TINGTING HONG portrait
  • Member, Diabetes & Metabolism Research Center
  • Associate Professor, Pharmacology And Toxicology
  • Investigator, Nora Eccles Harrison Cardiovascular Research & Training Institute

Research Interests

Dr. Hong is a cardiovascular pharmacologist who is an associate professor in the Department of Pharmacology and Toxicology in the College of Pharmacy, an investigator in the Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), and a faculty member of the Diabetes & Metabolism Research Center (DMRC) at the University of Utah. Dr Hong’s research focuses on understanding the regulation and remodeling of membrane microdomains of cardiomyocytes during heart failure progression. The Hong Laboratory studies how cardiomyocyte surface microdomains are organized to concentrate ion channels and signaling proteins for proper function and regulation in normal and failing hearts. The research interested includes the mechanisms of scaffolding protein and cytoskeleton-based maintenance of membrane structures and subdomains important in calcium signaling, turnover mechanisms of microdomains, and the mechanisms of heart failure progression. The goal is to identify, at the bench, new molecular and cellular targets that can be translated to develop new diagnostic and therapeutic tools for clinical management of heart failure.

 

Publications

  • Li J, Richmond B, Cluntun AA, Bia R, Walsh MA, Shaw K, Symons JD, Franklin S, Rutter J, Funai K, Shaw RM, Hong T. Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose. JCI Insight. 2023 Sep 22;8(18). doi: 10.1172/jci.insight.166713. PubMed PMID: 37639557; PubMed Central PMCID: PMC10561727. Published, 09/22/2023.
  • Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall DJ. A canine model of chronic ischemic heart failure. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H751-H761. doi: 10.1152/ajpheart.00647.2022. Epub 2023 Mar 24. PubMed PMID: 36961487; PubMed Central PMCID: PMC10151054. Published, 06/01/2023.
  • Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RM. GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res. 2023 Mar 17;132(6):744-746. doi: 10.1161/CIRCRESAHA.122.322294. Epub 2023 Feb 22. PubMed PMID: 36927183; PubMed Central PMCID: PMC10314823. Published, 03/17/2023.
  • Balderas E, Eberhardt DR, Lee S, Pleinis JM, Sommakia S, Balynas AM, Yin X, Parker MC, Maguire CT, Cho S, Szulik MW, Bakhtina A, Bia RD, Friederich MW, Locke TM, Van Hove JLK, Drakos SG, Sancak Y, Tristani-Firouzi M, Franklin S, Rodan AR, Chaudhuri D. Author Correction: Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment. Nat Commun. 2022 Jun 20;13(1):3532. doi: 10.1038/s41467-022-31304-5. PubMed PMID: 35725853; PubMed Central PMCID: PMC9209434. Published, 06/20/2022.
  • Pacheco C, Wei J, Shufelt C, C Hitzeman T, Cook-Wiens G, Pepine CJ, Handberg E, Anderson RD, Petersen J, Hong T, M Shaw R, Bairey Merz CN. Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker. Clin Cardiol. 2021 Nov;44(11):1586-1593. doi: 10.1002/clc.23726. Epub 2021 Sep 16. PubMed PMID: 34528718; PubMed Central PMCID: PMC8571552. Published, 11/2021.
  • Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM. Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. Elife. 2021 Oct 5;10. doi: 10.7554/eLife.69207. PubMed PMID: 34608863; PubMed Central PMCID: PMC8492060. Published, 10/05/2021.
  • Shah KS, Hale Hammond ME, Drakos SG, Anderson JL, Fang JC, Knowlton KU, Shaw RM. SARS-CoV-2 as an inflammatory cardiovascular disease: current knowledge and future challenges. Future Cardiol. 2021 Oct;17(7):1277-1291. doi: 10.2217/fca-2020-0188. Epub 2021 Mar 19. Review. PubMed PMID: 33739142; PubMed Central PMCID: PMC7986052. Published, 10/2021.
  • Li J, Agvanian S, Zhou K, Shaw RM, Hong T. Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure. Front Physiol. 2020;11:708. doi: 10.3389/fphys.2020.00708. eCollection 2020. PubMed PMID: 32670093; PubMed Central PMCID: PMC7327113. Published, 12/2020.
  • Xiao S, Shimura D, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw RM. Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest. 2020 Sep 1;130(9):4858-4870. doi: 10.1172/JCI134682. PubMed PMID: 32525845; PubMed Central PMCID: PMC7456223. Published, 09/01/2020.
  • Liu Y, Zhou K, Li J, Agvanian S, Caldaruse AM, Shaw S, Hitzeman TC, Shaw RM, Hong T. In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function. JACC Basic Transl Sci. 2020 Jun;5(6):561-578. doi: 10.1016/j.jacbts.2020.03.006. eCollection 2020 Jun. PubMed PMID: 32613144; PubMed Central PMCID: PMC7315191. Published, 06/2020.