MATTHEW S SIGMAN portrait
  • Peter J. Christine S. Stang Presidential Endowed Chair of Chemistry, Chemistry
  • Chair, Department of Chemistry, College Of Science
  • Distinguished Professor, Chemistry
801-585-0774

Publications

  • Yuan, Q.; Sigman, M. S.* “Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ‑Lactams,” J. Am. Chem. Soc. 2018, 140, 6527–6530. Published, 05/10/2018.
    https://pubs.acs.org/doi/abs/10.1021/jacs.8b02752
  • Patel, H. H.; Prater, M. B.; Squire Jr, S. O.§; Sigman, M. S.* “Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers,” J. Am. Chem. Soc. 2018, 140, 5895-5898. Published, 04/17/2018.
    https://pubs.acs.org/doi/abs/10.1021/jacs.8b02751
  • Santiago, C. B.; Guo, J.-Y.; Sigman, M. S.* “Predictive and Mechanistic Multivariate Linear Regression Models for Reaction Development,” Chem. Sci. 2018, 9, 2398-2412. Published, 01/22/2018.
    http://pubs.rsc.org/en/content/articlepdf/2014/SC/...
  • Koen H. Hendriks, K. H.; Robinson, S. G.; Braten, M. N.; Sevov, C. S.; Helms, B. A.; Sigman, M. S.; Minteer, S. D.; Sanford, M. S.* “High-Performance Oligomeric Catholytes for Effective Macromolecular Separation in Nonaqueous Redox Flow Batteries,” ACS Central Science, 2018, 4, 189-196. Published, 01/17/2018.
    https://pubs.acs.org/doi/abs/10.1021/acscentsci.7b...
  • Crawford, J. M.; Stone, E. A.; Metrano, A. J.; Miller, S. J.*; Sigman, M. S.* “Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones,” J. Am. Chem. Soc. 2018, 140, 868–871. Published, 01/04/2018.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b11303
  • Liao, K.; Liu, W.; Niemeyer, Z. L.; Ren, Z.; Bacsa, J.; Musaev, D. G.*; Sigman, M. S.*; Davies, H. M. L.* “Site-Selective Carbene-Induced C–H Functionalization Catalyzed by Dirhodium Tetrakis(triarylcyclopropanecarboxylate) Complexes,” ACS Catalysis 2018, 8, 678-682. Published, 12/18/2017.
    https://pubs.acs.org/doi/pdf/10.1021/acscatal.7b03...
  • Lancaster, L.; Hickey, D. P.; Sigman, M. S.; Minteer, S. D.; Wheeldon, I.* “Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation,” Chem. Comm. 2018, 54, 491-494. Published, 12/13/2017.
    http://pubs.rsc.org/en/content/articlelanding/2017...
  • Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.*; Toste, F. D.* “Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation Using Anionic-Phase Transfer Catalysis,” Angew. Chem. Int. Ed. 2018, 57, 589-593. Published, 11/23/2017.
    https://onlinelibrary.wiley.com/doi/full/10.1002/a...
  • Park, Y. Niemeyer, Z. L.; Yu, J.-Q.; Sigman, M. S.* “Quantifying Structural Effects of Amino Acid Ligands in Pd(II)-Catalyzed Enantioselective C−H Functionalization Reactions,” Organometallics, 2018, 37, 203-210. Cover Art. Published, 11/21/2017.
    https://pubs.acs.org/doi/abs/10.1021/acs.organomet...
  • Bischoff, A. J.; Nelson, B. M.; Niemeyer, Z. L.; Sigman, M. S.*; Movassaghi, M. “Quantitative Modeling of Bis(pyridine)silver (I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates,” J. Am. Chem. Soc. 2017, 139, 15539-15547. Published, 10/04/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b09541
  • Race, N. J.; Patel, H. H.; Sigman, M. S., “Science of Synthesis: Catalytic Oxidation in Organic Synthesis,” 2017, 1, 429. Published, 10/2017.
    https://science-of-synthesis.thieme.com/app/text/?...
  • Orlandi, M.; Toste, F. D.; Sigman, M. S.* “Multidimensional Correlations in Asymmetric Catalysis via Parameterization of Uncatalyzed Transition States,” Angew. Chem. Int. Ed. 2017, 56, 14080-14084.. Published, 09/13/2017.
  • Niemeyer, Z. L.; Pindi, S.; Khrakovsky, D. A.; Kuzniewski, C. N.; Hong, C. M.; Joyce, L. A.; Sigman, M. S.*; Toste, F. D. “Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization,” J. Am. Chem. Soc. 2017, 139, 12943-12946. Published, 09/08/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b08791
  • Macazo, F. C.; Hickey, D. P.; Abdellaoui, S.; Sigman, M. S.; Minteer, S. D.* “Polymer-Immobilized, Hybrid Multi-Catalyst Architecture for Enhanced Electrochemical Oxidation of Glycerol,” Chem. Comm. 2017, 53, 10310-10313. Published, 08/25/2017.
    http://pubs.rsc.org/en/content/articlelanding/2017...
  • Engl, P. S.; Santiago, C. B.; Gordon, C. P.; Liao, W.-C.; Fedorov, A.*; Copéret, C.*; Sigman, M. S.*; Togni, A.* “Exploiting and Understanding the Selectivity of Ru-NHC Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes,” J. Am. Chem. Soc. 2017, 139, 13117-13125. Published, 08/18/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b06947
  • Orlandi, M.; Hilton, M. J.; Yamamoto, E.; Toste, F. D.; Sigman, M. S.* “Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates,” J. Am. Chem. Soc. 2017, 139, 12688-12695. Published, 08/11/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b06917
  • James B. C. Mack, J. B. C.; Gipson, J. D.; Du Bois, J.*; Sigman, M. S.* "Ruthenium-Catalyzed C–H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives,” J. Am. Chem. Soc. 2017, 139, 9503–9506. Published, 06/29/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b05469
  • Keylor, M. H.; Niemeyer, Z. L.; Sigman, M. S.*; Tan, K. L.* “Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines,” J. Am. Chem. Soc. 2017, 139, 10613-10616. Published, 06/17/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b05409
  • Plata, R. E.; David E. Hill, D. E.; Haines, B. E.; Musaev, D. G.; Chu, L.; Hickey, D. P.; Sigman, M. S.; Yu, J.-Q.; Blackmond, D. G.* “Role for Pd(IV) in Catalytic Enantioselective C-H Functionalization with Monoprotected Amino Acid Ligands under Mild Conditions,” J. Am. Chem. Soc. 2017, 139, 9238–9245. Published, 06/12/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b03716
  • Christian, A. H.; Niemeyer, Z. L.; Sigman, M. S.*; Toste, F. D.* “Uncovering Subtle Ligand Effects of Phosphines Using Gold(I) Catalysis,” ACS Catalysis, 2017, 7, 3973–3978. Published, 05/10/2017.
  • Guo, J.-Y.; Minko, Y.; Santiago, C. B.; Sigman, M. S.* “Developing Comprehensive Computational Parameter Sets to Describe the Performance of Pyridine-Oxazoline and Related Ligands,” ACS Catalysis, ACS Catalysis 2017, 7, 4144-4151. Published, 05/05/2017.
    https://pubs.acs.org/doi/pdf/10.1021/acscatal.7b00...
  • Orlandi, M.; Jaime A. S. Coelho, J. A. S.; Hilton, M. J.; Toste, F. D.*, Sigman, M. S.* “Parameterization of Noncovalent Interactions for Transition State Interrogation in Catalysis,” J. Am. Chem. Soc. 2017, 139, 6803-6806.. Published, 05/05/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b02311
  • Chen, Z.-M.; Nervig, C. S.; DeLuca, R. J.; Sigman, M. S. “Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters,” Angew. Chem. Int. Ed., 2017, 56, 6651. Published, 05/03/2017.
    https://onlinelibrary.wiley.com/doi/full/10.1002/a...
  • Woods, B. P.; Orlandi, M.; Huang, C.-Y.; Sigman, M. S.; Doyle, A. G. “Nickel-catalyzed enantioselective reductive cross coupling of styrenyl aziridines,” J. Am. Chem. Soc. 2017, 139, 5688–5691.. Published, 04/13/2017.
  • Toste, F. D.*; Sigman, M. S.*; Miller, S. J.* “Pursuit of Non-Covalent Interactions for Strategic Site-Selective Catalysis,” Acc. Chem. Res. 2017, 50, 609-615.. Published, 03/21/2017.
    https://pubs.acs.org/doi/abs/10.1021/acs.accounts....
  • Liua, Y.; Hickey, D. P.; Guo, J.-Y.; Earl, E.; Abdellaouib, S.; Ross D. Milton, R. D.; Sigman, M. S.*; Minteer, S. D.*; Calabrese-Barton, S.* “Substrate Channeling in an Artificial Metabolon: A Molecular Dynamics Blueprint for an Experimental Peptide Bridge,” ACS Catalysis, 2017, 7, 2486-2493.. Published, 02/27/2017.
    https://pubs.acs.org/doi/abs/10.1021/acscatal.6b03...
  • Sevov, C. S.; Hickey, D. P.; Cook, M. E.; Robinson, S. G.; Barnett, S.; Minteer, S. D.*; Sigman, M. S.*; Sanford, M. S.* “A Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications,” J. Am. Chem. Soc., 2017, 139, 2924-2927. Press Release; Highlighted: Chem. & Eng. News. Cover. Spotlight: J. Am. Chem. Soc. 2017, 139, 3569. Published, 02/21/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b00147
  • Avila, C. M. & Patel, J. S.; Reddi, Y.; Saito, M.; Nelson, H. M.; Shunatona, H. P.; Sigman, M. S.; Sunoj, R. B.*; Toste, F. D.* (2017). Enantioselective Heck–Matsuda Arylations via Chiral Anion Phase Transfer of Aryl Diazonium Salts,. Angew. Chem. Int. Ed. 2017, 56, 5806. Published, 04/2017.
    http://onlinelibrary.wiley.com/doi/10.1002/anie.20...
  • Thornbury, R. T. & Saini, V.; Fernandes,T. A.; Santiago, C. B.; Talbot, E. P. A.; Sigman, M. S.; McKenna, J. M.; Toste, F. D.* (2017). The Development and Mechanistic Investigation of a Palladium-Catalyzed 1,3-Arylfluorination of Chromenes,. Chemical Science. 2890-2897. Published, 08/2017.
    http://pubs.rsc.org/en/content/articlepdf/2017/sc/...
  • Neel, A. J. & Hilton, M. J.; Sigman, M. S.*; Toste, F. D.* (2017). Exploiting noncovalent π interactions for catalyst design. Nature. 637–646. Published, 03/2017.
    https://www.nature.com/articles/nature21701
  • Zhang, C.; Tutkowski, B.; DeLuca, R. J.; Joyce, L. A.; Wiest, O.; Sigman, M. S.* “Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters,” Chem. Sci. 2017, 8, 2277-2282.. Published, 08/2017.
  • Hilton, M. J.; Sigman, M. S. (S)-4-(tert-BUTYL)-2-[4-(TRIFLUOROMETHYL)PYRIDIN-2-YL] (2016), Encyclopedia of Reagents for Organic Synthesis [Online], John Wiley & Sons Ltd., http://onlinelibrary.wiley.com/book/10.1002/047084289X. Published, 01/2016.
  • Race, N. J.; Schwalm, C. S.; Nakamuro, T.; Sigman, M. S.* “Palladium-Catalyzed Enantioselective Intermolecular Coupling of Phenols and Allylic Alcohols,” J. Am. Chem. Soc. 2016, 138, 15881-15884. Highlighted: Chem. & Eng. News 2016, 94 (48), 11.. Published, 12/05/2016.
  • Yamamoto, E.; Hilton, M. J.; Orlandi, M.; Saini, V.; Toste, F. D.; Sigman, M. S.* “Development and Analysis of a Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Acrylates Enabled by Chiral Anion Phase-Transfer,” J. Am. Chem. Soc. 2016, 138, 15877-15880.. Published, 11/22/2016.
  • Patel, H. H.; Sigman, M. S.* “Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols To Form Allylic Quaternary Centers,” J. Am. Chem. Soc. 2016, 138, 14226–14229. Published, 10/21/2016.
