• PhD, Biomedical Engineering / Neuroscience, Washington University School of Medicine
  • Postdoctoral training, Neuroscience, Stanford University School of Medicine

Research Summary

Noninvasive, drug-free therapy for mental health. We have developed a device, called DIADEM, for noninvasive deep brain therapies with ultrasonic waves. DIADEM is being applied in patients with depression, with safe and effective outcomes. DIADEM will be applied to people with major depression, generalized anxiety, PTSD, and chronic pain.


Kubanek J., Brown J., Ye P., Butts Pauly K., Moore T., Newsome W. Transcranial ultrasound selectively biases decision-making in primates. BioRxiv 486134 (2019).

Kubanek J., Shukla P., Das A., Baccus S., Goodman M. Ultrasound elicits behavioral responses through mechanical effects on neurons and ion channels in a simple nervous system. The Journal of Neuroscience, 1458-17 (2018).

Kubanek J. Neuromodulation with transcranial focused ultrasound. Neurosurgical Focus44 (2018).

Kubanek J. Optimal decision-making and matching are tied through diminishing returns.PNAS, doi:10.1073/pnas.1703440114 (2017).

Kubanek J., Shi J., Marsh J., Chen D., Deng C., Cui J. Ultrasound modulates ion channel currents. Scientific Reports 6 (2016).

Kubanek J., Li J., Snyder L.H. Motor role of parietal cortex in a monkey model of hemi- spatial neglect. PNAS. 112, E2067-72 (2015).

Kubanek J., Snyder L.H. Reward-based Decision Signals in Parietal Cortex Are Partially Embodied. The Journal of Neuroscience, 35(12):4869–81 (2015).

Kubanek J., Snyder L.H. Reward size governs repeat-switch decisions and strongly mod- ulates the activity of neurons in parietal cortex. Cerebral Cortex (2015).

Kubanek J., Schalk G. NeuralAct: A tool to visualize electrocorticographic (ECoG) activity on a three-dimensional model of the cortex. Neuroinformatics, 13, 167-74 (2015).

Kubanek J., Snyder L.H, Abrams R.A. Rewards and punishments act as distinct factors in guiding behavior. Cognition, 139, 154–167 (2015).

Kubanek J., Snyder L.H. Matching Behavior as a Tradeoff Between Reward Maximization and Demands on Neural Computation. F1000Research (2015).

Kubanek J., Hill J., Snyder L.H, Schalk G. Cortical alpha activity reflects the degree of confidence in committing to an action. Frontiers in Neuroscience 9, 243 (2015).

Kubanek J., Snyder L.H., Brunton B.W., Brody C., Schalk G. A low frequency oscillatory neural signal in humans encodes a developing decision variable. NeuroImage, 83, 795808 (2013).

Kubanek J., Wang C., Snyder L.H. Neuronal responses to target onset in oculomotor and somatomotor parietal circuits differ markedly in a choice task. Journal of Neurophysiology110.10, 2247-2256 (2013).

Kubanek J., Brunner P., Gunduz A., Poeppel D., Schalk G. The Tracking of Speech Envelope in the Human Cortex. PLOS ONE 8, no. 1 (2013).

Kubanek J., Miller K.J., Ojemann J.G., Wolpaw J.R., Schalk G. Decoding flexion of indi- vidual fingers using electrocorticographic signals in humans. Journal of Neural Engineering, vol. 6 pp. 66001 (2009).

Schalk G., Kubanek J., Miller K.J., Anderson N., Leuthardt E.C., Ojemann J.G., Lim- brick D., Moran D., Gerhardt L.A., Wolpaw J.R. Decoding Two-Dimensional Movement Trajectories Using Electrocorticographic Signals in Humans. Journal of Neural Engineering, 4, 264-275 (2007).