RYAN E LOOPER portrait
  • Associate Professor, Chemistry
  • Professor, Chemistry
  • Jon M. Huntsman Presidential Chair, Chemistry
801-585-0408

Publications

  • Dr. Kathryn Gunn & Dr. Matti Myllykoski , Dr. John Z. Cao , Manna Ahmed , Dr. Bofu Huang , Ms. Betty Rouaisnel , Dr. Bill H. Diplas , Mr. Michael M. Levitt , Dr. Ryan Looper , Dr. John G. Doench , Dr. Keith L. Ligon , Dr. Harley I. Kornblum , Dr. Samuel K. McBrayer , Dr. Ha (2023). (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers. Cancer Discovery. Published, 02/2023.
  • Rawson, Kaden B. & Neuberger, Travis; Smith, Tyler; Reddy, Hariprasada Reddy Kanna; Haussener, Travis J.; Sebahar, Paul R.; Looper, Ryan E.; Isaacson, Brad M.; Shero, John; Pasquina, Paul F. (2022). Antibiofilm potential of a negative pressure wound therapy foam loaded with a first-in-class tri-alkyl norspermidine-biaryl antibiotic. Journal of Biomedical Materials Research, Part B: Applied Biomaterials. Vol. 110, 1780-1788. Published, 06/2022.
  • Khan, Shakir-ul Haque & Banerjee, Aishwaryadev; Broadbent, Samuel; Noh, Seungbeom; Kim, Kyeong Heon; Bulbul, Ashrafuzzaman; Looper, Ryan E.; Mastrangelo, Carlos H.; Kim, Hanseup (2022). Characterization of a wake-up nano-gap gas sensor for ultra low power operation. Journal of Microelectromechanical Systems. Vol. 31, 791-801. Published, 06/2022.
  • Shi, Diana D & Savani, Milan R.; Levitt, Michael M.; Wang, Adam C.; Endress, Jennifer E.; Bird, Cylaina E.; Buehler, Joseph; Stopka, Sylwia A.; Regan, Michael S.; Lin, Yu-Fen; Puliyappadamba, Vinesh T.; Gao, Wenhua; Khanal, Januka; Evans, Laura; Lee, Joyce H.; Guo, Lei; (2022). De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. Vol. 40, 939-956.e16. Published, 06/2022.
  • Looper, Ryan E., Boger, Dale L. & Silver, Lynn L. (2021). Small Molecular Weapons against Multi-Drug Resistance. Accounts of Chemical Research. Vol. 54(13), 2785-2787. Published, 07/06/2021.
    https://doi.org/10.1021/acs.accounts.1c00246
  • Nelli, Matthew R., Heiitmier, Kendall M. & Looper, Ryan E. (2021). Dissecting the Nucleoside Antibiotics as Universal Translation Inhibitors. Accounts of Chemical Research. Vol. 54(13), 2798-2811. Published, 07/06/2021.
    https://doi.org/10.1021/acs.accounts.1c00221
  • Banerjee, Aishwaryadev , Khan, Shakir-Ul Haque , Broadbent, Samuel, Bulbul, Ashrafuzzaman , Kim, Kyeong Heon , Noh, Seungbeom , Looper, Ryan E., Mastrangelo, C. H. & Kim, H (2021). Molecular bridge-mediated ultralow-power gas sensing. Microsystems and Nanoengineering. Vol. 7. Published, 03/21/2021.
    https://www.nature.com/articles/s41378-021-00252-3
  • Miller, Mariel, Rogers, J. C., Badham, M. A., Reddy, H. K., Cadenas, L., Brightwell, E, Adams, J., Tyler, C., Sebahar, P. R., Hassener, T. J., Reddy, H. K., Looper, R. E. & Williams, D. L. (2020). Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms. PLOS ONE. Vol. 15. Published, 10/19/2020.
    https://doi.org/10.1371/journal.pone.0234832
  • Willilams, D. L., Kawaguchi, B., Taylor, N. B., Ally, G., Badahm, M. A. & Rogers, J. C. (2020). In vivo efficacy of a unique first-in-class antibiofilm antibiotic for biofilm-related wound infections caused by Acinetobacter baumannii. Biofilm. Vol. 2. Published, 07/27/2020.
    https://doi.org/10.1016/j.bioflm.2020.100032
  • Serrano, Catherine M. , Reddy Kanna Reddy, Hariprasada , Eiler, Daniel , Koch, Michael , Tresco, Ben I. C. , Barrows, Louis R. , VanderLinden, Ryan T. , Testa, Charles A. , Sebahar, Paul R. & Looper, Ryan E. (2020). Unifying aminohexopyranose nucleoside antibiotics; implications for antibiotic design. Angewandte Chemie. Vol. 59, 11330-11333. Published, 04/27/2020.
    https://onlinelibrary.wiley.com/doi/10.1002/anie.2...
