Jorgensen
  • Investigator, Howard Hughes Medical Institute
  • Adjunct Professor, Human Genetics
  • Adjunct Professor, Biomedical Engineering
  • Distinguished Professor, School Of Biological Sciences
  • Professor, School Of Biological Sciences

Publications

  • LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ & Jorgensen EM (2020). Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin. Developmental cell. Vol. 52, 88-103.e6. Published, 01/01/2020.
  • Kurshan PT, Merrill SA, Dong Y, Ding C, Hammarlund M, Bai J, Jorgensen EM & Shen K (2019). γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis. Neuron. Vol. 100, 150-166.e4. Published, 08/01/2019.
  • Watanabe S, Mamer LE, Raychaudhuri S, Luvsanjav D, Eisen J, Trimbuch T, Söhl-Kielczynski B, Fenske P, Milosevic I, Rosenmund C & Jorgensen EM (2019). Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis. Neuron. Vol. 98, 1184-1197.e6. Published, 08/01/2019.
  • Geisler, F., H. Gerhardus, K. Carberry, W. Davis, E.M. Jorgensen, C. Richardson, O. Bossinger, and R. E. Leube. 2016. A novel function for the MAP kinase SMA-5 in intestinal tube stability. Molecular Biology of the Cell 27, p3855-3868. Published, 12/01/2016.
  • Edelman, T. L. B. , K. A. McCulloch, A. Barr, C. Frøkjær-Jensen, E. M. Jorgensen, and A. E. Rougvie. 2016. Analysis of a lin-42/period null allele implicates all three isoforms in regulation of Caenorhabditis elegans molting and developmental timing. G3 6:4077-4086. Published, 12/2016.
  • Hess, J., M. Patra, L. Rangasamy, S. Konatschnig, O. Blacque, A. Jabbar, P. Mac, E.M. Jorgensen, R.B. Gasser, G. Gasser. 2016. Organometallic derivatization of the nematocidal drug monepantel leads to promising antiparasitic drug candidates. Chemistry 22, 16602-16612. Published, 10/05/2016.
  • Bend, E.G.,Y.Si, D.A. Stevenson, P. Bayrak-Toydemir, T.M. Newcomb, E.M. Jorgensen, K.J. Swoboda. NALCN channelopathies: distinguishing gain-of-functiona nd loss-of-function mutations. Neurology 87, p1131-1138. Published, 09/13/2016.
  • Wheeler, B.S., E. Anderson, C. Frøkjær-Jensen, Q. Bian, E.M. Jorgensen, B. J. Meyer. 2016. Chromosome-wide mechanisms to decouple gene expression from gene dose during sex-chromosome evolution. eLife 5:e17365. DOI: 10.7554/eLife.17365. Published, 08/30/2016.
  • Frøkjær-Jensen, C., N. Jain, L. Hansen, M.W. Davis, Y. Li, D. Zhao, K. Rebora, JR. Millet, X. Liu, SK. Kim, D. Dupuy, E.M. Jorgensen*, and A.Z. Fire*. 2016. An abundant class of non-coding DNA can prevent stochastic gene silencing in the C. elegans germline. Cell 166, p343-357. (*co-corresponding authors). Published, 06/30/2016.