  • Santiago, C. B.; Milo, A.; Sigman, M. S.* “Developing a Modern Approach To Account for Steric Effects in Hammett-Type Correlations,” J. Am. Chem. Soc. 2016, 138, 13424–13430. Published, 09/21/2016.
  • Chen, Z.-M.; Hilton, M. J.; Sigman, M. S.*; “Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols,” J. Am. Chem. Soc. 2016, 138, 11461-11464. Published, 08/29/2016.
  • Xu, L.-P.; Zhang, X.; McCammant, M. S.; Sigman, M. S.; Wu, Y.-D.; Wiest, O.*; “Mechanism and Selectivity in the Pd-Catalyzed Difunctionalization of Isoprene,” J. Org. Chem. 2016, 81, 7604-7611.. Published, 08/03/2016.
  • Zhang, C. & Tutkowski, B.; DeLuca, R. J.; Joyce, L. A.; Wiest, O.; Sigman, M. S (2016). Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters. The Royal Science of Chemistry. Published, 08/2016.
  • Sigman, M. S. *; Harper, K. C.; Bess, E. N.; Milo, A. “The Development of Multidimensional Analysis Tools for Asymmetric Catalysis and Beyond,” Acc. Chem. Res. 2016, 49, 1292–1301. Published, 05/24/2016.
  • McCammant, M. S.; Shigeta, T.; Sigman, M. S.* “Palladium-Catalyzed 1,3-Difunctionalization using Terminal Alkenes with Alkenyl Nonaflates and Aryl Boronic Acids,” Org. Lett. 2016, 18, 1792-1795.. Published, 03/28/2016.
  • Wheeldon, I.*; Minteer, S. D.; Banta, S.; Calabrese-Barton, S. Atanassov, P.; Sigman, M. S. “Substrate channeling as an approach to cascade reactions,” Nature Chem. 2016, 8, 299-309.. Published, 03/22/2016.
  • Neel, A. J.; Milo, A.; Sigman, M. S.*; Toste, F. D.* “Enantiodivergent Fluorination of Allylic Alcohols: Dataset Design Reveals Structural Interplay Between Achiral Directing Group and Chiral Anion,” J. Am. Chem. Soc. 2016, 138, 3863-3875.. Published, 03/11/2016.
  • Weldy, N. M.; Schafer, A. G.; Owens, C. P.; Herting, C. J.; Varela-Alvarez, A.; Chen, S.; Niemeyer, Z. L.; Musaev, D. G.*; Sigman, M. S.*; Davies, H. M. L.*; Blakey, S. B.* “Iridium(III)-bis(imidazolinyl)phenyl Catalysts for Enantioselective C–H Functionalization with Ethyl Diazoacetate,” Chem. Sci. 2016, 7, 3142-3146.. Published, 02/05/2016.
  • Milo, A., Neel, A. J.; Toste, F. D.*; Sigman, M. S.* “A Data-Driven Approach to Mechanistic Elucidation in Chiral Anion Catalysis,” Science, 2015, 347, 737-743. Perspective: Lu, T.; Wheeler, S. E. Harnessing weak interactions for enantioselective catalysis,” Science, 2015, 347, 719-720. Published, 02/13/2015.
  • Saini, V.; O’Dair, M. §; Sigman, M. S.* “Synthesis of Highly Functionalized Tri-and Tetrasubstituted Alkenes via Pd-Catalyzed 1,2-Hydrovinylation of Terminal 1,3-Dienes,” J. Am. Chem. Soc. 2015, 137, 608-611.. Published, 01/02/2015.
  • McCammant, M. S.; Sigman, M. S.* “Development and Investigation of a Site Selective Palladium-Catalyzed 1,4-Difunctionalization of Isoprene using Pyridine-Oxazoline Ligands,” Chem. Sci. 2015, 6, 1355-1361. . Published, 11/28/2014.
  • Vaden, R. M.; Gligorich, K. M.; Jana, R.; Sigman, M. S.; Welm, B. E. “The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and ER stress,” Breast Cancer Res., 2014, 16, 472.. Published, 11/26/2014.
  • Hickey, D. P.; McCammant, M. S.; Giroud, F.; Sigman, M. S.*, Minteer, S. D.* “Hybrid Enzymatic and Organic Electrocatalytic Cascade for the Complete Oxidation of Glycerol,” J. Am. Chem. Soc., 2014, 136, 15917-15920.. Published, 10/28/2014.
  • Bess, E. N.; Bischoff, A. J.§; Sigman, M. S.* “Designer Substrate Library for Quantitative, Predictive Modelling of Reaction Performance,” Proc. Nat. Acad. Sci. 2014, 111, 14698-14703.. Published, 10/14/2014.
  • Hilton, M. J.; Xu, L.-P.; Norrby, P.-O.; Wu, Y.-D.; Wiest, O.; Sigman, M. S.* “Investigating the Nature of Palladium Chain-Walking in the Enantioselective Redox-Relay Heck Reaction of Alkenyl Alcohols,” J. Org. Chem. 2014, 79, 11841-11850.. Published, 09/04/2014.
  • Stokes, B. J.; Liao, L.; de Andrade, A. §; Wang, Q.; Sigman, M. S.* “A Palladium-Catalyzed Three-Component-Coupling Strategy for the Differential Vicinal Diarylation of Terminal 1,3-Dienes,” Org. Lett. 2014, 16, 4666-4669.. Published, 08/27/2014.
  • Michel, B. M.; Steffens, L. D.; Sigman, M. S.* “The Wacker Oxidation” In Organic Reactions Volume 84; Denmark, S. E. Ed., John Wiley & Sons, Inc.: 2014; pp 75-414. Published, 07/2014.
  • Milo, A.; Bess, E. N.; Sigman, M. S.* "Interrogating Selectivity in Catalysis using Molecular Vibrations," Nature 2014, 507, 210-214. Published, 01/07/2014.
  • Bess, E. N.; Sigman, M. S., Linear Free Energy Relationships (LFERs) in Asymmetric Catalysis. In Asymmetric Synthesis II: More Methods and Applications, Christmann, M.; Bräse, S., Eds. Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, 2012; pp 363-370. Published, 12/2012.
  • Werner, E. W.; Mei, T.-S.; Burckle, A. J.; Sigman, M. S.* “Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy,” Science 2012, 338, 1455-1458. . Published, 12/2012.
    http://www.sciencemag.org/content/338/6113/1455.ab...
  • Liao, L.; Sigman, M. S.* “Palladium Sparteine Dichloride” e-EROS Encyclopedia of Reagents for Organic Synthesis, 2012. Published, 09/2012.
    http://onlinelibrary.wiley.com/o/eros/articles/rn0...
  • Jana, R.; Pathak, T. P.; Jensen, K. H.; Sigman, M. S.* “Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives,” Org. Lett. 2012, 14, 4074.. Published, 08/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol3016989
  • Pathak, T. P.; Osiak, J. G.§; Vaden, R. M.; Welm, B. E.; Sigman, M. S.* “Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles,” Tetrahedron 2012, 68, 5203-5208.. Published, 07/2012.
    http://www.sciencedirect.com/science/article/pii/S...
  • Saini, V.; Sigman, M. S.* “Palladium-Catalyzed 1,1-Difunctionalization of Ethylene,” J. Am. Chem. Soc. 2012, 134, 11372.. Published, 07/2012.
    http://pubs.acs.org/doi/abs/10.1021/ja304344h
  • Ridges, S.; Heaton, W. L.; Joshi, D.; Choi, H.; Eiring, A.; Batchelor, L.; Choudhry, P.; Manos, E. J.; Sofla, H.; Sanati, A.; Welborn, S.; Agarwal, A.; Spangrude, G. J.; Miles, R. R.; Cox, J. E.; Frazer, J. K.; Deininger, M.; Balan, K.; Sigman, M.; Müschen, M.; Perova, T.; Johnson, R.; Montpellier, B.; Guidos, C. J.; Jones, D. A.; Trede, N. S.* “Zebrafish screen identifies novel compound with selective toxicity against leukemia,” Blood 2012, 119, 5621. Published, 06/2012.
    http://bloodjournal.hematologylibrary.org/content/...
  • Stokes, B. J.; Opra, S. M.; Sigman, M. S. "Pd-Catalyzed Allylic C-H Aryl- and Vinylation Reactions of Primary- and Secondary Homoallylic Tosylates," J. Am. Chem. Soc. 2012, 134, 11408. Published, 06/2012.
    http://pubs.acs.org/doi/abs/10.1021/ja305403s
  • Sigman, M. S.*; Werner, E. W. “Imparting Catalyst-Control upon Classical Palladium-Catalyzed Alkenyl C‒H Bond Functionalization Reactions” Acc. Chem. Res. 2012, 45, 874-884.. Published, 06/2012.
    http://pubs.acs.org/doi/abs/10.1021/ar200236v
  • Harper, K. C.; Bess, E. N.; Sigman, M. S.* “Multidimensional Steric Parameters in the Analysis of Asymmetric Catalytic Reactions,” Nature Chem. 2012, 4, 366-374. . Published, 03/2012.
    http://www.nature.com/nchem/journal/v4/n5/full/nch...
  • Michel, B. W.; Sigman, M. S.* “Peroxide-Mediated Wacker Oxidations for Organic Synthesis,” Aldrichchica Acta 2011, 44, 55-61. Published, 12/2011.
    http://www.sigmaaldrich.com/etc/medialib/docs/Aldr...
  • Pathak, T. P.; Sigman, M. S.* “Applications of ortho-Quinone Methide Intermediates in Catalysis and Asymmetric Synthesis,” J. Org. Chem. 2011, 76, 9210-9215. Published, 10/16/2011.
    http://pubs.acs.org/doi/abs/10.1021/jo201789k
  • Harper, K. C.; Sigman, M. S.* “3-D Correlation of Steric and Electronic Free Energy Relationships Guides Asymmetric Propargylation,” Science 2011, 333, 1875-1878. Published, 09/30/2011.
    http://www.sciencemag.org/content/333/6051/1875.fu...
  • DeLuca, R. J.; Sigman, M. S.* “Anti-Markovnikov Hydroalkylation of Allylic Amine Derivatives via a Palladium-Catalyzed Reductive Cross-Coupling Reaction” J. Am. Chem. Soc. 2011, 133, 11454. Published, 07/05/2011.
    http://pubs.acs.org/doi/abs/10.1021/ja204080s
  • Werner, E. W.; Sigman, M. S.* “Operationally Simple and Highly (E)-Styrenyl-Selective Heck Reactions of Electronically Non-Biased Olefins” J. Am. Chem. Soc. 2011, 133, 9692-9695. Published, 05/31/2011.
    http://pubs.acs.org/doi/abs/10.1021/ja203164p
  • Michel, B. W.; Steffens, L. D.; Sigman, M. S.* “On the Mechanism of the Palladium-Catalyzed TBHP-Mediated Wacker-Type Oxidation of Alkenes using Quinoline-2-Oxazoline Ligands” J. Am. Chem. Soc. 2011, 133, 8317-8325. Published, 05/09/2011.
    http://pubs.acs.org/doi/abs/10.1021/ja2017043
  • Pathak, T. P.; Sigman, M. S.* “Palladium-Catalyzed Hydrofunctionalization of Vinyl Phenol Derivatives with Heteroaromatics” Org. Lett. 2011, 13, 2774-2777. Published, 04/21/2011.
    http://pubs.acs.org/doi/abs/10.1021/ol200913r
  • Liao, L.; Jana, R.; Urkalan, K. B.; Sigman, M. S.* “A Palladium-Catalyzed Three Component Cross-Coupling of Conjugated Dienes or Terminal Alkenes with Vinyl Triflates and Boronic Acids” J. Am. Chem. Soc. 2011, 133, 5784-5787. Published, 03/30/2011.
    http://pubs.acs.org/doi/abs/10.1021/ja201358b
  • McCombs, J. R.§; Michel, B. W.; Sigman, M. S.* “Catalyst-Controlled Wacker-Type Oxidation of Homoallylic Alcohols in the Absence of Protecting Groups” J. Org. Chem. 2011, 76, 3609-3613. Published, 03/29/2011.
    http://pubs.acs.org/doi/abs/10.1021/jo200462a
  • Podhajsky, S. M.; Iwai, Y.; Cook-Sneathen, A. §; Sigman, M. S.* “Asymmetric palladium-catalyzed hydroarylation of styrenes and dienes” Tetrahedron 2011, 67, 4435-4441. Published, 02/17/2011.
    http://www.sciencedirect.com/science/article/pii/S...
