Publications

• J. Li, M.T. Gambles, B. Jones, J.A. Williams, N.J. Camp, P.J. Shami, J. Yang, J. Kopeček, Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics Induce Apoptosis in Chronic Lymphocytic Leukemia Patient Cells by Crosslinking of CD20 and/or CD38 Receptors. Drug Delivery Translational Res. (2024) https://doi.org/10.1007/s13346-024-01629-3. Published, 01/2024.
• J. Kopeček, Hydrophilic Biomaterials: From Crosslinked and Self-Assembled Hydrogels to Polymer-Drug Conjugates and Drug-Free Macromolecular Therapeutics. Invited “Magnum Opus” manuscript. J. Controlled Release 373, 1-22 (2024). Published, 01/2024.
• M.T. Gambles, D. Sborov, P. Shami, J. Yang, J. Kopeček, Obinutuzumab-Based Drug-Free Macromolecular Therapeutics Synergizes with Topoisomerase Inhibitors. Macromol. Biosci. (2023) 2300375; https://doi.org/10.1002/mabi.202300375. Published, 10/15/2023.
• M.T. Gambles, J. Yang, J. Kopeček, Multi-Targeted Immunotherapeutics to Treat B Cell Malignancies. J. Controlled Release 358, 232-258 (2023); https://doi.org/10/1016/j.conrel.2022.08.045. Published, 05/05/2023.
• M.T. Gambles, J. Li, D.C. Radford, D. Sborov, P. Shami, J. Yang, J. Kopeček, Simultaneous Crosslinking of CD20 and CD38 Receptors by Drug-Free Macromolecular Therapeutics Enhances B Cell Apoptosis In Vitro and In Vivo. J. Controlled Release 350, 584-599 (2022); https://doi.org/10.1016/j.jconrel.2022.08.045. Published, 10/18/2022.
• Z.-H. Peng, C.M. Jogdeo, J. Li, Y. Xie, Y. Wang, Y.M. Sheinin, J. Kopeček, D. Oupický, Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model. Pharmaceutics 14, 1725 (2022); https://doi.org/10.3390/pharmaceutics14081725. Published, 08/22/2022.
• J. Wang, J. Yang, J. Kopecek, Nanomedicines in B Cell-Targeting Therapies. Acta Biomater. 137, 1-19 (2022); htpps://doi.org/10.1016/j.actbio.2021.10.024. Published, 10/14/2021.
• M.T. Gambles, J. Li, J. Wang, D. Sborov, J. Yang, J. Kopecek, Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells. Molecules 26, 4658 (2021); https://doi.org/10/3390/molecules26154658. Published, 07/31/2021.
• L. Li, J. Wang, D.C. Radford, J. Kopeček, J. Yang, Combination Treatment with Immunogenic and Anti-PD-L1 Polymer-Drug Conjugates of Advanced Tumors in a Transgenic MMTV-PyMT Mouse Model of Breast Cancer. J. Controlled Release, 332, 652-659 (2021). Published, 04/2021.
• Y. Li, L. Li, J. Wang, D.C. Radford, Z. Gu, J. Kopeček, J. Yang, Dendronized Polymer Conjugates with Amplified Immunogenic Cell Death for Oncolytic Immunotherapy. J. Controlled Release, 239, 1129-1138 (2020); https://doi.org/10.1016/j/jconrel.2020.10.041. Published, 10/2020.
• J. Kopeček, J. Yang, Polymer Nanomedicines. Adv. Drug Deliv. Rev. 156, 40-66 (2020); https://doi.org/10/1012/j.addr.2020.07.020. Published, 07/2020.
• D.C. Radford, J. Yang, M. Doan, L. Li. A.S. Dixon, S.C. Owen, J. Kopecek, Multivalent HER2-Binding Polymer Conjugates Facilitate Rapid Endocytosis and Enhance Intracellular Drug Delivery. J. Controlled Release 319, 285-299 (2020). Published, 03/2020.
• J. Wang, Y. Li, L. Li, J. Yang, J. Kopeček, Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model. Macromol. Biosci. (2020) 1900445; doi: 10.1002/mabi.201900445. Published, 03/2020.
• L. Li, Y. Li, C.-H. Yang, D.C. Radford, J. Wang, M. Janát-Amsbury, J. Kopecek, J. Yang, Inhibition of Immunosuppresive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking. Adv. Funct. Mater (2020) 1908961; https://doi.org/10.1002/admf.201908961. Published, 02/2020.
• L. Li, J. Wang, Y. Li, D.C. Radford, J. Yang, J. Kopecek, Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface. ACS Nano 13, 11422-11432 (2019). ACS Editors’ Choice. Published, 10/2019.
• J. Wang, L. Li, J. Yang, P.M. Clair, M. Glenn, D.M. Stephens, D.C. Radford, K.M. Kosak, M.W. Deininger, P.J. Shami, J. Kopecek, Drug-free Macromolecular Therapeutics Induce Apoptosis in Cells Isolated from Patients with B Cell Malignancies with Enhanced Apoptosis Induction by Pretreatment with Gemcitabine. Nanomedicine: NBM 16, 217-225 (2019). Published, 02/2019.
• L. Li, J. Yang, S. Soodvilai, J. Wang, P. Opanasopit, J. Kopecek, Drug-Free Albumin-Triggered Sensitization of Cancer Cells to Anticancer Drugs. J. Controlled Release 293, 84-93 (2019). Published, 01/2019.
• L. Zhang,Y. Fang, L. Li, J. Yang, D.C. Radford, J. Kopecek, Human Serum Albumin Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface. Macromol. Biosci. 18, 1800224 (2018); https://doi.org/10.1002/mabi.201800224. Published, 11/2018.
• J. Yang, L. Li, J. Kopeček, Biorecognition: A Key to Drug-free Macromolecular Therapeutics. Biomaterials 190-191, 11-23 (2019). Published, 10/2018.
• J. Yang, L. Li, J. Kopeček,Biorecognition: A Key to Drug-free Macromolecular Therapeutics. Biomaterials. https://10.1016/j.biomaterials.2018.10.007. Published, 10/2018.
• L. Li, J. Yang, J. Wang, J. Kopecek, Drug-Free Macromolecular Therapeutics Exhibit Amplified Apoptosis in G2/M Phase Arrested Cells. J. Drug Targeting (2018) doi: 10.1080/1061186X.2018.1521414. Published, 07/2018.
• L. Li, J. Yang, J. Wang, J. Kopecek, Amplification of CD20 Crosslinking in Rituximab Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics. ACS Nano 12, 3658-3670 (2018). Published, 02/2018.
• L. Li, J. Yang, J. Wang, J. Kopecek, Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway. Macromol. Biosci. 18(1), 1700196 (2018); doi: 10.1002/mabi.201700196. Highlighted in Advanced Science News http://www.advancedsciencenews.com/molecular-therapeutics-drug-free-cancer-treatment/. Published, 01/2018.
• J. Yang, R. Zhang, H. Pan, Y. Li, Y. Fang, L. Zhang, J. Kopecek, Backbone Degradable HPMA Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts. Mol. Pharmaceutics 14, 1384-1394 (2017); http://dx.doi.org/10.1021/acs.molpharmaceut.6b01005. Published, 08/2017.
• J. Yang, J. Kopeček, The Light at the End of the Tunnel-Second Generation HPMA Conjugates for Cancer Treatment. Curr. Opin. CXolloid Interface Sci. 31, 30-42 (2017). Published, 08/2017.
• B. Pelaz, C. Alexiou, R. Alvarez-Puebla, F. Alves, A. Andrews, S. Ashraf, L. Balogh, L. Ballerini, A. Bestetti, C. Brendel, S. Bossi, M. Carril, W. Chan, C. Chen, X. Chen, S. Shen, Z. Cheng, D. Cui, J. Du, C. Dullin, A. Escudero, N. Feliu, M. Gao, M. George, A. Grünweller, Z. Gu, Y. Gogotsi, N. Halas, N. Hampp, R. Hartmann, M. Hersam, P. Hunziker, J. Ji, X. Jiang, P. Jungebluth, P. Kadhiresan, K. Kataoka, A. Khademhosseini, J. Kopecek, N. Kotov, H. Krug, D.S. Lee, C.-M. Lehr, K.W. Leong, X.-J. Liang, M.L. Ling, L. Liz-Marzán, X. Ma, P. Macchiarini, H. Meng, H. Möhwald, P. Mulvaney, A. Nél, S. Nie, P. Nordlander, T. Okano, J. Oliviera, T.H. Park, R. Penner, M. Prato, V. Puntes, V. Rotello, A. Samarakoon, R. Schaak, Y. Shen, S. Sjoqvist, A.G. Skirtach, M. Sollman, M. Stevens, B.Z. Tang, R. Tietze, B. Udugama, H.-W. Sung, T. Weil, P. Weiss, I. Willner, Y. Wu, L. Yang, Z. Yue, Q. Zhang, Q. Zhang, X. Zhang, Y. Zhao, X. Zhou, W. Parak, Diverse Applications of Nanomedicine. ACS Nano 11, 2313-2381 (2017). Published, 06/2017.
• L. Zhang, Y. Fang, J. Yang, J. Kopecek, Drug-Free Macromolecular Therapeutics: Impact of Structure on Induction of Apoptosis in Raji B Cells. J. Controlled Release 263, 139-150 (2017); doi: 10.1016/j.jconrel.2016.12.025. Published, 04/2017.
• L. Zhang, Y. Fang, J. Kopecek, J. Yang, A New Construct of Antibody-Drug Conjugates for Treatment of Non-Hodgkin’s Lymphoma. Eur. J. Pharm. Sci. 103, 36-46 (2017). Elected Best Research Paper in European Journal of Pharmaceutical Sciences 2017. Published, 04/2017.
• R. Zhang, J. Yang, D.C. Radford, Y. Fang, J. Kopecek, FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate. Macromol. Biosci. 17, 1600125 (2017); doi: 10.1002/mabi.201600125. Published, 02/2017.
