Frank Bernd Sachse portrait
  • Associate Professor, Bioengineering
  • Privatdozent, Department of Electrical Engineering and Information Technology, Karlsruhe Institute of Technology, Germany
  • Faculty Investigator, Nora Eccles Harrison Cardiovascular Research and Training Institute

Research Statement

Cardiovascular diseases are the major cause of death in the developed world. My research aims at providing insights into structure and function of tissues, cells and proteins of the normal and diseased heart. This research is motivated by my interest in combining science, engineering and medicine to improve health in society, and the obvious need for improved care of cardiovascular diseases.

Research Keywords

  • Confocal microscopy
  • Computational modeling of cardiac biophysics
  • Cardiovascular diseases
  • Cardiac regenerative therapy

Presentations

  • Cardiac Physiome Workshop, Toronto, Canada. “Role of Cardiac Fibroblasts in Cardiac Remodeling“. Invited Talk/Keynote, Presented, 11/2017.
  • Biological Engineering Department Seminar, Utah State University, Logan, Utah, USA. “Advanced Microscopy Approaches to Study the Normal and Diseased Heart“. Invited Talk/Keynote, Presented, 10/2017.
  • European Society of Cardiology - Heart Failure Congress, Paris, France. “Cardiac Dyssynchrony and the Effects of Resynchronization“. Invited Talk/Keynote, Presented, 04/2017.
  • Introduction to Image Based Modeling, University of Utah, Salt Lake City, Utah, USA. “Confocal Microscopy-Based Modeling of Cardiac Cells and Tissues”. Invited Talk/Keynote, Presented, 04/2017.
  • 2017 Western Atrial Fibrillation Symposium, Park City, Utah, USA. “Using Fiber-Optics Imaging to Detect and Target Atrial Myopathy“. Invited Talk/Keynote, Presented, 02/2017.
  • Osher Life Long Learning, University of Utah, Salt Lake City, USA. “Novel Insights into Cardiac Disease by Microscopic Imaging”. Invited Talk/Keynote, Presented, 02/2017.
  • Utah Cardiac Recovery Symposium, Salt Lake City, USA. “Understanding cellular and microstructural remodeling through UCAR”. Invited Talk/Keynote, Presented, 01/2017.
  • Bioengineering Department Colloquium, University of Utah, Salt Lake City, Utah, USA “Clinical Translation of Confocal Microscopy“. Other, Presented, 10/2016.
  • Introduction to Image Based Modeling, University of Utah, Salt Lake City, Utah, USA “Confocal Microscopy-Based Modeling of Cardiac Cells and Tissues”. Invited Talk/Keynote, Presented, 03/2016.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Targets for AF Related Atrial Fibrosis: Insight from Fiberoptic Imaging“. Invited Talk/Keynote, Presented, 02/2016.
  • Minisymposium, SIAM Conference on Computational Sciences and Engineering, Salt Lake City, Utah, USA “Towards Multidomain Modeling of Cardiac Electrophysiology“ . Invited Talk/Keynote, Presented, 04/2015.
  • Imaging Seminar, Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA “Confocal Microscopy-Based Analysis of Cardiac Cells and Tissues” . Invited Talk/Keynote, Presented, 04/2015.
  • Seminar, Institute for Computational Engineering & Sciences, University of Texas, Austin, USA “Computational Modeling of Cardiac Tissues and Cells“ . Invited Talk/Keynote, Presented, 03/2015.
  • Western Atrial Fibrillation Symposium, Park City, Utah, USA “Confocal Insights into AFib Pathophysiology“ . Invited Talk/Keynote, Presented, 02/2015.
  • Imaging Seminar, Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA “Applications of Confocal Microscopy in Cardiac Research” . Invited Talk/Keynote, Presented, 11/2014.
  • International Conference of Cellvizio Users, Opio, France “Towards Intraoperative Imaging of Cardiac Tissues Using Fiber-Optics Confocal Microscopy: Feasibility of Automated Tissue Discrimination Based on Image Texture Analysis“ . Invited Talk/Keynote, Presented, 04/2014.
  • Workshop on Integrating Modalities and Scales in Life Science Imaging, MBI, Columbus, Ohio, USA “Deriving Macroscopic Parameters for Computational Modeling of Cardiac Tissues from High-Resolution Three-Dimensional Confocal Microscopy “ . Invited Talk/Keynote, Presented, 03/2014.
