Purinergic regulation of renal function - physiology, pathophysiology and experimental therapeutics. Role of purinergic signaling in diet-induced obesity and insulin resistance.
Dr. Kishore has more 30 years of research experience in renal physiology, pathophysiology and experimental therapeutics gained in India, Japan, Beligum and the United States, which includes the Intramural Research Program of the National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland. His current research focuses on the role of purinergic signaling in the genesis of clinically relevant water balance disorders and diet-induced obesity. Specifically, he investigates acquired nephrogenic diabetes insipidus (NDI) often seen in Veterans and geriatric population, such chronic lithium toxicity on the kidney and post-obstructve uropathy. Dr. Kishore and his collaborators identified and filed patents for novel drug targets for the treatment of acquired NDI and diet-induced obesity. In addition, Dr. Kishore and his collaborators developed and patented a novel method to induce proliferation of erythropoietin (EPO)-producing cells in the kidney. This model has clinical and biotechnological applications. Over the years, Dr. Kishore's research has been funded by the Department of Veterans Affairs, National Institute of Diabetes and Digestive and Kidney Diseases, National Foundation of Utah & Idaho, University of Utah Research Foundation, Western Institute for Biomedical Research and Eye Foundation of America.