• S.A. Low, C.V. Galliford, Y.L. Jones-Hall, J. Roy, J. Yang, P.S. Low, J. Kopecek, Healing Efficacy of Fracture-Targeted GSK3b Inhibitor-Loaded Micelles for Improved Fracture Repair, Future Medicine: Nanomedicine (Lond.) 12, 185-193 (2017); http://www.futuremedicine.com/doi/abs/10.2217/nnm-2016-0340. Published, 01/2017.
• L. Zhang, R. Zhang, J. Yang, J. Wang, J. Kopecek, Indium-based and Iodine-based Labeling of HPMA Copolymer-Epirubicin Conjugates: Impact of Structure on the In Vivo Fate. J. Controlled Release 235, 306-318 (2016). Published, 08/2016.
• J. Yang, J. Kopecek, Design of Smart HPMA Copolymer-Based Nanomedicines. J. Controlled Release 240, 9-23 (2016). Published, 06/2016.
• J.M. Hartley, J. Kopeček, Smart Polymer-Based Nanomedicines, In: Smart Pharmaceutical Nanocarriers, V.P. Torchilin, Ed., Imperial College Press, Chapter 11, pp. 373-413 (2016); ISBN: 978-1-78326-722-4. Published, 05/2016.
• J.M. Hartley, R. Zhang, M. Gudheti, J. Yang, J. Kopecek, Tracking and Quantifying Polymer Therapeutic Distribution on a Cellular Level Using 3D dSTORM. J. Controlled Release 231, 50-59 (2016). Published, 01/2016.
• R. Zhang, J. Yang, Y. Zhou, P.J. Shami, J. Kopecek, N-(2-Hydroxypropyl)methacrylamide Copolymer-drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. Macromol. Biosci. 16, 121-128 (2016). Published, 01/2016.
• J. Yang, J. Kopecek, Design of Smart HPMA Copolymer-Based Nanomedicines. J. Controlled Release (2015) http://dx.doi.org/10.1016/j.jconrel.2015.10.003. Published, 12/2015.
• J. Yang, J. Kopecek, Polymeric Biomaterials and Nanomedicines. J. Drug Deliv. Sci. Technol. 30, 318-330 (2015) . Published, 11/2015.
• T.-W. Chu, J. Feng, J. Yang, J. Kopeček, Hybrid Polymeric Hydrogels via Peptide Nucleic Acid (PNA)/DNA Complexation. J. Controlled Release 220, 608-616 (2015). Published, 10/2015.
• J. Yang, R. Zhang D.C. Radford, J. Kopeček, FRET-Trackable Biodegradable HPMA Copolymer-Epirubicin Conjugates for Ovarian Carcinoma Therapy. J. Controlled Release 218, 36-44 (2015). Published, 08/2015.
• S.A. Low, C.V. Galiford, J. Yang, P.S. Low, J. Kopeček, Biodistribution of Facture-Targeted GSK3β Inhibitor-Loaded Micelles for Improved Fracture Healing. Biomacromolecules 16, 3145-3153 (2015). Published, 07/2015.
• T.-W. Chu, J. Kopecek, Drug-Free Macromolecular Therapeutics – A New Paradigm in Polymeric Nanomedicines. Biomaterials Sci. 3, 908-922 (2015). Published, 06/2015.
• J.M. Hartley, T.-W. Chu, E.M. Peterson, R. Zhang, J. Yang, J. Harris, J. Kopeček, Super-Resolution Imaging and Quatitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell Surface Self-Assembly of Hybrid Nanoconjugates. ChemBioChem 16, 1725-1729 (2015). Published, 06/2015.
• Z.-H. Peng, J. Kopeček, Enhancing Accumulation and Penetration of HPMA Copolymer Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. J. Am. Chem. Soc. 137, 6726-6729 (2015). Published, 05/2015.
• J. Yang, J. Kopeček, Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics. In: Bioinspired Systems for Drug, Protein and Gene Delivery, Z.W. Gu, Ed., Chapter 1, pp. 1-27, Wiley 2015; ISBN: 978-3-527-33420-9. Published, 02/2015.
• R. Zhang, J. Yang, T.-W. Chu, J.M. Hartley, J. Kopeček, Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a “Drug-Free” Therapeutic System. Adv. Healthcare Mat. 4, 1054-1065 (2015). Published, 02/2015.
• T.-W. Chu, R. Zhang, J. Yang, M.P. Chao, P.J. Shami, J. Kopeček, A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. Theranostics 5, 834-846 (2015). Published, 02/2015.
• Z.-H. Peng, J. Kopeček, HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells. ACS Macro Letters 3, 1240-1243 (2014). Published, 12/2014.
• T.-W. Chu, K.M. Kosak, P.J. Shami, J. Kopeček, Drug-Free Macromolecular Therapeutics Induce Apoptosis of Patient Chronic Lymphocytic Leukemia Cells. Drug Delivery Translational Res. 4, 389-394 (2014). Published, 11/2014.
• Y. Zhou, J. Yang, R. Zhang, J. Kopeček, Combination Therapy of Prostate Cancer with HPMA Copolymer Conjugates Containing PI3K/mTOR Inhibitor and Docetaxel. Eur. J. Pharmaceutics Biopharm. 89, 107-115 (2014). Published, 11/2014.
• S.A. Low, J. Yang, J. Kopeček, Bone-Targeted Acid-Sensitive Doxorubicin Conjugate Micelles as Potential Osteosarcoma Therapeutics. Bioconjugate Chem. 25, 2012-2020 (2014). Published, 10/2014.
• R. Zhang, J. Yang, M. Sima, Y. Zhou, J. Kopeček, Sequential Combination Therapy of Ovarian Cancer with Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Paclitaxel and Gemcitabine Conjugates. Proc. Natl. Acad. Sci. USA 111(33), 12181-12186 (2014). Published, 08/2014.
• J. Yang, J. Kopeček, Macromolecular Therapeutics, J. Controlled Release 190, 288-303 (2014). Published, 07/2014.
• J. Yang, J. Kopeček, Polymeric Drugs, in: Encyclopedia of Polymeric Nanomaterials, S. Kobayashi, K. Müllen, Eds., Springer, (2014) pp. 1-9; doi: 10.1007/978-3-642-36199-9_225-1. Published, 06/2014.
• M. Kverka, J.M. Hartley, T.-W. Chu, J. Yang, R. Heidchen, J. Kopeček, Immunogenicity of Coiled-Coil Based Drug-Free Macromolecular Therapeutics. Biomatertials 35, 5886-5896 (2014). Published, 04/2014.
• Z.-H. Peng, J. Kopeček, Synthesis and Activity of Tumor-Homing Peptide iRGD and Histone Deacetylase Inhibitor Valproic Acid Conjugate. Bioorg. Med. Chem. Lett. 24, 1928-1933 (2014). Published, 03/2014.
• A. Duangjai, K. Luo, Y. Zhou, J. Yang, J. Kopeček, Combination Cytotoxicity of Backbone Degradable HPMA Copolymer Gemcitabine and Platinum Conjugates toward Human Ovarian Carcinoma Cells. Eur. J. Pharmaceutics Biopharm. 87, 187-196 (2014). Published, 02/2014.
• Y. Zhou, J. Yang, J. Rhim, J. Kopeček, HPMA Copolymer-based Combination Therapy Toxic to both Prostate Cancer Stem/Progenitor Cells and Differentiated Cells Induces Durable Anti-tumor Effects. J. Controlled Release 172, 946-953 (2013). Published, 12/2013.
• Z.-H. Peng, M. Sima, M.E. Salama, P. Kopečková, J. Kopeček, Spacer Length Impacts the Efficacy of Targeted Docetaxel Conjugates in Prostate Specific Membrane Antigen Expressing Prostate Cancer, J. Drug Targeting 21, 968-980 (2013). Published, 11/2013.
• N. Larson, J. Yang, A. Ray, D.L. Cheney, H. Ghandehari, J. Kopeček, Biodegradable Multiblock Poly(N-2-hydroxypropyl)methacrylamide Gemcitabine and Paclitaxel Conjugates for Ovarian Cancer Cell Combination Treatment, Int. J. Pharmaceutics 454, 435-443 (2013). Published, 10/2013.
• H. Pan, M. Sima, S.C. Miller, P. Kopečková, J. Yang, J. Kopeček, Promotion of Bone Formation in Ovariectomized Rats by High Molecular Weight Backbone Degradable HPMA Copolymer – Prostaglandin E₁ Conjugate, Biomaterials 34, 6528-6538 (2013). Published, 08/2013.
• J. Yang, J. Kopeček, Backbone Degradable and Coild-Coil Based Macromolecular Therapeutics, In: Bioinspired Systems for Drug and Gene Delivery, Z.W. Gu, Ed., Wiley and China Chemical Industry Press. Accepted, 06/2013.
• J. Kopeček, Polymer - Drug Conjugates: Origins, Progress to Date and Future Directions. Adv. Drug Delivery Rev. 65, 49-59 (2013). Published, 03/2013.
• R. Zhang, K. Luo, J. Yang, M. Sima, Y. Sun, M.M. Janát-Amsbury, J. Kopeček, Synthesis and Evaluation of Backbone Degradable Multiblock HPMA Copolymer Nanocarrier for the Systemic Delivery of Paclitaxel. J. Controlled Release 166, 66-74 (2013). Published, 02/2013.
• H. Pan, M. Sima, J. Yang, J. Kopeček, Synthesis of Long-Circulating Backbone Degradable HPMA Copolymer - Doxorubicin Conjugates and Evaluation of Molecular Weight Dependent Antitumor Efficacy. Macromol. Biosci. 13, 155-160 (2013). Published, 02/2013.
• Y. Zhou, J. Kopeček, Biological Rationale for the Design of Polymeric Anti-Cancer Nanomedicines. J. Drug Targeting 21, 1-26 (2013). Published, 01/2013.

