CHRISTOPHER PETER HILL portrait
  • Co-Chair Department of Biochemistry
  • Distinguished Professor, Department Of Biochemistry
  • Distinguished Professor, Biochemistry Research
801-585-5536

Research Keywords

  • Structural Biology
  • Proteasome Activation and Regulation
  • Protein Quality Control
  • HIV Structure and Host Interactions
  • ESCRT Pathway
  • Nucleosome Remodeling and Reorganization

Presentations

  • Invited Speaker, Millennium Pharmaceuticals, Inc. , , 2013.
  • Toledo University, Toledo, Ohio. , , 2018.
  • Imperial College, London, England. , , 2018.
  • Laboratory of Molecular Biology, Cambridge, England. , , 2018.
  • Arizona State University, Department of Chemistry and Biochemistry. , , 2014.
  • University of Colorado Medical Student, Structural Biology Graduate Student Retreat. , , 2014.
  • Academia Sinica, Taipei, Taiwan. , , 2014.
  • University of California at Santa Cruz, Department of Chemistry and Biochemistry. , , 2014.
  • Harvard medical School, Department of Biological Chemistry and Molecular Pharmacology. , , 2014.
  • Penn State College of Medicine, Biomedical Sciences Graduate Program, University Park, Pennsylvania. , , 2013.
  • Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts. , , 2013.
  • University of Texas Southwestern, Department of Biophyisics, Dallas, Texas. , , 2011.
  • University of Montana, Missoula, Montana. , , 2010.
  • Colorado State University, Fort Collins, Colorado. , , 2010.
  • Wake Forest University, Department of Biochemistry, Winston-Salem, North Carolina. , , 2009.
  • University of Washington, Department of Biochemistry, Seattle Washington. , , 2009.
  • University of Colorado, Biomolecular Structure Graduate Program, Denver, Colorado. , , 2009.
  • University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics, Minneapolis, Minnesota. , , 2009.
  • California Institute of Technology, Pasadena, California. , , 2009.
  • The Scripps Research Institute, Department of Molecular Biology, La Jolla, California. , , 2008.
  • University of Colorado at Boulder, Division of Biochemistry, Boulder, Colorado. , , 2007.
  • University of California at Berkeley, Departments of Chemistry and Molecular & Cell Biology, Berkeley, California. , , 2007.
  • Washington University, St. Louis, Missouri. , , 2006.
  • Vanderbilt University, Nashville, Tennessee. , , 2006.
  • Oklahoma State University, Stillwater, Oklahoma. , , 2006.
  • Duke University, Durham, North Carolina. , , 2006.
  • Weill Cornell Medical College, Department of Biochemistry, New York, New York. , , 2006.
  • University of North Carolina, Chapel Hill, North Carolina. , , 2006.
  • St. Jude Children's Research Hospital, Memphis, Tennessee. , , 2005.
  • University of Chicago, Department of Chemistry, Chicago, Illinois. , , 2005.
  • Hospital for Sick Children, Department of Structural Biology and Biochemistry, Toronto, Canada. , , 2005.
  • Boykin Symposium, Georgia State University, Atlanta, Georgia. , , 2005.
  • Baylor College of Medicine, Department of Biochemistry & Molecular Biology, Houston, Texas. , , 2004.
  • University of Arkansas, Department of Chemistry, Fayetteville, Arkansas. , , 2004.
  • Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, United Kingdom. , , 2004.
  • University of Alberta, Department of Biochemistry, Edmonton, Canada. , , 2004.
  • University of Colorado Health Sciences, School of Medicine, Denver, Colorado. , , 2004.
  • Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut. , , 2003.
  • Wayne State University, Department of Biochemistry and Molecular Biology, Detroit, Michigan. , , 2003.
  • Johns Hopkins University, Department of Biochemistry, Baltimore, Maryland. , , 2003.
  • University of California, San Francisco, Department of Pharmacy, San Francisco, California. , , 2003.
