Presentations

  • Thompson L, Wilson AS, Vazquez SR, Witt DM. Comparison of prolonged direct oral anticoagulant therapies for secondary venous thromboembolism prophylaxis. ASHP Mid-year Clinical Meeting, Anaheim, CA. Poster, Presented, 12/2023.
  • Jensen C, Vazquez SR, Wilson AS, Witt DM. Who are we bridging? Description of anticoagulated patients receiving injectable bridging therapy. ASHP Mid-year Clinical Meeting, Anaheim, CA. Poster, Presented, 12/2023.
  • Gilbert S, Magill A, Wilson AS, Witt DM, Jones AE. The effects of warfarin tablet strength on time in therapeutic range. 2023 American College of Clinical Pharmacy Annual Meeting, Dallas, TX. Poster, Presented, 11/2023.
  • Lam TLD, Brewster A, Johnson SA, Jones AE, Vasquez SR, Witt DM. Outcomes associated with isolated distal deep vein thrombosis: a comparative analysis of anticoagulation versus serial ultrasound monitoring. Thrombosis & Hemostasis Summit of North America, Chicago, IL. Poster, Presented, 10/2022.
  • Parks AL, Slager SL, Fang MC, Supiano MA, Katz PP, Witt DM. Focus group-guided development of a novel bleeding quality of life patient-reported outcome measure for older adults. Thrombosis & Hemostasis Summit of North America (selected as platform presentation), Chicago, IL. Presentation, Presented, 10/2022.
  • Wilson AS, Vazquez SR, Witt DM. Management of potential drug-drug interactions with nirmatrelvir-ritonavir and oral anticoagulants: a case series. Thrombosis & Hemostasis Summit of North America (selected as platform presentation), Chicago, IL. Presentation, Presented, 10/2022.
  • Wilson AS, Saunders JA, Vazquez SR, Jones AE, Fearon JM, Wegener PT, Witt DM. Feasibility Study of Patient Self-Management of Warfarin using the Fearon Algorithm. XXX Congress of the International Society of Thrombosis and Haemostasis, London, England. Poster, Presented, 07/2022.
  • Jones AE, Brewster A, Jolley M, Saunders J, Wilson A, Vazquez SR, Crowther MA, Witt DM. Real-world use of andexanet alfa for anti-Xa inhibitor reversal: a case series. XXX Congress of the International Society of Thrombosis and Haemostasis, London, England. Poster, Presented, 07/2022.
  • Chai-Adisaksopha C, Hikiji Watanabe A, Dilokthornsakul P, Navaravong L, Witt DM, Chaiyakunapruk N. Impact of pattern of anticoagulant on clinical outcomes in cancer patients who had atrial fibrillation. ISPOR 2022, Washington DC and Virtual. Poster, Presented, 05/2022.
  • Veettil SK, Harris J, Syeed MS, Thakkinstian A, Chaikledkaew U, Witt DM, Chaiyakunapruk N. Incremental net monetary benefit of direct oral anticoagulants for the prevention of venous thromboembolism after total knee or hip replacement: a systematic review and meta-analysis. ISPOR 2022, Washington DC and Virtual. Poster, Presented, 05/2022.
  • Saunders J, Vazquez SR, Jones AE, Fearon JM, Wegener P, Witt DM. Feasibility Study of the Fearon Algorithm in Warfarin Management. Anticoagulation Forum (virtual). Poster, Presented, 10/2021.
  • Lam TLD, Brewster A, Johnson SA, Jones AE, Vazquez SR, Witt DM. Outcomes associated with isolated distal deep vein thrombosis: a comparative analysis of anticoagulation vs. serial ultrasound monitoring. Anticoagulation Forum (virtual). Poster, Presented, 10/2021.
  • Jones AE, Vazquez SR, Barnes GD, Allen A, Anderson C, Woller SC, Stevens MD, Clark NP, Delate T, Crowther MA, Witt DM. Outcomes of non-bleeding patients on warfarin with an INR > 10, who received vitamin K or conservative therapy. XXIX Congress of the International Society of Thrombosis and Haemostasis (virtual). Poster, Presented, 07/2021.
  • Jones AE, Saunders JA, Vazquez SR, Fagerlin A, Witt DM. A survey of current anticoagulation patient education practices and development. XXIX Congress of the International Society of Thrombosis and Haemostasis (virtual). Poster, Presented, 07/2021.