  • Jana, R.; Pathak, T. P.; Sigman, M. S.* “Advances in Transition Metal (Pd, Ni, Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-Organometallics as Reaction Partners,” Chem. Rev. 2011, 111, 1417-1492. Published, 02/14/2011.
    http://pubs.acs.org/doi/abs/10.1021/cr100327p
  • Harper, K. C.; Sigman, M. S.* “Predicting and Optimizing Asymmetric Catalyst Performance Using the Principles of Experimental Design and Steric Parameters,” Proc. Nat. Acad. Sci. 2011, 108, 2179-2183. Published, 01/24/2011.
    http://www.pnas.org/content/early/2011/01/21/10133...
  • Jensen, K. H.; Webb, J. D.; Sigman, M. S.* “Advancing the Mechanistic Understanding of an Enantioselective Palladium-Catalyzed Alkene Difunctionalization Reaction,” J. Am. Chem. Soc. 2010, 132, 17471-17482. Published, 11/17/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja108106h
  • Jensen, K. H.; Sigman, M. S.* “Evaluation of Catalyst Acidity and Substrate Electronic Effects in a Hydrogen Bond-Catalyzed Enantioselective Reaction,” J. Org. Chem. 2010, 75, 7194-7201. Published, 10/04/2010.
    http://pubs.acs.org/doi/pdf/10.1021/jo1013806
  • Werner, E. W.; Sigman, M. S.* “A Highly Selective and General Palladium Catalyst for the Oxidative Heck Reaction of Electronically Non-Biased Olefins,” J. Am. Chem. Soc. 2010, 132, 13981-13983. Published, 09/21/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja1060998
  • Michel, B. W.; McCombs, J. R.; Winkler, A.; Sigman, M. S.* “Catalyst Contolled Wacker-Type Oxidation of Protected Allylic Amines,” Angew. Chem. Int. Ed. 2010, 49, 7312-7315. Published, 08/26/2010.
    http://onlinelibrary.wiley.com/doi/10.1002/anie.20...
  • Anderson, B. J.; Keith, J. A.; Sigman, M. S.* “Experimental and Computational Study of a Direct O2-Coupled Wacker Oxidation: Water Dependence in the Absence of Cu Salts,” J. Am. Chem. Soc. 2010, 132, 11872-11874. Published, 08/05/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja1057218
  • Liao, L.; Sigman, M. S.* “Palladium-Catalyzed Hydroarylation of 1,3-Dienes with Boronic Esters via Reductive Formation of π-Allyl Palladium Intermediates under Oxidative Conditions ” J. Am. Chem. Soc. 2010, 132, 10209-10211. Published, 07/08/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja105010t
  • Pathak, T. P.; Gligorich, K. M.; Welm, B. E.; Sigman, M. S.* “Synthesis and Preliminary Biological Studies of 3-Substituted Indoles Accessed by a Palladium-Catalyzed Enantioselective Alkene Difunctionalization Reaction” J. Am. Chem. Soc. 2010, 132, 7870-7871. Published, 05/20/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja103472a
  • Gustafson, J. L.; Sigman, M. S.*; Miller, S. J.* “Linear Free-Energy Relationship Analysis of a Catalytic Desymmetrization Reaction of a Diarylmethane-bis(phenol),” Org. Lett. 2010, 12, 2794-2797. Published, 05/20/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ol100927m
  • Werner, E. W.; Urkalan, K. B.; Sigman, M. S.* “PdII-Catalyzed Oxidative 1,1-Diarylation of Terminal Olefins,” Org. Lett. 2010, 12, 2848-2851. Published, 05/19/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ol1009575
  • Souza, L. W.; Miller, B. R.; Cammarota, R. C.; Lo, A.; Lopez, I.; Bergstrom, B. D.; Yuan-Shin Shiue, Y.- S.; Dishman, S. N.; Fettinger, J. C.; Sigman, M. S.*; Shaw, J. T.*, “Deconvoluting Nonlinear Catalyst-Substrate Effects in the Intramolecular Dirhodium-Catalyzed C‒H Insertion of Donor/Donor Carbenes using Data Science Tools,” ACS Catalysis, 2024, 14, 104-115. Published, 12/11/2023.
    https://doi.org/10.1021/acscatal.3c04256
  • Raghavan, P.; Hass, B. C.; Ruos, M. E.; Schleinitz, J.; Doyle, A. G.; Reisman, S. E.; Sigman, M. S.; Coley, C. W.* “Dataset Design for Building Models of Chemical Reactivity,” ACS Central Science 2023, 9, 2196-2204.. Published, 12/08/2023.
    https://doi.org/10.1021/acscentsci.3c01163
  • Matthews, A. D.; Peters, E.; Debenham, J. S.; Gao, Q., Nyamiaka, M. D.; Pan, J.; Zhang, L.-K.; Dreher, S. D.; Krska, S. W.; Sigman, M. S.* Uehling, M. R.* “Cu-Oxamate Promoted Cross-Coupling of a-Branched Amines and Complex Aryl Halides: Investigating Ligand Function Through Data Science,” ACS Catalysis, 2023, 13, 16195–16206. . Published, 12/05/2023.
    https://doi.org/10.1021/acscatal.3c04566
  • Pancoast, A. R.; McCormack, S. L.; Galinat, S.§; Walser-Kuntz, R.; Jett, B. M.; Sanford, M. S.; Sigman, M. S.* “Data Science Enabled Discovery of a Highly Soluble 2,2’-Bipyrimidine Anolyte for Application in a Flow Battery,” Chem. Sci. 2023, 14, 13734-13742.. Published, 11/02/2023.
    https://doi.org/10.1039/D3SC04084D
  • Morack, T.; Tyler E. Myers, T. E.; Karas, L. J.; Hardy, M. A.; Mercado, B. Q.; Sigman, M. S.*; Miller, S. J.* “An Asymmetric Aromatic Finkelstein Reaction: A Platform for Remote Diarylmethane Desymmetrization,” J. Am. Chem. Soc. 2023, 145, 22322–22328. Published, 10/03/2023.
    https://doi.org/10.1021/jacs.3c08727
  • Dotson JJ, van Dijk L, Timmerman JC & Grosslight S (2023). Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands. Journal of the American Chemical Society. Vol. 145, 110121110-121. Published, 01/01/2023.
  • Nistanaki SK, Williams CG, Wigman B, Wong JJ & Haas BC (2022). Catalytic asymmetric C-H insertion reactions of vinyl carbocations. Science (New York, N.Y.). Vol. 378, 108510911085-1091. Published, 12/01/2022.
  • Vaid TP, Cook ME, Scott JD & Borjesson Carazo M (2022). Theoretical and Experimental Investigation of Functionalized Cyanopyridines Yield an Anolyte with an Extremely Low Reduction Potential for Nonaqueous Redox Flow Batteries. Chemistry (Weinheim an der Bergstrasse, Germany). Vol. 28, e202202147e202202147. Published, 12/01/2022.
  • Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK & Timmerman JC (2022). Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Journal of the American Chemical Society. Vol. 144, 209552096320955-20963. Published, 11/01/2022.
  • Tang T, Jones E & Wild T (2022). Investigating Oxidative Addition Mechanisms of Allylic Electrophiles with Low-Valent Ni/Co Catalysts Using Electroanalytical and Data Science Techniques. Journal of the American Chemical Society. Vol. 144, 200562006620056-20066. Published, 11/01/2022.
  • Kelly SP, Shende VV, Flynn AR & Dan Q (2022). Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A. Journal of the American Chemical Society. Vol. 144, 193261933619326-19336. Published, 10/01/2022.
  • Xu EY, Werth J & Roos CB (2022). Noncovalent Stabilization of Radical Intermediates in the Enantioselective Hydroamination of Alkenes with Sulfonamides. Journal of the American Chemical Society. Vol. 144, 189481895818948-18958. Published, 10/01/2022.
  • Boni YT & Cammarota RC (2022). Leveraging Regio- and Stereoselective C(sp3)-H Functionalization of Silyl Ethers to Train a Logistic Regression Classification Model for Predicting Site-Selectivity Bias. Journal of the American Chemical Society. Vol. 144, 155491556115549-15561. Published, 09/01/2022.
  • Gnaim S, Bauer A, Zhang HJ, Chen L, Gannett C, Malapit CA, Hill DE, Vogt D, Tang T, Daley RA & Hao W (2022). Cobalt-electrocatalytic HAT for functionalization of unsaturated C-C bonds. Nature. Vol. 605, 687695687-695. Published, 05/01/2022.
  • Haas BC & Goetz AE (2022). Predicting relative efficiency of amide bond formation using multivariate linear regression. Proceedings of the National Academy of Sciences of the United States of America. Vol. 119, e2118451119e2118451119. Published, 04/01/2022.
  • Cammarota RC & Liu W (2022). Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C-H Functionalization Reactions. Journal of the American Chemical Society. Vol. 144, 188118981881-1898. Published, 03/01/2022.
  • Gensch T, Dos Passos Gomes G, Friederich P, Peters E & Gaudin T (2022). A Comprehensive Discovery Platform for Organophosphorus Ligands for Catalysis. Journal of the American Chemical Society. Vol. 144, 120512171205-1217. Published, 02/01/2022.
  • Cammarota RC & Liu W (2022). Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C-H Functionalization Reactions. Journal of the American Chemical Society. Vol. 144, 1881-1898. Published, 02/01/2022.
  • Zell D, Kingston C, Jermaks J, Smith SR & Seeger N (2022). Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. Vol. 143, 19078-19090. Published, 02/01/2022.
  • Dotson JJ (2022). A Data-Driven Approach to the Development and Understanding of Chiroptical Sensors for Alcohols with Remote γ-Stereocenters. Journal of the American Chemical Society. Vol. 143, 19187-19198. Published, 02/01/2022.
  • Gensch T, Dos Passos Gomes G, Friederich P, Peters E & Gaudin T (2022). A Comprehensive Discovery Platform for Organophosphorus Ligands for Catalysis. Journal of the American Chemical Society. Vol. 144, 1205-1217. Published, 02/01/2022.
  • Dherange BD & Kelly PQ (2022). Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines. Journal of the American Chemical Society. Vol. 143, 11337-11344. Published, 02/01/2022.
  • Zell D, Kingston C, Jermaks J, Smith SR & Seeger N (2022). Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. Vol. 143, 19078-19090. Published, 02/01/2022.
  • Dotson JJ (2022). A Data-Driven Approach to the Development and Understanding of Chiroptical Sensors for Alcohols with Remote γ-Stereocenters. Journal of the American Chemical Society. Vol. 143, 19187-19198. Published, 02/01/2022.
  • Dherange BD & Kelly PQ (2022). Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines. Journal of the American Chemical Society. Vol. 143, 11337-11344. Published, 02/01/2022.
  • Clements HD, Flynn AR, Nicholls BT, Grosheva D, Hyster TK & Sigman MS (2021). Workflow for Biocatalytic Reaction Performance Prediction and Analysis. ChemRxiv. Published, 12/23/2021.
  • Yan Y, Robinson SG, Vaid TP, Sigman MS & Sanford MS (2021). Simultaneously Enhancing the Redox Potential and Stability of Multi-Redox Organic Catholytes by Incorporating Cyclopropenium Substituents. Journal of the American Chemical Society. Vol. 143, 13450-13459. Published, 12/01/2021.
  • Saito M, Kawamata Y, Meanwell M, Navratil R, Chiodi D, Carlson E, Hu P, Chen L, Udyavara S, Kingston C, Tanwar M, Tyagi S, McKillican BP, Gichinga MG, Schmidt MA, Eastgate MD, Lamberto ML, He C, Tang T, Malapit C, Sigman MS, Minteer SD & Neurock M (2021). N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation. Journal of the American Chemical Society. Vol. 143, 7859-7867. Published, 12/01/2021.
  • Yan Y, Vogt DB, Sigman MS & Sanford MS (2021). Development of High Energy Density Diaminocyclopropenium-Phenothiazine Hybrid Catholytes for Non-Aqueous Redox Flow Batteries. Angewandte Chemie (International ed. in English). Vol. 60, 27039-27045. Published, 12/01/2021.
