Cynthia BURROWS portrait
  • Thatcher Presidential Endowed Chair of Biological Chemistry, Chemistry
  • Distinguished Professor, Chemistry
801-585-7290

Publications

  • A. M. Fleming & C. J. Burrows (2023). DNA Damage and Repair in G-Quadruplexes Impact Gene Expression. Handbook of Chem. Biol. of Nucleic Acids. Vol. 2, 1-19. Published, 05/20/2023.
    https://doi.org/10.1007/978-981-16-1313-5_38-1
  • Buriak JM, Akinwande D, Artzi N, Brinker CJ, Burrows C, Chan WCW, Chen C, Chen X, Chhowalla M, Chi L, Chueh W, Crudden CM, Di Carlo D, Glotzer SC, Hersam MC, Ho D, Hu TY, Huang J, Javey A, Kamat PV, Kim ID & Kotov NA (2023). Best Practices for Using AI When Writing Scientific Manuscripts. (pp. 409140934091-4093). Vol. 17. ACS nano. Published, 03/01/2023.
  • Q. Zhu, Y.Kapon, A. M. Fleming, S. Mishra, K. Santra, F. Tassinari, & S. R. Cohen, Y. Sang, D. Bhowmick, C. J. Burrows, Y. Paltiel, R. Naaman (2022). The Role of Electrons’ Spin in DNA Oxidative Damage Recognition. Cell Rep. Phys. Sci. Published, 12/2022.
  • Fleming AM & Xiao S (2022). Fluorophore-mediated Photooxidation of the Guanine Heterocycle. Journal of physical organic chemistry. Vol. 35. Published, 11/01/2022.
  • Fleming AM, Tran R & Omaga CA (2022). Second Harmonic Generation Interrogation of the Endonuclease APE1 Binding Interaction with G-Quadruplex DNA. Analytical chemistry. Vol. 94, 150271503215027-15032. Published, 11/01/2022.
  • A. M. Fleming, S. Xiao, M. B. Chabot, & C. J. Burrows (2022). Fluorophore-mediated Photooxidation of the Guanine Heterocycle. J. Phys. Org. Chem. Published, 11/2022.
  • Chabot MB (2022). Identification of the Major Product of Guanine Oxidation in DNA by Ozone. Chemical research in toxicology. Vol. 35, 180918131809-1813. Published, 10/01/2022.
  • A. M. Fleming, R. Tran, C. A. Omaga, S. A. Howpay Manage, C. J. Burrows, & J. C. Conboy (2022). Second harmonic generation interrogation of the endonuclease APE1 binding interaction with G-quadruplex DNA. Anal. Chem. Published, 10/2022.
  • M. B. Chabot, A. M. Fleming, & C. J. Burrows (2022). Identification of the major product of guanine oxidation in DNA by ozone. Chem. Res. Toxicol. Published, 10/2022.
  • Howpay Manage SA & Fleming AM (2022). Cysteine Oxidation to Sulfenic Acid in APE1 Aids G-Quadruplex Binding While Compromising DNA Repair. ACS chemical biology. Vol. 17, 258325942583-2594. Published, 09/01/2022.
  • Fleming AM (2022). Pseudouridine and N1-Methylpseudouridine Display pH-Independent Reaction Rates with Bisulfite Yielding Ribose Adducts. Organic letters. Vol. 24, 618261856182-6185. Published, 08/01/2022.
  • A. M. Fleming, S. Xiao, & C. J. Burrows (2022). Pseudouridine and N1-methylpseudouridine display pH-independent reaction rates with bisulfite yielding ribose adducts. Org. Lett. Published, 08/2022.
  • M. B. Chabot, A. M. Fleming, & C. J. Burrows (2022). Insights into the 5-carboxamido-5-formamido-2-iminohydantoin structural isomerization equilibria. J. Org. Chem. Published, 08/2022.
  • S. A. Howpay Manage, A. M. Fleming, H.-N. Chen, & C. J. Burrows (2022). Cysteine oxidation to sulfenic acid in APE1 aids G-quadruplex binding while compromising DNA repair. ACS Chem. Biol. Published, 08/2022.
  • C. J. Burrows & A. M. Fleming (2022). Response to ‘Hydroxyl radical is predominantly involved in oxidatively generated base damage to cellular DNA exposed to ionizing radiation,’ by Cadet et al. Int. J. Rad. Biol. Published, 07/2022.
  • Fleming AM (2022). Chemistry of ROS-mediated oxidation to the guanine base in DNA and its biological consequences. International journal of radiation biology. Vol. 98, 452460452-460. Published, 04/01/2022.
  • Fleming AM & Chabot MB (2022). Collateral Damage Occurs When Using Photosensitizer Probes to Detect or Modulate Nucleic Acid Modifications. Angewandte Chemie (International ed. in English). Vol. 61, e202110649e202110649. Published, 02/01/2022.
  • Galindo-Murillo R, Winkler L & Ma J (2022). Riboflavin Stabilizes Abasic, Oxidized G-Quadruplex Structures. Biochemistry. Vol. 61, 265275265-275. Published, 02/01/2022.