Grants, Contracts & Research Gifts

  • Overcoming barriers to warfarin patient self-management implementation in the US healthcare system. PI: Witt DM. AHRQ, 03/2021 - present. Total project budget to date: $1,345,475.00
  • Feasibility Study of the Fearon Algorithm in Warfarin Patient Self-Management. PI: Witt DM. Roche Diagnostics, 09/2018 - 04/2021. Total project budget to date: $65,000.00
  • Atrial Fibrillation Strategically Focused Research Network PCORI –AHA/ASA DECIDE Center titled STudying Effectiveness in Patient-centered care (STEP UP). PI: Angela Fagerlin, PhD. AHA/PCORI, 07/2018 - present. Total project budget to date: $5,000,000.00
  • Management of Direct Oral Anticoagulants to Lower Adverse Events in Atrial Fibrillation (MODEL-AF). PI: Jordan King, PharmD. ARHQ, 04/2018 - present. Total project budget to date: $1,175,409.00
  • Risk of Thromboembolism and Recurrent Gastrointestinal Hemorrhage in Patients Restarting and not Restarting Warfarin (ReTREAT). PI: Witt DM. CSL/Behring, 08/2010 - 10/2012. Total project budget to date: $250,000.00
  • Nonadherence with INR Monitoring and Anticoagulant Complications. PI: Witt DM. ASHP Foundation Junior Investigator Award, 06/2010 - 06/2012. Total project budget to date: $20,000.00

Research Interests

I have been actively involved in designing and conducting research projects for more than 30 years, with the principal areas of focus being 1) documentation of the clinical and economic impact of clinical pharmacy services; 2) providing optimized management of anticoagulation therapy; and 3) providing practical evidence-based solutions to contemporary dilemmas encountered by anticoagulation therapy providers in clinical practice. I joined the faculty at the University of Utah College of Pharmacy in large part to expand anticoagulation therapy research opportunities, foster additional collaborative research relationships and teams, and expand my opportunities to mentor investigators in training. In addition, I have strong relationships with researchers from Kaiser Permanente Colorado, the Veterans Administration, McMaster University, the University of Michigan, Brigham and Women’s Hospital, and the University of Utah.

