RYAN E LOOPER portrait
  • Professor, Chemistry

Publications

  • Travis J. Haussener, Paul R. Sebahar, Hariprasada K. Reddy, Dustin L. Williams and Ryan E. Looper “A Practical Synthesis of N-alkyl- and N’,N’-dialkyl polyamines”, Tetrahedron Letters. 2016, 57, 2845-2848. Published, 06/29/2016.
  • Srinivas R. Paladugu and Ryan E. Looper “Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.” Tetrahedron Lett. 2015, 56, 6332-6334. Published, 11/2015.
    http://www.pubfacts.com/detail/26594065/Preparatio...
  • Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper* “Synthesis of naamidine A, related natural products and analogs: selective access to N2-acyl-2-aminoimidazoles.” 2015, Submitted to Org. Lett. . Published, 09/11/2015.
    http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b0170...
  • Kihyeok Kwon, Travis J. Haissener and Ryan E. Looper "Preparation of mono-Cbz protected guanidines (Potassium carbobenzyloxycyanamide, carbbezyloxycyanamide potassium salt)" Org. Synth. 2015, 92, 91-102. Published, 03/25/2015.
    http://www.orgsyn.org/Content/pdfs/procedures/v92p...
  • Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm* “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor” Toxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378. Published, 01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/25265996
  • Ki-hyeok Kwon, Catherine M. Serrano, Michael Koch, Louis R. Barrows and Ryan E. Looper* “Synthesis of bicyclic guanidines via cascade hydroamination /Michael additions of mono-N-acylpropargylguanidines” Organic Letters, 2014, 16, 6048-6051. Published, 11/13/2014.
    http://pubs.acs.org/doi/abs/10.1021/ol502691w?jour...
  • Keith M. Gligorich, Rachel M. Vaden, Dawne N. Shelton, Guoying Wang, Cindy B. Matsen, Ryan E. Looper, Matthew S. Sigman, and Bryan E. Welm “Development of a Screen To Identify Selective Small Molecules Active Against Patient-Derived Metastatic and Chemoresistant Breast Cancer Cells” Breast Cancer Research, 2013 15(4), R58. PMID: 23879992. PMC4028696. Published, 07/23/2014.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC402869...
  • Kaitlin J. Basham, Vasudev R. Bhonde, Collin Keiffer, James B. C. Mack, Matthew Hess, Bryan E. Welm and Ryan E. Looper* “ Bis-aryloxadiazoles as effective activators of the aromatic hydrocarbon receptor” Bioorg. Med. Chem. Lett. 2014, 24, 2473-2476. DOI: 10.1016/j.bmcl.2014.04.013. Published, 06/01/2014.
    http://stephenson.pure.elsevier.com/en/publication...
  • Miao Yang, Shannon Odelberg, Dean Li and Ryan E. Looper* “Cationic-Rh(II) complexes for the synthesis of dihydropyrimidines from propargylureas” 2013, Tetrahedron, 69, 5744-5750. DOI:10.1016/j.tet.2013.04.071. Published, 07/08/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23807819
  • Vasudev R. Bhonde and Ryan E. Looper* “Carbamic acid, N-[[[(1,1 dimethylethoxy)carbonyl] amino](methylthio)methylene]-,1,1-dimethylethyl ester” Encyclopedia of Reagents for Organic Synthesis (eROS), 2013, in press. DOI: 10.1002/047084289X.rn01529. Published, 04/22/2013.
    http://onlinelibrary.wiley.com/doi/10.1002/0470842...
  • Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K. Schneider, Christine McMahon, Glenn Cowley, David Root, Benjamin L. Ebert, and William G. Kaelin Jr. “(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible” Science, 2013, 339, 1621-1625. DOI:10.1126/science.1231677. Published, 03/29/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23393090
  • Kaitlin J. Basham, Collin Keiffer, Dawne N. Shelton, Chris J. Leonard, Vasudev R. Bhonde, Hariprasad Vankayalapati, Brett Milash, David J. Bearss , Ryan E. Looper and Bryan E. Welm “Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.” J. Biol. Chem. 2013, 288(4), 2261-2270. Published, 01/25/2013.
    http://www.jbc.org/content/288/4/2261.abstract
  • Joseph B. Gibbons, Keith M. Gligorich, Bryan E. Welm and Ryan E. Looper* “Synthesis of the reported structures for kealiinines B and C” Organic Letters 2012, 14, 4734-4737. Published, 09/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol3019242
  • Travis J. Haussener and Ryan E. Looper* “An epoxide opening cascade to access the pactamycin core” Organic Letters 2012, 14, 3632–3635. . Published, 07/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol301461e
  • Gregory P. Tochtrop and Ryan E. Looper "Target-oriented synthesis/ Strategies for building focused libraries and their uses." In Chemical Genomics, Cambridge University Press, 2012. Published, 05/2012.
  • Peppi Koivunen*, Sungwoo Lee, Chris G Duncan, Giselle Lopez, Shakti Ramkissoon, Julie Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Gross, Ryan Looper, Keith Ligon, Roeland Verhaak, Hai Yan, and William G. Kaelin, Jr*. “Transformation by the (R) Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation” Nature, 2012 483, 484-488. Published, 03/2012.
    http://www.nature.com/nature/journal/v483/n7390/fu...
  • Ryan E. Looper and Robert M. Williams “Efficient Asymmetric Synthesis of N-tert- Butoxycarbonyl-a-Aminoacids using 4-tert-Butoxycarbonyl-5,6-Diphenylmorpholin-2-one: (R)-(N-tert-Butoxycarbonyl)allylglycine” Organic Synthesis 2012, 89, 394-403. Published, 03/2012.
    http://www.orgsyn.org/orgsyn/pdfs/v89p0394.pdf
  • Vasudev R. Bhonde and Ryan E. Looper* “A stereocontrolled synthesis of (+)-saxitoxin” J. Am. Chem. Soc. 2011, 133 20172–20174. Published, 11/12/2011.
  • Ryan E. Looper*, Travis J. Haussener and James B. C. Mack† “Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines” J. Org. Chem, 2011, 76 (16), 6967-6971. Published, 06/08/2011.
  • Catherine M. Serrano and Ryan E. Looper* “Rapid assembly of cytimidine through tandem Cu-catalyzed N-aryl amidation reactions” Organic Letters, 2011, 13, 5000-5003. Published, 05/07/2011.

