Frank Bernd Sachse portrait
  • Privatdozent, Department of Electrical Engineering and Information Technology, Karlsruhe Institute of Technology, Germany
  • Adjunct Associate Professor, Biomedical Engineering

Publications

  • F. B. Sachse (date unknown). F. B. Sachse and T. Seidel. Patient-specific modeling of structure and function of cardiac cells. In A. D. McCulloch, editor, Patient-Specific Modeling of the Cardiovascular System, 2. edition. Springer, Berlin, Heidelberg, New York, in press.. Accepted, .
  • M. C. Sanguinetti (date unknown). M. Sanguinetti, M. Tristani-Firouzi, and F. B. Sachse. Structural determinants and biophysical properties of hERG1 channel gating. In D. P. Zipes and J. Jalife, editors, Cardiac Electrophysiology: Fr.... Accepted, .
  • (date unknown). F. B. Sachse. Patient-specific modeling of structure and function of cardiac cells. In R. C. P. Kerckhoffs, editor, Patient-Specific Modeling of the Cardiovascular System, chapter 3, pages 43-61. Springer, Berlin, Heidelberg, New York, 1. edition, 2010. ISBN: 978-1-4419-6690-2.. Accepted, .
  • M. Sanguinetti (date unknown). M. Sanguinetti and F. B. Sachse. Structural determinants and biophysical properties of hERG1 channel gating. In D. P. Zipes and J. Jalife, editors, Cardiac Electrophysiology: From Cell to Bedside, chapter 12. W. B. Saunders Company, 7. edition, 2017. Accepted, .
  • Hsu (date unknown). C. L. Welsh, E. H. Ibrahim, F. B. Sachse, and E. W. Hsu. Noninvasive characterization of myocardial fiber structure using MRI. In E. H. Ibrahim, editor, Heart Mechanics: Magnetic Resonance Imaging - Mathematical Modeling, Pulse Sequences, and Image Analysis, chapter 5, pages 179-246. CRC Press, 2017. Accepted, .
  • (date unknown). F. B. Sachse, E. Savio-Galimberti, J. I. Goldhaber, and J. H. B. Bridge. Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging. Pac Symp Biocomp, 13:390-401, 2008. Accepted, .
  • O. Dössel (date unknown). S. Bauer, J.-C. Edelmann, G. Seemann, F. B. Sachse, and O. Dössel. Estimating intracellular conductivity tensors from confocal microscopy of rabbit ventricular tissue. In Biomed Tech (Berl), volume 58, 2013. Accepted, .
  • Wuelfers (date unknown). E. M. Wülfers, N. S. Torres, G. Lenis, H. Li, G. Seemann, O. Dössel, J. H. B. Bridge, and F. B. Sachse. An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts. In Biomed Tech (Berl), 57-1, 46-49, 2012. Accepted, .
  • Seemann (date unknown). G. Seemann, R. Moss, A. K. E. Kurz, O. Dössel, M. Tristani-Firouzi, and F. B. Sachse. A 2-state markov model of IKACh based on a membrane voltage dependent muscarinic M2 receptor... Accepted, .
  • (date unknown). G. Seemann, F. B. Sachse, M. Karl, D. L. Weiss, V. Heuveline, and O. Dössel. Framework for modular, flexible and efficient solving the cardiac bidomain equation using PETSc. In Prog Industrial Math ECMI 2008, Mathematics in Industry, pages 363-70, Berlin, Heidelberg, New York, 2010. Springer. Accepted, .
  • M. Sacks (date unknown). A high-fidelity 3d micromechanical model of ventricular myocardium. (pp. 168-17). Vol. 12738. Springer. Accepted, .
  • Sachse (date unknown). T. Seidel, T. Dräbing, G. Seemann, and F. B. Sachse. A semi-automatic approach for segmentation of three-dimensional microscopic image stacks of cardiac tissue. In S. Ourselin, D. Rueckert, and N. Smith, editors,. Accepted, .
  • Sachse (date unknown). Towards automated quantification of atrial fibrosis in images from catheterized fiber-optics confocal microscopy using convolutional neural networks. Springer. Accepted, .
  • (date unknown). K. Sohn, B. B. Punske, and F. B. Sachse. Relationship between maximal upstroke velocity of transmembrane voltage and minimum time derivative of extracellular potential. In Lecture Notes in Computer Science, volume 5528, pages 505-12. Springer. Accepted, .
  • (date unknown). F. B. Sachse, E. Savio-Galimberti, J. I. Goldhaber, and J. H. B. Bridge. Towards computational modeling of excitation-contraction coupling in cardiac myocytes: Reconstruction of structures and proteins from confocal imaging. In Pac Symp Biocomp, volume 14, pages 328-39. Accepted, .
  • (date unknown). T. G. McNary and F. B. Sachse. Modeling effects of strain-modulated membrane capacitance and conductance of K+ inward-rectifier on conduction velocity in cardiac tissue. In Proc Comp Cardiol. Accepted, .