  • Paladugu, Srinivas R, James, Chintelle K. & Looper, Ryan E. (2019). A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid. ACS Organic Letters. Vol. 21, 7999–8002. Published, 09/25/2019.
    https://doi.org/10.1021/acs.orglett.9b02986
  • Williams, DL, Epperson. RT, Ashton, NN, Taylor, NB, Kawaguchi B, Olsen, RE, Hassener, TJ, Sebahar, PR, Allyn, G & Looper, Ryan E (2019). In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection. Acta Biomater. Vol. 93, 36-49. Published, 07/15/2019.
    https://doi.org/10.1016/j.actbio.2019.01.055
  • Ashton, NN, Allyn, G, Porter, ST, Haussener, TJ, Sebahar, PR, Looper, RE & Williams, DL (2019). In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating. Acta Biomater. Vol. 93, 25-35. Published, 07/15/2019.
    https://doi.org/10.1016/j.actbio.2019.02.010
  • Banerjee, Aishwaryadev , Khan, Shakir-Ul Haque , Broadbent, Samuel, Likhite, Rugved , Looper, Ryan E., Kim, Hanseup & Mastrangelo, Carlos H. (2019). Batch-Fabricated α-Si Assisted Nanogap Tunneling Junctions. Nanomaterials. Vol. 9, 727. Published, 05/10/2019.
    https://doi.org/10.3390/nano9050727
  • Williams, Dustin L. (2019). Growth substrate may influence biofilm susceptibility to antibiotics. PLOS ONE. Published, 03/14/2019.
    https://doi.org/10.1371/journal.pone.0206774
  • Vaden, R. M, Guillen, K. P, Salvant, J. M.; , Santiago, C. B., Gibbons, J. B, Pathi, S. S., Arunachalam, S., Sigman, M. S., Looper, R. E. & Welm, B. E. (2018). A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine . ACS Publications. Published, 12/2018.
    https://pubs.acs.org/doi/abs/10.1021/acschembio.8b...
  • Philip, B., Yu DX, Silvis, M. R., Shin, C. H., Robinson, J. P., Robinson, G. L, Welker, A. E., Angel, S. N., Tripp, S. R., Sonnen, J. A., VanBrocklin, M. W., Gibbons, R. J., Looper, R. E., Colman, H. & Holmen, S. L. (2018). Mutant IDH1 Promotes Glioma Formation In Vivo. Cell Press. Vol. 430. Published, 09/2018.
    https://www.sciencedirect.com/science/article/pii/...
  • Laukka, T, Myllykoski, M, Looper, R. E & Koivunen, P. (2018). Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. Journal of Molecular Biology. Published, 09/2018.
    https://www.sciencedirect.com/science/article/pii/...
  • Tuomas Laukka & Matti Myllykoski, Ryan E. Looper, Peppi Koivunen (2018). “Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. Journal of Molecular Biology. Vol. 430. Published, 09/2018.
  • McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG & Kaelin WG (2018). Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. PubMed. Published, 08/2018.
    https://www.ncbi.nlm.nih.gov/pubmed/30220459
  • Philip B & Yu DX, Silvis MR, Shin CH, Robinson JP, Robinson GL, Welker AE, Angel SN, Tripp SR, Sonnen JA, VanBrocklin MW, Gibbons RJ, Looper RE, Colman H, Holmen SL (2018). Mutant IDH1 Promotes Glioma Formation In Vivo. PubMed. Published, 05/2018.
  • Divya Bharat & Divya Bharat, Rafaela Ramos Mororo Cavalcanti, Chrissa Petersen, Nathan Bageye, Brett Ronald Cutler, Marcella Melo Assis Costa, Renata Kelly Luna Gomes Ramos, Marina Ramos Ferreira, Youyou Li, Leena P Bharath, Emma Toolson, Paul Sebahar, Ryan E Looper (2018). Blueberry metabolites attenuate indices of lipotoxicity-induced endothelial dysfunction. PubMed. Published, 01/2018.
  • Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper* “Synthesis of naamidine A, related natural products and analogs: selective access to N2-acyl-2-aminoimidazoles.” 2015, Submitted to Org. Lett. . Published, 09/11/2015.
    http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b0170...
  • Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm* “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor” Toxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378. Published, 01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/25265996