Research Statement

Research Keywords

• Genetically Engineered Materials
• Drug Delivery Systems
• Biorecognition of Macromolecules
• Biodegradability of Polymers
• Bioconjugate Chemistry

Presentations

• J. Kopeček, Drug-free Macromolecular Therapeutics. 3rd Czech Annual Cancer Research Meeting, Olomouc, Czech Republic, November 18-20, 2024. Conference Paper, Refereed, Accepted, 11/20/2024.
• 3rd Czech Annual Cancer Research Meeting, Olomouc, Czech Republic, November 18-20, 2024. Invited Talk/Keynote, Accepted, 11/20/2024.
• I. Kendell, M.T. Gambles, J. Yang, J. Kopeček, Immunomodulation Improves Cancer Cell Clearance During Multi-Antigen T Cell Hybridizer Therapy. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• J. Li, J. Arnold, M. Sima, J. Kopeček, J. Yang, Combination of Multivalent DR5 Receptor Clustering Agonists and Histone Deacetylase Inhibitors for Treatment of Colon Cancer. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• S. Li, R. Aljassimi, J. Kopeček, D.J. Cross, J. Yang, Repurposing Paclitaxel via Vector-guided Brain Delivery for Alzheimer Disease Treatment. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• J. Li, S. Li, M.T. Gambles, J. Kopeček, D.W. Sborov, J. Yang, Development of A New Modality with Strong Cancer Immunotherapeutic Effect (CITE) for Multiple Myeloma Treatment. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• J. Li, H. Al Faruque, S. Hu-Lieskovan, J. Kopeček, J. Yang, Boosting Checkpoint Immunotherapy with 2nd Generation HPMA Polymer Conjugates with Synchronous PD-L1 Attenuation. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• H. Al Faruque, J. Li, D. Sborov, S. Hu-Lieskovan, J. Kopeček, J. Yang, Optimizing Immunotherapy of Ovarian Cancer - Nanomedicine Strategies for Heating ‘Cold’ Tumor with Concurrent PD-L1 Attenuation. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• S. Li. M.T. Gambles, D. Sborov, J. Yang, J. Kopeček, Novel Personalized Treatment for Multiple Myeloma: Multi-Antigen T Cell Hybridizers for T cell Activation. Annual Meeting of the American Association of Pharmaceutical Scientists (PharmSci 360), Salt Lake City, UT, October 20-23, 2024. Conference Paper, Refereed, Accepted, 10/23/2024.
• J. Kopeček, M.T. Gambles, S. Li, I. Kendell, J. Li, J. Yang, Drug-Free Macromolecular Therapeutics: Multi-Antigen T Cell Hybridizers. Annual Meeting of the Controlled Release Society, Bologna, Italy, July 8-12, 2024. Conference Paper, Refereed, Presented, 07/12/2024.
• J. Yang, J. Kopeček, Anticipating a New Wave of HPMA-based Polymer-drug Conjugates – Recent Progress and Perspectives in Cancer Therapy. Annual Meeting of the Controlled Release Society, Bologna, Italy, July 8-12, 2024. Conference Paper, Refereed, Presented, 07/12/2024.
• V.A. Ljubimov, T. Sun, J. Yang, J. Wang, L. Li, A.V. Ljubimov, E. Holler, J. Kopeček, J.Y. Ljubimova, K.L. Black, Artificial intelligence for effective treatment selection using biodegradable poly[(N-2-hydroxypropyl) methacrylamide] based nanodrugs for blood brain barrier delivery and immunotherapy of brain primary central nervous system lymphoma. Annual Meeting of the Controlled Release Society, Bologna, Italy, July 8-12, 2024. Conference Paper, Refereed, Presented, 07/12/2024.
• Annual Meeting of the Controlled Release Society, Bologna, Italy, July 8-12, 2024. Invited Talk/Keynote, Presented, 07/12/2024.
• I. Kendell, J. Kopeček, Immunomodulation Improves Cancer Cell Clearance by T Cells During Muti-Antigen T Cell Hybridizer Therapy. University of Utah Undergraduate Research Symposium, April 9, 2024. Conference Paper, Refereed, Presented, 04/09/2024.
• J. Li, M.T. Gambles, S. Li, J. Kopeček, D. Sborov, J. Yang, Development of Next Generation Antibody-Polymer-Drug Conjugates for Treatment of Multiple Myeloma. 65th ASH Annual Meeting and Exposition, San Diego, CA, December 9-12, 2023. Conference Paper, Refereed, Presented, 12/12/2023.
• D.J. Cross, S. Li, A. Jensen, M. Monson, M.T. Gambles, J. Wang, R. Aljassimi, S. Minoshima, J. Kopeček, J. Yang, Biodegradable Paclitaxel Conjugate for Alzheimer’s Disease Treatment. Society for Neuroscience 2023 Meeting, Washington, D.C., November 11-15, 2023. Conference Paper, Refereed, Presented, 11/15/2023.
• J. Yang, J. Kopeček, Polymer-Enhanced Chemo/Immuno Combinatory Therapy of Breast Cancer. 9th World Congress on Breast Cancer, San Diego, CA, November 6-7, 2023. Conference Paper, Refereed, Presented, 11/07/2023.
• S. Li, A. Jensen, M. Monson, M.T. Gambles, J. Wang, R. Aljassimi, S. Minoshima, J. Kopeček, D.J. Cross, J. Yang, Targeted Paclitaxel Conjugate for the Treatment of Alzheimer Disease. Annual Meeting of the Controlled Release Society, Las Vegas, NV, July 24-28, 2023. Conference Paper, Refereed, Presented, 07/25/2023.
• H.A. Faruque, J. Li, M. Cina, A. Young, S. Hu-Lieskovan, J. Kopeček, J. Yang, Nanomedicine Strategies for Heating Cold Tumors with Concurrent PD-L1 Attenuation. Annual Meeting of the Controlled Release Society, Las Vegas, NV, July 24-28, 2023. Conference Paper, Refereed, Presented, 07/25/2023.
• J. Yang, J. Li, M.T. Gambles, D. Sborov, J. Kopeček, Development of Next Generation Antibody-Polymer-Drug Conjugates. Annual Meeting of the Controlled Release Society, Las Vegas, NV, July 24-28, 2023. Conference Paper, Refereed, Presented, 07/25/2023.
• J. Li, J. Arnold, M. Sima, M. Abbasi, J. Kopeček, J. Yang, Multivalent DR5 Receptor Clustering Agonists for Treatment of Colon Cancer. Annual Meeting of the Controlled Release Society, Las Vegas, NV, July 24-28, 2023. Conference Paper, Refereed, Presented, 07/25/2023.
• M.T. Gambles, J. Li, S. Li, J. Yang, J. Kopeček, Artificial T Cell Activation Strategy Incorporating Receptor Crosslinking. Annual Meeting of the Controlled Release Society, Las Vegas, NV, July 24-28, 2023. Conference Paper, Refereed, Presented, 07/25/2023.
• J. Arnold, J. Li, J. Yang, J. Kopeček, Multivalent DR5 Receptor Clustering Agonists for Treatment of Colon Cancer. Utah Conference on Undergraduate Research, University of Utah, February 17, 2023. Conference Paper, Refereed, Presented, 02/17/2023.
• A.D. Jensen, J. Yang, M.B. Monson, T.W. Blake, S. Minoshima, J. Kopeček, D.J. Cross, Treatment of Alzheimer’s Disease Using Microtubule Stabilizing Drugs. Imaging Elevated Conference, Department of Radiology and Imaging Science, University of Utah, Salt Lake City, Utah, September 30-October 1, 2022. Conference Paper, Refereed, Presented, 10/01/2022.