  • Utah Cardiac Recovery Symposium, Salt Lake City, USA Invited by Profs. Selzman, Stehlik and Drakos „ Cardiac resynchronization effects on myocardial function and microstructure: how can this story help the recovery field?” . Invited Talk/Keynote, Presented, 01/2013.
  • IEEE EMBS Annual Conference, San Diego, USA Invited by Profs. Shyy and Sugiura „Mechanical Modulation of the Transverse Tubular System in Cardiac Myocytes” . Invited Talk/Keynote, Presented, 09/2012.
  • Seminar, Centre of Excellence for Toxicological Research, University of Parma, Italy Invited by Dr. Miragoli „Micro-Structural Remodeling of Ventricular Myocytes in Heart Failure and after Cardiac Resynchronization Therapy” . Invited Talk/Keynote, Presented, 06/2012.
  • Cardiac Mechanisms Workshop, Auckland, New Zealand Invited by Profs. Soeller and Ward „Mechanical Modulation of the Transverse Tubular System in Cardiomyocytes: Its Potential Role in Remodeling in Heart Disease” . Invited Talk/Keynote, Presented, 04/2012.
  • Workshop on Human Spare Body Parts, Tampere, Finland Invited by Prof. Hyttinen „Fiber-Optics Confocal Microscopy for Imaging of Cardiac Tissue” . Invited Talk/Keynote, Presented, 04/2012.
  • Biomedical Engineering Department Seminar, Johns Hopkins University, Baltimore Invited by Prof. McVeigh „Microscopic Characterization of Cells in Heart Failure and after Cardiac Resynchronization Therapy” . Invited Talk/Keynote, Presented, 11/2011.
  • Mauna Kea Technologies, Paris, France Invited by Dr. Lacombe „Towards Intrasurgical Imaging of Cardiac Tissue” . Other, Presented, 10/2011.
  • Joint Meeting of the Medical Engineering Center and British Heart Foundation, London, UK Invited by Prof. Razavi „Subcellular Remodeling in Heart Failure and after Cardiac Resynchronization Therapy” . Invited Talk/Keynote, Presented, 06/2011.
  • Cardiac Mechano-Electric Coupling and Arrhythmia Meeting, Oxford, UK „Stretch and the Cardiomyocyte Transverse Tubular System” . Invited Talk/Keynote, Presented, 09/2010.
  • Research in Progress Seminar, Cardiology Department, Primary Children’s Medical Center, Salt Lake City, Utah, USA „Intraoperative Mapping of Cardiac Tissue using Fiber-Optic Confocal Microscopy . Invited Talk/Keynote, Presented, 06/2010.
  • Institute of Regenerative Medicine Seminar, Tampere, Finland „Modeling in Cardiology" . Invited Talk/Keynote, Presented, 06/2010.
  • Seminar on Biomedical Image Quantification, Tampere, Finland „Fiber-Optics Confocal Microscopy” . Invited Talk/Keynote, Presented, 06/2010.
  • The Cardiac Physiome Conference: Multiscale and Multi-physics Mathematical Modelling Applied to the Heart, Cambridge, UK „A novel approach to multidomain modeling of electrical conduction in cardiac tissue“ . Invited Talk/Keynote, Presented, 08/2009.
  • Mechanics and Computation Seminar Series, Stanford University, USA “Imaging and Modeling of Cardiac Cells and Tissues” . Invited Talk/Keynote, Presented, 2009.
  • Computers in Cardiology Conference, Park City, Utah, USA “Imaging and Modeling of Cardiac Cells and Proteins” . Invited Talk/Keynote, Presented, 2009.
  • The Cardiac Physiome Conference: Multiscale and Multi-physics Mathematical Modelling Applied to the Heart, Cambridge, UK "A novel approach to multidomain modeling of electrical conduction in cardiac tissue“ . Invited Talk/Keynote, Presented, 2009.
  • NBCR Summer Institute on Cyberinfrastructure for Personalized Medicine, San Diego, USA “Patient-Specific Modeling of Structure and Function of Cardiac Cells” . Invited Talk/Keynote, Presented, 2009.
  • SIAM Life Sciences Conference, Montreal, Canada „Forward Looking Session - The Future of Model Sharing” . Invited Talk/Keynote, Presented, 08/2008.
  • IEEE EMBS Annual Conference, Lyon, France „Education for Biomedical Engineering Professionals–Crossing Boundaries between Disciplines” . Invited Talk/Keynote, Presented, 08/2007.
  • IV. Tissue Engineering Symposium, Tampere, Finland „Anatomical and Electro-Mechanical Modeling of Cardiac Cells” . Invited Talk/Keynote, Presented, 06/2007.
  • IV. Tissue Engineering Symposium, Tampere, Finland Invited by Profs. Rinne und Korpilahti „Anatomical and Electro-Mechanical Modeling of Cardiac Cells” . Invited Talk/Keynote, Presented, 2007.