  • Decher (date unknown). K. Wemhoener, C. Friedrich, B. Stallmeyer, A. J. Coffey, A. Grace, S. Zumhagen, G. Seebohm, B. Ortiz-Bonnin, S. Rinne, F. B. Sachse, E. Schulze-Bahr, and N. Decher. Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. Accepted, .
  • (date unknown). F. B. Sachse, A. P. Moreno, and J. A. Abildskov. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng, 36(1):41-56, 2008. Accepted, .
  • (date unknown). N. Decher, T. Gonzalez, A. K. Streit, F. B. Sachse, V. Renigunta, M. Soom, S. H. Heineman, J. Daut, and M. C. Sanguinetti. Structural Determinants of Kvβ1.3 Induced Channel Inactivation: A Hairpin Modulated by PIP2. EMBO J, 27(23):3164-74, 2008. Accepted, .
  • (date unknown). D. R. Piper, J. Rupp, F. B. Sachse, M. C. Sanguinetti, and M. Tristani-Firouzi. Cooperative interactions between R531 and basic residues in the voltage sensing module of hERG1 channels. Cell Physiol Biochem, 21:37-46, 2008. Accepted, .
  • (date unknown). D. Fernandez, J. Sargent, F. B. Sachse, and M. C. Sanguinetti. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Mol Pharm, 3(4):1159-67, 2008. Accepted, .
  • (date unknown). T. G. McNary, K. Sohn, B. Taccardi, and F. B. Sachse. Experimental and computational studies of strain-conduction velocity relationships in cardiac tissue. Prog Biophys Mol Biol.,97(2-3):383-400, 2008. Accepted, .
  • (date unknown). A. A. Rodríguez-Menchaca, R. A. Navarro-Polanco, T. Ferrer-Villada, J. Rupp, F. B. Sachse, M. Tristani-Firouzi, and J. A. Sánchez-Chapula. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A, 105(4):1364-8, 2008. Accepted, .
  • (date unknown). E. Savio-Galimberti, J. Frank, M. Inoue, J. I. Goldhaber, M. B. Cannell, J. H. B. Bridge, and F. B. Sachse. Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J, 95:2053-62, 2008. Accepted, .
  • (date unknown). C. Putzke, K. Wemhöner, F. B. Sachse, S. Rinne, G. Schlichthörl, X. T. Lia, L. Jae, I. Eckhardt, E. Wischmeyer, H. Wulf, R. Preisig-Müller, J. Daut, and N. Decher. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res, 75(1):59-68, 2007. Accepted, .
  • (date unknown). S. E. Geneser, R. M. Kirby, D. Xiu, and F. B. Sachse. Stochastic markovian modeling of electrophysiology of ion channels: Reconstruction of standard deviations in macroscopic currents. J Theor Biol, 245(4):627-637, 2007. Accepted, .
  • (date unknown). M. D. Perry, F. B. Sachse, and M. C. Sanguinetti. Structural basis of action for a human ether-a-go-go related gene 1 potassium channel activator. Proc Natl Acad Sci U S A, 104(34):13827-32, 2007. Accepted, .
  • (date unknown). G. Seemann, F. B. Sachse, D. L Weiss, L. J. Ptacek, and M. Tristani-Firouzi. Modeling of IK1 mutations in human left ventricular myocytes and tissue. Am J Physiol Heart Circ Physiol, 292(1):H549-59, 2007. Accepted, .
  • Hitchcock (date unknown). Toward cardiac tissue characterization using machine learning and light-scattering spectroscopy. Journal of Biomedical Optics. Accepted, .
  • Frank Sachse/Thomas Seidel (date unknown). Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics. Elsevier. Accepted, .
  • Sachse (date unknown). Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Elsevier. Accepted, .
  • Frank Sachse (date unknown). Li H, Lichter JG, Seidel T, Tomaselli GF, Bridge JH, Sachse FB. Circ Heart Fail. Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure. Circ Heart Fail, 8:1105-14, 2015. Accepted, .
  • Drakos (date unknown). N. Diakos, C. Selzman, F. B. Sachse, O. Wever-Pinzon, A. Catino, A. Kfoury, J. Stehlik, R. Alharethi, B. Reid, D. Miller, M. Salama, A. Zaitsev, J. Shibayama, H. Li, J. Fang, D. Li, and S. Drakos. Myocardial atrophy and chronic mechanical unloading of the failing human heart: im... Accepted, .
  • Hsu (date unknown). O. M. Abdullah, S. G. Drakos, N. A. Diakos, O. Wever-Pinzon, A. G. Kfoury, J. Stehlik, C. H. Selzman, B. B. Reid, K. Brunisholz, D. R. Verma, C. Myrick, F. B. Sachse, D. Y. Li, and E. W. Hsu. Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quant... Accepted, .
