RYAN E LOOPER portrait
  • Associate Professor, Chemistry

Presentations

  • Utah High School Summer Science Enrichment Program (U of U, July 2nd , 2015) “Antimicrobial resistance: a problem, a solution and a challenge for you”. Invited Talk/Keynote, Presented, 07/02/2015.
  • Northwest Regional ACS Meeting (Pocatello, ID , June 25th , 2015) “Synthetic and biological investigations of natural product inspired 2-aminoimidazole scaffolds”. Invited Talk/Keynote, Presented, 06/25/2015.
  • College of Science’s “Science at Breakfast” (Zion’s Bank, Salt Lake City, UT , January 15th, 2015) “Big Pharma, Little U” . Invited Talk/Keynote, Presented, 01/15/2015.
  • College of Pharmacy (University of Utah; November 5th, 2014) “New strategies to target chronic biofilm impaired wounds”. Invited Talk/Keynote, Presented, 11/05/2014.
  • Biointerface 2014 (San Francisco, CA; October 8th, 2014) “Medical Device Technologies: Potential to Treat and Prevent Biofilm Implant-Related Infections” . Invited Talk/Keynote, Presented, 10/08/2014.
  • Eli Lilly and Co. (Indianapolis, IN; March 9th , 2014) 16th Biennial Lilly Grantee Symposium “New Methods to Access Guanidinium Ion Natural Products” . Invited Talk/Keynote, Presented, 03/09/2014.
  • Amgen Inc., Young Investigators Award Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/17/2012.
  • Merck and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 10/03/2012.
  • Michigan State University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 09/04/2012.
  • 244th ACS National Meeting, Invited contribution to the Young Investigators Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 08/25/2012.
  • Eli Lilly and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 07/17/2012.
  • NSF Workshop, Endicott House, MIT “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 05/30/2012.
  • Colorado State University. Invited Talk/Keynote, Presented, 04/16/2012.
  • Case Western Reserve University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 04/05/2012.
  • University of Wisconsin-Madison “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/29/2012.
  • Sigma-Aldrich Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. Invited Talk/Keynote, Presented, 03/28/2012.
  • University of Copenhagen "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/14/2012.
  • Constellation Pharmaceuticals "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/09/2012.
  • Amgen Inc. "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/08/2012.
  • Boston University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 03/06/2012.
  • University of Pennsylvania "Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds". Invited Talk/Keynote, Presented, 03/05/2012.
  • Emory University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/29/2012.
  • Vanderbilt university "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/27/2012.
  • University of Alabama "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/25/2012.
  • Texas A&M University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 02/02/2012.
  • UC Santa Barbara "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 01/16/2012.
  • University of Texas southwestern medical center, Dallas "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/15/2011.
  • UC Irvine "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/09/2011.
  • "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 11/08/2011.
  • University of Notre Dame "Propargylguanidine hydroaminations and their application to important heterocyclic systems". Invited Talk/Keynote, Presented, 09/12/2011.

Research Groups

  • Kyle Nogales, Graduate Student. 12/2016 - present.
  • Ben Tresco, Undergraduate Student. 08/2016 - present.
  • Matt Nelli, Graduate Student. 08/2016 - present.
  • Melisa Rollins, Undergraduate Student. 08/2015 - present.
  • Cody Bender, Graduate Student. 08/2015 - present.
  • Emily Kirkeby, Undergraduate Student. Chemistry. 01/01/2015 - 05/02/2017.
  • Scott Eldridge, Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Samuel Broadbent, Graduate Student. Chemistry. 01/01/2015 - 01/01/2020.
  • Daniel Kurek , Undergraduate Student. Chemistry. 01/01/2015 - 05/03/2016.
  • Toni Guo, Visiting Student. 08/2012 - present.