Research Groups

  • Chao Huang, Postdoc. CARMA and CVRTI. 02/2106 - present. Awards/Scholarships/Stipends: NIH T32.
  • Marcus Blackburn, Undergraduate Student. Bioeng. 06/01/2017 - present.
  • Joachim Greiner, Visiting Student. 03/2017 - 10/2017. Awards/Scholarships/Stipends: PROMOS.
  • Aparna Chakkalakkal Sankarankutty, Graduate Student. Bioeng. 08/2016 - present.
  • Molly Streiff, Graduate Student. Bioeng. 08/2016 - present.
  • Jordan Johnson, Undergraduate Student. Bioeng. 01/2016 - present. Awards/Scholarships/Stipends: UROP.
  • Liza Zenger, Undergraduate Student. Biology. 10/2015 - 05/2017. Awards/Scholarships/Stipends: ACCESS.
  • Azmi Ahmad, Graduate Student. Bioeng. 08/2014 - present.
  • Chris Hunter, Technician. 12/2011 - present.

Research Equipment and Testing Expertise

  • Compute Server Cluster (Mac OSX).
  • Confocal microscope (Leica SP8 TCS).
  • Fiber-optics confocal microscope (Leica FCM 1000).
  • Spinning Disk Confocal Microscope (NCI).

Languages

  • French, functional.
  • German, fluent.