  • Sachse/Hitchcock (date unknown). C. Huang, A. K. Kaza, R. W. Hitchcock, and F. B. Sachse. Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores. Circ Cardiovasc Imaging, 6(5):739-46, 2013. Accepted, .
  • Kekenes-Huskey (date unknown). P. M. Kekenes-Huskey, Y. Cheng, J. E. Hake, F. B. Sachse, J. H. Bridge, M. J. Holst, J. A. McCammon, A. D. McCulloch, and A. P. Michailova. Modeling effects of l-type Ca2+ c... Accepted, .
  • Sachse (date unknown). Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction. Front Physiol. Accepted, .
  • Tristani-Firouzi/Seemann (date unknown). Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function. PLoS Comput Biol. Vol. 14(10), e1006438. Accepted, .
  • Marrouche/Sachse (date unknown). Catheterized fiber-optics confocal microscopy of the beating heart in-situ. Elsevier. Accepted, .
  • Frank Sachse (date unknown). J. Lichter, H. Li, and F. B. Sachse. Measurement of strain in cardiac myocytes at micrometer scale based on rapid scanning confocal microscopy and non-rigid image registration. Ann Biomed Eng, 44(10):3020-31, 2016. Accepted, .
  • I. Polejaeva and R. Ranjan (date unknown). I. A. Polejaeva, R. Ranjan, C. J. Davies, M. Regouski, J. Hall, A. L. Olsen, Q. Meng, H. M. Rutigliano, D. J. Dosdall, N. A. Angel, F. B. Sachse, T. Seidel, A. J. Thomas, R. Stott, K. E. Panter, P. M. Lee, A. J. Van Wettere, J. R. Stevens, Z. Wang, R. S. Macleod, N. F. Marrouche, and K. L. White. Increased susceptibility to atrial fibrillation secondary to atrial fibrosis in transgenic goats expressing transforming growth factor-β1. J. Cardiovasc Electrophysiol, 27(10):1220-9, 2016. Accepted, .
  • O. M. Abdullah (date unknown). O. M. Abdullah, T. Seidel, M. Dahl, A. D. Gomez, G. Yiep, J. Cortino, F. B. Sachse, K. H. Albertine, and E. W. Hsu. Diffusion tensor imaging and histology of developing hearts. NMR Biomed, 29(10):1338-49, 2016. Accepted, .
  • R. Sebastian (date unknown). Romero D, Camara O, Sachse F, Sebastian R. Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. PLoS One. 2016 Oct 7;11(10):e0164093. 2016. Accepted, .
  • M. Sanguinetti (date unknown). W. Wu, A. Gardener, F. B. Sachse, and M. C. Sanguinetti. Ginsenoside Rg3, a gating modifier of EAG family K+ channels. Mol Pharmacol, 90(4):469-82, 2016. Accepted, .
  • McNary (date unknown). T. G. McNary, K. W. Spitzer, H. Holloway, J. H. B. Bridge, P. Kohl, and F. B. Sachse. Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes. Prog Biophys Mol Biol. Accepted, .
  • Knighton (date unknown). Towards intraoperative quantification of atrial fibrosis using light-scattering spectroscopy and convolutional neural networks. Sensors. Accepted, .
  • Garg (date unknown). V. Garg, F. B. Sachse, and M. Sanguinetti. Tuning of EAG K+ channel inactivation: molecular determinants of amplification by mutations and a small molecule. Accepted, .
  • Kaza (date unknown). Intraoperative localization of cardiac conduction tissue regions using real-time fibre-optic confocal microscopy: First in human trial. Eur J Cardiothorac Surg. Accepted, .
  • A. Moreno (date unknown). A Mondal, DA Appadurai, NW Akoum, FB Sachse, AP Moreno.Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores. J Theor Biol. Accepted, .
  • Drakos (date unknown). Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nature Communications. Accepted, .
  • Lasher (date unknown). R. A. Lasher, A. Q. Pahnke, J. M. Johnson, F. B. Sachse, and R. W. Hitchcock. Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype. J Tissue Eng. Accepted, .
  • FB Sachse, Verma VK, Lee Y, Taleb I, Badolia R, Shankar TS, Kyriakopoulos CP (date unknown). Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ aging and mechanisms of disease. Vol. 7, 16. Accepted, .
  • W. Giles (date unknown). F. B. Sachse, R. B. Clark, and W. R. Giles. No fuzzy space for intracellular Na+ in healthy ventricular myocytes. J Gen Physiol, 149(7):683-7, 2017. Accepted, .
  • E. G. Moreno-Galindo. (date unknown). R. A. Navarro-Polanco, I. A. Aréchiga-Figueroa, P. D. Salazar-Fajardo, D. E. Benavides-Haro, J. C. Rodríguez-Elías, F. B. Sachse, M. Tristani-Firouzi, J. A. Sánchez-Chapula, and E. G. Moreno-Galindo. Voltage sensitivity of M. Accepted, .