Publications

  • Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana Shi, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Ryan E. Looper, Keith L. Ligon, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, Jr. “Direct Inhibition of BCAT by 2HG Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma” 2016 submitted to Science. Released, 10/2016.
  • Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons, Daniel Z. Kurek, Ryan E. Looper “Regioselective base-mediated cyclizations of mono-N acylpropargylguanadines” 2016, submitted to J. Org. Chem. Submitted, 08/2016.
  • Travis J. Haussener, Paul R. Sebahar, Hariprasada K. Reddy, Dustin L. Williams and Ryan E. Looper “A Practical Synthesis of N-alkyl- and N’,N’-dialkyl polyamines”, Tetrahedron Letters. 2016, 57, 2845-2848. Published, 06/29/2016.
  • Ki-Hyeok Kwon, Miao Yang, Anne V. Edwards and Ryan E. Looper “Exploring hydroamination-cycloaddition-fragmentation sequences to access polycyclicguanidines and vinyl-2-aminoimidazoles” 2016, submitted Organic Letters. Submitted, 01/2016.
  • Srinivas R. Paladugu and Ryan E. Looper “Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.” Tetrahedron Lett. 2015, 56, 6332-6334. Published, 11/2015.
    http://www.pubfacts.com/detail/26594065/Preparatio...
  • Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper* “Synthesis of naamidine A, related natural products and analogs: selective access to N2-acyl-2-aminoimidazoles.” 2015, Submitted to Org. Lett. . Published, 09/11/2015.
    http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b0170...
  • Kihyeok Kwon, Travis J. Haissener and Ryan E. Looper "Preparation of mono-Cbz protected guanidines (Potassium carbobenzyloxycyanamide, carbbezyloxycyanamide potassium salt)" Org. Synth. 2015, 92, 91-102. Published, 03/25/2015.
    http://www.orgsyn.org/Content/pdfs/procedures/v92p...
  • Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm* “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor” Toxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378. Published, 01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/25265996
  • Ki-hyeok Kwon, Catherine M. Serrano, Michael Koch, Louis R. Barrows and Ryan E. Looper* “Synthesis of bicyclic guanidines via cascade hydroamination /Michael additions of mono-N-acylpropargylguanidines” Organic Letters, 2014, 16, 6048-6051. Published, 11/13/2014.
    http://pubs.acs.org/doi/abs/10.1021/ol502691w?jour...
  • Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons and Ryan E. Looper* “Regioselectiv synthesis of N2-acyl-2-aminoimidazoles via base catalyzed cyclizations of mono-N- acylpropargylguanidines” 2014, in preparation.. In progress, 08/2014.
  • Rachel M. Vaden, Celine B. Santiago, Joseph B. Gibbons, Justin M. Salvant, Matthew S. Sigman, Ryan E. Looper and Bryan E. Welm* “The novel small molecule Zinaamidole induces intracellular Zn2+ dyshomeostasis and cancer-selective cell death via a caspase independent mechanism” 2014, submitted. Revise/resubmit(1), 08/2014.
  • Jing Fan, Xin Teng, Ling Liu, Ryan E. Looper and Joshua D. Rabinowitz* “Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate” ACS Chemical Biology 2014, ASAP. In progress, 08/2014.
  • Travis J. Haussener, Paul R. Sebahar, Ryan E. Looper* “Preparative synthesis of N-alkyl and N,N-dialkylplolyamines” manuscript in preparation for Tetrahedron Letters . In progress, 08/2014.
  • Catherine M. Serrano, Harriprasada R. Kanna Reddy, Daniel M. Eiller, Michael Koch, Louis R. Barrows, Thomas A. Steitz and Ryan E. Looper* “Simplified Amicetin analogues as anti-tubercular agents and analysis of their interaction with the ribosome” 2014, in preparation for J. Am. Chem. Soc.. In progress, 08/2014.
  • Ki-hyeok Kwon, Miao Yang and Ryan E. Looper* “Exploring hydroamination-cycloaddition-fragmentation sequences to access complex polycyclicguanidines and vinyl-2-aminoimidazoles” 2014, in preparation for Organic Letters.. In progress, 08/2014.
  • Travis Haussener, Hariprasada R. Kanna Reddy, Paul R. Sebahar, Ryan E. Looper* and Dustin L. Williams* “Polyamine-silicone coatings for reduced biofilm related infections in medical implants” 2014, in preparation. In progress, 08/2014.
