CHRIS M IRELAND portrait
  • Dean and L. S. Skaggs Presidential Endow Chair for Pharmacy, College Of Pharmacy
  • Director or Research Utah Asia Campus
  • Adjunct Professor, Chemistry
  • Professor, Medicinal Chemistry
  • Distinguished Professor, Medicinal Chemistry

Research Keywords

  • Marine Pharmacognosy

Languages

  • English, fluent.

Geographical Regions of Interest

  • Melanesia
    Fiji, Papua New Guinea, Solomon Islands, Vanuatu.
  • Oceania
    Australia.
  • South-Eastern Asia
    Philippines.

Publications

  • Lu, Z.; Ding, Y.; Li, X.C.; Djigbenou, D.R.; Grimberg, B.T.; Ferreira, D.; Ireland, C.M.; Van Wagoner, R.M. 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. Bioorg Med Chem. (2011) 22, 6604-7. Published, 11/2011.
  • Sasaki, S.; Tozawa, T.; Van Wagoner, R.M.; Ireland, C.M.; Harper, M.K.; Satoh, T. Strongylophorine-8, a pro-electrophilic compound from the marine sponge Petrosia (Strongylophora) corticata, provides neuroprotection through Nrf2/ARE pathway. Biochem Biophys Res Commun. (2011) 415, 6-10. Published, 11/2011.
  • Pimentel-Elardo,S.M; Buback,V.; Gulder, T.A.M.; Bugni, T.M.; Reppart, J.; Bringmann, G.; Ireland, C.M.; Schirmeister T.; Hentschel.U. New tetromycin derivatives with anti-trypanosomal and protease Inhibitory activities. Mar. Drugs (2011) 9, 1682-1697. Published, 10/2011.
  • Wei, X; Henriksen, N.M.; Skalicky, J.J.; Harper, M.K.; Cheatham, T.E.; Ireland, C.M.; Van Wagoner. R.M. Araiosamines A-D: Tris-bromoindole cyclic Guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. J. Org. Chem. (2011) 76, 5515-23. Published, 07/2011.
  • Sun, H.; Reinscheid, U.M.; Whitson, E.L.; d'Auvergne, E.; Ireland, C.M.; Navarro-Vázquez, A.; Griesinger, C. The challenge of large scale motion for RDC-based analysis of configuration: the case of fibrosterol sulfate A. J. Am. Chem. Soc. (2011) 133, 14629-14636. Published, 07/2011.
  • Lu, Z., Van Wagoner, R.M.; Harper, M.K.; Baker, H.L.; Hooper, J.N.; Bewley, C.A.; Ireland, C.M. Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J. Nat. Prod. (2011) 74, 185-93. Published, 02/2011.
  • Dolan, B.P.’ Li, L.; Veltri, C.A.; Ireland, C.M.; Bennink, J.R.; Yewdell, J.W. Distinct pathways generate peptides from defective ribosomal products for CD8+ T Cell immunosurveillance. J. Immunol. (2011) 186, 2065-72. Published, 01/2011.
  • Coombs, G.S.; Jia, Y.; Canning, C.A.; Veltri, C.A.; Covey, T.M.; Cheong, J.K.; Utomo, V.; Banerjee, N.; Zhang, Z.H.; Jadulco, R.C.; Concepcion, G. P.; Bugni, T.S.; Harper, M.K.; Mihalek, C.; Jones, C.M., Ireland, C.M.; Virshup, D.M. WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification J.Cell Sci. (2010) 123, 3357-3367. Published, 12/2010.
  • Wei, X.; Bugni, T.S.; Harper, M.K.; Sandoval, I.T.;Manos, E.J.; Swift, J.; Van Wagoner. R.M.; Jones, D.A.; Ireland, C.M. Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay. Mar. Drugs (2010) 8, 1769-78. Published, 08/2010.
  • Lu, Z.; Van Wagoner, R.M.; Harper, M.K.; Hooper, J.N.A.; Ireland. C.M. Two ring-A-aromatized bile acids from the marine sponge Sollasella moretonensis. Natural Product Communications (2010) 5, 1571-1574. Published, 08/2010.
  • Pimentel-Elardo, S.M.; Kozytska, S.; Bugni, T.S.; Ireland, C.M.; Moll, H.; Hentschel, U. Anti-parasitic compounds from Streptomyces sp. Strains isolated from mediterranean sponges Mar. Drugs (2010) 8, 373-380. Published, 08/2010.
  • Koch, M.; Bugni, T.S.; Sondossi, M.; Ireland, C.M.; Barrows, L.R. Exocarpic Acid Inhibits Mycolic Acid Biosynthesis in Mycobacterium tuberculosis Planta Med. (2010) 76, 1678-82. Published, 06/2010.
