JINDRICH Henry KOPECEK portrait
  • Distinguished Professor, Pharmaceutical Chemistry
  • Distinguished Professor, Biomedical Engineering
  • Honorary Professor, Sichuan University, Chengdu, China

Publications

  • Chu TW, Feng J, Yang J, Kopeček J (date unknown). Hybrid polymeric hydrogels via peptide nucleic acid (PNA)/DNA complexation. Vol. 220, 608-16. Accepted, .
  • Zhou Y, Yang J, Rhim JS, Kopeček J (date unknown). HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects. Vol. 172, 946-53. Accepted, .
  • Peng ZH, Kopeček J (date unknown). HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells. Vol. 3, 1240-1243. Accepted, .
  • Malugin A, Kopecková P, Kopecek J (date unknown). Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells. Vol. 124, 6-10. Accepted, .
  • Yang J, Kopeček J (date unknown). POLYMERIC BIOMATERIALS AND NANOMEDICINES. Vol. 30, 318-330. Accepted, .
  • Chu TW, Kosak KM, Shami PJ, Kopeček J (date unknown). Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells. Vol. 4, 389-94. Accepted, .
  • Kopecek J (date unknown). Hydrogel biomaterials: a smart future?. Vol. 28, 5185-92. Accepted, .
  • Pan H, Kopecková P, Liu J, Wang D, Miller SC, Kopecek J (date unknown). Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates. Vol. 24, 2270-80. Accepted, .
  • Yang J, Zhang R, Radford DC, Kopeček J (date unknown). FRET-trackable biodegradable HPMA copolymer-epirubicin conjugates for ovarian carcinoma therapy. Vol. 218, 36-44. Accepted, .
  • Yuan W, Yang J, Kopecková P, Kopecek J (date unknown). Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion. Vol. 130, 15760-1. Accepted, .
  • Low SA, Yang J, Kopeček J (date unknown). Bone-targeted acid-sensitive doxorubicin conjugate micelles as potential osteosarcoma therapeutics. Vol. 25, 2012-20. Accepted, .
  • Kopeček J (date unknown). HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS. Vol. 47, 5929-5946. Accepted, .
  • Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J (date unknown). Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Vol. 9, 1135-42. Accepted, .
  • Zhang L, Fang Y, Li L, Yang J, Radford DC, Kopeček J (date unknown). Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface. Vol. 18, e1800224. Accepted, .
  • Yang J, Kopeček J (date unknown). Design of smart HPMA copolymer-based nanomedicines. Vol. 240, 9-23. Accepted, .
  • Zhang L, Fang Y, Yang J, Kopeček J (date unknown). Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells. Vol. 263, 139-150. Accepted, .
  • Larson N, Yang J, Ray A, Cheney DL, Ghandehari H, Kopeček J (date unknown). Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. Vol. 454, 435-43. Accepted, .
  • Yang J, Zhang R, Christopher Radford D, Kopeček J (date unknown). Design and synthesis of FRET-trackable HPMA-based biodegradable conjugates for drug/gene delivery. Vol. 213, e58. Accepted, .
  • Yang J, Kopeček J (date unknown). The Light at the End of the Tunnel-Second Generation HPMA Conjugates for Cancer Treatment. Vol. 31, 30-42. Accepted, .
  • Low SA, Kopeček J (date unknown). Targeting polymer therapeutics to bone. Vol. 64, 1189-204. Accepted, .
  • Hongrapipat J, Kopecková P, Liu J, Prakongpan S, Kopecek J (date unknown). Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Vol. 5, 696-709. Accepted, .
  • Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopecková P, Lyubchenko Y, Higuchi WI, Kopecek J (date unknown). Osteotropic Peptide that differentiates functional domains of the skeleton. Vol. 18, 1375-8. Accepted, .
  • Zhang R, Yang J, Sima M, Zhou Y, Kopeček J (date unknown). Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. Vol. 111, 12181-6. Accepted, .