  • Li, P., S. Merrill, E.M. Jorgensen, and K. Shen. “Two clathrin adaptor protein complexes instruct axon-dendrite polarity.” Neuron 90, p564-580. Published, 05/04/2016.
  • Jang, S., J.C. Nelson, E.G. Bend, L. Rodríguez-Laureano,F.G. Tueros, L. Cartagenova, K. Underwood, E.M. Jorgensen and D.A. Colón-Ramos. (2016) Glycolytic enzymes localize to synapses under energy stress to support synaptic function. Neuron. doi:10.1016/j.neuron.2016.03.011. Published, 03/11/2016.
  • Schwartz, M.L., E.M. Jorgensen. 2016. SapTrap, a Toolkit for High-Throughput CRISPR/Cas9 Gene Modification in C. elegans. Genetics, In Press. Early online February 2, 2016 as 10.1534/genetics.115.184275. Published, 02/02/2016.
  • Alqadah, A., Y.-W. Hsieh, J.A. Schumacher, X. Wang, S.A. Merrill, G. Millington, B. Bayne, E.M. Jorgensen, C.-F. Chuang. 2016. SLO BK potassium channels couple gap junctions to inhibition of calcium signaling in olfactory neuron diversification. PLoS Genetics, 12, e1005654-e1005654. Published, 01/15/2016.
  • Jobson, M.A., C.M. Valdez, J. Gardner, L.R. Garcia, E.M. Jorgensen, and A.A. Beg. 2015. Spillover transmission is regulated by the excitatory GABA receptor LGC-35 in C. elegans. J. Neurosci. 35, p2803-2816. Published, 02/2015.
  • Hollopeter, G.H., J.J. Lange, Y. Zhang, T.N. Vu, M. Gu, M. Ailion, E.J. Lambie, B.D. Slaughter, J.R. Unruh, L. Florens, and E.M. Jorgensen. The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex. eLife (2014) Oct 10; 3 doi:10.7554/eLife.03648. Published, 10/2014.
  • Watanabe, S., T. Trimbuch, M. Camacho-Pérez, B.R. Rost, B. Brokowski, B. Söhl-Kielczynski, A. Felies, M.W. Davis, C. Rosenmund, and E.M. Jorgensen. 2014. Clathrin regenerates synaptic vesicles from endosomes. Nature 515, p228-233. • Mini-review: Vladan Lucic 2014. Nature 515, p207-208. Published, 10/2014.
  • Jorgensen, E.M. 2014. Animal evolution: looking for the first nervous system. Current Biology 24, pR655-R658. Review. Published, 07/2014.
  • Liu Q, Frerck M.J., Holman H.A., Jorgensen E.M., and R.D. Rabbitt. 2014. Exciting cell membranes with a blustering heat shock. Biophys J. 106, p1570-1577. Published, 04/2014.
  • Nix P., M. Hammarlund, L. Hauth, M. Lachnit , E.M. Jorgensen, and M. Bastiani. Axon regeneration genes identified by RNAi screening in C. elegans. 2014. J Neurosci. 34, p629-645. Published, 01/2014.
  • Kavalali, E., and E.M. Jorgensen. 2014. Visualizing Presynaptic Function. Nature Neuroscience 17, p10-16. Review. Published, 12/2013.
  • Ilovitsh, T., A. Meiri, C. Ebeling, R. Menon, J.M. Gerton, E.M. Jorgensen, and Z. Zalevsky. 2014. Improved localization accuracy in stochastic super-resolution fluorescence micoscopy by K-factor Image deshadowing. Biomedical Optics Express 5, p244–258. Published, 12/2013.