  • F. B. Sachse (date unknown). C. Huang, A. K. Kaza, R. W. Hitchcock, and F. B. Sachse. Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores. Circ Cardiovasc Imaging, 6(5):739-46, 2013. Accepted, .
  • Hitchcock (date unknown). D. P. Lackey, E. D. Carruth, R. A. Lasher, J. Boenisch, F. B. Sachse, and R. W. Hitchcock. Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue. Ann Biomed Eng, 39(11):2683-94, 2011. Accepted, .
  • Niederer (date unknown). S. A. Niederer, E. Kerfoot, A. P. Benson, O. Bernus, M. O. Bernabeu, C. Bradley, E. M. Cherry, R. Clayton, F. H. Fenton, A. Garny, E. Heidenreich, S. Land, M. Maleckar, P. Pathmanathan, G. Plank, J. F. Rodríguez, I. Roy, F. B. Sachse, G. Seemann, O. Skavhaug, and N. P. Smith. Verification of cardiac tissue electrophysiology simulators using an N-version benchmark. Philos Transact A Math Phys Eng Sci, 369(1954):4331-51, 2011. Accepted, .
  • Kohl (date unknown). T. A. Quinn, S. Granite, M. A. Allessie, C. Antzelevitch, C. Bollensdorff, G. Bub, R. A. B. Burton, E. Cerbai, P. S. Chen, M. Delmar, D. DiFrancesco, Y. E. Earm, I. R. Efimov, M. Egger, E. Entcheva, M. Fink, R. Fischmeister, M. R. Franz, A. Garny, W. R. Giles, T. Hannes, S. E. Harding, P. J. Hunter, G. Iribe, J. Jalife, C. R. Johnson, R. S. Kass, I. Kodama, G. Koren, P. Lord, V. S. Markhasin, S. Matsuoka, A. D. McCulloch, G. R. Mirams, G. E. Morley, S. Nattel, D. Noble, S. P. Olesen, A. V. Panfi... Prog Biophys Mol Biol. Accepted, .
  • Tristani-Firouzi (date unknown). E. G. Moreno-Galindo, J. A. Sánchez-Chapula, F. B. Sachse, J. A. Rodriguez-Paredes, M. Tristani-Firouzi, and R. A. Navarro-Polanco. Relaxation gating of the acetylcholine-activated inward rectifier K+ current (IKACh) is mediated by intrinsic voltage-sensitivity of the muscarinic receptor. J Physiol, 589(7):1755-67, 2011. Accepted, .
  • Punske (date unknown). K. Sohn, F. B. Sachse, A. P. Moreno, P. R. Ershler, A. R. Wende, E. D. Abel, and B. B. Punske. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse heart. IEEE Trans Biomed Eng, 58(11):3175-83, 2011. Accepted, .
  • Sanguinetti (date unknown). V. Garg, A. Stary-Weinzinger, F. B. Sachse, and M. Sanguinetti. Molecular determinants for activation of human ether-a-go-go related gene 1 potassium channels by 3-nitro-N-(4-phenoxyphenyl) benzamide. Mol Pharmacol, 80(4):630-7, 2011. Accepted, .
  • Sanguinetti (date unknown). M. Grunnet, J. Abbruzesse, F. B. Sachse, and M. C. Sanguinetti. Molecular determinants of hERG1 K+ channel activation by NS1643. Mol Pharmacol, 79(1):1-9, 2011. Accepted, .
  • Decher (date unknown). S. H. Limberg, M. F. Netter, C. Rolfes, S. Rinne, G. Schlichthoerl, M. Zuzarte, T. Vassiliou, R. Moosdorf, H. Wulf, J. Daut, F. B. Sachse, and N. Decher. TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes. Cell Physiol Biochem, 28:613-24, 2011. Accepted, .
  • N. Decher (date unknown). N. Decher, K. Wemhoener, S. Rinne, M. F. Netter, M. Zuzarte, M. I. Aller, S. G. Kaufmann, X. T. Li, J. Daut, F. B. Sachse, and S. K. G. Maier. Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem, 28(1):77-86, 2011. Accepted, .
  • (date unknown). Special Issue: Functional Imaging and Modeling of the Heart. Med Image Anal, 13(2):345, 2009. Accepted, .
  • Frank Sachse (date unknown). Localization of the sinoatrial and atrioventricular nodal region in neonatal and juvenile ovine hearts. PLoS. Accepted, .
  • Thomas Seidel and Frank Sachse (date unknown). Seidel T, Edelmann JC, Sachse FB. Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions. Ann Biomed Eng. 44(5):1436-48, 2016. Accepted, .