  • Hartley JM, Chu TW, Peterson EM, Zhang R, Yang J, Harris J, Kopeček J (date unknown). Super-Resolution Imaging and Quantitative Analysis of Membrane Protein/Lipid Raft Clustering Mediated by Cell-Surface Self-Assembly of Hybrid Nanoconjugates. Vol. 16, 1725-9. Accepted, .
  • Krimmer SG, Pan H, Liu J, Yang J, Kopeček J (date unknown). Synthesis and characterization of poly(ε-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] micelles for drug delivery. Vol. 11, 1041-51. Accepted, .
  • Zhang L, Zhang R, Yang J, Wang J, Kopeček J (date unknown). Indium-based and iodine-based labeling of HPMA copolymer-epirubicin conjugates: Impact of structure on the in vivo fate. Vol. 235, 306-318. Accepted, .
  • Kopecek J (date unknown). Biomaterials and drug delivery: past, present, and future. Vol. 7, 922-5. Accepted, .
  • Wu LC, Yang J, Kopeček J (date unknown). Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds. Vol. 32, 5341-53. Accepted, .
  • Ding H, Kopecková P, Kopecek J (date unknown). Self-association properties of HPMA copolymers containing an amphipathic heptapeptide. Vol. 15, 465-74. Accepted, .
  • Kopeček J, Yang J (date unknown). Smart self-assembled hybrid hydrogel biomaterials. Vol. 51, 7396-417. Accepted, .
  • Callahan J, Kopečkov P, Kopeček J (date unknown). Intracellular trafficking and subcellular distribution of a large array of HPMA copolymers. Vol. 10, 1704-14. Accepted, .
  • Sheparovych R, Roiter Y, Yang J, Kopeček J, Minko S (date unknown). Stimuli-responsive properties of peptide-based copolymers studied via directional growth of self-assembled patterns on solid substrate. Vol. 10, 1955-61. Accepted, .
  • Pan H, Liu J, Dong Y, Sima M, Kopecková P, Brandi ML, Kopecek J (date unknown). Release of prostaglandin E(1) from N-(2-hydroxypropyl)methacrylamide copolymer conjugates by bone cells. Vol. 8, 599-605. Accepted, .
  • Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J (date unknown). Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Vol. 5, 548-58. Accepted, .
  • Hartley JM, Zhang R, Gudheti M, Yang J, Kopeček J (date unknown). Tracking and quantifying polymer therapeutic distribution on a cellular level using 3D dSTORM. Vol. 231, 50-9. Accepted, .
  • Peng ZH, Kopeček J (date unknown). Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. Vol. 137, 6726-9. Accepted, .
  • Zhang L, Fang Y, Kopeček J, Yang J (date unknown). A new construct of antibody-drug conjugates for treatment of B-cell non-Hodgkin's lymphomas. Vol. 103, 36-46. Accepted, .
  • Cuchelkar V, Kopecková P, Kopecek J (date unknown). Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates. Vol. 8, 375-83. Accepted, .
  • Zhang R, Yang J, Chu TW, Hartley JM, Kopeček J (date unknown). Multimodality imaging of coiled-coil mediated self-assembly in a "drug-free" therapeutic system. Vol. 4, 1054-65. Accepted, .
  • Duangjai A, Luo K, Zhou Y, Yang J, Kopeček J (date unknown). Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells. Vol. 87, 187-96. Accepted, .
  • Luo K, Yang J, Kopečková P, Kopeček J (date unknown). Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Vol. 44, 2481-2488. Accepted, .
  • Yang J, Jacobsen MT, Pan H, Kopecek J (date unknown). Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels. Vol. 10, 445-54. Accepted, .
  • Liu J, Bauer H, Callahan J, Kopecková P, Pan H, Kopecek J (date unknown). Endocytic uptake of a large array of HPMA copolymers: Elucidation into the dependence on the physicochemical characteristics. Vol. 143, 71-9. Accepted, .
  • Kopeček J, Stanwix H (date unknown). Interview with Professor Jindřich Kopeček. Vol. 9, 577-9. Accepted, .