• M.T. Gambles, J. Li, D. Sborov, P. Shami, J. Yang, J. Kopeček, Simultaneous Crosslinking of CD20 and CD38 by Drug-Free Macromolecular Therapeutics Enhances B Cell Apoptosis In Vitro and In Vivo. Annual Meeting of the Controlled Release Society, Montreal, Canada, July 11-15, 2022. Conference Paper, Refereed, Presented, 07/12/2022.
• M.T. Gambles, J. Li, D.C. Radford, D. Sborov, P. Shami, J. Yang, J. Kopecek, Heteroreceptor Crosslinking Induces a Synergetic Therapeutic Response in Malignant B Cells. 18th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, February 22-24, 2022. Conference Paper, Refereed, Presented, 02/23/2022.
• J. Li, C.-H. Yang, D.C. Radford, M.T. Gambles, S. Hu-Lieskovan, A. Welm, B. Welm, C.M. Peterson, J. Kopecek, J. Yang, Optimized Immunotherapy for Cancer Treatment: Polymer-Enhanced Combination of Immunogenic Chemotherapy and PD-L1 Degradation. 18th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, February 22-24, 2022. Conference Paper, Refereed, Presented, 02/23/2022.
• J. Yang, M.T. Gambles, J. Li, D.C. Radford, D. Sborov, P. Shami, J. Kopecek, A New Platform Technology of Antibody-Polymer-Drug Conjugates with Potential Treatment of Hematologic Malignancies and Solid Tumors. 18th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, February 22-24, 2022. Conference Paper, Refereed, Presented, 02/23/2022.
• J. Kopecek, J. Yang, M.T. Gambles, J. Li, D.C. Radford, Smart Nanomedicines Based on Receptor Crosslinking. 18th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, February 22-24, 2022. Invited Talk/Keynote, Presented, 02/23/2022.
• M.T. Gambles, J. Wang, J. Li, D. Sborov, J. Yang, J. Kopecek, Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells. Annual Virtual Meeting of the Controlled Release Society, July 25-29, 2021. Conference Paper, Refereed, Presented, 07/27/2021.
• J. Kopecek, J. Yang, L. Li, J. Wang, D.C. Radford, M. Gambles, Crosslinking of Receptors as a Design Principle for Smart Nanomedicines. 2nd Biomedical Engineering & Instrumentation Summit (BEIS-2021), April 19-21, 2021 Virtual (Boston, MA). Invited Talk/Keynote, Presented, 04/19/2021.
• D.C. Radford, J. Yang, M.C. Doan, L. Li, A.S. Dixon, S.C. Owen, J. Kopeček, Hyper-crosslinking HER2 Receptors with Multivalent HPMA Copolymer-based Nanoconjugate Overcomes Endocytosis Resistance and Enhances Intracellular Drug Delivery. Annual Virtual Meeting of the Controlled Release Society, June 29-July 2, 2020. Conference Paper, Refereed, Presented, 07/01/2020.
• J. Wang, Y. Li, L. Li, J. Kopeček, Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Conference Paper, Refereed, Presented, 02/08/2020.
• L. Li, Y. Li, D.C. Radford, J. Wang, J. Kopeček, J. Yang, Polymer-Enhanced Combination of Immunogenic Chemotherapy and PD-L1 Degradation. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Conference Paper, Refereed, Presented, 02/08/2020.
• J. Kopecek, My First Sixty Years in Science. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Invited Talk/Keynote, Presented, 02/08/2020.
• J. Wang, L. Li, J. Yang, P. Clair, M. Glenn, D.M. Stephens, D.C. Radford, K.M. Kosak, M.W. Deininger, P.J. Shami, J. Kopeček, Drug-Free Macromolecular Therapeutics Induce Apoptosis in Cells Isolated from Clinical Patients with B Cell Malignancies with Enhanced Apoptosis Induction by Pretreatment with Gemcitabine. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Conference Paper, Refereed, Presented, 02/07/2020.
• D.C. Radford, J. Yang, M.C. Doan, L. Li, A.S. Dixon, S.C. Owen, J. Kopeček, Hyper-Crosslinking HER2 Receptors with Multivalent HPMA Copolymer-Based Nanoconjugate Overcomes Endocytosis Resistance and Enhances Cytotoxicity. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Conference Paper, Refereed, Presented, 02/07/2020.
• L. Li. J. Wang, J. Yang, J. Kopeček, Cell-Surface Crosslinking of CD20 Antigens to Treat Non-Hodgkin’s Lymphoma. International Symposium on Biomedical Materials for Drug/Gene Delivery, Salt Lake City, Utah, February 7-8, 2020. Conference Paper, Refereed, Presented, 02/07/2020.
• J. Kopecek, J. Yang, L. Li, Crosslinking of Receptors as a Design Principle for Smart Nanomedicines. International Conference on Colloid and Surface Science “Okinawa Colloids 2019”, The Busena Terrace, Okinawa, Japan, November 3-8, 2019. Invited Talk/Keynote, Presented, 11/08/2019.
• J. Kopecek, J. Yang, Combination of Chemo- and Immunotherapy for the Treatment of Experimental Cancers. Pharmaceutical Technology Innovations Meeting, Ritsumeikan University, Kyoto, Japan, November 5, 2019. Invited Talk/Keynote, Presented, 11/05/2019.
• J. Yang, J. Kopecek, L. Li, Polymer-Assisted Novel Combinatorial Chemo-Immunotherapy for Cure of Solid Tumors. International Symposium on Stimuli-Responsive Materials, Windsor, California, October 20-22, 2019. Invited Talk/Keynote, Presented, 10/21/2019.
• J. Kopecek, J. Yang, L. Li, J. Wang, Biorecognition – a Bridge from Self-Assembled Hydrogels to Drug-Free Macromolecular Therapeutics. 2019 Fall American Chemical Society Meeting, San Diego, California, August 25-29, 2019. Invited Talk/Keynote, Presented, 08/27/2019.
• J. Kopecek, J. Yang, L. Li, Crosslinking of Receptors as a Design Principle for Smart Nanomedicines. 83rd Prague Meeting on Macromolecules, Polymers in Medicine 2019, Institute of Macromolecular Chemistry, Prague, Czech Republic, June 23-27, 2019. Invited Talk/Keynote, Presented, 06/26/2019.
• J. Kopecek, J. Yang, Self-Assembly of Macromolecules at Cell Surface Triggers Apoptosis, West China College of Pharmacy, Sichuan University, Chengdu, China, April 30, 2019. Invited Talk/Keynote, Presented, 04/30/2019.
• J. Kopecek, J. Yang, New Approaches for Treatment of Resistant Lymphomas. 4th Symposium on Nanomedicine and MRI Applications, West China Hospital at Sichuan University, Sichuan, China, April 25, 2019. Invited Talk/Keynote, Presented, 04/25/2019.
• J. Kopecek, Drug-Free Macromolecular Therapeutics, College of Pharmacy, University of Southern California, Los Angeles, January 25, 2019. Invited Talk/Keynote, Presented, 01/25/2019.
• J. Kopecek, J. Yang, L. Li, J. Wang, Self-Assembly of Macromolecules at Cell Surface Triggers Apoptosis. Functional Polymers for Human Health Meeting, The Hebrew University of Jerusalem, Israel, October 28-30, 2018. Invited Talk/Keynote, Presented, 10/29/2018.
• J. Kopecek, Overview of Drug Delivery Systems for Gene and Vaccine Delivery, 1st Consortium Meeting on Clinical Application of LNA-mRNA Vaccine Technology, Japan Agency for Medical Research and Development, Tokyo, Japan. Invited Talk/Keynote, Presented, 09/07/2018.