Geographical Regions of Interest

  • Finland
  • Germany
  • Spain

Publications

  • C. Huang, S. Wasmund, R. W. Hitchcock, Nassir F. Marrouche, and F. B. Sachse. Catheterized fiber-optics confocal microscopy of the beating heart in-situ. Circ Cardiovasc Imaging, 10(10), 2017. Published, 10/2017.
  • M. Sanguinetti and F. B. Sachse. Structural determinants and biophysical properties of hERG1 channel gating. In D. P. Zipes and J. Jalife, editors, Cardiac Electrophysiology: From Cell to Bedside, chapter 12. W. B. Saunders Company, 7. edition, 2017. Published, 06/2017.
  • F. B. Sachse, R. B. Clark, and W. R. Giles. No fuzzy space for intracellular Na+ in healthy ventricular myocytes. J Gen Physiol, 149(7):683-7, 2017. Published, 06/2017.
  • A. A. Ahmad, M. Streiff, C. Hunter, Q. Hu, and F. B. Sachse. Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes. Prog Biophys Mol Biol, 2017. EPub 16 Jun. In press, 06/2017.
  • T. Seidel, A. C. Sankarankutty, and F. B. Sachse. Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics. Prog Biophys Mol Biol, 2017. EPub 11 Jul. In press, 06/2017.
  • A. Mondal, F. B. Sachse, and A. P. Moreno. Modulation of asymmetric flux in heterotypic gap junctions by pore shape, particle size and charge. Front Physiol, 8:206, 2017. Published, 04/2017.
  • C. L. Welsh, E. H. Ibrahim, F. B. Sachse, and E. W. Hsu. Noninvasive characterization of myocardial fiber structure using MRI. In E. H. Ibrahim, editor, Heart Mechanics: Magnetic Resonance Imaging - Mathematical Modeling, Pulse Sequences, and Image Analysis, chapter 5, pages 179-246. CRC Press, 2017. Published, 04/2017.
  • T. Seidel, S. Navankasattusas, A. Ahmad, N. A. Diakos, W. D. Xu, M. Tristani-Firouzi, M. J. Bonios, I. Taleb, D. Y. Li, C. H. Selzman, S. G. Drakos, and F. B. Sachse. Sheet-like remodeling of the transverse tubular system in human heart failure impairs excitation-contraction coupling and functional recovery by mechanical unloading. Circ, 135(17):1632-45, 2017. Published, 04/2017.
  • R. B. Clark, T. Schmidt, F. B. Sachse, D. Boyle, G. Firestein, and W. R. Giles. Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol, 595(3):635-45, 2017. Published, 02/2017.
  • A. A. Ahmad, C. Hunter, Q. Hu, and F. B. Sachse. Functional role of TRPC1 channels in neonatal cardiomyocytes. In Biophys J (Annual Meeting Abstracts), volume 112, page 97a, 2017. Published, 02/2017.
  • A. Mondal, D. A. Appadurai, N. W. Akoum, F. B. Sachse, and A. P. Moreno. Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores. J Theor Biol, 412:61-73. Published, 01/2017.
  • F. B. Sachse and T. Seidel. Patient-specific modeling of structure and function of cardiac cells. In A. D. McCulloch, editor, Patient-Specific Modeling of the Cardiovascular System, 2. edition. Springer, Berlin, Heidelberg, New York, in press. In press, 12/2016.
  • W. Wu, A. Gardener, F. B. Sachse, and M. C. Sanguinetti. Ginsenoside Rg3, a gating modifier of EAG family K+ channels. Mol Pharmacol, 90(4):469-82, 2016. Published, 10/2016.
  • O. M. Abdullah, T. Seidel, M. Dahl, A. D. Gomez, G. Yiep, J. Cortino, F. B. Sachse, K. H. Albertine, and E. W. Hsu. Diffusion tensor imaging and histology of developing hearts. NMR Biomed, 29(10):1338-49, 2016. Published, 10/2016.
  • Romero D, Camara O, Sachse F, Sebastian R. Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. PLoS One. 2016 Oct 7;11(10):e0164093. 2016. Published, 10/2016.
  • I. A. Polejaeva, R. Ranjan, C. J. Davies, M. Regouski, J. Hall, A. L. Olsen, Q. Meng, H. M. Rutigliano, D. J. Dosdall, N. A. Angel, F. B. Sachse, T. Seidel, A. J. Thomas, R. Stott, K. E. Panter, P. M. Lee, A. J. Van Wettere, J. R. Stevens, Z. Wang, R. S. Macleod, N. F. Marrouche, and K. L. White. Increased susceptibility to atrial fibrillation secondary to atrial fibrosis in transgenic goats expressing transforming growth factor-β1. J. Cardiovasc Electrophysiol, 27(10):1220-9, 2016. Published, 10/2016.
  • J. Lichter, H. Li, and F. B. Sachse. Measurement of strain in cardiac myocytes at micrometer scale based on rapid scanning confocal microscopy and non-rigid image registration. Ann Biomed Eng, 44(10):3020-31, 2016. Published, 10/2016.
  • A Mondal, DA Appadurai, NW Akoum, FB Sachse, AP Moreno.Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores. J Theor Biol. Accepted, 08/2016.