  • Fowers KD, Kopeček J (date unknown). Targeting of multidrug-resistant human ovarian carcinoma cells with anti-P-glycoprotein antibody conjugates. Vol. 12, 502-14. Accepted, .
  • Pelaz B, Alexiou C, Alvarez-Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WC, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grünweller A, Gu Z, Halas NJ, Hampp N, Hartmann RK, Hersam MC, Hunziker P, Jian J, Jiang X, Jungebluth P, Kadhiresan P, Kataoka K, Khademhosseini A, Kopeček J, Kotov NA, Krug HF, Lee DS, Lehr CM, Leong KW, Liang XJ, Ling Lim M, Liz-Marzán LM, Ma X, Macchiarini P, Meng H, Möhwald H, Mulvaney P, Nel AE, Nie S, Nordlander P, Okano T, Oliveira J, Park TH, Penner RM, Prato M, Puntes V, Rotello VM, Samarakoon A, Schaak RE, Shen Y, Sjöqvist S, Skirtach AG, Soliman MG, Stevens MM, Sung HW, Tang BZ, Tietze R, Udugama BN, VanEpps JS, Weil T, Weiss PS, Willner I, Wu Y, Yang L, Yue Z, Zhang Q, Zhang Q, Zhang XE, Zhao Y, Zhou X, Parak WJ (date unknown). Diverse Applications of Nanomedicine. Vol. 11, 2313-2381. Accepted, .
  • Dušek K, Dušková-Smrčková M, Yang J, Kopeček J (date unknown). Coiled-Coil Hydrogels. Effect of Grafted Copolymer Composition and Cyclization on Gelation. Vol. 42, 2265-2274. Accepted, .
  • Johnson RN, Kopečková P, Kopeček J (date unknown). Biological activity of anti-CD20 multivalent HPMA copolymer-Fab' conjugates. Vol. 13, 727-35. Accepted, .
  • Hongrapipat J, Kopecková P, Prakongpan S, Kopecek J (date unknown). Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. Vol. 351, 259-70. Accepted, .
  • Liu J, Kopečková P, Pan H, Sima M, Bühler P, Wolf P, Elsässer-Beile U, Kopeček J (date unknown). Prostate-cancer-targeted N-(2-hydroxypropyl)methacrylamide copolymer/docetaxel conjugates. Vol. 12, 412-22. Accepted, .
  • Yang J, Luo K, Pan H, Kopečková P, Kopeček J (date unknown). Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. Vol. 71, 294-302. Accepted, .
  • Kopecek J, Yang J (date unknown). Peptide-directed self-assembly of hydrogels. Vol. 5, 805-16. Accepted, .
  • Xu C, Kopecek J (date unknown). Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly. Vol. 25, 674-82. Accepted, .
  • Zhang R, Luo K, Yang J, Sima M, Sun Y, Janát-Amsbury MM, Kopeček J (date unknown). Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. Vol. 166, 66-74. Accepted, .
  • Wu K, Liu J, Johnson RN, Yang J, Kopecek J (date unknown). Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface. Vol. 49, 1451-5. Accepted, .
  • Wang J, Li L, Yang J, Clair PM, Glenn MJ, Stephens DM, Radford DC, Kosak KM, Deininger MW, Shami PJ, Kopeček J (date unknown). Drug-free macromolecular therapeutics induce apoptosis in cells isolated from patients with B cell malignancies with enhanced apoptosis induction by pretreatment with gemcitabine. Vol. 16, 217-225. Accepted, .
  • Low SA, Galliford CV, Jones-Hall YL, Roy J, Yang J, Low PS, Kopeček J (date unknown). Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair. Vol. 12, 185-193. Accepted, .
  • Pan H, Sima M, Yang J, Kopeček J (date unknown). Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy. Vol. 13, 155-60. Accepted, .
  • Zhou Y, Yang J, Kopeček J (date unknown). Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Vol. 33, 1863-72. Accepted, .
