MICHAEL EUGENE ENGEL portrait
  • Adjunct Associate Professor, Oncological Sciences
  • Adjunct Associate Professor, Pediatrics
  • Assistant Professor, Pediatrics

Research Keywords

  • Childhood Acute Leukemia
  • Hematopoiesis

Presentations

  • Targeting LSD1 in relapsed leukemia—Molecular foundations and phase I clinical trial. Huntsman Cancer Institute-Hematologic Malignancies Disease Oriented Team Symposium, Salt Lake City, UT. , , 2017.
  • MD/PhD, is it right for me? Society for Advancing Chicanos/Hispanics and Native Americans in Science (SACNAS) National Meeting. Salt Lake City, UT. , , 2017.
  • Breaking Bad: the GFI1 transcriptional repressor complex as a therapeutic target in acute leukemia. University of Virginia School of Medicine, Charlottsville, VA. , , 2017.
  • NICD—GFI1—LSD1 axis inhibition by the LSD1 inhibitor, SP-2577, as a therapeutic strategy for relapsed/refractory T-ALL. POETIC Summer Research Conference, Canmore, Alberta, CA. , , 2017.
  • GFI1 SUMOylation and LSD1 recruitment in transcriptional control and granulocyte differentiation. Rutgers University and the Cancer Institute of New Jersey, New Brunswick, NJ. , , 2015.
  • Rational Cancer Treatment. University of Mississippi School of Medicine and Batson Children’s Hospital, Jackson, MS. , , 2015.
  • The Notch—GFI1—LSD1 axis as a therapeutic opportunity in T-ALL. University of Utah and Huntsman Cancer Institute, Hematology/Oncology Fellow Research Conference, Salt Lake City, UT. , , 2014.
  • Notch disrupts GFI1 SUMOylation to support its anti-apoptotic role in T-ALL. Center for Children’s Cancer Research “Supergroup” presentation. University of Utah and Huntsman Cancer Institute, 2013. , , 2013.
  • SUMOylation governs recruitment of epigenetic effectors to GFI1-regulated genes to control survival in T-ALL, Molecular Medicine Research Training Program Symposium, Park City, UT. , , 2013.
  • Overcoming pathologic co-dependency between Notch and GFI1 reveals a new therapeutic opportunity in T-ALL. University of Alabama-Birmingham and Children’s Hospital of Alabama, Birmingham, AL. , , 2013.
  • A role for MTG proteins in Notch signaling. Research in Progress, Huntsman Cancer Institute, Salt Lake City, UT. , , 2011.
  • Notch signaling in hematopoiesis: It gets by with a little help from a friend. Center for Children's Cancer Research "Supergroup" presentation. University of Utah and Huntsman Cancer Institute, 2011. , , 2011.
  • An unexpected role for MTG16 in Notch Signaling? New insights from new tools. Huntsman Cancer Institute-Multidisciplinary Cancer Research Retreat. Salt Lake City, UT. , , 2010.
  • MTG16 and the Notch transcription complex: New partners in hematopoietic cell fate specification. Indiana University School of Medicine and the Herman B. Wells Center for Pediatric Research, Indianapolis, IN. , , 2010.
  • A patnership between MTG16 and Notch in cell fate specification: Implications for normal and malignant hematopoiesis. Oklahoma University Health Sciences Center. Oklahoma City, OK. , , 2010.
  • Targeting the Notch transcription complex in acute myeloid leukemia pathogenesis. Medical University of South Carolina and the Hollings Cancer Institute, Charleston, SC. , , 2009.
  • MTG16 regulates Notch-dependent lineage allocation in hematopoiesis. University of Utah and the Huntsman Cancer Institute-Research Conference, Salt Lake City, UT. , , 2009.
  • Phosphorylation-mediated control of gene expression by the myeloid translocation gene protein, MTG16: Implications for hematopoietic stem cell self renewal and leukemogenesis. American Society of Pediatric Hematology/Oncology. San Francisco, CA. , , 2006.