Presentations

  • Discovery and Development of the first selective ribosomal P-site inhibitors Pacific Univeristy. Invited Talk/Keynote, Presented, 11/2022.
  • Discovery and Development of the first selective ribosomal P-site inhibitors Western Washington University. Invited Talk/Keynote, Presented, 10/2022.
  • NIAID Workshop on Antimicrobial Resistance. Invited Talk/Keynote, Presented, 06/2022.
  • Denver University, Engineering the Aminohexose-Cytosine Antibiotics as Selective P-site Inhibitors. Invited Talk/Keynote, Presented, 03/04/2021.
  • Pfizer, Inc. Groton CT, Discovery and Development of the first selective ribosomal P-site inhibitors. Invited Talk/Keynote, Presented, 01/16/2020.
  • Gordon Research Conference on Natural Products . Invited Talk/Keynote, Presented, 08/01/2019.
  • Nucleosides and Nucleotides GRC, Engineering the Aminohexose-Cytosine Antibiotics as Selective P-site Inhibitors. Invited Talk/Keynote, Presented, 06/25/2017.
  • Montana State University, Synthetic Studies on the Paralytic Shellfish Toxins. Invited Talk/Keynote, Presented, 03/03/2017.
  • Dartmouth, Synthetic Studies on the Paralytic Shellfish Toxins. Invited Talk/Keynote, Presented, 11/17/2016.
  • Utah Valley University, Synthetic Studies on the Paralytic Shellfish Toxins. Invited Talk/Keynote, Presented, 11/01/2016.
  • Colorado State University, Synthetic Studies on the Paralytic Shellfish Toxins. Invited Talk/Keynote, Presented, 09/17/2016.
  • Utah High School Summer Science Enrichment Program (U of U, July 2nd , 2015) “Antimicrobial resistance: a problem, a solution and a challenge for you”. Invited Talk/Keynote, Presented, 07/02/2015.
  • Northwest Regional ACS Meeting (Pocatello, ID , June 25th , 2015) “Synthetic and biological investigations of natural product inspired 2-aminoimidazole scaffolds”. Invited Talk/Keynote, Presented, 06/25/2015.
  • College of Science’s “Science at Breakfast” (Zion’s Bank, Salt Lake City, UT , January 15th, 2015) “Big Pharma, Little U” . Invited Talk/Keynote, Presented, 01/15/2015.
  • College of Pharmacy (University of Utah; November 5th, 2014) “New strategies to target chronic biofilm impaired wounds”. Invited Talk/Keynote, Presented, 11/05/2014.
  • Biointerface 2014 (San Francisco, CA; October 8th, 2014) “Medical Device Technologies: Potential to Treat and Prevent Biofilm Implant-Related Infections” . Invited Talk/Keynote, Presented, 10/08/2014.
  • Eli Lilly and Co. (Indianapolis, IN; March 9th , 2014) 16th Biennial Lilly Grantee Symposium “New Methods to Access Guanidinium Ion Natural Products” . Invited Talk/Keynote, Presented, 03/09/2014.
  • Amgen Inc., Young Investigators Award Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/17/2012.
  • Merck and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/03/2012.
  • Michigan State University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 09/04/2012.
  • 244th ACS National Meeting, Invited contribution to the Young Investigators Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 08/25/2012.
  • Eli Lilly and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 07/17/2012.
  • NSF Workshop, Endicott House, MIT “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 05/30/2012.
  • Colorado State University. Invited Talk/Keynote, Presented, 04/16/2012.
  • Case Western Reserve University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 04/05/2012.
  • University of Wisconsin-Madison “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/29/2012.
  • Sigma-Aldrich Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/28/2012.
  • University of Copenhagen "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/14/2012.
  • Constellation Pharmaceuticals "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/09/2012.
  • Amgen Inc. "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/08/2012.
  • Boston University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/06/2012.
  • University of Pennsylvania "Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds". Invited Talk/Keynote, Presented, 03/05/2012.
  • Emory University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/29/2012.
  • Vanderbilt university "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/27/2012.
  • University of Alabama "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/25/2012.
  • Texas A&M University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/02/2012.
  • UC Santa Barbara "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 01/16/2012.
  • University of Texas southwestern medical center, Dallas "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/15/2011.
  • UC Irvine "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/09/2011.
  • "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/08/2011.
  • University of Notre Dame "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 09/12/2011.

Research Groups

  • Kyle Nogales, Graduate Student. 12/2016 - present.
  • Ben Tresco, Undergraduate Student. 08/2016 - present.
  • Matt Nelli, Graduate Student. 08/2016 - present.
  • Melisa Rollins, Undergraduate Student. 08/2015 - present.
  • Cody Bender, Graduate Student. 08/2015 - present.
  • Emily Kirkeby, Undergraduate Student. Chemistry. 01/01/2015 - 05/02/2017.
  • Daniel Kurek , Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Samuel Broadbent, Graduate Student. Chemistry. 01/01/2015 - 01/01/2020.
  • Scott Eldridge, Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Toni Guo, Visiting Student. 08/2012 - present.