  • Malapit C, Tanwar M, Pendergast AD, Udyavara S, Beck WD, Smith RE, Kadic S, Primo T, Wu AD, Stone T, White HS, Neurock M, Sigman MS & Shelley SD (2021). Electrochemical cobalt-catalyzed selective carboxylation of benzyl halides with CO2 enabled by low-coordinate cobalt electrocatalysts. ChemRxiv. Published, 11/05/2021.
  • Dotson JJ, Anslyn EV & Sigman MS (2021). A Data-Driven Approach to the Development and Understanding of Chiroptical Sensors for Alcohols with Remote γ‐Stereocenters. Journal of the American Chemical Society. Vol. 143, 19187-19198. Published, 11/04/2021.
  • Zell D, Kingston C, Jermaks J, Smith SR, Seeger N, Wassmer J, Sirois LE, Han C, Zhang H, Sigman MS & Gosselin F (2021). Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. Vol. 143, 19078-19090. Published, 11/04/2021.
  • Williams WL, Zeng L, Gensch T, Sigman MS, Doyle AG & Anslyn EV (2021). The Evolution of Data-Driven Modeling in Organic Chemistry. ACS central science. Vol. 7, 1622-1637. Published, 11/01/2021.
  • Li M, Odom SA, Roberston LA, Vaid T, Agarwal G, Doan HA, Suduwella TM, Bheemireddy SR, Assary RS, Zhang L, Sigman MS & Minteer SD (2021). Experimental Protocols for Studying Organic Non-aqueous Redox Flow Batteries. ACS Energy Letters. Vol. 60, 3932-3943. Published, 10/18/2021.
  • De Jesus Silva J, Bartalucci N, Jelier B, Grosslight S, Gensch T, Schunemann C, Muller B, Kamer PCJ, Coperet C, Sigman MS & Togni A (2021). Development and Molecular Understanding of a Pd-Catalyzed Cyanation of Aryl Boronic Acids Enabled by High-Throughput Experimentation and Data Analysis. Helvetica Chimica Acta. Vol. 104. Published, 10/04/2021.
  • Newman-Stonebraker SH, Smith SR, Borowski JE, Mensch T, Peters EB, Johnson HC, Sigman MS & Doyle AG (2021). Univariate classification of phosphine ligation state and reactivity in cross-coupling catalysis. Science (New York, N.Y.). Vol. 374, 301-308. Published, 10/01/2021.
  • Werth J & Sigman MS (2021). Linear Regression Model Development for Analysis of Asymmetric Copper-Bisoxazoline Catalysis. ACS catalysis. Vol. 11, 3916-3922. Published, 10/01/2021.
  • Kraus SL, Ross SP & Sigman MS (2021). Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction. Organic letters. Vol. 23, 2505-2509. Published, 10/01/2021.
  • Kelly SP, Shende VV, Flynn AR, Dan Q, Ye Y, Smith JL, Tsukamoto S, Sigman MS & Sherman DH (2021). Structural and Data Science-Driven Analysis to Assess Substrate Specificity of Diketopiperazine Reverse Prenyltransferase NotF: Cascade Biocatalytic Synthesis of (–)-Eurotiumin A. ChemRxiv. Published, 09/06/2021.
  • Gnaim S, Bauer A, Zhang HJ, Chen L, Gannet C, Malapit C, Hill D, Vogt D, Tang T, Daley R, Quertenmont M, Beck WD, Kandahari E, Vantourout JC, Pierre-Georges Echeverria PG, Abruna H, Blackmond D, Minteer S, Reisman S, Sigman MS & Baran PS (2021). Cobalt-Electrocatalytic Hydrogen Atom Transfer for Functionalization of Unsaturated C–C Bonds. Nature. Published, 08/25/2021.
  • Gensch T, Smith SR, Colacot TJ, Timsina Y, Xu G, Glasspoole BW & Sigman MS (2021). Design and Application of a Screening Set for Monophosphine Lig-ands in Metal Catalysis. ChemRxiv. Published, 08/13/2021.
  • Rein J, Meinhardt JM, Wahlman JLH, Sigman MS & Lin S (2021). An Explosophore-Based Approach Towards the Prediction of Energetic Material Sensitivity Properties. ChemRxiv. Published, 08/10/2021.
  • Griffin JD, Vogt DB, Du Bois J & Sigman MS (2021). Mechanistic Guidance Leads to Enhanced Site-Selectivity in C–H Oxidation Reactions Catalyzed by Ruthenium bis(Bipyridine) Complexes. ACS Catalysis. Vol. 11, 10479-10486. Published, 08/09/2021.
  • Christensen M, Yunker LPE, Adedeji F, Roch LM, Mensch T, dos Passos Gomes G, Zepel T, Sigman MS, Aspuru-Guzik A & Hein JE (2021). Data-science driven autonomous process optimization. Communications Chemistry. Vol. 4. Published, 08/02/2021.
  • Griffin JD, Pancoast AR & Sigman MS (2021). Interrogation of 2,2'-Bipyrimidines as Low-Potential Two-Electron Electrolytes. Journal of the American Chemical Society. Vol. 143, 992-1004. Published, 08/01/2021.
  • Robinson SG, Mack JBC, Alektiar SN, Du Bois J & Sigman MS (2021). Electrochemical Ruthenium-Catalyzed C-H Hydroxylation of Amine Derivatives in Aqueous Acid. Organic letters. Vol. 22, 7060-7063. Published, 08/01/2021.
  • Dherange BD, Kelly PQ, Liles JP, Sigman MS & Levin MD (2021). CarbonAtomInsertioninto Pyrroles and Indoles Promoted by Chlorodiazirines. Journal of the American Chemical Society. Vol. 143, 11337–11344. Published, 07/21/2021.
  • Kulik HJ & Sigman MS (2021). Advancing Discovery in Chemistry with Artificial Intelligence: From Reaction Outcomes to New Materials and Catalysts. (pp. 2335−2336). Vol. 54. Accounts of chemical research. Published, 05/18/2021.
  • Miró J, Gensch T & Ellwart M (2021). Enantioselective Allenoate-Claisen Rearrangement Using Chiral Phosphate Catalysts. Journal of the American Chemical Society. Vol. 142, 6390-6399. Published, 04/01/2021.
  • Levin MD & Ovian JM (2021). Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides. Journal of the American Chemical Society. Vol. 142, 14831-14837. Published, 04/01/2021.
  • Ross SP, Rahman AA & Sigman MS (2021). Development and Mechanistic Interrogation of Interrupted Chain-Walking in the Enantioselective Relay Heck Reaction. Journal of the American Chemical Society. Vol. 142, 10516-10525. Published, 04/01/2021.
  • Rosales AR, Ross SP, Helquist P, Norrby PO, Sigman MS & Weist O (2021). Transition State Force Field for the Asymmetric Redox-Relay Heck Reaction. Journal of the American Chemical Society. Vol. 142, 9700-9707. Published, 04/01/2021.
  • DeLano TJ, Dibrell SE, Lacker CR, Pancoast AR, Poremba KE, Cleary L, Sigman MS & Reisman SE (2021). Nickel-Catalyzed Asymmetric Reductive Cross-Coupling of α-Chloroesters with (Hetero)Aryl Iodides. Chemical Science. Vol. 12, 7758-7762. Published, 02/09/2021.
  • Mack JBC & Gipson JD (2021). Correction to "Ruthenium-Catalyzed C-H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives". (pp. 3016). Vol. 143. Journal of the American Chemical Society. Published, 02/01/2021.
  • Shrestha, Anuska, Hendriks, Koen H. , Sigman, Matthew S. , Minteer, Shelley D. & Sanford, Melanie S. (2021). Realization of an Asymmetric Non‐Aqueous Redox Flow Battery through Molecular Design to Minimize Active Species Crossover and Decomposition. Chemistry A European Journal. Vol. 26, 5369-5373. Published, 01/12/2021.
    https://chemistry-europe.onlinelibrary.wiley.com/d...
  • Reisman SE & Sarpong R (2021). Organic Chemistry: A Call to Action for Diversity and Inclusion. The Journal of organic chemistry. Vol. 85, 10287-10292. Published, 01/01/2021.
  • Prater MB & Sigman MS (2021). Enantioselective Synthesis of Alkyl Allyl Ethers via Palladium-Catalyzed Redox-Relay Heck Alkenylation of O-Alkyl Enol Ethers. Israel journal of chemistry. Vol. 60, 452-460. Published, 01/01/2021.
  • Yuan Q, Prater MB & Sigman MS (2020). Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy. Advanced synthesis & catalysis. Vol. 362, 326-330. Published, 12/23/2020.
  • Reisman SE & Sarpong R (2020). Organic Chemistry: A Call to Action for Diversity and Inclusion. Organic letters. Vol. 22, 6223-6228. Published, 12/01/2020.
  • Li J & Grosslight S (2020). Site-selective acylation of natural products with BINOL-derived phosphoric acids. ACS catalysis. Vol. 9, 9794-9799. Published, 11/01/2020.
  • Robinson, Sophia G., Wu, Xiangyu, Sigman, Matthew S. & Lin, Song (2020). RETURN TO ISSUEPREVARTICLENEXT Mechanistic Studies Inform Design of Improved Ti(salen) Catalysts for Enantioselective [3 + 2] Cycloaddition. Journal of the American Chemical Society. Vol. 142, 18471-18482. Published, 10/16/2020.
    https://pubs.acs.org/doi/10.1021/jacs.0c07128
  • Christian AH, Jia S, Cao W & Zhang P (2020). A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation. Journal of the American Chemical Society. Vol. 141, 12657-12662. Published, 10/01/2020.
  • Crawford JM (2020). Conformational Dynamics in Asymmetric Catalysis: Is Catalyst Flexibility a Design Element?. Synthesis. Vol. 51, 1021-1036. Published, 10/01/2020.
  • Hendriks KH, Robinson SG, Braten MN & Sevov CS (2020). High-Performance Oligomeric Catholytes for Effective Macromolecular Separation in Nonaqueous Redox Flow Batteries. ACS central science. Vol. 4, 189-196. Published, 10/01/2020.
  • Reid JP & Proctor RSJ (2020). Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines. Journal of the American Chemical Society. Vol. 141, 19178-19185. Published, 10/01/2020.
  • Bahamonde A & Al Rifaie B (2020). Enantioselective Markovnikov Addition of Carbamates to Allylic Alcohols for the Construction of α-Secondary and α-Tertiary Amines. Journal of the American Chemical Society. Vol. 141, 8708-8711. Published, 09/01/2020.
  • Allen JR & Bahamonde A (2020). Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction. Journal of the American Chemical Society. Vol. 141, 8670-8674. Published, 09/01/2020.
  • Robinson SG & Yan Y (2020). Developing a Predictive Solubility Model for Monomeric and Oligomeric Cyclopropenium-Based Flow Battery Catholytes. Journal of the American Chemical Society. Vol. 141, 10171-10176. Published, 09/01/2020.
  • Reisman SE & Sarpong R (2020). Organic Chemistry: A Call to Action for Diversity and Inclusion. ACS central science. Vol. 6, 1241-1247. Published, 09/01/2020.
  • Sandford C & Fries LR (2020). Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization. Journal of the American Chemical Society. Vol. 141, 18877-18889. Published, 09/01/2020.
  • Werth, Jacob & Sigman, Matthew S. (2020). Connecting and Analyzing Enantioselective Bifunctional Hydrogen Bond Donor Catalysis Using Data Science Tools. Journal of the American Chemical Society. Vol. 142, 16382-16391. Published, 08/26/2020.
    https://pubs.acs.org/doi/abs/10.1021/jacs.0c06905
  • Werth J & Sigman MS (2020). Connecting and Analyzing Enantioselective Bifunctional Hydrogen Bond Donor Catalysis Using Data Science Tools. Journal of the American Chemical Society. Vol. 142, 16382-16391. Published, 08/26/2020.
  • Levin, Mark D. , Ovian, John M. , Read, Jacquelyne, Sigman, Matthew S. & Jacobsen, Eric N. (2020). Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides. Journal of the American Chemical Society. Vol. 142, 14831-14837. Published, 08/17/2020.
    https://pubs.acs.org/doi/10.1021/jacs.0c07043
  • Reisman, Sarah E. , Sarpong, Richmond, Sigman, Matthew S. & Yoon, Tehshik P. (2020). Organic Chemistry: A Call to Action for Diversity and Inclusion. The Journal of Organic Chemistry. Vol. 85, 10287-10292. Published, 08/10/2020.