  • Stavros Drakos (date unknown). Diakos NA, Selzman CH, Stehlik J, Sachse FB, Kfoury AG, Koliopoulou A, McKellar S, Fang JC, Li DY, Drakos SG.Reply: does size matter? In search of a physiological definition of myocardial atrophy. J Am Coll Cardiol. 65(19):2156-7, 2015. Accepted, .
  • (date unknown). T. G. McNary, J. H. Bridge, and F. B. Sachse. Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy. Biophys J, 100(10):L53-55, 2011. Accepted, .
  • (date unknown). J. Abbruzzese, F. B. Sachse, M. Tristani-Firouzi, and M. C. Sanguinetti. Modification of hERG1 channel gating by Cd2+. J Gen Physiol, 136(2):203-24. Accepted, .
  • (date unknown). E. G. Moreno-Galindo, G. F. Barrio-Echavarria, J. C. Vasquez, N. Decher, F. B. Sachse, M. Tristani-Firouzi, J. A. Sanchez-Chapula, and R. A. Navarro-Polanco. Molecular basis for a high-potency open channel block of Kv1.5 channel by the endocannabinoid anandamide. Mol Pharmacol, 77(5):751-8, 2010. Accepted, .
  • Cannon-Albright (date unknown). Evidence for a heritable contribution to atrial fibrillation associated with fibrosis. JACC Clin Electrophysiol. Accepted, .
  • Hitchcock/Kaza (date unknown). An imaging protocol to discriminate specialized conduction tissue during congenital heart surgery. Semin Thorac Cardiovasc Surg. Accepted, .
  • Colli (date unknown). A matched-filter based algorithm for subcellular classification of t-system in cardiac tissues. Biophys J. Accepted, .
  • Bragard/Sachse (date unknown). Extended bidomain modeling of defibrillation: Quantifying virtual electrode strengths in fibrotic myocardium. Front Physiol. Vol. 10, 337. Accepted, .
  • Seidel/Sachse (date unknown). Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart. Front Physiol. Accepted, .
  • Mondal (date unknown). A. Mondal, F. B. Sachse, and A. P. Moreno. Modulation of asymmetric flux in heterotypic gap junctions by pore shape, particle size and charge. Front Physiol, 8:206, 2017. Accepted, .
  • Seidel, Drakos and Sachse (date unknown). T. Seidel, S. Navankasattusas, A. Ahmad, N. A. Diakos, W. D. Xu, M. Tristani-Firouzi, M. J. Bonios, I. Taleb, D. Y. Li, C. H. Selzman, S. G. Drakos, and F. B. Sachse. Sheet-like remodeling of the transverse tubular system in human heart failure impairs excitation-contraction coupling and functional recovery by mechanical unloading. Circ, 135(17):1632-45, 2017. Accepted, .
  • Sanguinetti (date unknown). W. Wu, F. B. Sachse, A. Gardner, and M. C. Sanguinetti. Stoichiometry of altered hERG1 channel gating by small molecule activators. J Gen Physiol, 143(4):499-512, 2014. Accepted, .
  • Sachse (date unknown). J. Lichter, E. Carruth, C. Mitchell, A. S. Barth, T. Aiba, D. A. Kass, G. F. Tomaselli, J. H. Bridge, and F. B. Sachse. Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy. J Mol Cell Cardiol, 72:186-195, 2014. Accepted, .
  • Sachse/Bridge (date unknown). N. S. Torres, F. B. Sachse, L. Izu, J. I. Goldhaber, K. W. Spitzer, and J. H. Bridge. A modified local control model for Ca2+ transients in cardiomyocytes: Junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol, 68:1-11, 2014. Accepted, .
  • Niels Decher (date unknown). Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N. Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J Mol Cell Cardiol, 80C:186-95, 2015. Accepted, .
  • Giles (date unknown). R. B. Clark, T. Schmidt, F. B. Sachse, D. Boyle, G. Firestein, and W. R. Giles. Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol, 595(3):635-45, 2017. Accepted, .
  • Punske (date unknown). K. Sohn, A. R. Wende, E. D. Abel, A. P. Moreno, F. B. Sachse, and B. B. Punske. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol, 98:746-57, 2013. Accepted, .
  • F. B. Sachse (date unknown). F. B. Sachse, N. S. Torres, E. Savio-Galimberti, T. Aiba, D. A. Kass, G. F. Tomaselli, and J. H. Bridge. Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res, 110:588-97, 2012. Accepted, .
  • A. A. Ahmad (date unknown). Modulation of calcium transients in cardiomyocytes by transient receptor potential canonical 6 channels. Front Physiol. Accepted, .
  • Q. Hu (date unknown). Location and function of transient receptor potential canonical channel 1 in ventricular myocytes. J Mol Cell Cardiol. Accepted, .
  • Moreno (date unknown). A. Mondal, D. A. Appadurai, N. W. Akoum, F. B. Sachse, and A. P. Moreno. Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores. J Theor Biol, 412:61-73. Accepted, .