  • Seidel T, Edelmann JC, Sachse FB. Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions. Ann Biomed Eng. 44(5):1436-48, 2016. Published, 05/2016.
  • Huang C, Sachse FB, Hitchcock RW, Kaza AK. Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy. PLoS One. 11(1):e0147667, 2016. Published, 01/2016.
  • Li H, Lichter JG, Seidel T, Tomaselli GF, Bridge JH, Sachse FB. Circ Heart Fail. Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure. Circ Heart Fail, 8:1105-14, 2015. Published, 11/2015.
  • Diakos NA, Selzman CH, Stehlik J, Sachse FB, Kfoury AG, Koliopoulou A, McKellar S, Fang JC, Li DY, Drakos SG.Reply: does size matter? In search of a physiological definition of myocardial atrophy. J Am Coll Cardiol. 65(19):2156-7, 2015. Published, 05/2015.
  • Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N. Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J Mol Cell Cardiol, 80C:186-95, 2015. Published, 03/2015.
  • K. Wemhoener, C. Friedrich, B. Stallmeyer, A. J. Coffey, A. Grace, S. Zumhagen, G. Seebohm, B. Ortiz-Bonnin, S. Rinne, F. B. Sachse, E. Schulze-Bahr, and N. Decher. Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J Mol Cell Cardiol, 2014. Published, 12/2014.
  • C. Huang, A. K. Kaza, R. W. Hitchcock, and F. B. Sachse. Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores. Circ Cardiovasc Imaging, 6(5):739-46, 2013. Published, 11/2014.
  • N. Diakos, C. Selzman, F. B. Sachse, O. Wever-Pinzon, A. Catino, A. Kfoury, J. Stehlik, R. Alharethi, B. Reid, D. Miller, M. Salama, A. Zaitsev, J. Shibayama, H. Li, J. Fang, D. Li, and S. Drakos. Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for ventricular assist device-induced cardiac recovery. J Am Coll Cardiol, 64(15):1602-12, 2014. Published, 11/2014.
  • O. M. Abdullah, S. G. Drakos, N. A. Diakos, O. Wever-Pinzon, A. G. Kfoury, J. Stehlik, C. H. Selzman, B. B. Reid, K. Brunisholz, D. R. Verma, C. Myrick, F. B. Sachse, D. Y. Li, and E. W. Hsu. Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation. NMR Biomed, 27(11):1378-86, 2014. Published, 11/2014.
  • J. Lichter, E. Carruth, C. Mitchell, A. S. Barth, T. Aiba, D. A. Kass, G. F. Tomaselli, J. H. Bridge, and F. B. Sachse. Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy. J Mol Cell Cardiol, 72:186-195, 2014. Published, 04/2014.
  • W. Wu, F. B. Sachse, A. Gardner, and M. C. Sanguinetti. Stoichiometry of altered hERG1 channel gating by small molecule activators. J Gen Physiol, 143(4):499-512, 2014. Published, 04/2014.
  • N. S. Torres, F. B. Sachse, L. Izu, J. I. Goldhaber, K. W. Spitzer, and J. H. Bridge. A modified local control model for Ca2+ transients in cardiomyocytes: Junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol, 68:1-11, 2014. Published, 04/2014.
  • M. Sanguinetti, M. Tristani-Firouzi, and F. B. Sachse. Structural determinants and biophysical properties of hERG1 channel gating. In D. P. Zipes and J. Jalife, editors, Cardiac Electrophysiology: From Cell to Bedside, chapter 12. W. B. Saunders Company, 6. edition, 2013. Published, 11/2013.
  • S. Bauer, J.-C. Edelmann, G. Seemann, F. B. Sachse, and O. Dössel. Estimating intracellular conductivity tensors from confocal microscopy of rabbit ventricular tissue. In Biomed Tech (Berl), volume 58, 2013. Published, 10/2013.
  • R. A. Navarro-Polanco, I. A. Aréchiga-Figueroa, P. D. Salazar-Fajardo, D. E. Benavides-Haro, J. C. Rodríguez-Elías, F. B. Sachse, M. Tristani-Firouzi, J. A. Sánchez-Chapula, and E. G. Moreno-Galindo. Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K+ current by choline in feline atrial myocytes. J Physiol, 591:4273-86, 2013. Published, 06/2013.
  • C. Huang, A. K. Kaza, R. W. Hitchcock, and F. B. Sachse. Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores. Circ Cardiovasc Imaging, 6(5):739-46, 2013. Published, 06/2013.
  • T. Seidel, T. Dräbing, G. Seemann, and F. B. Sachse. A semi-automatic approach for segmentation of three-dimensional microscopic image stacks of cardiac tissue. In S. Ourselin, D. Rueckert, and N. Smith, editors, Lecture Notes in Computer Science, volume 7945, pages 300-7. Springer, 2013. Published, 06/2013.
  • K. Sohn, A. R. Wende, E. D. Abel, A. P. Moreno, F. B. Sachse, and B. B. Punske. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol, 98:746-57, 2013. Published, 02/2013.