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  • De Jesus, Silva, Ferreira, Marco A. B. , Fedorov, Alexey, Sigman, Matthew S. & Coperet, Chistophe (2020). Molecular-level insight in supported olefin metathesis catalysts by combining surface organometallic chemistry, high throughput experimentation, and data analysis. Royal Society of Chemistry. Vol. 26, 6593-6926. Published, 07/14/2020.
    https://pubs.rsc.org/en/content/articlepdf/2020/sc...
  • Kwon Y, Li J, Reid JP & Crawford JM (2020). Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration. Journal of the American Chemical Society. Vol. 141, 6698-6705. Published, 06/01/2020.
  • Yan Y & Robinson SG (2020). Mechanism-Based Design of a High-Potential Catholyte Enables a 3.2 V All-Organic Nonaqueous Redox Flow Battery. Journal of the American Chemical Society. Vol. 141, 15301-15306. Published, 06/01/2020.
  • Tsai, Cheng-Che, Sandford, Christopher, Wu, Tao, Chen, Buyun, Sigman, Matthew S. & Toste, Dean F. (2020). Enantioselective Intramolecular Allylic Substitution via Synergistic Palladium/Chiral Phosphoric Acid Catalysis: Insight into Stereoinduction through Statistical Modeling. Angeandte Chemie, International Edition. Vol. 59, 14647-14655. Published, 05/26/2020.
    https://onlinelibrary.wiley.com/doi/abs/10.1002/an...
  • Tsai CC, Sandford C, Wu T, Che B, Sigman MS & Toste FD (2020). Enantioselective Intramolecular Allylic Substitution via Synergistic Palladium/Chiral Phosphoric Acid Catalysis: Insight into Stereoinduction through Statistical Modeling. Angewandte Chemie (International ed. in English). Vol. 59, 14647-14655. Published, 05/26/2020.
  • Robinson, Sophia G., Mack, James B. C. , Alektier, Sara N. , Du Bois, J. & Sigman, Matthew S. (2020). Electrochemical Ruthenium-Catalyzed C–H Hydroxylation of Amine Derivatives in Aqueous Acid. Organic Letters. Vol. 22, 7060-7063. Published, 05/18/2020.
    https://pubs.acs.org/doi/abs/10.1021/acs.orglett.0...
  • Ferreira MAB, De Jesus Silva J & Grosslight S (2020). Noncovalent Interactions Drive the Efficiency of Molybdenum Imido Alkylidene Catalysts for Olefin Metathesis. Journal of the American Chemical Society. Vol. 141, 10788-10800. Published, 05/01/2020.
  • Allen JR & Bahamonde A (2020). Correction to "Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction". Journal of the American Chemical Society. Vol. 141, 12420. Published, 05/01/2020.
  • Albright H, Riehl PS, McAtee CC & Reid JP (2020). Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles. Journal of the American Chemical Society. Vol. 141, 1690-1700. Published, 05/01/2020.
  • Rosales, Anthony, R, Ross, Sean P. , Helquist, Per, Norrby, Per-Ola, Sigman, Matthew S. & Wiest, Olaf (2020). Transition State Force Field for the Asymmetric Redox-Relay Heck Reaction. Journal of the American Chemical Society. Vol. 142, 9709707. Published, 04/05/2020.
    https://pubs.acs.org/doi/abs/10.1021/jacs.0c01979
  • Shrestha A & Hendriks KH (2020). Realization of an Asymmetric Non-Aqueous Redox Flow Battery through Molecular Design to Minimize Active Species Crossover and Decomposition. Chemistry (Weinheim an der Bergstrasse, Germany). Vol. 26, 5369-5373. Published, 04/01/2020.
  • Robinson SG (2020). Integrating Electrochemical and Statistical Analysis Tools for Molecular Design and Mechanistic Understanding. Accounts of chemical research. Vol. 53, 289-299. Published, 04/01/2020.
  • Reid, Jolene, Hu, Mingyou, Ito, Susumu, Huang, Banruo, Hong, Cynthia M., Xiang, Hengye, Sigman, Matthew S. & Toste, Dean F. (2020). Strategies for remote enantiocontrol in chiral gold(III) complexes applied to catalytic enantioselective -Diels–Alder reactions. Chemical Science. Vol. 11, 6450-6456. Published, 03/19/2020.
    https://pubs.rsc.org/en/content/articlepdf/2020/sc...
  • Miro, Javier, Gensch, Tobias, Ellwart, Mario, Han, Seo-Jung, Lin, Hsin-Hui, Sigman, Matthew S. & Toste, Dean F. (2020). Enantioselective Allenoate-Claisen Rearrangement Using Chiral Phosphate Catalysts. Journal of the American Chemical Society. Vol. 142, 6390-6399. Published, 03/17/2020.
    https://pubs.acs.org/doi/10.1021/jacs.0c01637
  • Ross, Sean P. , Rahman, Ajara A. & Sigman, Matthew S. (2020). Development and Mechanistic Interrogation of Interrupted Chain-Walking in the Enantioselective Relay Heck Reaction. Journal of the American Chemical Society. Vol. 142, 10516-10525. Published, 03/15/2020.
    https://pubs.acs.org/doi/10.1021/jacs.0c03589
  • Mack JBC, Walker KL & Robinson SG (2020). Mechanistic Study of Ruthenium-Catalyzed C-H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest. Journal of the American Chemical Society. Vol. 141, 972-980. Published, 03/01/2020.
  • Hickey DP, Sandford C & Rhodes Z (2020). Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates. Journal of the American Chemical Society. Vol. 141, 1382-1392. Published, 03/01/2020.
  • Liu J & Yuan Q (2020). Enantioselective construction of remote tertiary carbon-fluorine bonds. Nature chemistry. Vol. 11, 710-715. Published, 03/01/2020.
  • Hickey DP, Sandford C & Rhodes Z (2020). Correction to "Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates". Journal of the American Chemical Society. Vol. 141, 15464. Published, 03/01/2020.
  • Zhao S, Gensch T & Murray B (2020). Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization. Science (New York, N.Y.). Vol. 362, 670-674. Published, 02/01/2020.
  • Robinson, Sophia G. & Sigman, Matthew S. (2020). Integrating Electrochemical and Statistical Analysis Tools for Molecular Design and Mechanistic Understanding. Accounts of Chemical Research. Vol. 53, 289-299. Published, 01/10/2020.
    https://pubs.acs.org/doi/10.1021/acs.accounts.9b00...
  • Yuan Q (2020). Palladium-Catalyzed Enantioselective Alkenylation of Enelactams Using a Relay Heck Strategy. Chemistry (Weinheim an der Bergstrasse, Germany). Vol. 25, 10823-10827. Published, 01/01/2020.
  • Vaden RM, Guillen KP, Salvant JM, Santiago CB & Gibbons JB (2020). A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A. ACS chemical biology. Vol. 14, 106-117. Published, 01/01/2020.
  • Albright, H & Riehl, P. S.; McAtee, C. C.; Reid, J. P.; Ludwig, J. R.; Karp, L. A.; Zimmerman, P.; Sigman, M. S.; Schindler, C. S (2019). Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles. Journal of The American Chemical Society. Vol. 141, 1690-1700. Published, 12/31/2019.
    https://pubs.acs.org/doi/10.1021/jacs.8b11840
  • Reid, J. P & Proctor, R. S. J.; Sigman, M. S.*; Phipps, R. J.* (2019). Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines. Journal of The American Chemical Society. Vol. 141, 19178-19185. Published, 11/11/2019.
  • Sandford, C. & Fries, L. R.§; Ball, T. E.; Minteer, S. D.*; Sigman, M. S.* (2019). Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization. Journal of The American Chemical Society. Vol. 141, 18877-18889. Published, 11/04/2019.
  • Engl PS, Santiago CB, Gordon CP & Liao WC (2019). Correction to "Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes". Journal of the American Chemical Society. Vol. 140, 18227-18228. Published, 11/01/2019.
  • Woods BP & Orlandi M (2019). Correction to "Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines". Journal of the American Chemical Society. Vol. 140, 7744-7745. Published, 11/01/2019.
  • Yuan, Q & Prater, M. B.; Sigman, M. S (2019). Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy. Advanced Synthesis and Catalysis. Vol. 362, 362-330. Published, 10/24/2019.
    https://doi.org/10.1002/adsc.201901239
  • Reid JP (2019). Holistic prediction of enantioselectivity in asymmetric catalysis. Nature. Vol. 571, 343-348. Published, 10/01/2019.
  • Li, J. & Grosslight, S.; Miller, S. J.*; Sigman, M. S.*; Toste, F. D.* (2019). Site-Selective Acylation of Natural Products with BINOL-Derived Phosphoric Acids. ACS Catalysis. Vol. 11, 9794-9799. Published, 10/01/2019.
  • Prater, M. B & Sigman, M. S (2019). Enantioselective Synthesis of Alkyl Allyl Ethers via Palladium-Catalyzed Redox-Relay Heck Alkenylation of O-Alkyl Enol Ethers. Israel Journal of Chemistry. Published, 09/11/2019.
    https://doi.org/10.1002/ijch.201900077
  • Yan, Y & Robinson, S. G.; Sigman, M. S.; Sanford, M. S (2019). Mechanism-based design of a high-potential catholyte enables a 3.2 V all-organic non-aqueous redox flow battery. Journal of The American Chemical Society. Vol. 141, 15301-15306. Published, 09/10/2019.
  • Hickey, D. P. & Sandford, C.; Rhodes, Z.; Gensch, T.; Fries, L. R. §; Sigman, M. S.*; Minteer, S. D (2019). Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low Valent Co(I) Intermediates. Journal of The American Chemical Society. Vol. 141, 1382-1392. Published, 09/04/2019.
  • Christian, A. H & Jia, S.; Zhang, P.; Meza, A. T.; Sigman, M. S.; Chang, C. J.*; Toste, F. D (2019). A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation. Journal of The American Chemical Society. Vol. 141, 12657-12662. Published, 07/30/2019.
  • Reid, J. P & Sigman, M. S (2019). A Platform for Holistic Prediction of Enantioselectivity in Asymmetric Catalysis. Nature. Vol. 571, 343-348. Published, 07/17/2019.
  • Liu, J. & Yuan, Q.; Toste, F. D.; Sigman, M. S (2019). Enantioselective Construction of Remote Tertiary Carbon-Fluorine Bonds. Nature Chemistry. Vol. 11, 71-715. Published, 07/15/2019.
  • Yuan, Q & Sigman. M. S. (2019). Palladium-Catalyzed Enantioselective Alkenylation of Enelactams using a Relay Heck Strategy. Chemistry A European Journal. Vol. 25, 10823-10827. Published, 06/19/2019.
  • Chen, Z.-M & Liu, J.; Guo, J.-Y.; Loch, M.; DeLuca, R. J.; Sigman, M. S (2019). Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives. Royal Society of Chemistry. Vol. 10, 7426-7250. Published, 06/17/2019.
  • Robinson, S. G. & Yan, Y.; Hendriks, K. H.; Sanford, M. S.*; Sigman, M. S (2019). Developing a Predictive Solubility Model for Monomeric and Oligomeric Flow Battery Electrolytes. Journal of The American Chemical Society. Vol. 141, 10171-110176. Published, 06/15/2019.
  • Ferreira, M. A. B & Silva, J. D. J.; Grosslight, S.; Fedorov, A.*; Sigman, M. S.*; Copéret, C (2019). Non-Covalent Interactions Drive the Efficiency of Molybdenum Im-ido Alkylidene Catalysts for Olefin Cross Metathesis. Journal of The American Chemical Society. Vol. 141, 10788-10800. Published, 06/10/2019.
  • Allen, J. R & Bahamonde, A.; Furukawa, Y.; Sigman, M. S (2019). Enantioselective N–alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction. Journal of The American Chemical Society. Vol. 141, 8670-8674. Published, 06/05/2019.