  • A. Kaza (date unknown). Huang C, Sachse FB, Hitchcock RW, Kaza AK. Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy. PLoS One. 11(1):e0147667, 2016. Accepted, .
  • (date unknown). F. B. Sachse, A. P. Moreno, G. Seemann, and J. A. Abildskov. A model of electrical conduction in cardiac tissue including fibroblasts. Ann Biomed Eng, 37(5):874-89. Accepted, .
  • (date unknown). F. B. Sachse and G. Seemann. Special issue: Functional imaging and modelling of the heart. Med Image Anal, 13(2):345. Accepted, .
  • (date unknown). A. Lopez-Izquierdo, D. Ponce-Balbuena, T. Ferrer, F. B. Sachse, M. Tristani-Firouzi, and J. A. Sánchez-Chapula. Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico. Cell Physiol Biochem, 24(3-4):153-60. Accepted, .
  • (date unknown). R. A. Lasher, R. W. Hitchcock, and F. B. Sachse. Towards modeling of cardiac micro-structure with catheter-based confocal microscopy: A novel approach for dye delivery and tissue characterization. IEEE Trans Med Imaging, 28(8):1156-64. Accepted, .
  • (date unknown). M. D. Perry, F. B. Sachse, J. Abbruzzese, and M. C. Sanguinetti. PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance. Proc Natl Acad Sci U S A, 106(47):20075-80. Accepted, .
  • M. Streiff (date unknown). Super-resolution imaging of TRPC1 channels in ventricular cardiomyocytes. Proc Cardiac Mechano-Electric Coupling and Arrhythmias. Accepted, .
  • (date unknown). T. G. McNary, J. H. B. Bridge, and F. B. Sachse. Change in ellipticity of transverse tubules during strain in rabbit ventricular myocytes. In Proc 6th Annual Mountain West Biomedical Engineering Conference, 2010. Accepted, .
  • Sachse (date unknown). Adult rabbit left ventricle RNAseq. NIH. Accepted, .
  • A. C. Sankarankutty (date unknown). Intra-subject and inter-subject variability in remodeling of cardiac tissues of heart failure patients. Uncertainty Quantification for Cardiac Models. Accepted, .
  • Kaza (date unknown). Towards identification of conductive tissue in pediatric heart surgery using fiber optic confocal microscopy. Western Thoracic Surgical Association. Accepted, .
  • A. A. Ahmad (date unknown). Non-RyR calcium leak of the sarcoplasmic reticulum is governed by TRPC1 in cardiomyocytes. (pp. 384a). Vol. 116. Biophys J (Annual Meeting Abstracts). Accepted, .
  • Sachse (date unknown). Functional role of TRPC1 channels in neonatal cardiomyocytes. Cell. Accepted, .
  • (date unknown). N. S. Torres, A. Rock, E. Savio-Galimberti, F. B. Sachse, and J. H. B. Bridge. Occurrence of spontaneous sparks in ventricular myocytes from junctional and non-junctional RyR clusters. In Biophys J (Annual Meeting Abstracts), 2010. Accepted, .
  • (date unknown). N. S. Torres, R. Larbig, A. Rock, F. B. Sachse, K. D. Philipson, J. I. Goldhaber, and J. H. B. Bridge. Sodium current-induced release of calcium from the sarcoplasmic reticulum in rabbit ventricular myocytes. In Biophys J (Annual Meeting Abstracts), 2010. Accepted, .
  • Sachse (date unknown). E. Savio, J. Frank, M. Inoue, J. Goldhaber, M. B. Cannell, J. H. B. Bridge, and F. B. Sachse. High-resolution three-dimensional confocal microscopy reveals novel structures in rabbit ventricular myocyte t-tubules. In Biophys. J (Annual Meeting Abstracts), 2007. Accepted, .
  • Sachse (date unknown). Towards detection of conduction tissue during cardiac surgery: Light at the end of the tunnel?. Heart Rhythm. Accepted, .
  • Frank Sachse (date unknown). Catheter-based optical approaches for cardiovascular medicine: Progress, challenges and new directions. IOP. Accepted, .
  • Fink (date unknown). Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Prog Biophys Mol Biol. Accepted, .
  • R. H. Clayton (date unknown). Models of cardiac tissue electrophysiology: Progress, challenges and open questions. Prog Biophys Mol Biol. Accepted, .

Research Statement

Cardiovascular diseases are the major cause of death in the developed world. My research aims at providing insights into structure and function of tissues, cells and proteins of the normal, aging and diseased heart. This research is motivated by my interest in combining science, engineering and medicine to improve health in society, and the obvious need for improved care of cardiovascular diseases.

Presentations

  • Oslo University Hospital, Norway, “Remodeling of the Transverse Tubular System and Proteins Underlying Excitation-Contraction Coupling in Aging vs. Failing Human Heart”. , Presented, 2021.