  • Focus on the Physician-Scientist Workforce. Association of American Medical Colleges (AAMC) Learn-Serve-Lead National Meeting, Boston, MA. , , 2017.
  • Effective Scientific Communication—Moderator for opening plenary session. CFAS/ORR/GDI National Meeting, Salt Lake City, UT. , , 2016.
  • Optimizing the environment for Faculty engaged in Graduate Medical Education. Association of American Medical Colleges National Meeting. Baltimore, MD. , , 2015.
  • GFI1 SNAG domain methylation directs LSD1 recruitment to control transcription and cell fate determination in hematopoiesis. American Society of Hematology National Meeting, Orlando, FL. , , 2015.
  • Growth Factor Independence (GFI)-1 post-translational modification in hematopoietic differentiation. American Society for Pediatric Hematology/Oncology National Meeting, Chicago, IL. , , 2014.
  • LSD1 as a surrogate target for GFI1 inhibition in T-ALL, Aspen Pediatric Hematology/Oncology Research Conference—In conjunction with University of Colorado-Denver. Aspen, CO. , , 2014.
  • Myeloid translocation gene (MTG)-16 nucleocytoplasmic transport contributes to erythroid differentiation in murine erythroleukemia cells. National Institutes of Diabetes and Digestive and Kidney Diseases-Conference on non-malignant hematology, Bethesda, Maryland, USA. , , 2012.
  • Being all things to all people: An expanding role for MTG16 in hematologic malignancy. , , 2011.
  • Myeloid Translocation Gene (MTG) 16 and Notch Signaling in erythropoiesis. , , 2011.
  • Myeloid translocation gene (MTG)-16 binds intracellular domains of Notch receptors to coordinate Notch-dependent cell fate specification. American Society of Hematology National Meeting, New Orleans, LA. , , 2009.
  • Phosphorylation of the MTG16 NHR4 domain by A-kinase regulates NCoR binding and transcriptional repression, Newman Society Scientific Retreat, Nashville, TN. , , 2007.
  • MTG16-mediated transcriptional repression and NCoR interaction are regulated by A-kinase. American Association for Cancer Research, Los Angeles, CA. , , 2007.
  • Post-translational modifications of MTG16. Vanderbilt Medical Center Research Forum. 2005. Vanderbilt University Medical Center. Nashville, TN. , , 2005.
  • The role of Rho proteins in TGF-beta signaling. FASEB Summer Research Conference-Receptors and Signal Transduction. Copper Mountain, Colorado. , , 1998.
  • The Immunophilin FKBP12 Interacts with the TGF- β Type I receptor. International Symposium on Second Messengers. Nashville, TN. , , 1995.
  • Secretion and Purification of Recombinant Aprotinin Analogs from the Methylotropic Yeast Pichia Pastoris. International Symposium of the Protein Society-San Diego, CA. , , 1994.
  • Speaker, American Cancer Society, “Knowledge, Skill and Passion are not enough...mobilizing the public to support pediatric cancer research”. American Cancer Society Gala. Salt Lake City, UT. , , 2017.
  • Speaker, National Institutes of Health, “Preparing for a career as an MD/PhD trained physician-scientist”, NIH Graduate Student Career Fair. Bethesda, MD. , , 2017.
  • Speaker, Society for Advancement of Chicanos/Hispanics and Native Americans in Science, “MD/PhD, is it right for me?”. SACNAS National Meeting. Salt Lake City, UT. , , 2017.
  • Speaker, Alex's Lemonade Stand Foundation, “We must go faster; the story of a boy we might have helped". Fund raising event for Pediatric Cancer Research. , , 2016.
  • Speaker, Intercultural Cancer Council, “On being a physician-scientist: valuable lessons learned along the way”. Native American Student Mentoring Workshop, Huntsman Cancer Institute. , , 2015.
  • Speaker, Huntsman Cancer Institute, Utah High School Science Educators. , , 2014.