  • Bahamonde, A & Al Rifaie, B.; Martín-Heras, V.; Allen, J. R.; Sigman, M. S (2019). Enantioselective Markovnikov Addition of Carbamates to Trisubstituted Allylic Alcohols for the Construction of α-Tertiary Amines. Journal of The American Chemical Society. Vol. 141, 8708-8711. Published, 05/24/2019.
  • Sandford, C & Edwards, M. A.; Klunder, K. J.; Hcrawickey, D. P.; Li, M.; Sigman, M. S.*; White, H. S.*; Minteer, S. D (2019). An Organic Chemist’s Guide to Electroanalytical Tools for Studying Reaction Mechanisms. Chemical Science. Vol. 10, 6406-6422. Published, 05/23/2019.
  • Kwon, Y & Li, J.; Reid, J. P.; Crawford, J. M.; Jacob, R.; Sigman, M. S.*; Toste, F. D.*; Miller, S. J (2019). Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration. Journal of The American Chemical Society. Vol. 141, 6698-6705. Published, 05/01/2019.
  • Biswas S, Kubota K & Orlandi M (2019). Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis. Angewandte Chemie (International ed. in English). Vol. 57, 589-593. Published, 04/01/2019.
  • Crawford, J. M. & Sigman, Matthew. S (2019). Conformational Dynamics in Asymmetric Catalysis: Is Catalyst Flexibility a Design Element?. Synthesis. Vol. 51, 1021-1036. Published, 01/31/2019.
  • Vaden, R. M & Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.*; Welm, B. E (2019). A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A. ACS Chemical Biology. Vol. 14, 106-117. Published, 01/18/2019.
  • Mack, J. & B. C.; Walker, K. L.; Robinson, S. G.; Zare, R. N. *; Sigman, M. S.*; Waymouth, R. M.*; Du Bois, J. (2019). Mechanistic Studies of Ruthenium-Catalyzed C–H Hydroxylation Reveal an Unexpected Pathway for Catalyst Arrest. Journal of the American Chemical Society. Vol. 141, 972-980. Published, 01/16/2019.
    https://pubs.acs.org/doi/abs/10.1021/jacs.8b10950
  • Race NJ (2019). Enantioselective C2-Alkylation of Indoles through a Redox-Relay Heck Reaction of 2-Indole Triflates. Chemistry (Weinheim an der Bergstrasse, Germany). Vol. 25, 512-515. Published, 01/01/2019.
  • Nir Hananya, & Jolene P. Reid, Ori Green, Matthew S. Sigman and Doron Shabat (2018). Rapid chemiexcitation of phenoxy-dioxetane luminophores yields ultrasensitive chemiluminescence assays. Chemical Science. Vol. 10, 1380-1385. Published, 11/19/2018.
    https://pubs.rsc.org/en/content/articlelanding/201...
  • Shibin Zhao & Tobias Gensch, Benjamin Murray, Zachary L. Niemeyer, Matthew S. Sigman, Mark R. Biscoe (2018). Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization. University of Utah. Vol. 362, 670-674. Published, 11/09/2018.
    http://science.sciencemag.org/content/362/6415/670
  • Nicholas J. Race & Qianjia Yuan, Prof. Matthew S. Sigman (2018). Enantioselective C2‐Alkylation of Indoles through a Redox‐Relay Heck Reaction of 2‐Indole Triflates. Chemistry A European Journal. Vol. 25, 512-515. Published, 11/06/2018.
    https://onlinelibrary.wiley.com/doi/full/10.1002/c...
  • Advances in density functional theory (DFT) mean that it is now possible to study catalytic reactions with sufficient accuracy that the results compare favourably with experiment. These high-level calculations have been applied to understand and predict variations in catalytic performance from one catalyst to another, but can require substantial computational resources. By contrast, multivariate linear regression (MLR) methods are rapidly becoming versatile, statistical tools for predicting and understanding the roles of catalysts and substrates and act as a useful complement to complex transition state calculations, with a substantially lower computational cost. Herein, we compare these approaches, DFT calculations and data analysis techniques, and discuss their ability to provide meaningful predictions of catalyst performance. Examples of applications are selected to demonstrate the advantages and limitations of both tools. Several ongoing challenges in the predictions of reaction outcomes are also highlighted. Published, 10/01/2018.
    https://www.nature.com/articles/s41570-018-0040-8#...
  • Jaime A. S. Coelho & Akira Matsumoto, Manuel Orlandi Margaret J. Hilton, Matthew S. Sigman and F. Dean Toste (2018). Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions. Chemical Science. Vol. 9, 7153-7158. Published, 08/2018.
    https://pubs.rsc.org/en/content/articlelanding/201...
  • Crawford JM & Stone EA (2018). Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones. Journal of the American Chemical Society. Vol. 140, 868-871. Published, 07/01/2018.
  • Toni T. Metsanen & Katrina W. Lexa, Celine B. Santiago, Cheol K. Chung, Yingju Xu, Zhijian Liu, Guy R. Humphrey, Rebecca T. Ruck, Edward C. Sherer and Matthew S. Sigman (2018). Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir). Chemical Science. Vol. 9, 6922-6927. Published, 07/2018.
  • Patel HH & Prater MB (2018). Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers. Journal of the American Chemical Society. Vol. 140, 5895-5898. Published, 06/01/2018.
  • Yuan Q (2018). Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams. Journal of the American Chemical Society. Vol. 140, 6527-6530. Published, 06/01/2018.
  • Lancaster L & Hickey DP (2018). Bioinspired design of a hybrid bifunctional enzymatic/organic electrocatalyst for site selective alcohol oxidation. Chemical communications (Cambridge, England). Vol. 54, 491-494. Published, 03/01/2018.

Research Statement

The development of versatile synthetic methods has enhanced the ability to rapidly construct biologically relevant molecules and new organic materials. The goal of the Sigman Group is discovering and developing new practical catalytic reactions with broad substrate scope, excellent chemoselectivity, and high stereoselectivity. We believe the best strategy for developing new classes of catalysts applicable to organic synthesis is using mechanistic insight to guide the discovery process. This allows us to design new reaction motifs or catalysts in which unique bond constructions can be implemented furthering new approaches to molecule construction. As we gain a deeper fundamental understanding into the nature of catalysis, our long-term goal of de novo design of catalysts applicable to various useful reactions may be realized.

Presentations

  • 2024 Felix Serratosa Conference, lecture 1, Barcelona, Spain, January 2024. Invited Talk/Keynote, Presented, 01/2024.
  • 2024 Felix Serratosa Conference, Barcelona, Spain, January 2024. Invited Talk/Keynote, Presented, 01/2024.
  • Merck, West Point, “Developing Data Science Tools for Organic Reaction Development,” December 2023, Pennsylvania, USA. Invited Talk/Keynote, Presented, 12/2023.
  • Research in Progress, Department of Biochemistry, “Developing Data Science Tools for Organic Reaction Development,” University of Utah, December 2023. Invited Talk/Keynote, Presented, 12/2023.
  • 24th National Organic Chemistry Symposium, Argentina, “Developing Data Science Tools for Organic Reaction Development,” November 2023. Invited Talk/Keynote, Presented, 11/2023.
  • International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto Japan, “Developing Data Science Tools for Organic Reaction Development,” Kyoto, Japan, November 2023. Invited Talk/Keynote, Presented, 11/2023.
  • Utah Award, Salt Lake City, “Developing Data Science Tools for Organic Reaction Development,” November 2023. Invited Talk/Keynote, Presented, 11/2023.
  • University of Valladolid, “Developing Data Science Tools for Organic Reaction Development,” Spain, October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • Biogen (virtual), “Developing Data Science Tools for Organic Reaction Development,” October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • University of Alcalá, Spain, “Developing Data Science Tools for Organic Reaction Development,” October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • Universidad de Huelva, “Developing Data Science Tools for Organic Reaction Development,” Spain, October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • University of Sevilla, “Developing Data Science Tools for Organic Reaction Development,” Spain, October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • University of Zaragoza, “Developing Data Science Tools for Organic Reaction Development,” Spain, October 2023. Invited Talk/Keynote, Presented, 10/2023.
  • “New Frontiers in Organic Chemistry”, “Developing Data Science Tools for Organic Reaction Development,” Crete, Greece, September 2023. Invited Talk/Keynote, Presented, 09/2023.
  • Syngenta (virtual), “Developing Data Science Tools for Organic Reaction Development,” September 2023. Invited Talk/Keynote, Presented, 09/2023.
  • Frontiers in Synthetic and Medicinal Chemistry Virtual Lecture Series Sponsored by Pharmaron, “Developing Data Science Tools for Organic Reaction Development,” August 2023 (virtual). Invited Talk/Keynote, Presented, 08/2023.
  • Merck symposium, University of Michigan, “Developing Data Science Tools for Organic Reaction Development,” August 2023. Invited Talk/Keynote, Presented, 08/2023.
  • 22nd European Symposium on Organic Chemistry (ESOC 2023), “Data Science Meets Reaction Optimization,” July 2023, Ghent, Belgium. Invited Talk/Keynote, Presented, 07/2023.
  • Samuel M. McElvain Seminar (student invited lecture), University of Wisconsin, “Data Science Meets Reaction Optimization,” May 2023, Madison, Wisconsin. Invited Talk/Keynote, Presented, 05/2023.
  • University of Denver, “Data Science Meets Reaction Optimization,” May 2023. Invited Talk/Keynote, Presented, 05/2023.
  • Stille Symposium, Colorado State University, “Data Science Meets Reaction Optimization,” May 2023, Fort Colins, Colorado. Invited Talk/Keynote, Presented, 05/2023.
  • Genentech Seminar Series, “Data Science Meets Organo- and Bio-catalytic Asymmetric Catalyst Development,” April 2023, San Francisco, CA. Invited Talk/Keynote, Presented, 04/2023.
  • University of Texas, San Antonio (student invited lecture), “Data Science Meets Reaction Optimization,” April 2023, San Antonio, Texas. Invited Talk/Keynote, Presented, 04/2023.
  • Solvay Workshop: New ways to do chemistry - Emerging technologies for synthetic methodology, “Data Science Meets Reaction Optimization,” April 2023, Brussels, Belgium. Invited Talk/Keynote, Presented, 04/2023.
  • Heck Lectureship in honor of the Heck Award, University of Delaware, “Data Science Meets Organic Chemistry,” March 2023. Invited Talk/Keynote, Presented, 03/2023.
  • CaRLa Winter School 2023, February 20, 2023, “Data Science Tools for Prediction Objectives in Organic Chemistry,” Heidelberg, Germany . Invited Talk/Keynote, Presented, 02/20/2023.
  • CaRLa Winter School 2023, February 20, 2023, “A Primer to Becoming a Data Chemist,” Heidelberg, Germany. Invited Talk/Keynote, Presented, 02/20/2023.
  • Merck & Co, Inc., November 17, 2022, “Data Science Tools for Prediction Objectives in Organic Chemistry,” Rahway, New Jersey. Invited Talk/Keynote, Presented, 11/17/2022.
  • Dartmouth College, November 2, 2022, “Data Science Tools for Prediction Objectives in Organic Chemistry,” Hanover, New Hampshire. Invited Talk/Keynote, Presented, 11/02/2022.
  • Batsheva de Rothschild seminar on Strong Bond Activation, October 25, 2022, “Data Science Tools for Prediction Objectives in Organic Chemistry,” Dead Sea, Israel. Invited Talk/Keynote, Presented, 10/25/2022.
  • AbbVie 2022 Platform Chemistry Technology Seminar Series, October 12, 2022, “Developing Data Science Tools for Prediction Objectives in Organic Chemistry” (virtual). Invited Talk/Keynote, Presented, 10/12/2022.
  • European Winter-School on Physical Organic Chemistry, September 28, 2022, “Data Science Meets Physical Organic Chemistry and Reaction Development,” Ischia, Italy. Invited Talk/Keynote, Presented, 09/28/2022.
  • Achieving Scientific Excellence through Interdisciplinary and Collaborative Research Symposium @ACS meeting, August 23rd, 2022, “Applying Data Science Tools to Organic Chemistry: a Case Study in Collaborative Research,” Chicago ACS meetings. Invited Talk/Keynote, Presented, 08/23/2022.
  • CCHF Sunset Symposium @ACS meeting, August 21, 2022, “Developing data science tools for applications in C-H functionalization reactions,” Chicago ACS meetings. Invited Talk/Keynote, Presented, 08/21/2022.