  • Barrows, L.R.; Matainaho, T.K.; Ireland, C.M.; Miller, S.; Carter, G.T.; Bugni, T.; Rai, P.; Gideon, O.; Manoka, B; Piskaut, P.; Banka, R.; Kiapranis, R.; Noro, J.N.; Pond, C.D.; Andjelic, C.D.; Koch, M.; Harper, M.K.; Powan, E.; Pole, A.R.; Jensen, J.B. Making the most of Papua New Guinea's biodiversity: Establishment of an integrated set of programs that link botanical survey with pharmacological assessment in "The Land of the Unexpected" Pharm Biol. (2009) 47, 795-808. Published, 2009.
  • Marshall, K.M.; Andjelic, C.D.; Tasdemir, D.; Concepción, G.P.; Ireland, C.M.; Barrows, L.R. Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Mar. Drugs (2009) 25, 196-209. Published, 2009.
  • McCulloch, M.W.B.; Bugni, T.S.; Concepcion, G.P.; Coombs, G.S.; Harper, M.K.; Kaur, S.; Mangalindan, G.C.; Mutizwa, M.M.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M. Carteriosulfonic acids A−C, GSK-3β inhibitors from a Carteriospongia sp. J. Nat. Prod. (2009) 72, 1651-6. Published, 2009.
  • Koch, M.; Bugni, T.S.; Pond, C.D.; Sondossi, M.; Dindi, M.; Piskaut, P.; Ireland, C.M.; Barrows, L.R. Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid. Planta Med. (2009) 75, 1326-30. Published, 2009.
  • Whitson, E.L.; Bugni, T.S.; Chockalingam, P.; Concepcion, G.; Feng, X.; Jin, G.; Harper, Mary Kay; Mangalindan, G.; Mcdonald, L.A.; Ireland, C.M. Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa; Sterol dimers that inhibit PKCzeta J. Org. Chem. (2009) 74, 5902–08. Published, 2009.
  • Bugni,T.S.; Andjelic, C.D.; Pole, A.R.; Rai, P.; Ireland, C.M.; Barrows, L.R. Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation. Fitoterapia (2009) 80, 270-3. Published, 2009.
  • Labarbera,D.V.; Modzelewska, K.; Glazar, A.I.; Gray, P.D.; Kaur, M.; Liu, T.; Grossman,D.; Harper, M.K.; Kuwada, S.K.; Moghal, N.; Ireland, C.M. The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells. Anticancer Drugs (2009) 20, 425-36. Published, 2009.
  • McCulloch, M.W.B.; Coombs, G.S.; Banerjee, N.; Bugni,T.S.; Cannon, K.M.;Harper, M.K.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M. Psammaplin A as a general activator of cell based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg. Med. Chem. (2009) 17, 2189-98. Published, 2009.
  • Whitson, E.L.; Ratnayake, A.S.; Bugni, T.S.; Harper, M.K.; Ireland, C.M. Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp. J. Org. Chem. (2009) 74,1156-62. Published, 2009.
  • Mohammed, K.A.; Jadulco, R.C., Bugni, T.S.; Harper, M.K.; Sturdy, M.; Ireland, C.M. Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway J. Med. Chem. (2008) 51, 1402-5. Published, 2008.
  • Bugni, T.S.; Richards, B.; Bhoite, L.; Cimbora, D.; Harper. M.K.; Ireland, C.M. Marine natural product libraries for high-throughput screening and rapid drug discovery. J Nat. Prod. (2008) 71, 1095-98. Published, 2008.
  • Whitson, E.L.; Bugni, T.S.; ,Chockalingam, P.S.; Concepcion, G.P.; Harper, M.K.; He, M.; Hooper, J.N.A.; Mangalindan, G.C.; Ritacco, F.; Ireland, C.M. Spheciosterol sulfates, PKCζ inhibitors from a Philippine sponge Spheciospongia sp. J Nat. Prod. (2008) 71, 1213-7. Published, 2008.
  • Noro, J.C.; Barrows, L.R.; Gideon, O.G.; Ireland, C.M.; Koch, M.; Matainaho, T.; Piskaut, P.; Pond, C.D.; Bugni, T.S. Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. J. Nat. Prod. (2008) 71, 1623-24. Published, 2008.
  • McCulloch, M.W.B.; Coombs, G.S.; Banerjee, N.; Bugni,T.S.; Cannon, K.M.;Harper, M.K.; Veltri, C.A.; Virshup, D.M.; Ireland, C.M. Psammaplin A as a general activator of cell based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg. Med. Chem. (2008) 16, epub. Published, 2008.
  • Bugni, T.S.; Harper, M.K.; McCulloch, M.W.B.; Reppart, J.; Ireland, C.M. Fractionated Marine Invertebrate extract libraries for drug discovery. Molecules (2008) 13, 1372-83. Published, 2008.
  • Whitson, E.L.; Ratnayake, A.S.; Bugni, T.S.; Harper, M.K.; Ireland, C.M. Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp. J. Org. Chem. (2008) epub. Published, 2008.