Publications

  • Hill J, Saunders JA, Vazquez S, Witt DM. Clinical outcomes associated with anti-Xa-monitored enoxaparin for venous thromboembolism prophylaxis. Pharmacotherapy 2023; Accepted for publication. Accepted, 12/2023.
  • Crowther MA, Jones AE, Witt DM. Warfarin is the preferred therapy for patients with thrombotic APS: Back to the Future. Journal of the American College of Cardiology 2023;81:31-33. Published, 01/2023.
  • Rosovsky RP, Kline-Rogers E, Lake L, Minichiello T, Piazza G, Ragheb B, Beth Waldron B, Witt DM, Moll S. Direct oral anticoagulants in obese patients with venous thromboembolism: results of an expert consensus panel. American Journal of Medicine 2023;136:523-533. Published, 01/2023.
  • Amirtabar A, Vazquez SR, Saunders JA, Witt DM. Antiplatelet therapy indication in patients also prescribed direct oral anticoagulants. Journal of Thrombosis and Thrombolysis 2023;55:185-188. Published, 01/2023.
  • Cline L, Generoso EMG, D'Apice N, Dellinger SK, Tovey A, Clark NP, Nui F, Hui R, Hale SA, Ramsey T, Pontoppidan K, Ekmekdjian H, Fink K, Witt DM, Crowther MA, Delate T. Effectiveness and safety of direct oral anticoagulants in patients with venous thromboembolism and creatinine clearance < 30 mL/min. Journal of Thrombosis and Thrombolysis 2023;55:355-364. Published, 01/2023.
  • Mangrum JS, Saunders JA, Chaiyakunapruk N, Witt DM, King JB. A scoping review of direct oral anticoagulant ambulatory management practices. Journal of Thrombosis and Thrombolysis 2023;55:700-709. Published, 01/2023.
  • Wilson AS, Slager S, Jones AE, Vazquez SR, Barnes G, Slyvester K, Chan L, Ragheb B, Witt DM. A qualitative study evaluating provider perceptions of implementing warfarin patient self-management in the United States’ healthcare system. Journal of the American College of Clinical Pharmacy 2023;6: 1295-1303. Published, 01/2023.
  • Wilson AS, Slager S, Jones AE, Vazquez SR, Barnes G, Slyvester K, Chan L, Ragheb B, Witt DM. A qualitative study exploring patient experiences and opinions of warfarin patient self-management in the US healthcare system. Journal of the American College of Clinical Pharmacy 2023; Accepted for publication. Accepted, 01/2023.
  • Derington CG, Goodrich GK, Xu S, Clark NP, Reynolds K, An J, Witt DM, Smith DH, O’Keeffe-Rosetti M, Lang DT, Ho PM, Cheetham TC, Comer AC, and King JB. Association of Direct Oral Anticoagulation Management Strategies With Clinical Outcomes for Adults With Atrial Fibrillation. JAMA Network Open 2023;6(7):e2321971. Published, 01/2023.
  • Abbinanti A, Witt DM, Saunders J, Jones AE, Young DC. Venous thromboembolism management in patients with cystic fibrosis. Pediatric Pulmonology 2023; EPub ahead of print. Accepted, 01/2023.
  • Wilson AS, Triller DM, Allen A, Burnett A, Gouveia-Pisano JA, Brenner A, Pritchard B, Medico C, Vazquez SR, Witt DM, Barnes GD. Digital dashboards for oral anticoagulation management: a literature scoping review. Journal of Thrombosis and Thrombolysis 2023; EPub ahead of print. Published, 01/2023.
  • Chai-Adisaksopha C, Watanabe AH, Dilokthornsakul P, Navaravong L, Witt DM, Chaiyakunapruk N. Impact of type of anticoagulant on clinical outcomes in cancer patients who had atrial fibrillation. Science Reports 2023;13:10937. Published, 01/2023.
  • Gamvroulas EM, Jones AE, Saunders JA, Jones TL, Witt DM. Trends in antiplatelet strategies 12-months following coronary stent placement in anticoagulated patients. BMC Cardiovascular Disorders 2023;23:117. Published, 01/2023.
  • Fleming R, Vazquez SR, Witt DM. Implementation and evaluation of a warfarin patient self-management (PSM) program among experienced patients in a US academic health system. Journal of Thrombosis and Thrombolysis 2023; Accepted for publication. Accepted, 01/2023.
  • Ballif M, Vazquez SR, Saunders J, Witt DM. Prevalence of antiphospholipid antibody syndrome misclassification in an academic health system. Thrombosis Research 2022:S0049-3848(22)00459-5. Published, 01/2022.
  • Jones AE, McCarty MM, Brito JP, Noseworthy PA, Cavanaugh KL, Cameron KA, Barnes GD, Steinberg BA, Witt DM, Crossley GH, Passman R, Kansal P, Hargraves I, Schmidt M, Jackson E, Guzman A, Ariotti A, Pershing ML, Herrick J, Montori VM, Fagerlin A, Ozanne EM; STEP-UP AFIB Writing Group. Randomized evaluation of decision support interventions for atrial fibrillation: Rationale and design of the RED-AF study. American Heart Journal 2022;248:42-52. Published, 01/2022.
  • Saunders J, Vazquez SR, Jones AE, Fearon JM, Wegener P, Wilson A, Witt DM. Feasibility study of the Fearon Algorithm in anticoagulation service guided warfarin management. Thrombosis Update 2022;7:100105. Published, 01/2022.