  • Gilead Sciences, August 18, 2022, “Data Science Tools for Reaction Optimization” (virtual. Invited Talk/Keynote, Presented, 08/18/2022.
  • Organometallic Gordan Research Conference, July 14, 2022, “Data Science Tools for Organometallic Catalysis,” Newport, RI. Invited Talk/Keynote, Presented, 07/14/2022.
  • International School on Organometallic Chemistry “Marcial Moreno Mañas“, June 17, 2022, “Data Science Tools for Reaction Development,” Santiago, Spain. Invited Talk/Keynote, Presented, 06/17/2022.
  • ACS 26th Annual Green Chemistry & Engineering Conference, June 2022: “Development of Data Science Tools for Catalyst Development” (virtual). Invited Talk/Keynote, Presented, 06/01/2022.
  • IBM Group Meeting (Zurich), April 19th, 2022, “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis” (virtual). Invited Talk/Keynote, Presented, 04/19/2022.
  • Victor J. Chambers Lecture, University of Rochester, April 2022: “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,” Rochester, NY. Invited Talk/Keynote, Presented, 04/05/2022.
  • Victor J. Chambers Lecture, University of Rochester, April 2022: “Applying Data Science Tools to Develop Predictive Models in Organic Chemistry,” Rochester, NY. Invited Talk/Keynote, Presented, 04/04/2022.
  • Victor J. Chambers Lecture, University of Rochester, April 2022: “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis,” Rochester, NY. Invited Talk/Keynote, Presented, 04/01/2022.
  • CHEM-Reaxys Symposia, October 22nd, 2021, “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis,” (Virtual). Invited Talk/Keynote, Presented, 10/22/2021.
  • Bayer Process Chemistry Conference, October 6th, 2021, “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis,” (Virtual). Invited Talk/Keynote, Presented, 10/06/2021.
  • Dow Seminar Series, 09/30, 2021, “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis,” (Virtual). Invited Talk/Keynote, Presented, 09/30/2021.
  • Award Symposium for Shannon Stahl, Fall ACS Meeting, 08/23/2021, “Using Data Science to Explore and Exploit Monodentate Phosphines in Catalysis,” (Virtual). Invited Talk/Keynote, Presented, 08/23/2021.
  • Virtual Integration of Synthesis with Theory and AI, July 13, 2021, Data Science Meets Physical Organic Chemistry,” (Virtual). Invited Talk/Keynote, Presented, 07/13/2021.
  • 2021 Scientific Advancement Seminar Program, Boehringer-Ingelheim, March 25th, 2021, “Data Science Meets Physical Organic Chemistry,” (Virtual). Invited Talk/Keynote, Presented, 03/25/2021.
  • ENJ @60, Harvard University. Invited Talk/Keynote, Presented, 02/01/2021.
  • Center for Molecular Electrocatalysis Seminar, November 4th, 2020, “Data Science Meets Physical Organic Chemistry,” (Virtual). Invited Talk/Keynote, Presented, 11/04/2020.
  • NSF-AI Institute Workshop, October 14, 2020, “Data Science Meets Physical Organic Chemistry,” (Virtual). Invited Talk/Keynote, Presented, 10/14/2020.
  • Indiana Organic Seminar Symposium, “Data Intensive Physical Organic Chemistry”. Invited Talk/Keynote, Presented, 02/24/2020.
  • “Student Invite”, Philadelphia Organic Chemists’ Club, “Integrating Data Science Tools into Reaction Development”. Invited Talk/Keynote, Presented, 11/22/2019.
  • Workshop on Electrochemistry, National Academy of Sciences, “Integrating Data Science Tools into Molecular Design in Electrocatalysis and Energy Applications”. Invited Talk/Keynote, Presented, 11/18/2019.
  • “AbbVie Lecture”, University of Chicago, “Integrating Data Science Tools into Reaction Development”. Invited Talk/Keynote, Presented, 11/15/2019.
  • ACS Princeton Fall Organic Symposium, Princeton, NJ, “Data Science in Reaction Development using Physical Organic Chemistry”. Invited Talk/Keynote, Presented, 11/01/2019.
  • Advancing of Molecular Sciences by Machine Learning and Quantum Chemistry, Emory University, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 10/11/2019.
  • ORGANIC CHEMISTRY DAY @PAVIA, Pavia, Italy, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 09/30/2019.
  • Summer School on Dispersion, Paderborn, Germany, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 07/25/2019.
  • Summer School on Dispersion, Paderborn, Germany, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 07/16/2019.
  • “Grad Program Distinguished Lecturer Series” The Scripps Research Institute, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 06/10/2019.
  • Canadian Chemistry Conference, “Emerging Tools Symposium”, Quebec City, Canada, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 06/04/2019.
  • ACS Meeting, James Flack Norris Symposium Honoring Eric Anslyn, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 04/28/2019.
  • “Lectures in Modern Chemistry”, University of British Columbia, “Developing Modern Data Analysis Tools for Synthesis & Catalysis”. Invited Talk/Keynote, Presented, 04/09/2019.
  • “Novartis Lecture,” California Institute of Technology, “Data Intensive Physical Organic Chemistry. Invited Talk/Keynote, Presented, 02/02/2019.
  • 10th Singapore International Chemistry Conference, Singapore, “Developing modern physical organic analysis tools for synthesis, catalysis, and energy,”. Invited Talk/Keynote, Presented, 12/2018.
  • The Hong Kong University of Science and Technology, “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,”. Invited Talk/Keynote, Presented, 12/2018.
  • Lehrstuhl für Organische Chemie, Technische Universitaet München, “Developing modern physical organic analysis tools for synthesis, catalysis, and energy,” Germany,. Invited Talk/Keynote, Presented, 11/2018.
  • Merck, West Point, PA “Developing modern physical organic analysis tools for synthesis, catalysis, and energy,”. Invited Talk/Keynote, Presented, 11/2018.
  • GlaxoSmithKline, Collegeville, PA “Developing modern physical organic analysis tools for synthesis, catalysis, and energy,” . Invited Talk/Keynote, Presented, 11/2018.
  • Pfizer, Groton, CN “Short Course: Developing Modern Physical Organic Analysis Toolsfor Optimization, Analysis, and Molecular Design,”. Invited Talk/Keynote, Presented, 11/2018.
  • Department ChemieLudwig-Maximilians-Universität München, Developing modern physical organic analysis tools for synthesis, catalysis, and energy,” . Invited Talk/Keynote, Presented, 11/2018.
  • Latin-American Congress of Chemistry, Havana, Cuba, “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,. Invited Talk/Keynote, Presented, 10/2018.
  • Frontiers in Chemistry: ArmChemFront,“Developing modern physical organic analysis tools for synthesis, catalysis, and energy,”Yerevan,. Invited Talk/Keynote, Presented, 10/2018.
  • 2018 Frontiers Symposium at the University of Illinois at Urbana-Champaign, “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,”. Invited Talk/Keynote, Presented, 10/2018.
  • University of Minnesota, Student-Invited Seminar Series, “Developing modern physical organic analysis tools for synthesis, catalysis, and energy,”. Invited Talk/Keynote, Presented, 09/2018.
  • Technische Universität Berlin,Germany,“Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,”. Invited Talk/Keynote, Presented, 07/2018.
  • Stereochemistry Gordon Research Conference, Salve Regina, RI, “Data-Driven Methods to Identify and Exploit Non Covalent Interactions in Asymmetric Catalysis,” . Invited Talk/Keynote, Presented, 07/2018.
  • Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet Goettingen, Germany, “Developing Modern Physical Organic Analysis Tools,”. Invited Talk/Keynote, Presented, 07/2018.
  • Bayer AGResearch & Development, Pharmaceuticals, Wuppertal, Germany, “Developing Modern Physical Organic Analysis Tools,” . Invited Talk/Keynote, Presented, 07/2018.
  • RWTH Aachen University, Germany, “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,”. Invited Talk/Keynote, Presented, 07/2018.
  • Novartis, Basel, Switzerland, “Developing Modern Physical Organic Analysis Tools,”. Invited Talk/Keynote, Presented, 06/2018.
  • City College of New York, Salzberg Chemistry Seminar, “Developing Modern Physical Organic Analysis Tools,”. Invited Talk/Keynote, Presented, 05/2018.
  • Genentech, South San Francisco, CA, “Short Course on Multivariate Analysis in Catalysis,”. Invited Talk/Keynote, Presented, 05/2018.
  • University of Maryland, “Developing Modern Physical Organic Analysis Tools,”. Invited Talk/Keynote, Presented, 04/2018.
  • Organic Reactions Catalysis Society, San Diego, CA, “Enantioselective Formation of Remote Tertiary and Quaternary Chiral Centers,” . Invited Talk/Keynote, Presented, 04/2018.
  • Florida Heterocycles Conference, Gainesville Florida “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,” . Invited Talk/Keynote, Presented, 03/2018.
  • Spring ACS Meeting, New Orleans: James Flack Norris Award in Physical Organic ChemistryHonoring Cindy Burrows“Developing and Applying Modern Physical Organic Analysis Tools to Synthesis, Catalysis, and Energy,”. Invited Talk/Keynote, Presented, 03/2018.
  • “2018 Schleyer Lecture” University of Georgia “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry,”. Invited Talk/Keynote, Presented, 02/2018.
  • MilliporeSigma, Milwaukee, WI “Bringing Modern Data Analysis Tools to Predictionand Understanding in Organic Chemistry,”. Invited Talk/Keynote, Presented, 02/2018.
  • Modern Trends in Inorganic Chemistry, Pune, India, “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,” . Invited Talk/Keynote, Presented, 12/2017.
  • Indo-US Workshop on Organometallics, Lonavla, India, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry,”. Invited Talk/Keynote, Presented, 12/2017.
  • IIT Satellite Conference on Organometallic Chemistry, IIT Bombay, Mumbai, India “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 12/2017.
  • “Schulich Faculty Colloquium” Technion –Israel Institute of Technology Schulich Colloquium, Haifa, Israel, “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 12/2017.
  • Meeting of the Minds sponsored by Millipore, Cambridge, MA, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry,” . Invited Talk/Keynote, Presented, 11/2017.
  • Novartis, Cambridge, MA, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry,”. Invited Talk/Keynote, Presented, 10/2017.
  • SACNAS, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry,”. Invited Talk/Keynote, Presented, 10/2017.
  • ICSN,Gif-sur-Yvette, France, “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 09/2017.
  • “Summer School”, ICIQ, Tarragona, Spain, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 09/2017.
  • “Summer School”, ICIQ, Tarragona, Spain, “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 09/2017.
  • International Symposium -Catalysis for Sustainable Chemical Synthesis, Freiburg, Germany“Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 09/2017.
  • AbbVie, Chicago, Illinois “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 08/2017.
  • ACS DC, Symposium on Computational Approaches to Catalysis, “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 08/2017.
  • CCHF Virtual Symposium “Bringing Modern Data Analysis Tools to Prediction and Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 07/2017.
  • IUPAC Conference, Sao Paolo, Brazil, “Enantioselective formation of remote chiral centersthrough Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 07/2017.
  • KAIST, South Korea, “Bringing Modern Data Analysis Tools to Predictionand Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 05/2017.
  • Seoul National University, “Enantioselective formation of remote chiral centersthrough Pd-catalyzed alkene functionalization,” . Invited Talk/Keynote, Presented, 05/2017.
  • ACS Symposiumfor ACS award for ACS Award for Creative Work in Synthetic Organic Chemistry. Invited Talk/Keynote, Presented, 04/2017.
  • University of Notre Dame, “Enantioselective formation of remote chiral centers through Pd-catalyzed alkene functionalization,. Invited Talk/Keynote, Presented, 04/2017.
  • University of Missouri Organic Chemistry Day, “Enantioselective formation of remote chiral centersthrough Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 04/2017.
  • University of Missouri, “Bringing Modern Data Analysis Tools to Predictionand Understanding in Organic Chemistry”. Invited Talk/Keynote, Presented, 04/2017.
  • West Virginia University. Invited Talk/Keynote, Presented, 03/2017.
  • Symposium for Eric Jacobsen (2016 Award for Creativity in Molecular Design and Synthesis), New Jersey. Invited Talk/Keynote, Presented, 12/2016.