• J. Kopecek, J. Yang, L. Li, Challenges and Innovation in Next Generation Nanoscience, Nanotech & Nanotechnology EuroSciCon Conference, Paris, France, July 12-13, 2018. Invited Talk/Keynote, Presented, 07/12/2018.
• J. Kopecek, Frontiers of Biomedical Materials, 13th Frontier Scientists Workshop Organized by Korean Academy of Science and Technology, Salt Lake City, Utah, June 17-19, 2018. Invited Talk/Keynote, Presented, 06/18/2018.
• J. Kopeček, Design of Smart Biomaterials and Nanomedicines. Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka, Japan. Invited Talk/Keynote, Presented, 06/06/2018.
• J. Kopeček, Design of Macromolecular Therapeutics. Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan. Invited Talk/Keynote, Presented, 06/04/2018.
• J. Kopeček, Design of Smart Macromolecular Therapeutics. 33rd Annual Meeting of the Academy of Pharmaceutical Science and Technology, Japan, Shizuoka, May 30 – June 1, 2018. T&A Higuchi Award Lecture. Invited Talk/Keynote, Presented, 06/01/2018.
• J. Kopeček, Design of Smart Polymeric Nanomedicines, Astellas Pharma, Yaizu City, Japan. Invited Talk/Keynote, Presented, 06/01/2018.
• J. Kopeček, Biorecognition – a Bridge from Smart Biomaterials to Macromolecular Therapeutics. Polymer Chemistry Division, Tokyo Institute of Technology, Japan. Invited Talk/Keynote, Presented, 05/29/2018.
• J. Kopeček, Design of Macromolecular Therapeutics, Daichi-Sankyo, Tokyo, Japan. Invited Talk/Keynote, Presented, 05/28/2018.
• J. Kopeček, J. Yang, Design of Smart Polymeric Nanomedicines. TechConnect World Innovation Symposium, Anaheim, California, May 13-16, 2018. Invited Talk/Keynote, Presented, 05/14/2018.
• J. Kopecek, Biorecognition – a Bridge from Smart Biomaterials to Drug-free Macromolecular Therapeutics, Topics in Bioengineering Seminar Series, Harvard University, Boston, MA . Invited Talk/Keynote, Presented, 04/03/2018.
• J. Kopecek, Polymer-Drug Conjugates for Cancer Treatment: Design, Development, and Future Potential, Translational Genomics Research Institute (TGen), Phoenix, AZ. Invited Talk/Keynote, Presented, 03/02/2018.
• J. Kopeček, Polymer Therapeutics for Cancer Treatment, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague. Invited Talk/Keynote, Presented, 11/07/2017.
• J. Kopecek, Crosslinking of Cell Receptors Triggers Apoptosis. 5th International Symposium on Smart Biomaterials, University of Shanghai, China. Invited Talk/Keynote, Presented, 10/18/2017.
• J. Kopeček, J. Yang, Design of Smart Polymeric Nanomedicines,China Pharmaceutical University, Nanjing, China. Invited Talk/Keynote, Presented, 05/26/2017.
• J. Kopeček, J, Yang, Design of Smart Polymeric Nanomedicines, 3rd Symposium on Nanomedicine & MRI Applications, West China Hospital, Chengdu, Sichuan, China. Invited Talk/Keynote, Presented, 05/23/2017.
• J. Kopeček, J. Yang, Drug-Free Macrmolecular Therapeutics: A New Paradigm in Nanomedicine, Hainan Medical University, Haikou, Hainan, China. Invited Talk/Keynote, Presented, 05/18/2017.
• J. Kopeček, J. Yang, Design of Smart Polymeric Nanomedicines. College of Pharmacy, Setsunam University, Osaka, Japan. Invited Talk/Keynote, Presented, 12/2016.
• J. Yang, L. Zhang, Y. Fang, J. Kopeček, A New Construction of Antibody-Epirubicin Conjugate. 3rd International Conference on Biomaterials Science (ICBS2016), Tokyo, Japan, November 28-30, 2016. Presented by Dr. J. Yang. Conference Paper, Refereed, Presented, 11/2016.
• J. Kopeček, J. Yang, Y. Fang, L. Zhang, J. Wang, L. Li, Crosslinking of Cell Surface Receptors Triggers Apoptosis. 3rd International Coference on Biomaterials Science (ICBS2016), Tokyo, Japan, November 28-30, 2016. Invited Talk/Keynote, Presented, 11/2016.
• J. Yang, L. Zhang, Y. Fang, J. Kopeček, When HPMA-Based Polymer Meets Antibody-Drug Conjugates. International Symposium on Stimuli-Responsive Materials. Santa Rosa, CA, October 23-25, 2016. Presented by Dr. J. Yang. Invited Talk/Keynote, Presented, 10/2016.
• J. Kopeček, J. Yang, Design of Smart Polymeric Nanomedicines. 14th Annual Nanomedicine and Drug Delivery Symposium, NanoDDS’16, Johns Hopkins University, Baltimore, MD, September 16-18, 2016. Invited Talk/Keynote, Presented, 09/2016.
• J. Yang, T.-W. Chu, J.M. Hartley, R. Zhang, J. Kopeček, Drug-Free Macromolecular Therapeutics – A New Paradigm in Nanomedicines. 10th World Biomaterials Congress, Montreal, Canada, May 17-22, 2016. Conference Paper, Refereed, Presented, 05/2016.
• J. Kopeček, J. Yang, Self-Assembly of Nanoconjugates at the Cell Surface Triggers Apoptosis. 251st American Chemical Society National Meeting, San Diego, California, March 13-17, 2016. Invited Talk/Keynote, Presented, 03/2016.
• J. Kopeček, T.-W. Chu, J. Yang, R. Zhang, J.M. Hartley, Drug-Free Macromolecular Therapeutics – A New Paradigm in Polymeric Nanomedicines. Pacifichem 2015, Honolulu, Hawaii, December 15-20, 2015. Invited Talk/Keynote, Presented, 12/17/2015.
• J. Kopeček, Polymeric Biomaterials and Nanomedicines. Department of Biomedical Engineering, Columbia University. Symposium in honor of Prof. K. Leong's 60th Birthday. November 6, 2015, New York, NY. Invited Talk/Keynote, Presented, 11/06/2015.
• J. Yang, R. Zhang, D.C. Radford, J. Kopeček, FRET-Trackable Biodegradable HPMA Copolymer-Epirubicin Conjugates for Ovarian Carcinoma Therapy. 11th International Symposium on Stimuli-Responsive Materials, Santa Rosa, California, October 25-27, 2015. Conference Paper, Refereed, Presented, 10/27/2015.
• J. Kopeček, J. Yang, Polymeric Biomaterials and Nanomedicines. 11th International Symposium on Stimuli-Responsive Materials, Santa Rosa, California, October 25-27, 2015. Invited Talk/Keynote, Presented, 10/25/2015.
• D.C. Radford, J. Yang, R. Zhang, J. Kopeček, A FRET-Based Imaging Strategy to Rapidly Quantify Biodegradation of Degradable Nanomedicines. Conference NanoUtah2015, University of Utah, Salt Lake City, Utah, October 13, 2015. Conference Paper, Refereed, Presented, 10/13/2015.
• D.C. Radford, J. Yang, R. Zhang, J. Kopeček, A FRET-Based Imaging Strategy to Rapidly Quantify Biodegradation of Degradable Nanomedicines. Biomedical Engineering Society 2015 Annual Meeting, Tampa, Florida, October 7-10, 2015. Conference Paper, Refereed, Presented, 10/09/2015.
• J. Kopeček, Frontiers in Biomedical Materials. Invited seminar: Department of Chemical and Biomedical Engineering, Iowa State University, Ames, Iowa. Invited Talk/Keynote, Presented, 10/2015.
• J.M. Hartley, TW. Chu, E. Peterson, R. Zhang, J. Yang, J. Harris, J. Kopeček Characterizing the Effects of Hybrid Nanoconjugates on Lymphoma Plasma Membranes Using dSTORM and Pair-Correlation Analysis. 13th International Nanomedicine & Drug Delivery Symposium, Seattle, WA, September 16-18, 2015. Conference Paper, Refereed, Presented, 09/17/2015.