  • Geriatrics/GRECC Translational Research Grand Rounds, University of Utah, USA “Aging of Excitation-Contraction Coupling of Cardiomyocytes”. , Presented, 2020.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Catheterized Optical Approaches for Detecting of Atrial Remodeling”. , Presented, 2020.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Detecting Cellular Atrial Remodeling Using Confocal Microscopy”. , Presented, 2019.
  • Biophysical Society Meeting, Baltimore, MD, USA “Career Planning for Graduate Students”. , Presented, 2019.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA. “Catheterized Fiber-Optics Confocal Microscopy for Mapping of Atrial Fibrosis”. , Presented, 2018.
  • Osher Life Long Learning, University of Utah, Salt Lake City, USA. “New Microscopy Techniques and Their Application in Cardiology”. , Presented, 2018.
  • Cardiac Physiome Workshop, Toronto, Canada. “Role of Cardiac Fibroblasts in Cardiac Remodeling“. , Presented, 2017.
  • Biological Engineering Department Seminar, Utah State University, Logan, Utah, USA. “Advanced Microscopy Approaches to Study the Normal and Diseased Heart“. , Presented, 2017.
  • European Society of Cardiology - Heart Failure Congress, Paris, France. “Cardiac Dyssynchrony and the Effects of Resynchronization“. , Presented, 2017.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA. “Using Fiber-Optics Imaging to Detect and Target Atrial Myopathy“. , Presented, 2017.
  • Osher Life Long Learning, University of Utah, Salt Lake City, USA. “Novel Insights into Cardiac Disease by Microscopic Imaging”. , Presented, 2017.
  • Utah Cardiac Recovery Symposium, Salt Lake City, USA. “Understanding cellular and microstructural remodeling through UCAR”. , Presented, 2017.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Targets for AF Related Atrial Fibrosis: Insight from Fiberoptic Imaging“. , Presented, 2016.
  • Minisymposium, SIAM Conference on Computational Sciences and Engineering, Salt Lake City, Utah, USA “Towards Multidomain Modeling of Cardiac Electrophysiology“. , Presented, 2015.
  • Imaging Seminar, Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA “Confocal Microscopy-Based Analysis of Cardiac Cells and Tissues”. , Presented, 2015.
  • Seminar, Institute for Computational Engineering & Sciences, University of Texas, Austin, USA “Computational Modeling of Cardiac Tissues and Cells“. , Presented, 2015.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Confocal Insights into AFib Pathophysiology“. , Presented, 2015.
  • Imaging Seminar, Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA “Applications of Confocal Microscopy in Cardiac Research”. , Presented, 2014.
  • International Conference of Cellvizio Users, Opio, France “Towards Intraoperative Imaging of Cardiac Tissues Using Fiber-Optics Confocal Microscopy: Feasibility of Automated Tissue Discrimination Based on Image Texture Analysis“. , Presented, 2014.
  • Workshop on Integrating Modalities and Scales in Life Science Imaging, MBI, Columbus, Ohio, USA “Deriving Macroscopic Parameters for Computational Modeling of Cardiac Tissues from High-Resolution Three-Dimensional Confocal Microscopy “. , Presented, 2014.
  • Utah Cardiac Recovery Symposium, Salt Lake City, USA Invited by Profs. Selzman, Stehlik and Drakos „ Cardiac resynchronization effects on myocardial function and microstructure: how can this story help the recovery field?”. , Presented, 2013.
  • IEEE EMBS Annual Conference, San Diego, USA Invited by Profs. Shyy and Sugiura „Mechanical Modulation of the Transverse Tubular System in Cardiac Myocytes”. , Presented, 2012.
  • Seminar, Centre of Excellence for Toxicological Research, University of Parma, Italy Invited by Dr. Miragoli „Micro-Structural Remodeling of Ventricular Myocytes in Heart Failure and after Cardiac Resynchronization Therapy”. , Presented, 2012.
  • Workshop on Human Spare Body Parts, Tampere, Finland Invited by Prof. Hyttinen „Fiber-Optics Confocal Microscopy for Imaging of Cardiac Tissue”. , Presented, 2012.
  • Cardiac Mechanisms Workshop, Auckland, New Zealand Invited by Profs. Soeller and Ward „Mechanical Modulation of the Transverse Tubular System in Cardiomyocytes: Its Potential Role in Remodeling in Heart Disease”. , Presented, 2012.
  • Biomedical Engineering Department Seminar, Johns Hopkins University, Baltimore Invited by Prof. McVeigh „Microscopic Characterization of Cells in Heart Failure and after Cardiac Resynchronization Therapy”. , Presented, 2011.
  • Joint Meeting of the Medical Engineering Center and British Heart Foundation, London, UK Invited by Prof. Razavi „Subcellular Remodeling in Heart Failure and after Cardiac Resynchronization Therapy”. , Presented, 2011.