  • Yang J, Wu K, Konák C, Kopecek J (date unknown). Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers. Vol. 9, 510-7. Accepted, .
  • Chu TW, Yang J, Zhang R, Sima M, Kopeček J (date unknown). Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis. Vol. 8, 719-30. Accepted, .
  • Li L, Yang J, Soodvilai S, Wang J, Opanasopit P, Kopeček J (date unknown). Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs. Vol. 293, 84-93. Accepted, .
  • Pan H, Yang J, Kopecková P, Kopecek J (date unknown). Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction. Vol. 12, 247-52. Accepted, .
  • Li L, Yang J, Wang J, Kopeček J (date unknown). Drug-free macromolecular therapeutics exhibit amplified apoptosis in G2/M phase arrested cells. Vol. 27, 566-572. Accepted, .
  • Yang J, Li L, Kopeček J (date unknown). Biorecognition: A key to drug-free macromolecular therapeutics. Vol. 190-191, 11-23. Accepted, .
  • Li L, Yang J, Wang J, Kopeček J (date unknown). Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway. Vol. 18. Accepted, .
  • Zhang R, Yang J, Radford DC, Fang Y, Kopeček J (date unknown). FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate. Vol. 17. Accepted, .
  • Zhou Y, Yang J, Zhang R, Kopeček J (date unknown). Combination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxel. Vol. 89, 107-15. Accepted, .
  • Zhou Y, Kopeček J (date unknown). Biological rationale for the design of polymeric anti-cancer nanomedicines. Vol. 21, 1-26. Accepted, .
  • Kopeček J (date unknown). Polymer-drug conjugates: origins, progress to date and future directions. Vol. 65, 49-59. Accepted, .
  • Segal E, Pan H, Ofek P, Udagawa T, Kopecková P, Kopecek J, Satchi-Fainaro R (date unknown). Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics. Vol. 4, e5233. Accepted, .
  • Johnson RN, Kopecková P, Kopecek J (date unknown). Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20. Vol. 20, 129-37. Accepted, .
  • Shiah JG, Konák C, Spikes JD, Kopecek J (date unknown). Influence of pH on aggregation and photoproperties of n-(2-hydroxypropyl)methacrylamide copolymer-meso-chlorin e6 conjugates. Vol. 5, 119-26. Accepted, .

Research Statement

Research in the Kopeček Biomedical Polymers Laboratory focuses on two main areas: 

Macromolecular therapeutics. Recent research focuses on the design of backbone degradable, long-circulating polymer carriers that contain enzymatically degradable oligopeptide sequences in the main chain. These N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug (epirubicin, gemcitabine, paclitaxel) conjugates have demonstrated enhanced efficacy in the treatment of animal tumor models when compared to non-degradable HPMA copolymer conjugates or free drugs. Combination therapy targeting both tumor-initiating and differentiated cancer cell populations is also studied.

Drug-free macromolecular therapeutics. A new therapeutic approach for the treatment of B cell malignancies has been developed.The effectiveness of the new system is based on biorecognition events without the participation of low molecular weight drugs. Apoptosis of cells can be initiated by the biorecognition of complementary peptide/oligonucleotide motifs at the cell surface resulting in the crosslinking of slowly internalizing receptors. Drug-free macromolecular therapeutics (DFMT) are composed from two nanoconjugates: 1) bispecific engager, Fab’-MOTIF1 (anti-CD20 Fab’ fragment conjugated with coiled-coil forming peptide or morpholino oligonucleotide), and 2) a crosslinking (effector) component P-(MOTIF2)(HPMA copolymer or human serum albumin grafted with multiple copies of complementary oligopeptide or morpholino oligonucleotide).The efficacy of the system was validated in vitroin vivo and on cells isolated from patients with various subtypes of B cell malignancies.

Research Keywords

  • Drug Delivery Systems
  • Biodegradability of Polymers
  • Genetically Engineered Materials
  • Biorecognition of Macromolecules
  • Bioconjugate Chemistry

Presentations

  • Visiting Professor: Universite Paris-Nord. , , 2000.