  • Veettil SK, Harris J, Syeed S, Thakkinstian A, Chaikledkaew U, Witt DM, Chaiyakunapruk N. Incremental net monetary benefit of direct oral anticoagulants for the prevention of venous thromboembolism after total knee or hip replacement: a systematic review and meta-analysis. Thrombosis Research 2022;216:74-83. Published, 01/2022.
  • Yao C, Jones AE, Slager S, Fagerlin A, Witt DM. Exploring clinician perspectives on patients with atrial fibrillation who are not prescribed anticoagulation therapy. PEC Innovation 2022;1:100062. Published, 01/2022.
  • Witt DM. Is It Time to Reevaluate Current International Normalized Ratio Targets for Asian Patients Following Mechanical Heart Valve Replacement? JAMA Network Open 2022;5(2):e2146034. Published, 01/2022.
  • Vazquez SR, Wilson AS, Witt DM. Management of potential drug-drug interactions with nirmatrelvir-ritonavir and oral anticoagulants: a case series. Journal of Thrombosis and Thrombolysis 2022;54:583-586. Published, 01/2022.
  • Wiercioch W, Nieuwlaat R, Dahm P, Iorio A, Mustafa RA, Neumann I, Rochwerg B, Manja V, Alonso-Coello P, Ortel TL, Santesso N, Vesely SK, Akl EA, Schünemann HJ, Bates SM, Cuker A, Lim W, Monagle P, Kunkle R, Witt DM, Kahn SR, McLintock C, Rezende SM, Zakai NA; ASH VTE Panels Working Group. Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines. Journal of Clinical Epidemiology 2021;138:115-127. Published, 01/2021.
  • Nieuwlaat R, Wiercioch W, Brozek J, Santesso N, Kunkle R, Alonso Coello P, Anderson D, Bates SM, Cushman M, Dahm P, Iorio A, Lim W, Lyman GH, Middeldorp S, Monagle P, Mustafa RA, Neumann I, Ortel T, Rochwerg B, Vesely SK, Witt DM, Cuker A, Schünemann HJ. How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines. Blood Advances 2021;5:4721-4726. Published, 01/2021.
  • Rose AJ, Witt DM, Azran C, Nissan R. Seven key parameters that facilitate clinical pharmacy practice: a comparison between Israel and the United States. Israel Journal of Health Policy Research 2021;10:37. Published, 01/2021.
  • Zang J, Wang X, Liu X, Larsen TB, Witt DM, Ye Z, Thabane L, Li G, Lip GYH. Comparative effectiveness and safety of direct acting oral anticoagulants in nonvalvular atrial fibrillation for stroke prevention: a systematic review and meta-analysis. European Journal of Epidemiology 2021;36:793-812. Published, 01/2021.
  • Jones AE, Saunders J, Vazquez S, Fagerlin A, Witt DM. A survey of current anticoagulation patient education practices and development. Thrombosis Research 2021;208:11-13. Published, 01/2021.
  • Tekarli M, Turner K, Witt D. Association between flash glucose monitors and A1C: A retrospective pre-post analysis. Innovations in Pharmacy 2021;12:Article 10. Published, 01/2021.
  • Onundarson PT, Palsson R, Witt DM, Gudmundsdottir BR. Replacement of traditional prothrombin time monitoring with the new Fiix prothrombin time increases the efficacy of warfarin without increasing bleeding. A review article. Thrombosis Journal 2021;19:72. Published, 01/2021.
  • Wilson AS, Vazquez SR, Saunders JA, Witt DM. Concordance of experienced-based maintenance warfarin dosing vs. algorithm-based dosing. Thrombosis Update 2021:6:100093. Published, 01/2021.
  • Hiatt J, Vazquez SR, Witt DM. Provider perceptions of extended venous thromboembolism prophylaxis for hospitalized medically ill patients. Thrombosis Update 2021;Epub ahead of print. Published, 01/2021.
  • Lai N, Jones AE, Johnson SA, Witt DM. Anticoagulant therapy management of venous thromboembolism recurrence occurring during anticoagulant therapy: a descriptive study. Journal of Thrombosis and Thrombolysis 2021;52:414-418. Published, 01/2021.
  • Johnson SA, Signor EA, Lappe KL, Shi J, Jenkins SL, Wikstrom SW, Kronencke RD, Hallowell D, Jones AE, Witt DM. A comparison of natural language processing to ICD-10 codes for identification and characterization of pulmonary embolism. Thrombosis Research 2021;203:190-195. Published, 01/2021.
  • Johnson SA, Jones AE, Young E, Jennings C, Simon K, Fleming RP, Witt DM. A risk-stratified approach to venous thromboembolism prophylaxis with aspirin or warfarin following total hip and knee arthroplasty: A cohort study. Thrombosis Research 2021;206:120-127. Published, 01/2021.
  • Brewster A, Jones AE, Johnson SA, Saunders JA, Witt DM. Outcomes of isolated distal thrombosis managed with serial compression ultrasonography. Thrombosis Research 2021;208:66-70. Published, 01/2021.
  • Witt DM. A better way to monitor warfarin therapy? Blood 2021;137:2713-2714. Published, 01/2021.