  • C. Burrows, J. Harper, W. Sander and D. Tantillo, “Solvation Effects in Organic Chemistry,” J. Org. Chem. 2022, 87, 1599-1601. DOI: 10.1021/acs.joc.1c03148. (Editorial for special issue.). Published, 02/2022.
  • A. M. Fleming, M. B. Chabot, N. L. B. Nguyen, & C. J. Burrows (2022). Collateral damage occurs when using photosensitizer probes to detect or modulate nucleic acid modifications. Angew. Chem. Int. Ed. Eng. Published, 02/2022.
  • R. Galindo-Murillo, L. Winkler, J. Ma, F. Hanelli, A. M. Fleming, C. J. Burrows, & T. E. Cheatham, III (2022). Riboflavin stabilizes abasic, oxidized G-quadruplex structures. Biochemistry. Published, 02/2022.
  • Burrows CJ & Harper JB (2022). Solvation Effects in Organic Chemistry. (pp. 159916011599-1601). Vol. 87. The Journal of organic chemistry. Published, 02/01/2022.
  • A. M. Fleming & C. J. Burrows (2022). Chemistry of ROS-Mediated Oxidation of the Guanine Base in DNA and its Biological Consequences. Intl. J. Radiat. Published, 01/2022.
  • A. M. Fleming & S. A. Howpay Manage, and C. J. Burrows (2021). Binding of AP endonuclease 1 to G-quadruplex DNA depends on the N-terminal domain, Mg2+ and ionic strength. ACS Bio. & Med. Chem. Au. Published, 10/29/2021.
  • A. M. Fleming & C. J. Burrows (2021). Oxidative stress-mediated epigenetic regulation by G-quadruplexes. NAR Cancer. Published, 09/16/2021.
  • A. M. Fleming & N. J. Mathewson, S. A. Howpay Manage and C. J. Burrows (2021). Nanopore dwell-time analysis permits sequencing and conformational assignment of pseudouridine in SARS-CoV-2. ACS Cent. Sci. Published, 09/15/2021.
  • R. A. Rogers & M. Meyer, K. M. Stewart, G. M. Eyring, A. M. Fleming, and C. J. Burrows (2021). Hysteresis in poly-2`-deoxycytidine i-motif folding is impacted by the method of analysis as well as loop and stem lengths. Biopolymers. Published, 07/18/2021.
  • A. M. Fleming, S. C. J. Redstone & C. J. Burrows (2020). Oxidative DNA Damage and Repair in G-Quadruplexes. DNA Damage, DNA Repair and Disease, M. Dizdaroglu and R. S. Lloyd, Eds., RSC (London),. Vol. 1. Published, 11/2020.
  • C. J. Burrows (2020). Welcoming our new sister journal Accounts of Materials Research. Acc. Chem. Res. Published, 11/2020.
  • A. M. Fleming & C. J. Burrows (2020). Iron Fenton oxidation of 2′-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not hydroxyl radical. Chem. Commun. Vol. 56. Published, 08/2020.
  • A. M. Fleming & C. J. Burrows (2020). On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics. Chem. Soc. Rev. Vol. 49. Published, 08/2020.
  • A. M. Fleming, J. Zhu, M. Jara-Espejo & C. J. Burrows (2020). Cruciform DNA sequences in gene promoters can impact transcription upon oxidative modification of 2′-deoxyguanosine. Biochemistry. Vol. 59. Published, 06/2020.
  • C. J. Burrows (2020). Confronting Racism in Chemistry Journals. Acc. Chem. Res. Published, 06/2020.
  • M. Jara-Espejo, A. M. Fleming & C. J. Burrows (2020). Potential G-quadruplex forming sequences and N6-methyladenosine co-localize at human pre-mRNA intron splice sites. ACS Chem. Biol. Vol. 15. Published, 05/2020.
  • C. J. Burrows (2020). Key References: A New Feature in Accounts. Acc. Chem. Res. Published, 05/2020.
  • J. Oh, A. M. Fleming, J. Xu, J. Chong, C. J. Burrows & D. Wang (2020). RNA polymerase II stalls on oxidative DNA damage via a "torsion-latch" mechanism involving lone pair-pi and CH-pi interactions. PNAS. Vol. 117. Published, 04/2020.
  • C. J. Burrows (2020). First Accounts: The Capstone of a Tenure Tour. Vol. 53, Acc. Chem. Res.. Published, 04/2020.
  • C. J. Burrows, et al. (2020). Update to Our Reader, Reviewer, and Author Communities - April 2020. Acc. Chem. Res. Published, 04/2020.
  • A. M. Fleming & C. J. Burrows (2020). Interplay of guanine oxidation and G-quadruplex folding in gene promoters. J. Am. Chem. Soc. Vol. 142. Published, 01/2020.