• Z.-H. Peng, J. Li, Y. Xie, Y. Wang, F. Yu, Y. Chen, J.E. Talmadge, J. Kopeček, D. Oupický, MMP-2-Repsonsive Polymeric CXCR4 Antagonist for Inhibiting Breast Cancer Growth and Metastasis. 13th International Nanomedicine & Drug Delivery Symposium, Seattle, WA, September 16-18, 2015. Conference Paper, Refereed, Presented, 09/17/2015.
• J. Yang, R.Zhang, D.C. Radford, J. Kopeček, FRET-Trackable Biodegradable HPMA Copolymer-Epirubicin Conjugates for Ovarian Carcinoma Therapy – In Vitro and In Vivo Evaluation. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015 . Conference Paper, Refereed, Presented, 06/15/2015.
• R. Zhang, J. Yang, M. Sima, T.-W. Chu, J.M. Hartley, J. Kopeček, Multimodality Imaging of Coiled-Coil Mediated Self-Assembly in a Drug-Free Therapeutic System. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015. Conference Paper, Refereed, Presented, 06/15/2015.
• J.M. Hartley, TW. Chu, E. Peterson, R. Zhang, J. Harris, J. Yang J. Kopeček, Quantitative Analysis of Lymphoma Membrane Organization after Self-Assembly of Hybrid Nanoconjugates on the Cell Surface. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015. Conference Paper, Refereed, Presented, 06/15/2015.
• D.C. Radford, J. Yang, R. Zhang, J. Kopeček, A FRET-Based Strategy to Monitor and Quantitate Biodegradation of Backbone Degradable HPMA Copolymers. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015. Conference Paper, Refereed, Presented, 06/15/2015.
• T.-W. Chu, R. Zhang, J. Yang, M.P. Chao, P.J. Shami, J. Kopeček, A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015 . Conference Paper, Refereed, Presented, 06/15/2015.
• L. Zhang, R. Zhang, J. Yang, J. Kopeček, Dual-Radioisotope HPMA Copolymer-Drug Conjugate for In Vivo Imaging Studies. 17th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah, June 14-17, 2015. Conference Paper, Refereed, Presented, 06/15/2015.
• J. Kopeček, T.-W. Chu, J. Yang, R. Zhang, J. Hartley, Self-Assembly of Nanoconjugates at Cell Surface Triggers Cancer Cell Apoptosis. 3rd Nanomedicine for Imaging and Treatment Conference, Cedar-Sinai Medical Center, Los Angeles, California, March 13-14, 2015. Invited Talk/Keynote, Presented, 03/13/2015.
• J. Kopeček, J. Yang, Recent Advances in Polymeric Nanomedicines. International Symposium on Translational Nanomedicine, Sun Yat-Sen University, Guangzhou, China, January 8-10, 2015. Invited Talk/Keynote, Presented, 01/08/2015.
• J. Kopeček, T.-W. Chu, J. Yang, R. Zhang, P. Shami, Self-Assembly of Nanoconjugates at Cell Surface Induces Apoptosis. 10th International Symposium on Stimuli-Responsive Materials, Santa Rosa, California, October 26-28, 2014. Opening lecture. Invited Talk/Keynote, Presented, 10/26/2014.
• J. Kopeček, J. Yang, Rational Design of Macromolecular Therapeutics, Department of Polymer Science, Peking University, Beijing, China. Invited Talk/Keynote, Presented, 09/23/2014.
• J. Kopeček, J. Yang, Rational Design of Macromolecular Therapeutics. Chinese Pharmaceutics Conference, Changsha, Hunan Province, China, September 19-22, 2014. Plenary lecture. Invited Talk/Keynote, Presented, 09/20/2014.
• J. Kopeček, T.-W. Chu, R. Zhang, J. Yang, P. Shami, J.M. Hartley, Self-Assembly of Nanoconjugates Triggers Cancer Cell Suicide. 3rd Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2014), Suzhou, China, September 16-19, 2014. Invited Talk/Keynote, Presented, 09/16/2014.
• J. Kopeček, J. Yang, Rational Design of Macromolecular Therapeutics, East China Normal University, Shanghai, China. Invited Talk/Keynote, Presented, 09/15/2014.
• J. Kopeček, Frontiers of Biomedical Materials, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague. Invited Talk/Keynote, Presented, 05/30/2014.
• J. Kopeček, Hydrogels: From Soft Contact Lenses and Implants to Self-Assembled Nanomaterials. 247th American Chemical Society Meeting, Dallas, Texas, March 16-20, 2014 . Invited Talk/Keynote, Presented, 03/17/2014.
• J. Kopeček, Frontiers of Biomedical Materials, University of Miami, College of Engineering Distinguished Speaker Series, March 3, 2014. Invited Talk/Keynote, Presented, 03/03/2014.
• J. Kopeček, J. Yang, Biodegradable HPMA Copolymers for Systemic Drug Delivery. Third Sino-German Symposium “Nanomaterials for Biomedical Applications”, Hangzhou, China, October 28-31, 2013 . Invited Talk/Keynote, Presented, 10/29/2013.
• J. Kopeček, Contribution of O. Wichterle to the Global Polymer Science in General and to Biomedical Polymers in Particular (in Czech). Meeting to Celebrate 100th Annversary of Professor Wichterle’s Birth, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, October 24, 2013 . Invited Talk/Keynote, Presented, 10/24/2013.
• J. Kopeček, J. Yang, Rational Design and Synthesis of Macromolecular Therapeutics. ACS Workshop “Polymers in Medicine and Biology”, Santa Rosa, Sonoma Valley, California, October 9-12, 2013. Invited Talk/Keynote, Presented, 10/10/2013.
• J. Kopeček, J. Yang, Rational Design of Macromolecular Therapeutics. 246th American Chemical Society National Meeting, Indianapolis, Indiana, September 8-12, 2013 . Invited Talk/Keynote, Presented, 09/10/2013.
• J. Kopeček, J. Yang, Biorecognition Motifs in the Design of Self-Assembling Biomaterials and Nanomedicines, 15th IUPAC International Symposium Macromolecular Complexes (MMC-15) Hyatt Regency Greenville, South Carolina, August 13-16, 2013 . Invited Talk/Keynote, Presented, 08/14/2013.
• J. Kopeček, J. Yang, Design and Biorecognition of Water-Soluble Macromolecular Therapeutics, Joint Symposium of the 5th Utah-Inha DDS & Advanced Therapeutic Research Center Symposium and the 7th International Symposium on Intelligent DDS, Sheraton Incheon Hotel, Incheon, Korea, May 23-24, 2013 . Invited Talk/Keynote, Presented, 05/24/2013.
• J. Kopeček, Frontiers of Biomedical Materials, XIX. General Meeting of the Learned Society (Academy) of the Czech Republic, Prague, Carolinum, May 20, 2013 . Invited Talk/Keynote, Presented, 05/20/2013.
• J. Kopeček, J. Yang, Smart Biomaterials and Macromolecular Therapeutics, 2nd International Conference on Biomaterial Science (ICBS2013), Tsukuba, Japan, March 20-22, 2013 . Invited Talk/Keynote, Presented, 03/20/2013.
• J. Kopeček, Design and Biorecognition of Water-Soluble Macromolecular Therapeutics, 2nd Nanomedicine for Imaging and Treatment Conference, Cedars-Sinai Medical Center, Los Angeles, California, March 15-16, 2013 . Invited Talk/Keynote, Presented, 03/15/2013.