  • Speaker, Hyundai Hope On Wheels, Handprint Ceremony Speaker, Salt Lake City, UT. , , 2011.
  • Speaker, Hyundai Hope On Wheels, Handprint Ceremony Speaker, Nashville, TN. , , 2009.
  • Speaker, Leukemia and Lymphoma Society, Man and Woman of the year kick-off dinner "A Tale of 3 Friends". Nashville, TN. , , 2008.
  • Speaker, Leukemia and Lymphoma Society, Man and Woman of the year celebration. Nashville, TN. , , 2007.
  • Presenter, Vanderbilt University Medical Alumni Association, Medical Research, as student’s perspective. , , 2000.
  • Growth Factor Independence (GFI)-1 post-translational modifications in hematopoietic differentiation. , , 2014.
  • Mtgr1 is required for GSI-induced paneth cell differentiation. , , 2013.
  • Lamb C, McClellan D, Bareyan D, Sharma S, and Engel ME. Mechanism of action of the LSD1 inhibitor, SP-2577. Poster session presented at Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Poster, Presented, 2017.
  • Broadway J, Casey M, Bareyan D, and Engel ME. HDAC recruitment by GFI1 as a determinant of neutrophil differentiation. Poster session presented at Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Poster, Presented, 2017.
  • McDermott M, McClellan D, Velinder M, Bareyan D, Lucente H and Engel ME. LSD1 inhibitor SP-2509 effects on T-ALL cell growth reflect structural and enzymatic contributions by LSD1. Poster session presented at HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Poster, Presented, 2014.
  • Corpuz MJB, McClellan D, Singer J, Velinder M, Bareyan D, Lucente H, Maese L and Engel ME. Effect of LSD1 in hematopoiesis depends upon enzymatic and non-enzymatic functions of LSD1. Poster session presented at Undergraduate Research Symposium in Chemical and Biological Sciences, University of Maryland, Baltimore, MD. Poster, Presented, 2014.
  • Trane AL, Singer J, Bareyan D, Velinder M, McClellan D, Lucente H, Maese L, and Engel ME. Regulation of Myeloid Translocation Gene (MTG)-16 in erythropoiesis by inducible nuclear translocation. Poster session presented at Molecular Medicine and Medical School Research Retreat, Deer Valley Resort, Park City, UT. Poster, Presented, 2014.
  • Corpuz MJB, McClellan D, Singer J, Velinder M, Bareyan D, Lucente H, Maese L and Engel ME. Effect of LSD1 in hematopoiesis depends upon enzymatic and non-enzymatic functions of LSD1. Poster session presented at HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Poster, Presented, 2014.
  • Innes B, Bareyan D, Singer J, Lucente H, McClellan D, Velinder M, Engel ME. Enforced nuclear localization of MTG16 suppresses terminal erythropoiesis in murine erythroleukemia cells. Poster session presented at HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah School of Medicine, Salt Lake City, UT. Poster, Presented, 2013.
  • Fadul J, Engel ME, Lessnick S. Novel interactions of NKX2.2: A partnership with MTG16 in Ewing Sarcoma pathogenesis. Poster session presented at Society for Developmental Biology—Southwest Regional Meeting, University Guest House and Conference Center, University of Utah, Salt Lake City, UT. Poster, Presented, 2013.
  • Skaug C, Bareyan D, Singer J, Engel ME. MTG16 nucleocytoplasmic transport correlates with altered hemoglobinization of murine erythroleukemia cells. Poster session presented at HCI Summer Internship Program Research Symposium, Health Sciences Education Building, University of Utah, Salt Lake City, UT. Poster, Presented, 2012.
  • Quinton R, Bareyan D, Andrade DL, Singer J, McLellan D, Engel ME. Myeloid Translocation Gene (MTG) 16 and the Notch pathway in in vitro erythropoiesis. Poster session presented at Eccles Institute of Human Genetics, Salt Lake City, UT. Poster, Presented, 2011.