  • Visiting Professor: Tokyo Women's Medical University. , , 1999.
  • Visiting Professor: Academy of Sciences of the Czech Republic. , , 1995.
  • Visiting Professor: University of Utah. , , 1986.
  • Visiting Professor: Universite Paris-Nord. , , 1983.
  • Distinguished Lectureship, Nagai Foundation, Tokyo. , , 1997.
  • Opening Lecture, 34th IUPAC International Symposium on Macromolecules. , , 1992.
  • Barre's Lecture, Universite de Montreal. , , 1990.
  • Kopecek J, Kopeckova P: Relationship Between the Structure of Polymeric Drug Carriers and their Subcellular Fate. World Polymer Congress IUPAC MACRO, Beijing, China. , , 2002.
  • Kopecek J, Kopeckova P: Genetically Engineered Biomaterials and Drug Delivery Systems. International Conference in Advances in Biomaterials for Reconstructive Medicine, Capri, Italy. , , 2002.
  • Lu Z-R, Shiah J-G, Kopeckova P, Kopecek J: Antitumor Activity of Polymerizable Antibody Fab' Targeted Mesochlorin e6 in Photodynamic Therapy in Mice. 93rd American Association of Cancer Research Annual Meeting, San Francisco, California. , , 2002.
  • Nori A, Tijerina M, Jensen K, Kopeckova P, Kopecek J: Cytoplasmic Delivery and Nuclear Targeting of Synthetic Macromolecules. 7th European Symposium on Controlled Drug Delivery, Noordwijk aan Zee, The Netherlands. , , 2002.
  • Tijerina M, Kopeckova P, Kopecek J: Subcellular Trafficking and Compartmentalization of HPMA Copolymer - Mce6 Conjugates in a Human Ovarian Carcinoma Affects Anticancer Activity. Gordon Research Conference, "Drug Carriers in Medicine and Biology," Ventura, California. , , 2002.
  • Tang A, Kopeckova P, Kopecek J: Lymphoma-Targeting Polymeric Drug Carriers Mediated by Synthetic Epitopes. Gordon Research Conference, "Drug Carriers in Medicine and Biology," Ventura, California. , , 2002.
  • Wang D, Pechar M, Bromme D, Kopeckova P, Kopecek J: Synthesis and In Vitro Evaluation of Cathepsin K Inhibitor - Polymer Conjugates. 2nd General Meeting of the International Proteolytic Society, Freising near Munich, Germany. , , 2001.
  • Kopecek J, Tang A, Ding H, Prodinger WM: Genetically Engineered Epitopes in the Design of Targeted Drugs. 16th Ann. Meeting of the American Association of Pharmaceutical Scientists, Denver, Colorado. , , 2001.
  • Tijerina M, Kopeckova P, Kopecek J: Nuclear Delivery of HPMA Copolymer-Mce6 Conjugates Utilizing a Nuclear Localization Signal. 16th Ann. Meeting of the American Association of Pharmaceutical Scientists, Denver, Colorado. , , 2001.
  • Tang A, Kopecek J: Biorecognition of Epitopes Presented on a Peptide Scaffold and Selction of Targeting Moieties for the Design of New Polymeric Drug Carriers. 16th Ann. Meeting of the American Association of Pharmaceutical Scientists, Denver, Colorado. , , 2001.
  • Luo Y, Bernshaw NJ, Lu Z-R, Kopecek J, Li H, Prestwich GD: Hyaluronic Acid Containing Bioconjugates: Targeted Delivery of Anti-cancer Drug Doxorubicin to Cancer Cells. 16th Ann. Meeting of the American Association of Pharmaceutical Scientists, Denver, Colorado. , , 2001.
  • Kopecek J: Novel Biomaterials from Synthetic and Genetically Engineered Polymers. Gordon Research Conference, Polymers (East), Colby Sawyer College, New Hampshire. , , 2001.