  • Cardiac Mechano-Electric Coupling and Arrhythmia Meeting, Oxford, UK „Stretch and the Cardiomyocyte Transverse Tubular System”. , Presented, 2010.
  • Research in Progress Seminar, Cardiology Department, Primary Children’s Medical Center, Salt Lake City, Utah, USA „Intraoperative Mapping of Cardiac Tissue using Fiber-Optic Confocal Microscopy. , Presented, 2010.
  • Seminar on Biomedical Image Quantification, Tampere, Finland „Fiber-Optics Confocal Microscopy”. , Presented, 2010.
  • Institute of Regenerative Medicine Seminar, Tampere, Finland „Modeling in Cardiology". , Presented, 2010.
  • The Cardiac Physiome Conference: Multiscale and Multi-physics Mathematical Modelling Applied to the Heart, Cambridge, UK „A novel approach to multidomain modeling of electrical conduction in cardiac tissue“. , Presented, 2009.
  • Mechanics and Computation Seminar Series, Stanford University, USA “Imaging and Modeling of Cardiac Cells and Tissues”. , Presented, 2009.
  • The Cardiac Physiome Conference: Multiscale and Multi-physics Mathematical Modelling Applied to the Heart, Cambridge, UK "A novel approach to multidomain modeling of electrical conduction in cardiac tissue“. , Presented, 2009.
  • Computers in Cardiology Conference, Park City, Utah, USA “Imaging and Modeling of Cardiac Cells and Proteins”. , Presented, 2009.
  • NBCR Summer Institute on Cyberinfrastructure for Personalized Medicine, San Diego, USA “Patient-Specific Modeling of Structure and Function of Cardiac Cells”. , Presented, 2009.
  • SIAM Life Sciences Conference, Montreal, Canada „Forward Looking Session - The Future of Model Sharing”. , Presented, 2008.
  • IEEE EMBS Annual Conference, Lyon, France „Education for Biomedical Engineering Professionals–Crossing Boundaries between Disciplines”. , Presented, 2007.
  • IV. Tissue Engineering Symposium, Tampere, Finland „Anatomical and Electro-Mechanical Modeling of Cardiac Cells”. , Presented, 2007.
  • IV. Tissue Engineering Symposium, Tampere, Finland Invited by Profs. Rinne und Korpilahti „Anatomical and Electro-Mechanical Modeling of Cardiac Cells”. , Presented, 2007.
  • Introduction to Image Based Modeling, University of Utah, Salt Lake City, Utah, USA. “Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart”. Other, Presented, 2018.
  • Introduction to Image Based Modeling, University of Utah, Salt Lake City, Utah, USA. “Confocal Microscopy-Based Modeling of Cardiac Cells and Tissues”. Other, Presented, 2017.
  • Bioengineering Department Colloquium, University of Utah, Salt Lake City, Utah, USA “Clinical Translation of Confocal Microscopy“. Other, Presented, 2016.
  • Introduction to Image Based Modeling, University of Utah, Salt Lake City, Utah, USA. “Confocal Microscopy-Based Modeling of Cardiac Cells and Tissues”. Other, Presented, 2016.
  • Mauna Kea Technologies, Paris, France Invited by Dr. Lacombe „Towards Intrasurgical Imaging of Cardiac Tissue”. Other, Presented, 2011.

Research Groups

  • Colton White, . 2021 - present.
  • Tyler Whitley, . 2021 - present. Awards/Scholarships/Stipends: UROP.
  • Abbie Saccomanno, . 2021 - 2022.
  • Andrea Corbin, . Biomedical Engineering. 2020 - 2022.
  • Sarthak Tiwari, . Biomedical Engineering. 2020 - present. Awards/Scholarships/Stipends: UROP.
  • Brian Cottle, . Biomedical Engineering. 2019 - 2022.
  • Vipin Verma, . 2019 - 2022.
  • Karl Schriewer, . Biomedical Engineering. 2019 - present. Awards/Scholarships/Stipends: UROP.
  • Mark Warren, . 2018 - 2020.
  • Jordan Johnson, . Biomedical Engineering. 2018 - 2019. Awards/Scholarships/Stipends: NIH.
  • Marcus Blackburn, . Biomedical Engineering. 2017 - 2019. Awards/Scholarships/Stipends: UROP, AHA and Dee Foundation.
  • Aparna Chakkalakkal Sankarankutty, . Biomedical Engineering. 2016 - 2021.
  • Molly Streiff, . Biomedical Engineering. 2016 - 2021.
  • Chao Huang, . 2015 - 2019. Awards/Scholarships/Stipends: NIH T32 / AHA.
  • Azmi Ahmad, . Biomedical Engineering. 2014 - 2019.
  • Chris Hunter, . CVRTI. 2011 - 2020.

Languages

  • French, Functional.
  • German, Fluent.

Geographical Regions of Interest

  • Finland
  • Germany
  • Spain