Research Groups

• Lara Schlickmann, Undergraduate Student. 10/02/2023 - present.
• Ivan Wang, Other. 09/15/2023 - present.
• Sophie Hu-Lieskovan, Other. 06/01/2023 - present.
• Isaac Kendel, Undergraduate Student. Biomedical Engineering. 05/18/2023 - present. Awards/Scholarships/Stipends: UROP stipend.
• Monika Sima, Technician. Biomedical Engineering. 01/02/2023 - present.
• Mudassir Abbasi, Visiting Student. Molecular Pharmaceutics. 10/17/2022 - 04/10/2023. Awards/Scholarships/Stipends: IRSIP Fellowship from the Higher Educational Commission of Pakistan.
• Shannuo Li, Graduate Student. Molecular Pharmaceutics . 08/04/2022 - 12/2025. Awards/Scholarships/Stipends: Curci Foundation Fellowship.
• M. Tommy Gambles, Graduate Student. 07/01/2022 - 12/31/2023. Awards/Scholarships/Stipends: Skaggs Graduate Fellowship.
• Hasan Faruque, Postdoc. Molecular Pharmaceutics . 06/01/2022 - present. Awards/Scholarships/Stipends: NIH.
• Jaden Arnold, Undergraduate Student. Biomedical Engineering. 04/01/2022 - 12/15/2023. Awards/Scholarships/Stipends: UROP.
• Thomas McPartlon, Graduate Student. Graduate Rotating Student. 09/01/2021 - 10/07/2021. Awards/Scholarships/Stipends: Department Support.
• Yunyue Zhang, Undergraduate Student. Biology. 06/14/2021 - 04/15/2022. Awards/Scholarships/Stipends: UROP.
• Madison Parrot, Undergraduate Student. Pharmaceutical Chemistry / Summer Undergraduate Program. 06/14/2021 - 08/18/2021. Awards/Scholarships/Stipends: Summer UG Research Stipend.
• Inush Kalana, Postdoc. 06/01/2021 - 01/14/2022. Awards/Scholarships/Stipends: NIH/DoD.
• Aparna Shukla, Postdoc. 04/01/2021 - 08/31/2022. Awards/Scholarships/Stipends: NIH.
• Jiahui Li, Graduate Student. Molecular Pharmaceutics . 12/2020 - 05/2025. Awards/Scholarships/Stipends: NIH.
• Jiayue Feng, Other. 11/02/2020 - 07/30/2021.
• Michael (Tommy) Gambles, Graduate Student. Molecular Pharmaceutics . 05/2020 - 12/31/2023. Awards/Scholarships/Stipends: Skaggs Fellowship.
• KEHINDE SALAKO, Visiting Student. FULBRIGHT FELLOW FROM UNIVERSITY OF LAGOS, NIGERIA. 10/01/2019 - 04/30/2020. Awards/Scholarships/Stipends: Fulbright Fellowship.
• Goshen Cao, Graduate Student. Biological Chemistry. 01/14/2019 - 03/08/2019. Awards/Scholarships/Stipends: Rotating student from BC Program.
• Christian Bode, Visiting Student. Pharmaceutics and Pharmaceutical Chemistry. 11/01/2018 - 04/30/2019. Awards/Scholarships/Stipends: From Phillips University Marburg, Germany.
• Yachao Li, Visiting Student. Pharmaceutics and Pharmaceutical Chemistry. 10/2018 - 09/2019. Awards/Scholarships/Stipends: From Sichuan University.
• Zhou Zhou, Visiting Faculty. On sabbatical from Sichuan University. 10/01/2018 - 09/30/2019.
• Sirima Soodvilai, Visiting Student. Pharmaceutics and Pharmaceutical Chemistry. 10/2017 - 05/2018. Awards/Scholarships/Stipends: Royal Golden Jubilee Ph.D. Program Award (from Thailand).
• Elise Wilson-McGary, Other. College of Pharmacy PharmD research projects. 09/01/2017 - 04/30/2019.
• Christian Kodele, Undergraduate Student. 11/2016 - 05/2018.
• Lian Li, Ph.D., Postdoc. Pharmaceutics and Pharmaceutical Chemistry. 09/2016 - 08/2020.
• Mai Doan, Undergraduate Student. Bioengineering. 07/2016 - 06/2018. Awards/Scholarships/Stipends: UROP award.
• Yixin Fang, Ph.D., Postdoc. 01/2016 - 06/2017.
• Libin Zhang, Ph.D., Postdoc. Pharmaceutics and Pharmaceutical Chemistry. 02/2015 - 11/2017.
• Jiawei Wang, Graduate Student. Pharmaceutics and Pharmaceutical Chemistry. 01/2015 - 04/2021. Awards/Scholarships/Stipends: Arcturus Fellowship.
• Jiayue (Joy) FENG, Undergraduate Student. Bioengineering. 01/2014 - 12/2017.
• D. Christopher Radford, Graduate Student. Bioengineering. 01/2013 - 02/2022. Awards/Scholarships/Stipends: F31.
• Jiyuan (Jane) Yang, Research Professor. Pharmaceutics and Pharmaceutical Chemistry. 11/2003 - present. Awards/Scholarships/Stipends: DoD; NIH.