  • Kopecek J: Macromolecular Therapeutics: From Design to Clinical Trials. American Association of Colleges of Pharmacy Meeting, Toronto, Canada. , , 2001.
  • Kopecek J: Long-Circulating Polymer and Nanoparticle Systems: Formulation and Characterization Millennial World Congress of Pharmaceutical Sciences, San Francisco, California. , , 2000.
  • Shiah J-G, Dvorak M, Kopeckova P, Sun Y, Peterson CM, Kopecek J: Therapeutic Efficacy of Long-Circulating HPMA Copolymer-Doxorubicin Conjugates. 91st Annual Meeting of the American Association for Cancer Research, San Francisco, California. , , 2000.
  • Omelyanenko V, Kopeckova P, Kopecek J: Interactions Between IgG Molecule and Hydrophobic Drug Tethered to the Antibody Surface via Polymer Chain. 41st Annual Meeting of the Biophysical Society, New Orleans, LA. , , 1997.
  • Kopecek J: Biorecognizable Polymers: Synthesis, Structure, and Bioactivity. Japan-US Seminar on Macromolecular Architecture and Engineering, Sendai, Japan. , , 1996.
  • Shen H-R, Spikes JD, Kopeckova P, Kopecek J: Tailor-Made Polymers as a Tool to Study the Mechanism of Photosensitized Crosslinking of Proteins. 36th IUPAC International Symposium on Macromolecules, Seoul, Korea. , , 1996.
  • Shen H-R, Spikes JD, Kopeckova P, Kopecek J: Tailor-Made Polymers as a Tool to Model Photosensitized Crosslinking of Proteins. Fourth Pacific Polymer Conference, Koloa, Kauai, Hawaii. , , 1995.
  • Kopeckova P, Omelyanenko V, Shiah J-G, Kopecek J: Biorecognizable Water-Soluble Carriers of Anticancer Drugs. Fourth Pacific Polymer Conference, Koloa, Kauai, Hawaii. , , 1995.
  • Kopecek J, Kopeckova P: Targeted and Site-Specific Drug Delivery Using Hydrophilic Polymers. 1st Spanish-Portuguese Conference on Drug Delivery, Santiago de Compostela, Spain. , , 1995.
  • Kopecek J, Ghandehari H, Yeh P-H, Kopeckova P: Tailor-Made Synthesis of Degradable Hydrogels. 36th Microsymposium, "High-Swelling Gels," Prague, Czech Republic. , , 1995.
  • Chiu H-C, Kopeckova P, Kopecek J: Enzymatic Degradability of Poly(a-Amino Acids) as Polymeric Drug Carriers. IUPAC International Symposium on Functional and High Performance Polymers, Taipei, Taiwan. , , 1994.
  • Shen H-R, Spikes JD, Kopeckova P, Kopecek J: Photosensitized Crosslinking of Proteins Modelled by N-(2-Hydroxypropyl)methacrylamide Copolymers Containing Histidine of Lysine. Annual Fall Meeting of the Biomedical Engineering Society, Tempe, Arizona. , , 1994.
  • Kopecek J, Kopeckova P: Biorecognizable Polymers: Structure - Properties Relationship. 7th Int. Symposium on Polymer Analysis and Characterization, Les Diablerets, Switzerland. , , 1994.
  • Kopecek J, Kopeckova P: Tailor-Made Synthesis of Biorecognizable Polymers. ACS Spring Meeting, Division of Polymer Chemistry, San Diego, CA. , , 1994.
  • Kopecek J, Kopeckova P: Biocompatible and Biorecognizable Polymers: Synthesis and Properties. The Monte Verita Conference on Biocompatible Materials Systems, Ascona, Switzerland. , , 1993.
  • Konak C, Rathi RC, Kopeckova P, Kopecek J: Solubility and Association of N-(2-Hydroxypropyl)methacrylamide Copolymers Containing N-2-Hydroxyethylpiperazine-N'-Ethanesulfonic Acid Side Chains in Aqueous Solvents. 33rd Prague Microsymposium on Macromolecules: Optics and Dynamics of Polymers, Prague, Czech Republic. , , 1993.