  • St. Louis University School of Medicine, Department of Biochemistry and Molecular Biology, St. Louis, Missouri. , , 2002.
  • University of Texas Southwestern, Department of Physiology, Dallas, Texas. , , 2002.
  • University of California at San Diego, Department of Biology, San Diego, California. , , 2002.
  • University of California, Santa Cruz, Department of Molecular Cellular and Developmental Biology, Santa Cruz, California. , , 2002.
  • University of Indiana, Department of Biochemistry, Indianapolis, Indiana. , , 2002.
  • Louisiana State University, Department of Biochemistry and Molecular Biology, Baton Rouge, Louisiana. , , 2002.
  • University of California at Irvine, Department of Biochemistry, Irvine, California. , , 2001.
  • Stanford University, Department of Biological Sciences, Palo Alto, California. , , 2001.
  • University of Washington, Department of Biochemistry, Seattle, Washington. , , 2001.
  • University of Arizona, Department of Biochemistry, Tucson, Arizona. , , 2000.
  • Utah State University at Logan, Chemistry Department, Logan, Utah. , , 2000.
  • University of Utah, Biosciences Symposium, Salt Lake City, Utah. , , 2000.
  • The Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts. , , 2000.
  • The Wistar Institute, Structural Biology Program, Philadelphia, Pennsylvania. , , 2000.
  • University of California at San Francisco, Department of Pharmaceutical Chemistry, San Francisco, California. , , 2000.
  • University of Madison at Wisconsin, Biochemistry Department, of Madison, Wisconsin. , , 2000.
  • University of California at Berkeley, Chemistry Department, Berkeley, California. , , 1999.
  • California Institute of Technology, Chemistry Division, Pasadena, California. , , 1999.
  • Occidental College, Biochemistry Department, Los Angeles, California. , , 1999.
  • University of California at Riverside, Biochemistry Department, Riverside, California. , , 1999.
  • Kimmel Cancer Center at Jefferson, Philadelphia, Pennsylvania. , , 1999.
  • University of California at Davis, Biochemistry Department, Davis, California. , , 1998.
  • University of Virginia, Center for Structural Biology, Charlottesville, Virginia. , , 1998.
  • University of California at Los Angeles, Molecular Biology Institute, Los Angeles, California. , , 1997.
  • Medical College of Wisconsin, Biochemistry Department, Milwaukee, Wisconsin. , , 1997.
  • Purdue University, Biology Department, West Lafayette, Indiana. , , 1997.
  • Harvard Medical School, Biochemistry Department, Boston, Massachusetts. , , 1997.
  • Emory University, Biochemistry Department, Atlanta, Georgia. , , 1996.
  • Iowa University, Biochemistry Department, Iowa City, Iowa. , , 1995.
  • California State University at Fullerton, Biochemistry Department, Fullerton, California. , , 1995.
  • Denison University, Biochemistry Department, Granville, Ohio. , , 1995.
  • University of Texas Medical Center at Galveston, Sealy Center for Molecular Biology, Galveston, Texas. , , 1995.
  • 27th Annual Symposium of The Protein Society, Award Session, Boston, Massachusetts. , , 2013.
  • Blaffer Seminar, MD Anderson Cancer Center, Houston, Texas. , , 2010.
  • Eccles Visiting Scholar (5 seminars), Southern Utah University, Cedar City, Utah. , , 2004.
  • Australian Society for Biochemistry and Molecular Biology: Session on HIV Proteins, Canberra, Australia. , , 1996.
  • Keystone conference of cryo-electron microscopy, Lake Tahoe, California. , , 2018.
  • Asian Crystallographic Association, Auckland, New Zealand. , , 2018.
  • Telluride Science Research Center Chromatin Structure and Dynamics, Telluride, Colorado. , , 2016.
  • Taiwanese Biophysics Society. , , 2014.
  • University of York, Dodson Symposium, Heslington, United Kingdom. , , 2013.