  • Keith M. Gligorich, Rachel M. Vaden, Dawne N. Shelton, Guoying Wang, Cindy B. Matsen, Ryan E. Looper, Matthew S. Sigman, and Bryan E. Welm “Development of a Screen To Identify Selective Small Molecules Active Against Patient-Derived Metastatic and Chemoresistant Breast Cancer Cells” Breast Cancer Research, 2013 15(4), R58. PMID: 23879992. PMC4028696. Published, 07/23/2014.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC402869...
  • Kaitlin J. Basham, Vasudev R. Bhonde, Collin Keiffer, James B. C. Mack, Matthew Hess, Bryan E. Welm and Ryan E. Looper* “ Bis-aryloxadiazoles as effective activators of the aromatic hydrocarbon receptor” Bioorg. Med. Chem. Lett. 2014, 24, 2473-2476. DOI: 10.1016/j.bmcl.2014.04.013. Published, 06/01/2014.
    http://stephenson.pure.elsevier.com/en/publication...
  • Miao Yang, Shannon Odelberg, Dean Li and Ryan E. Looper* “Cationic-Rh(II) complexes for the synthesis of dihydropyrimidines from propargylureas” 2013, Tetrahedron, 69, 5744-5750. DOI:10.1016/j.tet.2013.04.071. Published, 07/08/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23807819
  • Vasudev R. Bhonde and Ryan E. Looper* “Carbamic acid, N-[[[(1,1 dimethylethoxy)carbonyl] amino](methylthio)methylene]-,1,1-dimethylethyl ester” Encyclopedia of Reagents for Organic Synthesis (eROS), 2013, in press. DOI: 10.1002/047084289X.rn01529. Published, 04/22/2013.
    http://onlinelibrary.wiley.com/doi/10.1002/0470842...
  • Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K. Schneider, Christine McMahon, Glenn Cowley, David Root, Benjamin L. Ebert, and William G. Kaelin Jr. “(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible” Science, 2013, 339, 1621-1625. DOI:10.1126/science.1231677. Published, 03/29/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23393090
  • Kaitlin J. Basham, Collin Keiffer, Dawne N. Shelton, Chris J. Leonard, Vasudev R. Bhonde, Hariprasad Vankayalapati, Brett Milash, David J. Bearss , Ryan E. Looper and Bryan E. Welm “Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.” J. Biol. Chem. 2013, 288(4), 2261-2270. Published, 01/25/2013.
    http://www.jbc.org/content/288/4/2261.abstract
  • Joseph B. Gibbons, Keith M. Gligorich, Bryan E. Welm and Ryan E. Looper* “Synthesis of the reported structures for kealiinines B and C” Organic Letters 2012, 14, 4734-4737. Published, 09/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol3019242
  • Travis J. Haussener and Ryan E. Looper* “An epoxide opening cascade to access the pactamycin core” Organic Letters 2012, 14, 3632–3635. . Published, 07/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol301461e
  • Gregory P. Tochtrop and Ryan E. Looper "Target-oriented synthesis/ Strategies for building focused libraries and their uses." In Chemical Genomics, Cambridge University Press, 2012. Published, 05/2012.
  • Peppi Koivunen*, Sungwoo Lee, Chris G Duncan, Giselle Lopez, Shakti Ramkissoon, Julie Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Gross, Ryan Looper, Keith Ligon, Roeland Verhaak, Hai Yan, and William G. Kaelin, Jr*. “Transformation by the (R) Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation” Nature, 2012 483, 484-488. Published, 03/2012.
    http://www.nature.com/nature/journal/v483/n7390/fu...
  • Ryan E. Looper and Robert M. Williams “Efficient Asymmetric Synthesis of N-tert- Butoxycarbonyl-a-Aminoacids using 4-tert-Butoxycarbonyl-5,6-Diphenylmorpholin-2-one: (R)-(N-tert-Butoxycarbonyl)allylglycine” Organic Synthesis 2012, 89, 394-403. Published, 03/2012.
    http://www.orgsyn.org/orgsyn/pdfs/v89p0394.pdf
  • Vasudev R. Bhonde and Ryan E. Looper* “A stereocontrolled synthesis of (+)-saxitoxin” J. Am. Chem. Soc. 2011, 133 20172–20174. Published, 11/12/2011.
  • Ryan E. Looper*, Travis J. Haussener and James B. C. Mack† “Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines” J. Org. Chem, 2011, 76 (16), 6967-6971. Published, 06/08/2011.
  • Catherine M. Serrano and Ryan E. Looper* “Rapid assembly of cytimidine through tandem Cu-catalyzed N-aryl amidation reactions” Organic Letters, 2011, 13, 5000-5003. Published, 05/07/2011.