  • P. M. Kekenes-Huskey, Y. Cheng, J. E. Hake, F. B. Sachse, J. H. Bridge, M. J. Holst, J. A. McCammon, A. D. McCulloch, and A. P. Michailova. Modeling effects of l-type Ca2+ current and Na+-Ca2+ exchanger on Ca2+ trigger flux in rabbit myocytes with realistic t-tubule geometries. Front Physiol, 3:351, 2012. Published, 11/2012.
  • K. Sohn, A. R. Wende, E. D. Abel, A. P. Moreno, F. B. Sachse, , and B. B. Punske. Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia. Exp Physiol, 2012. In press, 11/2012.
  • T. G. McNary, K. W. Spitzer, H. Holloway, J. H. B. Bridge, P. Kohl, and F. B. Sachse. Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes. Prog Biophys Mol Biol, 110:218-25, 2012. Published, 10/2012.
  • E. M. Wülfers, N. S. Torres, G. Lenis, H. Li, G. Seemann, O. Dössel, J. H. B. Bridge, and F. B. Sachse. An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts. In Biomed Tech (Berl), 57-1, 46-49, 2012. Published, 10/2012.
  • G. Seemann, R. Moss, A. K. E. Kurz, O. Dössel, M. Tristani-Firouzi, and F. B. Sachse. A 2-state markov model of IKACh based on a membrane voltage dependent muscarinic M2 receptor approach. In Proc Comp Cardiol, 2012. Published, 10/2012.
  • V. Garg, F. B. Sachse, and M. Sanguinetti. Tuning of EAG K+ channel inactivation: molecular determinants of amplification by mutations and a small molecule. J Gen Physiol, 140(3):307-24, 2012. Published, 09/2012.
  • R. A. Lasher, A. Q. Pahnke, J. M. Johnson, F. B. Sachse, and R. W. Hitchcock. Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype. J Tissue Eng, 3(1):2041731412455354, 2012. Published, 07/2012.
  • F. B. Sachse, N. S. Torres, E. Savio-Galimberti, T. Aiba, D. A. Kass, G. F. Tomaselli, and J. H. Bridge. Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res, 110:588-97, 2012. Published, 02/2012.
  • R. H. Clayton, O. M. Bernus, E. M. Cherry, H. Dierckx, F. H. Fenton, D. Olmos Liceaga, L. Mirabella, A.V. Panfilov, F. B. Sachse, G. Seemann, and H. Zhang. Models of cardiac tissue electrophysiology: Progress, challenges and open questions. Prog Biophys Mol Biol, 104:22-48, 2011. Published, 06/2011.
  • M. Fink, S. A. Niederer, E. M. Cherry, F. H. Fenton, J. T. Koivumäki, G. Seemann, R. Thul, H. Zhang, F. B. Sachse, D. Beard, E. J. Crampin, and N. P. Smith. Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Prog Biophys Mol Biol, 104:2-21, 2011. Published, 06/2011.
  • N. Decher, K. Wemhoener, S. Rinne, M. F. Netter, M. Zuzarte, M. I. Aller, S. G. Kaufmann, X. T. Li, J. Daut, F. B. Sachse, and S. K. G. Maier. Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem, 28(1):77-86, 2011. Published, 06/2011.
  • M. Grunnet, J. Abbruzesse, F. B. Sachse, and M. C. Sanguinetti. Molecular determinants of hERG1 K+ channel activation by NS1643. Mol Pharmacol, 79(1):1-9, 2011. Published, 06/2011.
  • V. Garg, A. Stary-Weinzinger, F. B. Sachse, and M. Sanguinetti. Molecular determinants for activation of human ether-a-go-go related gene 1 potassium channels by 3-nitro-N-(4-phenoxyphenyl) benzamide. Mol Pharmacol, 80(4):630-7, 2011. Published, 06/2011.
  • S. H. Limberg, M. F. Netter, C. Rolfes, S. Rinne, G. Schlichthoerl, M. Zuzarte, T. Vassiliou, R. Moosdorf, H. Wulf, J. Daut, F. B. Sachse, and N. Decher. TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes. Cell Physiol Biochem, 28:613-24, 2011. Published, 06/2011.
  • D. P. Lackey, E. D. Carruth, R. A. Lasher, J. Boenisch, F. B. Sachse, and R. W. Hitchcock. Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue. Ann Biomed Eng, 39(11):2683-94, 2011. Published, 06/2011.
  • S. A. Niederer, E. Kerfoot, A. P. Benson, O. Bernus, M. O. Bernabeu, C. Bradley, E. M. Cherry, R. Clayton, F. H. Fenton, A. Garny, E. Heidenreich, S. Land, M. Maleckar, P. Pathmanathan, G. Plank, J. F. Rodríguez, I. Roy, F. B. Sachse, G. Seemann, O. Skavhaug, and N. P. Smith. Verification of cardiac tissue electrophysiology simulators using an N-version benchmark. Philos Transact A Math Phys Eng Sci, 369(1954):4331-51, 2011. Published, 06/2011.
  • E. G. Moreno-Galindo, J. A. Sánchez-Chapula, F. B. Sachse, J. A. Rodriguez-Paredes, M. Tristani-Firouzi, and R. A. Navarro-Polanco. Relaxation gating of the acetylcholine-activated inward rectifier K+ current (IKACh) is mediated by intrinsic voltage-sensitivity of the muscarinic receptor. J Physiol, 589(7):1755-67, 2011. Published, 06/2011.
