MARGARET DEANGELIS portrait
  • Adjunct Professor, Population Health Sciences
  • Adjunct Professor, Ophthalmology & Visual Science
  • Associate Professor, Ophthalmology & Visual Science

Research Statement

Dr. DeAngelis is currently a Professor at the University of Utah School of Medicine and has focused her career on vision research since 1999, when she received a post-doctoral fellowship training grant on macular degeneration as part of the Molecular Basis of Eye Disease program at Harvard Medical School. Working in collaboration with clinicians throughout her career, she has recruited, ascertained, and developed large patient populations of both families and unrelated case-controls to study the genetic and epidemiologic underpinnings of both common and rare ophthalmic conditions. 

Presentations

  • AMDGene Consortium Presentation, National Institutes of Health, Bethesda, MD. , , 2011.
  • A New Era in Our Understanding of Age-related Macular Degeneration-Part 2, North Start Optometry Seminars 2011, Salt Lake City, Utah. , , 2011.
  • A New Era in Our Understanding of Age-related Macular Degeneration-Part 1, North Start Optometry Seminars 2011, Salt Lake City, Utah. , , 2011.
  • Systems biology based approach for characerizing pathways underlying the complex disease, age-related macular degeneration. University of Utah, Department of Biomedical Engineering, Salt Lake City, Utah. , , 2011.
  • Arnold and Mabel Beckman Initiative for Macular Research Task force/Presentation, Beckman Foundation, Irvine, CA. , , 2011.
  • A role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. University of utah, Department of Ophthalmology and Visual Sciences Faculty Meeting, Salt Lake City, Utah. , , 2011.
  • Elucidating the underlying mechanisms of the complex genetic disorger age-related macular degeneration. Advances in Vision Research Meeting. University of Utah School of Medicine, Salt Lake City, Utah. , , 2011.
  • Are There Any More Genes to Find in AMD? The American Academy of Ophthalmology Annual Meeting, Chicago, IL. , , 2010.
  • How we can predict and prevent blindness caused by complex diseases of the posterior eye? Tilganga Eye Center, Kathmandu, Nepal. , , 2010.
  • Identification of Underlying Mechanisms of the Complex Disorder Age-Related Macular Degeneration. University of Otago Christchurch School of Medicine, Christ Church, New Zealand. , , 2010.
  • Identifying new genes and pathways for age-related macular degeneration using a systems biology-based approach. Harvard Medical School, Department of Ophthalmology Research Faculty Meeting, Boston MA. , , 2010.
  • Lucentis Pharmacogenomics and Diagnostics in Retinal Disease. Genentech USA, Inc., Boston, MA. , , 2009.
  • RORA, a potential therapeutic target for neovascular age-related macular degeneration. Vision Research Conference, Fort Lauderdale, FL. , , 2009.
  • Identifying Underlying Mechanisms of Age-Related Macular Degeneration for the Development of Appropriate Preventive and Therapeutic Interventions. University of Nebraska, Department of Genetics, Cell Biology and Anatomy, Omaha, NE. , , 2009.
  • Identification of Underlying Mechanisms of the Complex Disorder, Age-Related Macular Degeneration. University Utah, Moran Eye Center, Salt Lake City, UT. , , 2009.
  • Systems Based Approach to Identify Potential Therapeutic Targets for Age-Related Macular Degeneration. University Utah, Moran Eye Center, Salt Lake City, UT. , , 2009.
  • Identifying underlying mechanisms for neovascular AMD: A systems-based approach. Research Meeting, Schepens Research Eye Institute, Boston, MA. , , 2009.
  • Systems Based Approach to Curing Age-Related Macular Degeneration. Leadership Meeting, Massachusetts Eye and Ear Infirmary, Boston, MA. , , 2009.
  • Can we predict and prevent age-related macular degeneration? Public Forum, Massachusetts Eye and Ear Infirmary, Boston, MA. , , 2009.
  • Our Eyes: why sometimes we have difficulty seeing. 5th Grade Classroom, Woodside Intermediate School, Cromwell, CT. , , 2009.
  • Using Gene Expression Microarrays to Identify Pathways and Potential Therapeutic Targets for Age-Related Macular Degeneration. University of Southern California, Catalina Island, CA. , , 2009.
  • Arnold and Mabel Beckman Initiative for Macular Research Task force/Presentation, Beckman Foundation, Irvine, CA. , , 2009.
  • Dry Eye Syndrome, Observant, LLC, Waltham, MA. , , 2008.
  • Genetic and Epidemiological Factors Contributing to Risk of AMD. Scientific Advisory Board, Bausch and Lomb, Boston, MA. , , 2007.
  • Variants in HTRA1 Influence Risk of Neovascular Age-Related Macular Degeneration. Aegean Retina Conference, Rhodes, Greece. , , 2007.
  • Novel Alleles in the LOC387715/HTRA1 region both reduce and increase risk of neovascular Age-Related Macular Degeneration. NEI Site visit, Massachusetts Eye and Ear Infirmary, Boston, MA. , , 2007.
  • Novel Alleles in the LOC387715/HTRA1 region both reduce and increase risk of neovascular Age-Related Macular. Research Meeting, Harvard Partners' Center for Genomics and Genetics, Boston, MA. , , 2007.
  • Genetic and Epidemiological Factors Contributing to Risk of Age-related Macular Degeneration. Research Faculty Meeting, Harvard Medical School Department of Ophthalmology, Boston, MA. , , 2006.
  • Identification of Biomarkers for the Wet Form of Age-Related Macular Degeneration. Board of Directors Meeting, Massachusetts Lions' Eye Research Fund, Boston, MA. , , 2006.
  • Environmental and Genetic Influences on Age-Related Macular Degeneration. Annual Retreat Boston, MA Harvard Medical School Department of Ophthalmology. , , 2005.
  • The Genetics of Age-Related Macular Degeneration: An Overview. AMD Symposium, Boston, MA Massachusetts Eye & Ear Infirmary. , , 2003.
  • Extremely Discordant Sibpair Study of the Neovascular Form of Age-related Macular Degeneration. Association for Research in Vision and Ophthalmology, Fort Lauderdale, FL. , , 2002.
  • Curing Age-Related Macular Degeneration in our Lifetime, Achievement Awards for College Scientists (ARCS) Meeting 2011, Salt Lake City, Utah. , , 2011.
  • Invited Speaker, "Are There Any More Genes to Find in AMD?”, Retina Subspecialty Day 2010: A Panretinal Perspective, American Academy of Ophthalmology, Chicago, IL. , , 2010.
  • Identifying Genetic and Epidemiological Markers for Age-Related Diseases: Age-Related Macular Degeneration Risk and Progression, Baylor College of Medicine, Human Genome Sequencing Center and the Department of Molecular and Human Genetics, Houston, TX. , , 2008.
  • Genetic and Epidemiological Factors Contributing to Risk of AMD, Louisiana State University Health Sciences Center, Neuroscience Center of Excellence, New Orleans, LA. , , 2006.
  • Speaker, Schepens Eye Research Institute, Presentation to the community about the genetics and epidemiology associated with Age-related Macular Degeneration. , , 2010.
  • Speaker, Massachusetts Eye and Ear Infirmary, Presentation to the community about the genetics and epidemiology associated with Age-related Macular Degeneration. , , 2009.
  • Speaker, Massachusetts Eye and Ear Infirmary, Presentation to the community about the genetics and epidemiology associated with Age-related Macular Degeneration. , , 2003.