  • Kopecek J, Kopeckova P, Gu Z-W, Chiu H-C, Putnam D: Design and Synthesis of Targetable Polymer-Drug Conjugates NATO Advanced Study Institute, "Targeting of Drugs: Advances in System Constructs," Cape Sounion Beach, Greece. , , 1993.
  • Kopecek J, Kopeckova P, Rathi RC, Yeh P-Y, Takada S, Ghandehari H: Polymeric Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract NATO Advanced Study Institute, "Targeting of Drugs: Advances in System Constructs," Cape Sounion Beach, Greece. , , 1993.
  • Kopecek J, Kopeckova P: Biorecognizable Polymers. 2nd International Conference on Frontiers of Polymers and Advanced Materials, Jakarta, Indonesia. , , 1993.
  • Kopecek J: Novel Polymes for Drug Targeting Workshop, "Opportunities in the 21st Century for Biomedical Polymers," Div. Polym. Chem., Am. Chem. Soc., Palm Springs, California. , , 1992.
  • Gu Z-W, Kopecek J: Synthesis And Characterization of Water-Soluble Polymeric Prodrugs of Zn (II)- Phthalocyanine Tetraamine. Third Annual Fall Meeting of the Biomedical Engineering Society, University of Utah, Salt Lake City, Utah. , , 1992.
  • Chiu H-C, Kopeckova P, Zalipsky S, Kopecek J: Effect of Chemical Modification by Poly(ethylene oxide) on Enzyme-Substrate Interactions, Third Annual Fall Meeting of the Biomedical Engineering Society, University of Utah, Salt Lake City, Utah. , , 1992.
  • Rathi RC, Rihova B, Kopeckova P, Kopecek J: Bioadhesive Polymers for Colon-Specific Drug Delivery. Third Annual Fall Meeting of the Biomedical Engineering Society, University of Utah, Salt Lake City, Utah. , , 1992.
  • Yeh P-Y, Kopeckova P, Kopecek J: Hydrogels for Colon-Specific Oral Delivery of Protein/Peptide Drugs. Third Annual Fall Meeting of the Biomedical Engineering Society, University of Utah, Salt Lake City, Utah. , , 1992.
  • Kopecek J: Biocompatible and Biorecognizable Polymers. 4th European Polymer Federation Sympsosium on Polymeric Materials, Baden-Baden, Germany. , , 1992.
  • Konak C, Rathi RC, Kopeckova P, Kopecek J: Effect of Amphiphilic Side-Chains on Solution on Properties of Drug Carriers Based on N-(2-Hydroxypropyl)methacrylamide Copolymers. 34th IUPAC International Symposium on Macromolecules, Prague. , , 1992.
  • Rathi RC, Rihova B, Kopeckova P, Kopecek J: Bioadhesive Water Soluble Polymeric Carriers on Colon Specific Drug Delivery. 34th IUPAC International Symposium on Macromolecules, Prague. , , 1992.
  • Kopecek J: Tailor-Made Synthesis of Biomedical Polymers. Opening Lecture, 34th IUPAC International Symposium on Macromolecules, Prague. , , 1992.
  • Kopecek J: Bioadhesive Polymers for Colon-Specific Drug Delivery. 2nd Jerusalem Conference on Pharmaceutical Sciences and Clinical Pharmacology, Jerusalem, Israel. , , 1992.
  • Kopecek J: Hydrophilic Polymers for Site-Specific Oral Drug Delivery. ACS Symposium on Advances in Bioconjugate Chemistry, San Francisco. , , 1992.
  • Wedge S, Duncan R, Kopeckova P, Ulbrich K, Strohalm J, Kopecek J: Polymer-Bound Anthracyclines: Antitumour Action and Mechanism of Action PAM Group Meeting of the EORTC, Vienna, Austria. , , 1991.