  • K. Sohn, F. B. Sachse, A. P. Moreno, P. R. Ershler, A. R. Wende, E. D. Abel, and B. B. Punske. The maximal downstroke of epicardial potentials as an index of electrical activity in mouse heart. IEEE Trans Biomed Eng, 58(11):3175-83, 2011. Published, 06/2011.
  • T. A. Quinn, S. Granite, M. A. Allessie, C. Antzelevitch, C. Bollensdorff, G. Bub, R. A. B. Burton, E. Cerbai, P. S. Chen, M. Delmar, D. DiFrancesco, Y. E. Earm, I. R. Efimov, M. Egger, E. Entcheva, M. Fink, R. Fischmeister, M. R. Franz, A. Garny, W. R. Giles, T. Hannes, S. E. Harding, P. J. Hunter, G. Iribe, J. Jalife, C. R. Johnson, R. S. Kass, I. Kodama, G. Koren, P. Lord, V. S. Markhasin, S. Matsuoka, A. D. McCulloch, G. R. Mirams, G. E. Morley, S. Nattel, D. Noble, S. P. Olesen, A. V. Panfilov, N. A. Trayanova, U. Ravens, S. Richard, D. S. Rosenbaum, Y. Rudy, F. Sachs, F. B. Sachse, D. A. Saint, U. Schotten, O. Solovyova, P. Taggart, L. Tung, A. Varró, P.G. Volders, K. Wang, J. N. Weiss, E. Wettwer, E. White, R. Wilders, R. L. Winslow, and P. Kohl. Minimum information about a cardiac electrophysiology experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol, 107(1):4-10, 2011. Published, 06/2011.
  • T. G. McNary, J. H. Bridge, and F. B. Sachse. Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy. Biophys J, 100(10):L53-55, 2011. Published, 05/2011.
  • F. B. Sachse. Patient-specific modeling of structure and function of cardiac cells. In R. C. P. Kerckhoffs, editor, Patient-Specific Modeling of the Cardiovascular System, chapter 3, pages 43-61. Springer, Berlin, Heidelberg, New York, 1. edition, 2010. ISBN: 978-1-4419-6690-2. Published, 10/2010.
  • M. Grunnet, J. Abbruzesse, F. B. Sachse, and M. C. Sanguinetti. Molecular determinants of hERG1 K+ channel activation by NS1643. In press, 10/2010.
  • T. G. McNary, J. H. B. Bridge, and F. B. Sachse. Change in ellipticity of transverse tubules during strain in rabbit ventricular myocytes. In Proc 6th Annual Mountain West Biomedical Engineering Conference, 2010. Published, 09/2010.
  • G. Seemann, F. B. Sachse, M. Karl, D. L. Weiss, V. Heuveline, and O. Dössel. Framework for modular, flexible and efficient solving the cardiac bidomain equation using PETSc. In Prog Industrial Math ECMI 2008, Mathematics in Industry, pages 363-70, Berlin, Heidelberg, New York, 2010. Springer. Published, 08/2010.
  • J. Abbruzzese, F. B. Sachse, M. Tristani-Firouzi, and M. C. Sanguinetti. Modification of hERG1 channel gating by Cd2+. J Gen Physiol, 136(2):203-24. Published, 05/2010.
  • E. G. Moreno-Galindo, G. F. Barrio-Echavarria, J. C. Vasquez, N. Decher, F. B. Sachse, M. Tristani-Firouzi, J. A. Sanchez-Chapula, and R. A. Navarro-Polanco. Molecular basis for a high-potency open channel block of Kv1.5 channel by the endocannabinoid anandamide. Mol Pharmacol, 77(5):751-8, 2010. Published, 05/2010.
  • R. H. Clayton, O. M. Bernus, E. M. Cherry, H. Dierckx, F. H. Fenton, L. Mirabella, A.V. Panfilov, F. B. Sachse, G. Seemann, and H. Zhang. Models of cardiac tissue electrophysiology: Progress, challenges and open questions. Prog Biophys Mol Biol. In press, 05/2010.
  • M. Fink, S. A. Niederer, E. M. Cherry, F. H. Fenton, J. T. Koivumäki, G. Seemann, R. Thul, H. Zhang, F. B. Sachse, D. Beard, E. J. Crampin, and N. P. Smith. Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Prog Biophys Mol Biol, 2010. In press, 03/2010.
  • N. S. Torres, A. Rock, E. Savio-Galimberti, F. B. Sachse, and J. H. B. Bridge. Occurrence of spontaneous sparks in ventricular myocytes from junctional and non-junctional RyR clusters. In Biophys J (Annual Meeting Abstracts), 2010. Published, 02/2010.
  • N. S. Torres, R. Larbig, A. Rock, F. B. Sachse, K. D. Philipson, J. I. Goldhaber, and J. H. B. Bridge. Sodium current-induced release of calcium from the sarcoplasmic reticulum in rabbit ventricular myocytes. In Biophys J (Annual Meeting Abstracts), 2010. Published, 02/2010.
  • Special Issue: Functional Imaging and Modeling of the Heart. Med Image Anal, 13(2):345, 2009. Published, 06/2009.
  • T. G. McNary and F. B. Sachse. Modeling effects of strain-modulated membrane capacitance and conductance of K+ inward-rectifier on conduction velocity in cardiac tissue. In Proc Comp Cardiol. Published, 2009.
  • F. B. Sachse, E. Savio-Galimberti, J. I. Goldhaber, and J. H. B. Bridge. Towards computational modeling of excitation-contraction coupling in cardiac myocytes: Reconstruction of structures and proteins from confocal imaging. In Pac Symp Biocomp, volume 14, pages 328-39. Published, 2009.