Presentations

  • Utah High School Summer Science Enrichment Program (U of U, July 2nd , 2015) “Antimicrobial resistance: a problem, a solution and a challenge for you”. Invited Talk/Keynote, Presented, 07/02/2015.
  • Northwest Regional ACS Meeting (Pocatello, ID , June 25th , 2015) “Synthetic and biological investigations of natural product inspired 2-aminoimidazole scaffolds”. Invited Talk/Keynote, Presented, 06/25/2015.
  • College of Science’s “Science at Breakfast” (Zion’s Bank, Salt Lake City, UT , January 15th, 2015) “Big Pharma, Little U” . Invited Talk/Keynote, Presented, 01/15/2015.
  • College of Pharmacy (University of Utah; November 5th, 2014) “New strategies to target chronic biofilm impaired wounds”. Invited Talk/Keynote, Presented, 11/05/2014.
  • Biointerface 2014 (San Francisco, CA; October 8th, 2014) “Medical Device Technologies: Potential to Treat and Prevent Biofilm Implant-Related Infections” . Invited Talk/Keynote, Presented, 10/08/2014.
  • Eli Lilly and Co. (Indianapolis, IN; March 9th , 2014) 16th Biennial Lilly Grantee Symposium “New Methods to Access Guanidinium Ion Natural Products” . Invited Talk/Keynote, Presented, 03/09/2014.
  • Amgen Inc., Young Investigators Award Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/17/2012.
  • Merck and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/03/2012.
  • Michigan State University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 09/04/2012.
  • 244th ACS National Meeting, Invited contribution to the Young Investigators Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 08/25/2012.
  • Eli Lilly and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 07/17/2012.
  • NSF Workshop, Endicott House, MIT “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 05/30/2012.
  • Colorado State University. Invited Talk/Keynote, Presented, 04/16/2012.
  • Case Western Reserve University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 04/05/2012.
  • University of Wisconsin-Madison “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/29/2012.
  • Sigma-Aldrich Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/28/2012.
  • University of Copenhagen "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/14/2012.
  • Constellation Pharmaceuticals "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/09/2012.
  • Amgen Inc. "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/08/2012.
  • Boston University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/06/2012.
  • University of Pennsylvania "Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds". Invited Talk/Keynote, Presented, 03/05/2012.
  • Emory University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/29/2012.
  • Vanderbilt university "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/27/2012.
  • University of Alabama "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/25/2012.
  • Texas A&M University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/02/2012.
  • UC Santa Barbara "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 01/16/2012.
  • University of Texas southwestern medical center, Dallas "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/15/2011.
  • UC Irvine "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/09/2011.
  • "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/08/2011.
  • University of Notre Dame "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 09/12/2011.

Research Groups

  • Kyle Nogales, Graduate Student. 12/2016 - present.
  • Ben Tresco, Undergraduate Student. 08/2016 - present.
  • Matt Nelli, Graduate Student. 08/2016 - present.
  • Melisa Rollins, Undergraduate Student. 08/2015 - present.
  • Cody Bender, Graduate Student. 08/2015 - present.
  • Emily Kirkeby, Undergraduate Student. Chemistry. 01/01/2015 - 05/02/2017.
  • Scott Eldridge, Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Samuel Broadbent, Graduate Student. Chemistry. 01/01/2015 - 01/01/2020.
  • Daniel Kurek , Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Toni Guo, Visiting Student. 08/2012 - present.