  • FASEB Meeting Ubiquitin and Cellular Regulation, Saxtons River, Vermont. , , 2012.
  • University of Kansas, COBRE Symposium, Lawrence, Kansas. , , 2012.
  • American Society for Biochemistry and Molecular Biology Special Symposia, Biochemistry and Cell Biology of ESCRTs in Health and Disease, Snowbird, Utah. , , 2010.
  • 24th Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design, National Institutes of Health, Bethesda, Maryland. , , 2010.
  • 23rd Annual Symposium of The Protein Society, Boston, Massachusetts. , , 2009.
  • American Society for Biochemistry and Molecular Biology, 2009 Annual Meeting, New Orleans, Louisiana. , , 2009.
  • Structural Biology Interest Group, National Institutes of Health, Bethesda, Maryland. , , 2009.
  • FASEB Summer Research Conference: Molecular Biophysics of Cellular Membranes, Saxtons River, Vermont. , , 2008.
  • Structural Analysis of Supramolecular Assemblies by Hybrid Methods, Lake Tahoe, California. , , 2008.
  • 21th Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design, National Institutes of Health, Bethesda, Maryland. , , 2007.
  • American Society for Biochemistry and Molecular Biology, 2007 Annual Meeting, Washington, D.C. , , 2007.
  • Cold Spring Harbor Conference: The Ubiquitin Family, Cold Spring Harbor, New York. , , 2007.
  • Macromolecular Crystallography in Biology and Medicine, Vanderbilt University, Nashville, Tennessee. , , 2005.
  • International Union of Crystallography Conference, Florence, Italy. , , 2005.
  • Keystone Symposia, Ubiquitin and Signaling, Taos, New Mexico. , , 2005.
  • University of York, Dodson Symposium, Heslington, United Kingdom. , , 2004.
  • BioScience2004, Biochemical Society, Glasgow, United Kingdom. , , 2004.
  • FASEB Summer Research Conference: Ubiquitin and Cellular Regulation, Saxtons River, Vermont. , , 2004.
  • Eisenberg Symposium, University of California, Los Angeles, California. , , 2004.
  • Gordon Research Conference: Proteins, Holderness, New Hampshire. , , 2003.
  • Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design , National Institutes of Health, Bethesda, Maryland. , , 2003.
  • Cologne Spring Meeting, University of Cologne, Germany. , , 2003.
  • Cold Spring Harbor Conference: Molecular Chaperones and the Heat Shock Response, Cold Spring Harbor, New York. , , 2002.
  • American Crystallographic Association Annual Conference, Los Angeles, California. , , 2001.
  • FASEB Summer Research Conference: Ubiquitin and Protein Degradation, Saxtons River, Vermont. , , 2001.
  • Karolinska Institute Nobel Conference, Stockholm, Sweden. , , 2001.
  • ASM Annual Symposium, Orlando, Florida. , , 2001.
  • EMBO Workshop on Ubiquitin-Proteasome Pathway and Cellular Regulation, Utrecht, The Netherlands. , , 2000.
  • International Union of Crystallography Conference, Glasgow, Scotland. , , 1999.
  • FASEB Summer Research Conference: Ubiquitin and Protein Degradation, Saxtons River, Vermont. , , 1999.
  • Gordon Research Conference: Proteins, Holderness, New Hampshire. , , 1999.
  • Cold Spring Harbor Conference: Biology of Proteolysis, Cold Spring Harbor, New York. , , 1999.
  • Weber Immunology Retreat, Heber, Utah. , , 1998.
  • FASEB Summer Research Conference: Ubiquitin and Protein Degradation, Saxtons River, Vermont. , , 1997.
  • Conference on Structural Biology of AIDS, National Institutes of Health, Bethesda, Maryland. , , 1997.
  • Conference on Structural Biology of AIDS, National Institutes of Health, Bethesda, Maryland. , , 1996.
  • American Crystallographic Association Annual Conference, Montreal, Quebec, Canada. , , 1995.
  • Conference on Structural Biology of AIDS, National Institutes of Health, Bethesda, Maryland. , , 1995.
  • 12th West Coast Protein Crystallography Workshop, Asilomar, California. , , 1995.