Languages

• Czech, fluent.
• English, fluent.
• German, fluent.
• Russian, functional.

Geographical Regions of Interest

• China
  Collaborations with Sichuan University.
• Czech Republic
  Collaboration with the Czech Academy of Sciences and The National Cancer Institute of the Czech Republic.

Grants, Contracts & Research Gifts

• Backbone-degradable Polymer-drug Conjugates for Treatment of Alzheimer Disease. PI: J. Yang, D. Cross. Alzheimer Association, 07/01/2022 - 01/31/2025. Total project budget to date: $150,000.00
• Multivalent Polymer-Peptide Antagonist (MPPA) Capable of Superior PD-L1 Inhibition Compared to Existing PD-L1 Antibodies. PI: J. Kopeček. Nanotechnology Characterization Laboratory (NIH/NCI), 12/01/2021 - present. Total project budget to date: $1,000,000.00
• Drug-Free Macromolecular Therapeutics RO1 CA246716. PI: J. Kopeček. NIH/NCI, 12/01/2019 - 11/30/2024. Total project budget to date: $1,744,220.00
• DR5 Targeted Nanoconjugates. PI: J. Kopeček, J. Yang. Bastion Biologics, 04/15/2019 - 01/31/2020. Total project budget to date: $68,933.00
• Long-Circulating Epirubicin KT-1 Conjugate for Treatment of Solid Tumor. PI: J. Kopeček. Nanotechnology Characterization Laboratory (NIH/NC), 11/01/2017 - 06/30/2021. Total project budget to date: $1,000,000.00
• Albumin-based Combination Therapeutics for the Treatment of B-Cell Lymphomas. PI: J. Kopeček. Huntsman Cancer Institute, 07/01/2017 - 06/30/2019. Total project budget to date: $80,000.00
• Project 50503163 Bastion Biologics. PI: J. Kopeček. Rituximab Therapeutics, 12/01/2016 - 06/30/2017. Total project budget to date: $50,000.00
• Unrestricted industrial support. PI: J. Kopeček. 01/2016 - present. Total project budget to date: $50,000.00
• Long-Circulating Targeted Nanomedicines for Leukemia Treatment. PI: P. Shami. Huntsman Cancer Institute Seed Grant, 01/01/2016 - 12/31/2016. Total project budget to date: $20,000.00
• A New Therapeutic Approach for Lymphoproliferative Disorder. PI: J. Kopeček. Huntsman Cancer Institute Seed Grant, 01/01/2016 - 12/31/2016. Total project budget to date: $20,000.00
• Backbone Degradable Polymer-Drug Conjugates for the Treatment of Ovarian Cancer. PI: J. Kopecek. NIH/CA/STTR Phase II with TheraTarget, Inc.; U of U subcontract , 09/01/2014 - 02/28/2017. Total project budget to date: $995,235.00
• FRET Imaging Trackable Long-Circulating Biodegradable Nanomedicines for Ovarian Cancer Therapy. PI: J. Kopeček. Department of Defense Grant, 09/01/2013 - 08/31/2015. Total project budget to date: $372,500.00
• Drug-Free Macromolecular Therapeutics. PI: J. Kopeček. NIH/NIGMS, 07/01/2011 - 10/31/2019. Total project budget to date: $2,326,458.00

Patents

• Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases. Status: Published. Inventors: Jindrich (Henry) Kopecek, Scott C. Miller, Pavla Kopeckova, Dong Wang. File date 03/30/2005. Assignee: The University of Utah. Country: Eur Patent Ofc.
• Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases. Status: Published. Inventors: Dong Wang, Jindrich (Henry) Kopecek, Scott C. Miller, Pavla Kopeckova. File date 11/28/2006. Assignee: The University of Utah. Country: United States.
• A Conjugate of a Polymer, An Anti-Angiogenesis Agent and a Targeting Moiety, and Uses Thereof in the Treatment of Bone Related Angiogenesis Conditions. Status: Published. Inventors: Ronit Satchi-Fainaro, Ehud Segal, Jindrich (Henry) Kopecek, Pavla Kopeckova, Huaizhong Pan. File date 05/21/2009. Assignee: The University of Utah. Country: Eur Patent Ofc.
• Polymeric Drug Delivery Conjugates and Methods of Making and Using Thereof. Status: Published. Inventors: Huaizhong Pan, Pavla Kopeckova, Jiyuan Yang, Jindrich (Henry) Kopecek. File date 03/07/2011. Assignee: The University of Utah. Country: Eur Patent Ofc.
• Compositions and Methods for Inducing Apoptosis. Status: Published. Inventors: Jindrich (Henry) Kopecek, Te-Wei Chu, Jiyuan Yang. File date 03/11/2014. Assignee: The University of Utah. Country: Japan.
• Compositions and Methods for Inducing Apoptosis. Status: Published. Inventors: Jindrich (Henry) Kopecek, Jiyuan Yang, Te-Wei Chu. File date 09/09/2015. Assignee: The University of Utah. Country: United States.
• Polymeric Drug Delivery Conjugates and Methods of Making and Using Thereof. Status: Published. Inventors: H. Pan, J. Yang, P. Kopečková, K. Luo, J. Kopeček. File date 12/2016.
• Macromolecular Delivery Systems for Non-invasive Imaging, Evaluation, and Treatment of Arthritis and Other Inflammatory Diseases. Status: Published. Inventors: D. Wang, J. Kopeček, S.C. Miller, P. Kopečková. File date 12/2019.
• Bone Fracture Repair by Targeting of Agents that Promote Bone Healing. Status: Published. Inventors: S. Low, J. Yang, P. Low, C. Galliford, J. Kopeček, J. Yang. File date 12/2019.
• Compositions and methods for inducing apoptosis. Status: Published. Inventors: J. Kopeček, J. Yang, T.-W. Chu. File date 12/2019.
• Compositions and methods for using albumin-based nanomedicines. Status: Published. Inventors: J. Kopeček, J. Yang. File date 12/2021.

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