Research Statement

The Jorgensen laboratory is identifying the proteins that function at the synapse to release and recycle synaptic vesicles. To identify these molecules, we have undertaken a genetic analysis of neurotransmission in the nematode Caenorhabditis elegans. C. elegans is particularly advantageous for such studies for several reasons: First, mutants with defective synapses are viable and can be studied as adults. Second, we can select for mutants with defective neurotransmission using drug resistance screens. Third, we can characterize mutant synapses at the ultrastructural and electrophysiological levels. So far the lab has identified over 30 genes that are required for normal synaptic transmission. Some of these genes are required for synaptic vesicle exocytosis and some are required for synaptic vesicle endocytosis. The precise function of these proteins is being determined using electophysiological, biochemical, fluorescence and electron microscopic techniques.

Presentations

  • NSF Neuronex 3rd Annual Meeting (Virtual due to travel restrictions). Invited Talk/Keynote, Presented, 10/2020.
  • MIT Neurotech 2016 Symposium, Boston, MA. Invited Talk/Keynote, Presented, 11/29/2016.
  • MIT MGH-Molecular Biology Seminar, Boston, MA 02114. Invited Talk/Keynote, Presented, 11/27/2016.
  • Neuroscience 2016 The Ultrastructural Basis of Synaptic Transmission & Plasticity Symposia, San Diego, CA. Invited Talk/Keynote, Presented, 11/16/2016.
  • Institute of Science & Technology Colloquium, Klosterneuburg, Austria. Invited Talk/Keynote, Presented, 10/24/2016.
  • HHMI Janelia Conference Genetic Manipulation Conference. Invited Talk/Keynote, Presented, 10/07/2016.
  • The Graduate Program in Neuroscience, University of Washington, Seattle, WA. Invited Talk/Keynote, Presented, 10/03/2016.
  • Gordon Research Conference Synaptic Transmission. Invited Talk/Keynote, Presented, 08/14/2016.
  • Gordon Research Conference Protein Processing, Trafficking & Secretion, New London, NH. Invited Talk/Keynote, Presented, 07/24/2016.
  • Gordon Research Conference Cell Biology of the Neuron, Waterville Valley, NH. Invited Talk/Keynote, Presented, 06/26/2016.
  • Gordon Research Conference Lysosomes & Endocytosis. Invited Talk/Keynote, Presented, 06/12/2016.
  • iBiology Video "Erik Jorgensen: Reccycling Synaptic Vesicles", 2016. Presentation, Presented, 06/01/2016.
    https://www.ibiology.org/ibioseminars/synaptic-tra...
  • HHMI Janelia Conference 'Molecular Mechanisms in the Synapse', Ashburn, VA. Invited Talk/Keynote, Presented, 05/03/2016.
  • NIH NINDS 2016 Robert Whitney Newcomb Memorial Lecture, Bethesda, MD. Invited Talk/Keynote, Presented, 03/14/2016.
  • University of California, San Francisco, Dept of Neuroscience Seminar Series, San Francisco, CA. Invited Talk/Keynote, Presented, 01/2016.
  • Brigham Young University, Dept of Physiology & Developmental Biology Seminar Series, Provo, UT. Invited Talk/Keynote, Presented, 11/2015.
  • 5th Bonn Humboldt Award Winners’ Forum, Bonn, Germany. Invited Talk/Keynote, Presented, 10/2015.
  • University of Chicago 4th Annual Brain Awareness Day, Chicago, IL. Invited Talk/Keynote, Presented, 10/2015.
  • Max Planck Institute for Brain Research Neuroscience Lecture Series, Frankfurt, Germany. Invited Talk/Keynote, Presented, 10/2015.
  • OHSU Vollum Institute Seminar Series, Portland, OR. Invited Talk/Keynote, Presented, 04/2015.
  • UCSD Dart Neuroscience Seminar Series, San Diego, CA. Invited Talk/Keynote, Presented, 04/2015.
  • Roger Eckert Lecture, 11th Göttingen Meeting of the German Neuroscience Society, Göttingen, Germany. Invited Talk/Keynote, Presented, 03/2015.
  • Sunposium 2015, Max Planck Florida Institute, Palm Beach, FL. Invited Talk/Keynote, Presented, 03/2015.
  • University of Utah Pharmaceutical Chemistry Seminar, Salt Lake City, UT. Invited Talk/Keynote, Presented, 02/2015.
  • University of Utah Ctr for Nanomedicine Seminar, Salt Lake City, UT. Invited Talk/Keynote, Presented, 02/2015.
  • University of Texas Southwestern Neuroscience Seminar, Dallas, TX. Invited Talk/Keynote, Presented, 01/2015.
  • UC-Berkeley Life Sciences Division Seminar, Berkeley, CA. Invited Talk/Keynote, Presented, 01/2015.
  • Lawrence Berkeley National Laboratory Seminar, Berkeley, CA, . Invited Talk/Keynote, Presented, 01/2015.
  • Harvard Medical School Neurobiology Seminar Series, Boston, MA. Invited Talk/Keynote, Presented, 10/2014.
  • Kansas State University Biology Seminar, Manhatten, KS. Invited Talk/Keynote, Presented, 10/2014.
  • 3rd Int’l Symposium on Protein Trafficking in Health and Disease, University Medical Center, Hamburg, Germany . Invited Talk/Keynote, Presented, 09/2014.
  • Gordon Research Conference GRS Synaptic Transmission Keynote Speaker, Waterville Valley, NH . Invited Talk/Keynote, Presented, 08/2014.
  • SFB 629 Symposium ‘Intracellular Transport’, Institut für Neurobiologie, Münster, Germany. Invited Talk/Keynote, Presented, 06/2014.
  • Gordon Research Conference: Cell Biology of the Neuron . Invited Talk/Keynote, Presented, 06/2014.
  • HHMI Janelia ‘Genetic Manipulation of Neuronal Activity III’, Ashburn, VA. Invited Talk/Keynote, Presented, 05/2014.
  • Keystone Symposium ‘Frontiers of Structural Biology’ at Snowbird, UT, . Invited Talk/Keynote, Presented, 04/2014.
  • Trends in Microscopy 2014, Life Imaging Ctr in ZBSA, Freiberg, Germany. Invited Talk/Keynote, Presented, 03/2014.
  • D. A. Harmon Endowed Lecture, Oklahoma Research Fdn,, Oklahoma City OK . Invited Talk/Keynote, Presented, 02/2014.
  • NYU Neuroscience Colloquium Series, NYU Langone Medical Ctr, New York, NY . Invited Talk/Keynote, Presented, 01/2014.
  • UC-Berkeley Life Sciences Division Seminar, Berkeley, CA. Invited Talk/Keynote, Presented, 01/2014.