Languages

  • English, Fluent.

Publications

  • Forest KT, Hill CP (date unknown). Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level. Vol. 31, vii-viii. Accepted, .
  • Han H, Monroe N, Sundquist WI, Shen PS, Hill CP (date unknown). The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Vol. 6. Accepted, .
  • Nielson JR, Fredrickson EK, Waller TC, Rendón OZ, Schubert HL, Lin Z, Hill CP, Rutter J (date unknown). Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. Vol. 68, 673-685.e6. Accepted, .
  • Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Chou DH (date unknown). Novel four-disulfide insulin analog with high aggregation stability and potency. Vol. 11, 195-200. Accepted, .
  • Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D (date unknown). An asymmetric interface between the regulatory and core particles of the proteasome. Vol. 18, 1259-67. Accepted, .
  • Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP (date unknown). Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. Vol. 287, 37371-82. Accepted, .
  • Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS (date unknown). Characterization of resistance to a potent D-peptide HIV entry inhibitor. Vol. 16, 28. Accepted, .
  • Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP (date unknown). FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. Vol. 60, 294-306. Accepted, .
  • Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S (date unknown). Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. Accepted, .
  • Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI (date unknown). Activation of the retroviral budding factor ALIX. Vol. 85, 9222-6. Accepted, .
  • Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP (date unknown). A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Vol. 6. Accepted, .
  • Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS (date unknown). Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Vol. 365, 502-505. Accepted, .
  • Strenge KB, DiPaola CP, Miller LE, Hill CP, Whitmore RG (date unknown). Multicenter study of lumbar discectomy with Barricaid annular closure device for prevention of lumbar disc reherniation in US patients: A historically controlled post-market study protocol. Vol. 98, e16953. Accepted, .
  • Kessler JL, Kang G, Qin Z, Kang H, Whitby FG, Cheatham TE 3rd, Hill CP, Li Y, Yu SM (date unknown). Peptoid Residues Make Diverse, Hyperstable Collagen Triple-Helices. Vol. 143, 10910-10919. Accepted, .
  • Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S (date unknown). Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo. Vol. 39. Accepted, .
  • Hill CP, Damodaran O, Walsh P, Jevon GP, Blyth CC (date unknown). Balamuthia amebic meningoencephalitis and mycotic aneurysms in an infant. Vol. 45, 45-8. Accepted, .
  • Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D'Orso I, Hill CP, Planelles V (date unknown). Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal. Vol. 12, e0109821. Accepted, .
  • Hemmis CW, Heard SC, Hill CP (date unknown). Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13. Vol. 294, 9659-9665. Accepted, .
  • Sarabia I, Novis CL, Macedo AB, Takata H, Nell R, Kakazu JC, Furler RL, Shakya B, Schubert HL, Hill CP, DePaula-Silva AB, Spivak AM, Trautmann L, Planelles V, Bosque A (date unknown). Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS. Vol. 12, 682182. Accepted, .
  • Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP (date unknown). Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Vol. 8. Accepted, .
  • VanderLinden RT, Hemmis CW, Yao T, Robinson H, Hill CP (date unknown). Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. Vol. 292, 9493-9504. Accepted, .
  • Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J (date unknown). Vms1p is a release factor for the ribosome-associated quality control complex. Vol. 9, 2197. Accepted, .
  • Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W (date unknown). UNC119 is required for G protein trafficking in sensory neurons. Vol. 14, 874-80. Accepted, .
  • Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W (date unknown). UNC119 is required for G protein trafficking in sensory neurons. Vol. 14, 874-80. Accepted, .
  • Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP (date unknown). Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). Vol. 290, 13490-9. Accepted, .
  • Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP (date unknown). Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. Vol. 408, 697-713. Accepted, .
  • Monroe N, Hill CP (date unknown). Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. Vol. 428, 1897-911. Accepted, .
  • Ragab AA, Hodges FS, Hill CP, McGuire RA, Tucci M (date unknown). Dynamic anterior cervical plating for multi-level spondylosis: Does it help?. Vol. 1, 41-6. Accepted, .
  • Tsai FTF, Hill CP (date unknown). Same structure, different mechanisms?. Vol. 9. Accepted, .
  • Dagan Y, Qazilbash MM, Hill CP, Kulkarni VN, Greene RL (date unknown). Evidence for a quantum phase transition in Pr2-xCe(x)CuO4-delta from transport measurements. Vol. 92, 167001. Accepted, .
  • Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP (date unknown). Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. Vol. 288, 10188-94. Accepted, .
  • Monroe N, Han H, Shen PS, Sundquist WI, Hill CP (date unknown). Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Vol. 6. Accepted, .
  • Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS (date unknown). Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets. Vol. 24, 446-63. Accepted, .
  • Hill CP, Sundquist WI (date unknown). Building a super elongation complex for HIV. Vol. 2, e00577. Accepted, .
  • Vander Linden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (date unknown). Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Vol. 57, 901-911. Accepted, .
  • Han H, Hill CP (date unknown). Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4. Vol. 47, 37-45. Accepted, .
  • Schubert HL, Wittmeyer J, Kasten MM, Hinata K, Rawling DC, Héroux A, Cairns BR, Hill CP (date unknown). Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler. Vol. 110, 3345-50. Accepted, .
  • Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP (date unknown). The oligomeric state of the active Vps4 AAA ATPase. Vol. 426, 510-25. Accepted, .
  • Han H, Schubert HL, McCullough J, Monroe N, Purdy MD, Yeager M, Sundquist WI, Hill CP (date unknown). Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. Vol. 295, 435-443. Accepted, .
  • Stadtmueller BM, Hill CP (date unknown). Proteasome activators. Vol. 41, 8-19. Accepted, .
  • Kish-Trier E, Hill CP (date unknown). Structural biology of the proteasome. Vol. 42, 29-49. Accepted, .
  • Hill CP, Babst M (date unknown). Structure and function of the membrane deformation AAA ATPase Vps4. Vol. 1823, 172-81. Accepted, .
  • Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (date unknown). Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding. Vol. 6, e27466. Accepted, .
  • Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (date unknown). Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. Vol. 85, 632-7. Accepted, .
  • VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (date unknown). Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. (pp. 487). Vol. 61. Accepted, .