  • 1stInternational Editor’s symposium on chemistry (IESC), Seoul, Korea. Invited Talk/Keynote, Presented, 12/2016.
  • Southwestern Medical School, Dallas, Texas. Invited Talk/Keynote, Presented, 12/2016.
  • Boehringer Ingelheim. Invited Talk/Keynote, Presented, 11/2016.
  • University of Münster, Germany. Invited Talk/Keynote, Presented, 11/2016.
  • Max Plank Institute, Muelhiem, Germany. Invited Talk/Keynote, Presented, 11/2016.
  • Bristol-Myers-Squibb (Drug Discovery, New Brunswick), October . Invited Talk/Keynote, Presented, 10/2016.
  • Merck (Rahway), October 2016. Invited Talk/Keynote, Presented, 10/2016.
  • New York University. Invited Talk/Keynote, Presented, 10/2016.
  • Bristol-Myers-Squibb (Process, New Brunswick) . Invited Talk/Keynote, Presented, 10/2016.
  • Liebig College Lectureship (Short Course), Giessen, Germany. Invited Talk/Keynote, Presented, 08/2016.
  • Elemento-Organic Chemistry Symposium, Nankai, China. Invited Talk/Keynote, Presented, 07/2016.
  • Keio University, Tokyo, Japan. Invited Talk/Keynote, Presented, 07/2016.
  • International symposium on homogeneous catalysis, Kyoto, Japan. Invited Talk/Keynote, Presented, 07/2016.
  • Organic Reactions Lecture, University of Michigan. Invited Talk/Keynote, Presented, 05/2016.
  • KAIST, South Korea, “Enantioselective formation of remote chiral centersthrough Pd-catalyzed alkene functionalization,”. Invited Talk/Keynote, Presented, 05/2016.
  • University of North Carolina, Wilmington. Invited Talk/Keynote, Presented, 05/2016.
  • Semmelhack Lectureship, Princeton University. Invited Talk/Keynote, Presented, 05/2016.
  • Distinguished Colloquium, University of Utah. Invited Talk/Keynote, Presented, 04/2016.
  • Symposium honoring Scott Miller, San Diego ACS meeting. Invited Talk/Keynote, Presented, 03/2016.
  • Frontiers in Chemistry, Lecture, Wayne State University. Invited Talk/Keynote, Presented, 03/2016.
  • Symposium honoring Scott Miller, San Diego ACS meeting. Invited Talk/Keynote, Presented, 03/2016.
  • Shanghai institute of Organic Chemistry. Invited Talk/Keynote, Presented, 12/2015.
  • Aldrich Lectureship, University of Nevada, Reno, Dec. 2015. Invited Talk/Keynote, Presented, 12/2015.
  • Novartis (Singapore), Dec. 2015. Invited Talk/Keynote, Presented, 12/2015.
  • Jiaotong University, Shanghai, China, Dec. 2015. Invited Talk/Keynote, Presented, 12/2015.
  • Novartis (Shanghai) Dec. 2015. Invited Talk/Keynote, Presented, 12/2015.
  • Pfizer (Groton), Nov. 2015. Invited Talk/Keynote, Presented, 11/2015.
  • Queens University CREATE lectureship, Canada. Invited Talk/Keynote, Presented, 11/2015.
  • Novartis, Basal, Switzerland, October 2015. Invited Talk/Keynote, Presented, 10/2015.
  • Banff Symposium on Organic Chemistry, Oct. 2015. Invited Talk/Keynote, Presented, 10/2015.
  • 11th National Conference on Physical Organic Chemistry, Beijing Municipal Tsinghua University. Invited Talk/Keynote, Presented, 09/2015.
  • Molecular Science Forum Lecture, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China . Invited Talk/Keynote, Presented, 09/2015.
  • Symposium honoring Melanie Sanford, Boston ACS meeting, August 2015. Invited Talk/Keynote, Presented, 08/2015.
  • Millennium Pharmaceuticals, Cambridge, July 2015. Invited Talk/Keynote, Presented, 07/2015.
  • ACS Division of Organic Chemistry Symposium (Austin, Texas), July 2015. Invited Talk/Keynote, Presented, 07/2015.
  • Gordon Research Conference on Organometallic Chemistry (Rhode Island), July 2015. Invited Talk/Keynote, Presented, 07/2015.
  • Division of Organic Chemistry Research Symposium, July 2015. Invited Talk/Keynote, Presented, 07/2015.
  • Summer Symposium in Green Chemistry and Catalysis, UT Austin, July 2015. Invited Talk/Keynote, Presented, 07/2015.
  • Bristol Myers Squib Lecturer, Columbia University, June 2015. Invited Talk/Keynote, Presented, 06/2015.
  • Harvard University, May 2015. Invited Talk/Keynote, Presented, 05/2015.
  • Student Invited Symposium, Stanford University, May 2015. Invited Talk/Keynote, Presented, 05/2015.
  • Janssen Sciences (Brussels, Belgium), May 2015 . Invited Talk/Keynote, Presented, 05/2015.
  • Bristol Synthesis Meeting, Bristol, England, April 2015. Invited Talk/Keynote, Presented, 04/2015.
  • Purdue University, April 2015. Invited Talk/Keynote, Presented, 04/2015.
  • University of Indiana, April 2015. Invited Talk/Keynote, Presented, 04/2015.
  • University of York, England, April 2015, . Invited Talk/Keynote, Presented, 04/2015.
  • University of Bristol, England, April 2015. Invited Talk/Keynote, Presented, 04/2015.
  • Denver ACS, Award Symposium for Abigail Doyle, March 2015. Invited Talk/Keynote, Presented, 03/2015.
  • 2015 BMS-UCLA Lecturer, University of California, Los Angeles, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” February 2015. Invited Talk/Keynote, Presented, 02/2015.
  • Abbvie Pharmaceuticals, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” Chicago, December 2014. Invited Talk/Keynote, Presented, 12/2014.
  • University of Montreal, Canada, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” December 2014. Invited Talk/Keynote, Presented, 12/2014.
  • McGill University, Canada, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” December 2014. Invited Talk/Keynote, Presented, 12/2014.
  • Centre in Green Chemistry and Catalysis Lecturer, Sherbrooke University, Canada, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” December 2014. Invited Talk/Keynote, Presented, 12/2014.
  • Brown and Williamson Lecturer University of Louisville, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” November 2014. Invited Talk/Keynote, Presented, 11/2014.
  • Novartis (Boston), “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” November 2014. Invited Talk/Keynote, Presented, 11/2014.
  • Nagoya University, Japan, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” October 2014. Invited Talk/Keynote, Presented, 10/2014.
  • 2nd International Conference on Organometallics and Catalysis, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” Nara, Japan, October 2014. Invited Talk/Keynote, Presented, 10/2014.
  • Gilead Pharmaceuticals (San Francisco), “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” October 2014. Invited Talk/Keynote, Presented, 10/2014.
  • 18th National Symposium on Organometallic Chemistry, “Palladium-Catalyzed Alkene Functionalization Reactions for Synthesis,” Lanzhou, China, August 2014. Invited Talk/Keynote, Presented, 08/2014.
  • Gordon Research Conference on Reactions and Processes, July 2014. Invited Talk/Keynote, Presented, 07/2014.
  • “The Future of Asymmetric Catalysis” Telluride Science Research conference, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” June 2014. Invited Talk/Keynote, Presented, 06/2014.
  • School of Organic Chemistry “Corbella”, Italy, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” June 2014. Invited Talk/Keynote, Presented, 06/2014.
  • Burgenstock conference on stereochemistry, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” Switzerland, May 2014. Invited Talk/Keynote, Presented, 05/2014.
  • University California at Davis, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” May 2014. Invited Talk/Keynote, Presented, 05/2014.
  • University of Geneva, Switzerland, “Enantioselective Intermolecular Heck Reactions,” May 2014. Invited Talk/Keynote, Presented, 05/2014.
  • Aldrich Lecture, SUNY Buffalo, “Controlling and Analyzing Selectivity in Asymmetric Catalysis,” April 2014. Invited Talk/Keynote, Presented, 04/2014.
  • Netherlands’ Catalysis and Chemistry Conference, “Enantioselective Intermolecular Heck Reactions,” Noordwijkerhout, Netherlands, March 2014. Invited Talk/Keynote, Presented, 03/2014.

Research Groups

  • Sierra Hart, Graduate Student. 01/2022 - present.
  • Austin LeSueur, Graduate Student. 01/2022 - present.
  • Sara McCormack, Graduate Student. 01/2022 - present.
  • Therese Wild, Graduate Student. 01/2022 - present.
  • Anna Bell, Undergraduate Student. 12/2021 - present.
  • Melissa Hardy, Postdoc. 10/2021 - present. Awards/Scholarships/Stipends: American Cancer Society Fellow.
  • Sarah Lefave, Research Professor. 08/2021 - present.
  • Andrii Varenikov, Postdoc. 08/2021 - present.
  • Lucy Van Dijk, Postdoc. 07/2021 - present.
  • Tim McFadden, Graduate Student. 01/2021 - present.
  • Mohammad Samha, Graduate Student. 01/2021 - present.
  • Veronica O'Connor, Graduate Student. 01/2021 - present.
  • Beck Miller, Graduate Student. 01/2021 - present.
  • Jordan Dotson, Postdoc. 07/2020 - present. Awards/Scholarships/Stipends: NIH Postdoctoral Fellow.
  • David Vogt, Postdoc. 07/2020 - present.
  • Autumn Flynn, Postdoc. 07/2020 - present.
  • Shelby Galinat, Undergraduate Student. 05/2020 - 07/2022.
  • Brittany Haas, Graduate Student. 01/2020 - present.
  • Jordan Liles, Graduate Student. 01/2020 - present.
  • Tyler Ball, Undergraduate Student. 10/2019 - 07/2022.
  • Julie Hofstra, Postdoc. 08/2019 - 12/2021. Awards/Scholarships/Stipends: NIH Postdoctoral Fellow.
  • Jacob Werth, Postdoc. 08/2019 - present.
  • Jianbo Liu, Postdoc. 02/2017 - 02/2019.
  • Morgan Rivera, Undergraduate Student. 12/2016 - 07/2017.
  • Buthaina Al Rifai'e, Graduate Student. 12/2016 - 10/2021.
  • Toni Metsänen, Postdoc. 08/2015. 08/2016 - 11/2017.
  • Jonathan Ruchti, Postdoc. 08/2016 - 11/2017.
  • Manuel Orlandi, Postdoc. 08/2016 - 11/2017.
  • Ryan DeLuca, Research Professor. 03/2016 - 08/2021.
  • Ana Bahamonde, Visiting Student. 09/2015 - 12/2015.
  • Jamie Allen, Graduate Student. 08/2015 - 06/2019.
  • Jingyao Guo, Graduate Student. 08/2015 - 07/2021.
  • Sophia Robinson, Graduate Student. 08/2015 - 10/2020.
  • Matt Prater, Graduate Student. 08/2015 - 11/2020.
  • Zhi-Min Chen, Visiting Student. 07/2015 - 01/2016.
  • Takashi Shigeta, Visiting Student. 06/2015 - 03/2016.
  • Jennifer Crawford, Graduate Student. 05/2015 - 05/2021.
  • Nicholas Race, Visiting Student. 04/2015 - 07/2018.
  • David Schiedler, Visiting Student. 01/2015 - 01/2016.
  • Eiji Yamamoto, Visiting Student. 01/2015 - 01/2016.
  • Yury Minko, Postdoc. Chemistry. 12/2014 - 12/2016.
  • Benjamin Buckley, Visiting Faculty. Chemistry. 11/2014 - 12/2015.
  • Bin Cheng, Visiting Student. Chemistry. 11/2014 - 12/2015.
  • David Hickey, Postdoc. Chemistry. 11/2014 - 08/2020.
  • John Gipson, Graduate Student. 10/2014 - 10/2018.
  • Christine Nervig, Graduate Student. 10/2014 - 12/2016.
  • Christiane Schwalm, Postdoc. Chemistry. 09/2014 - 01/2015.
  • Chun Zhang, Postdoc. Chemistry. 09/2014 - 07/2017.
  • Elizabeth Greenhalgh, Undergraduate Student. 02/2014 - 08/2016.
  • Zach Niemeyer, Graduate Student. 12/2013 - 08/2017.