  • Oscarsson S, Kopecek J: Susceptibility of Zymogens Adsorbed at Solid-Liquid Interfaces to Enzymatically Catalyzed Hydrolysis. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Krinick NL, Rihova B, Kopecek J: Targetable Polymeric Carriers of Photosensitive Drugs 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Kopeckova P, Chiu H-C, Zalipsky S, Kopecek J: Enzymatic Activity of Poly(Ethylene Oxide) Modified Chymotrypsin Towards Low-and High-Molecular Weight Substrates. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Rathi RC, Rihova B, Kopeckova P, Kopecek J: Bioadhesive Water Soluble Polymeric Drug Carriers for Site Specific Drug Delivery 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah,. , , 1990.
  • Yen H-R, Andrade JD, Kopecek J: Optically Controlled Ligand Delivery. 1. Copolymers Containing 2-Nitrobenzyl Bonds 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Yen H-R, Andrade JD, Kopecek J: Optically Controlled Ligand Delivery. 2. Copolymers Containing a-Methylphenacyl Bonds. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Kopecek J: The Potential of Water-Soluble Polymers in Targeted Drug Delivery. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Kopeckova P, Ikesue K, Kopecek J: Cleavage of Oligopeptide Side-Chains Attached to Polymeric Carrier by Guinea Pig Brush Border Membrane Enzymes. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Brondsted H, Kopecek J: Hydrogels for Colon-Specific Oral Drug Delivery. 45th Northwest/10th Rocky Mountain Regional Meeting of the ACS, Salt Lake City, Utah. , , 1990.
  • Ulbrich K, Rihova B, Kopecek J, Duncan R: Water Soluble Polymeric Carriers in Targeted and Site Specific Drug Delivery Symposium on Physiologic Mechanisms and Pathologies Involved in Drug Targeting and Imaging, Compiegne, France. , , 1990.
  • Zhang J, Yang Z, Kopecek J, Andrade JD: Crosslinkable PEO-Containing Polymeric Surfactants. 8th Int. Symposium on Surfactants in Solution, Gainesville, Florida. , , 1990.
  • Andrade JD, Lin N-N, Hlady V, Herron J, Christensen D, Kopecek J: Immunosensors: Remaining Problems in the Development of Remote, Continuous, Multi-Channel Devices for Coagulation of Proteins. Int. Symposium, "Biomation in the 21st Century," Nihon University, Japan. , , 1990.
  • Kopecek J: Targetable Polymeric Anticancer Drugs: Temporal Control of Drug Activity. The New York Academy of Sciences Conference, "Temporal Control of Drug Delivery," New York. , , 1990.
  • Kopecek J, Kopeckova P: Water-Soluble Polymers as Targetable Drug Carriers. 198th ACS National Meeting, Division of Medicinal Chemistry, Miami Beach, Florida. , , 1989.
  • Duncan R, Seymour LW, Ulbrich K, Kopecek J: Development of Targetable Polymeric Drug Carriers for Delivery of Anthracyclines 6th NCI-EORTC Symposium on New Drugs in Cancer Therapy, Amsterdam. , , 1989.
  • Lin J-N, Herron J, Kopecek J, Andrade JD: Ab-Ag Interactions on Silica Substrates for Immunosensors 40th Annual Conference on Engineering in Medicine and Biology, Niagara Falls, NY. , , 1987.
  • Kopecek J: Synthetic Water-Soluble Copolymers as Drug Carriers ACS Fall 1987 Meeting, New Orleans, Division of Microbial and Biochemical Technology. , , 1987.
  • Wang D, Miller S, Kopeckova P, Kopecek J. Design and Synthesis of Polymeric Bone-Targeted Drug Delivery System. Poster, Presented, 2003.
  • Wang D, Miller S, Sima M, Kopeckova P, Kopecek J. Bone-Targeted Drug Delivery Systems. Poster, Presented, 2003.

Languages

  • English, Fluent.
  • Czech, Fluent.
  • Russian, Functional.
  • German, Fluent.