  • K. Sohn, B. B. Punske, and F. B. Sachse. Relationship between maximal upstroke velocity of transmembrane voltage and minimum time derivative of extracellular potential. In Lecture Notes in Computer Science, volume 5528, pages 505-12. Springer. Published, 2009.
  • R. A. Lasher, R. W. Hitchcock, and F. B. Sachse. Towards modeling of cardiac micro-structure with catheter-based confocal microscopy: A novel approach for dye delivery and tissue characterization. IEEE Trans Med Imaging, 28(8):1156-64. Published, 2009.
  • A. Lopez-Izquierdo, D. Ponce-Balbuena, T. Ferrer, F. B. Sachse, M. Tristani-Firouzi, and J. A. Sánchez-Chapula. Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico. Cell Physiol Biochem, 24(3-4):153-60. Published, 2009.
  • M. D. Perry, F. B. Sachse, J. Abbruzzese, and M. C. Sanguinetti. PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance. Proc Natl Acad Sci U S A, 106(47):20075-80. Published, 2009.
  • F. B. Sachse, A. P. Moreno, G. Seemann, and J. A. Abildskov. A model of electrical conduction in cardiac tissue including fibroblasts. Ann Biomed Eng, 37(5):874-89. Published, 2009.
  • F. B. Sachse and G. Seemann. Special issue: Functional imaging and modelling of the heart. Med Image Anal, 13(2):345. Published, 2009.
  • F. B. Sachse, E. Savio-Galimberti, J. I. Goldhaber, and J. H. B. Bridge. Sub-micrometer anatomical models of the sarcolemma of cardiac myocytes based on confocal imaging. Pac Symp Biocomp, 13:390-401, 2008. Published, 12/2008.
  • F. B. Sachse, A. P. Moreno, and J. A. Abildskov. Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng, 36(1):41-56, 2008. Published, 12/2008.
  • A. A. Rodríguez-Menchaca, R. A. Navarro-Polanco, T. Ferrer-Villada, J. Rupp, F. B. Sachse, M. Tristani-Firouzi, and J. A. Sánchez-Chapula. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A, 105(4):1364-8, 2008. Published, 12/2008.
  • E. Savio-Galimberti, J. Frank, M. Inoue, J. I. Goldhaber, M. B. Cannell, J. H. B. Bridge, and F. B. Sachse. Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys J, 95:2053-62, 2008. Published, 12/2008.
  • T. G. McNary, K. Sohn, B. Taccardi, and F. B. Sachse. Experimental and computational studies of strain-conduction velocity relationships in cardiac tissue. Prog Biophys Mol Biol.,97(2-3):383-400, 2008. Published, 12/2008.
  • D. R. Piper, J. Rupp, F. B. Sachse, M. C. Sanguinetti, and M. Tristani-Firouzi. Cooperative interactions between R531 and basic residues in the voltage sensing module of hERG1 channels. Cell Physiol Biochem, 21:37-46, 2008. Published, 12/2008.
  • N. Decher, T. Gonzalez, A. K. Streit, F. B. Sachse, V. Renigunta, M. Soom, S. H. Heineman, J. Daut, and M. C. Sanguinetti. Structural Determinants of Kvβ1.3 Induced Channel Inactivation: A Hairpin Modulated by PIP2. EMBO J, 27(23):3164-74, 2008. Published, 12/2008.
  • D. Fernandez, J. Sargent, F. B. Sachse, and M. C. Sanguinetti. Structural basis for ether-a-go-go-related gene K+ channel subtype-dependent activation by niflumic acid. Mol Pharm, 3(4):1159-67, 2008. Published, 12/2008.
  • C. Putzke, K. Wemhöner, F. B. Sachse, S. Rinne, G. Schlichthörl, X. T. Lia, L. Jae, I. Eckhardt, E. Wischmeyer, H. Wulf, R. Preisig-Müller, J. Daut, and N. Decher. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res, 75(1):59-68, 2007. Published, 12/2007.
  • M. D. Perry, F. B. Sachse, and M. C. Sanguinetti. Structural basis of action for a human ether-a-go-go related gene 1 potassium channel activator. Proc Natl Acad Sci U S A, 104(34):13827-32, 2007. Published, 12/2007.
  • G. Seemann, F. B. Sachse, D. L Weiss, L. J. Ptacek, and M. Tristani-Firouzi. Modeling of IK1 mutations in human left ventricular myocytes and tissue. Am J Physiol Heart Circ Physiol, 292(1):H549-59, 2007. Published, 12/2007.
  • S. E. Geneser, R. M. Kirby, D. Xiu, and F. B. Sachse. Stochastic markovian modeling of electrophysiology of ion channels: Reconstruction of standard deviations in macroscopic currents. J Theor Biol, 245(4):627-637, 2007. Published, 12/2007.
  • E. Savio, J. Frank, M. Inoue, J. Goldhaber, M. B. Cannell, J. H. B. Bridge, and F. B. Sachse. High-resolution three-dimensional confocal microscopy reveals novel structures in rabbit ventricular myocyte t-tubules. In Biophys. J (Annual Meeting Abstracts), 2007. Published, 01/2007.