014.