Languages

  • English, Fluent.

Publications

  • Hartnett ME, DeAngelis MM (date unknown). The Role of Reactive Oxygen Species and Oxidative Signaling in Retinopathy of Prematurity. Humana (Springer). Accepted, .
  • Jakobiec FA, Zakka FR, D'Amato R, Deangelis MM, Walton DS, Rao RC (date unknown). Unilateral sporadic retinal dysplasia: results of histopathologic, immunohistochemical, chromosomal, genetic, and VEGF-A analyses. (pp. 579-86). Vol. 15. Accepted, .
  • Schaumberg DA, Chasman D, Morrison MA, Adams SM, Guo Q, Hunter DJ, Hankinson SE, DeAngelis MM (date unknown). Prospective study of common variants in the retinoic acid receptor-related orphan receptor alpha gene and risk of neovascular age-related macular degeneration. Vol. 128, 1462-71. Accepted, .
  • Hageman GS, Gehrs K, Lejnine S, Bansal AT, Deangelis MM, Guymer RH, Baird PN, Allikmets R, Deciu C, Oeth P, Perlee LT (date unknown). Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. Vol. 5, 420-40. Accepted, .
  • Deangelis MM, Silveira AC, Carr EA, Kim IK (date unknown). Genetics of age-related macular degeneration: current concepts, future directions. Vol. 26, 77-93. Accepted, .
  • Feehan M, Hartman J, Durante R, Morrison MA, Miller JW, Kim IK, Deangelis MM (date unknown). Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. Vol. 12, 83. Accepted, .
  • Jelcick AS, Yuan Y, Leehy BD, Cox LC, Silveira AC, Qiu F, Schenk S, Sachs AJ, Morrison MA, Nystuen AM, Deangelis MM, Haider NB (date unknown). Genetic variations strongly influence phenotypic outcome in the mouse retina. Vol. 6, e21858. Accepted, .
  • Jun G, Nicolaou M, Morrison MA, Buros J, Morgan DJ, Radeke MJ, Yonekawa Y, Tsironi EE, Kotoula MG, Zacharaki F, Mollema N, Yuan Y, Miller JW, Haider NB, Hageman GS, Kim IK, Schaumberg DA, Farrer LA, DeAngelis MM (date unknown). Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology. Vol. 6, e25775. Accepted, .
  • DeAngelis MM (date unknown). Utah BioHealth Initiative. University of Utah. Accepted, .