Languages

  • English, Fluent.

Publications

  • Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Chandrasekharan M, Theisen E, Liu F, Sharma S, Maese L and Engel ME (date unknown). Notch alters sumoylation to govern GFI1 protein stability and support its transcriptional repression function. Accepted, .
  • Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Chandrasekharan M, Theisen E, Liu F, Sharma S and Engel ME (date unknown). Lysine Specific Demethylase-1 inhibition as a therapeutic strategy that leverages the requirement for Growth Factor Indepndence-1 in Notch-driven T-ALL. Accepted, .
  • Andrade D, Maese L, Singer J, Bareyan D, McClellan D, Lucente H, Quinton R, Chandrasekharan M, Liu F, and Engel ME (date unknown). Sumoylation regulates the half-life of Growth Factor Independence (GFI)-1 to modulate transcriptional repression. Accepted, .
  • Andrade D, Singe J, Bareyan D, McClellan D, Lucente H, Chandrasekharan M, and Engel ME (date unknown). Notch and PIAS3 differentially regulate sumoylation of GFI1 to modulate transcriptional repression. Accepted, .
  • Andrade DL, Bareyan D, Singer J, Quinton R, Engel ME (date unknown). Regulation of GFI1 proteins by Notch intracellular domains. Accepted, .
  • Mangrum DS, Shams S, Downie J, von Schwelder U, Rodic V, Engel ME, Barnette P, Frazer JK, Trede N, Pei D, Cheng C, Mullighan C, Yang J, Miles R, Schiffman JD (date unknown). Focal 22q11.22 loss combined with IKZF1 alterations predict very poor outcome in childhood acute lymphoblastic leukemia. Accepted, .
  • Mariotti J, Nguyen HN and Engel ME (date unknown). Structure—function relationships between RUNX1-MTG fusion proteins and core components of the Notch transcription complex. Accepted, .
  • Engel ME, and Hiebert SW (date unknown). Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.. (pp. 127-147). Vol. 145, Springer. Accepted, .
  • Engel ME, McDonnell MA, Law BK, Moses HL (date unknown). Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. Vol. 274, 37413-20. Accepted, .
  • Kawabata M, Imamura T, Miyazono K, Engel ME, Moses HL (date unknown). Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha. Vol. 270, 29628-31. Accepted, .
  • Frangoul H, Wills M, Crossno C, Engel M, Domm J (date unknown). Acyclovir-resistant herpes simplex virus pneumonia post-unrelated stem cell transplantation: a word of caution. Vol. 11, 942-4. Accepted, .
  • Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW (date unknown). Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Vol. 28, 6234-47. Accepted, .
  • Sarkar DK, Pastorcic M, De A, Engel M, Moses H, Ghasemzadeh MB (date unknown). Role of transforming growth factor (TGF)-beta Type I and TGF-beta type II receptors in the TGF-beta1-regulated gene expression in pituitary prolactin-secreting lactotropes. Vol. 139, 3620-8. Accepted, .
  • Mixon BA, Eckrich MJ, Lowas S, Engel ME (date unknown). Vincristine, irinotecan, and temozolomide for treatment of relapsed alveolar rhabdomyosarcoma. Vol. 35, e163-6. Accepted, .
  • Engel ME, Datta PK, Moses HL (date unknown). RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. Vol. 273, 9921-6. Accepted, .
  • Fagan E, Slone J, Shoemaker A, Black J, Berlin J, Engel ME (date unknown). Neuroendocrine carcinoma in an adolescent with hypercortisolemia. Vol. 34, 117-119. Accepted, .
  • Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert SW (date unknown). Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification. Vol. 30, 1852-63. Accepted, .
  • Engel ME, Hickstein DD, Bauer TR Jr, Calder C, Manes B, Frangoul H (date unknown). Matched unrelated bone marrow transplantation with reduced-intensity conditioning for leukocyte adhesion deficiency. Vol. 37, 717-8. Accepted, .
  • Vedvick T, Buckholz RG, Engel M, Urcan M, Kinney J, Provow S, Siegel RS, Thill GP (date unknown). High-level secretion of biologically active aprotinin from the yeast Pichia pastoris. Vol. 7, 197-201. Accepted, .
  • Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS (date unknown). Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Vol. 7, e51205. Accepted, .
  • Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL (date unknown). Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Vol. 12, 27-36. Accepted, .
  • Engel ME, Hiebert SW (date unknown). The enemy within: dormant retroviruses awaken. (pp. 517-8). Vol. 16. Accepted, .
  • Engel ME (date unknown). Rho GTP-Binding Proteins and the C-Jun N-Terminal Kinase Cascade. Ph.D. Thesis. Vanderbilt University. Accepted, .
  • Engel ME, Datta PK, Moses HL (date unknown). Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation. (pp. 111-22). Vol. 30-31. Accepted, .