  • A. M. Fleming, A. Alenko, J. P. Kitt, A. M. Orendt, P. F. Flynn, J. M. Harris, and C. J. Burrows, “Structural elucidation of bisulfite adducts to pseudouridine that result in deletion signatures during reverse transcription of RNA,” J. Am. Chem. Soc. 2019, 141,16450-16460. DOI: 10.1021/jacs.9b08630. Published, 09/2019.
  • A. M. Fleming, J. Zhu, Y. Ding, and C. J. Burrows, “Location dependence of the transcriptional response of G-quadruplexes in gene promoters under oxidative stress,” Nucleic Acids Res. 2019, 47, 5049-5060. DOI: 10.1093/nar/gkz207. Published, 06/2019.
  • A. M. Fleming, J. Zhu, S. A. Howpay Manage, and C. J. Burrows “Human NEIL3 gene expression is regulated by epigenetic-like oxidative DNA modification,” J. Am. Chem. Soc. 2019, 141, 11036-11049. DOI: 10.1021/jacs.9b01847. Published, 06/2019.
  • B. Thapa, S. P. Hebert, B. H. Munk, C. J. Burrows, and H. B. Schlegel, “Computational Study of the Formation of C8, C5 and C4 Guanine:Lysine Adducts via Oxidation of Guanine by Sulfate Radical,” J. Phys. Chem. A 2019, 123, 5150-5163. DOI: 10.1021/acs.jpca.9b03598. Published, 05/2019.
  • N. An, A. M. Fleming, N. C. Rosecrans, Y. Liao, C. J. Burrows “Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites: 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine and 2′-Deoxycytidine,” Methods in Mol. Biol. 2019, 1973, 15-25. Published, 04/2019.
  • A. M. Fleming, J. Zhu, Y. Ding, S. Esders, and C. J. Burrows, “Oxidative modification of guanine in a potential Z-DNA-forming sequence of a gene promoter impacts gene expression,” Chem. Res. Toxicol. 2019, 32, 899-909. DOI: 10.1021/acs.chemrestox.9b00041. Published, 03/2019.
  • V. Khoddami, A. Yerra, T. L. Mosbruger, A. M. Fleming, C. J. Burrows, and B. R. Cairns, “Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution,” Proc. Natl. Acad. Sci. 2019, 118, 6784-6789. DOI: 10.1073/pnas.1817334116. Published, 03/2019.
  • J. Wu, S. J. Sturla, C. J. Burrows, and A. M. Fleming, ”Impact of DNA oxidation on toxicology: From quantification to genomics,” Chem. Res. Toxicol. 2019, 32, 345-347. DOI: 10.1021/acs.chemrestox.9b00046. Published, 02/2019.
  • A. M. Fleming, N. L. B. Nguyen, and C. J. Burrows, “Colocalization of m6A and G-quadruplex-forming sequences in viral RNA (HIV, Zika, hepatitis B, and SV40) suggests topological control of adenosine N6-methylation,” ACS Cent. Sci. 2019, 5, 218-228. DOI: 10.1021/acscentsci.8b00963. Published, 02/2019.
  • S. C. J. Redstone, A. M. Fleming, and C. J. Burrows, “Oxidative modification of the potential G-quadruplex sequence in the PCNA gene promoter can turn on transcription,” Chem. Res. Toxicol. 2019, 32, 437-446. DOI: 10.1021/acs.chemrestox.8b00332. Published, 01/2019.
  • S. Mishra, V. S. Poonia, C.Fontanesi, R. Naaman, A. M. Fleming, and C. J. Burrows “Effect of oxidative damage on charge and spin transport in DNA,” J. Am. Chem. Soc. 2019, 141, 123-126. DOI: 10.1021/jacs.8b12014. Published, 01/2019.
  • W. A. Vinyard, A. M. Fleming, and C. J. Burrows, “Characterization of G-quadruplexes in the Chlamydomonas reinhardtii genome and effects of polyamines and magnesium on stability,” Biochemistry, 2018, 57, 6551-6561. DOI: 10.1021/acs.biochem.8b00749. Published, 11/09/2018.
  • Y. Ding, A. M. Fleming, and C. J. Burrows, “Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes,” Sci. Rep. 2018, 8, 15679. DOI:10.1038/s41598-018-33944-4. Published, 10/24/2018.
  • C. S. Tan, A. M. Fleming, H. Ren, C. J. Burrows and H. S. White, “γ-Hemolysin nanopore is sensitive to guanine-to-inosine substitutions in double-stranded DNA at the single-molecule level,” J. Am. Chem. Soc. 2018, 140, 14224-14234. DOI: 10.1021/jacs.8b08153. Published, 09/30/2018.
  • R. A. Rogers, A. M. Fleming, and C. J. Burrows, “A Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters,” ACS Omega 2018, 3, 9630–9635. DOI: 10.1021/acsomega.8b01551. Published, 08/21/2018.
  • J. Zhu, A. M. Fleming, and C. J. Burrows, “The RAD17 promoter sequence contains a potential G-quadruplex that folds in a tail-dependent fashion,” ACS Chem. Biol. 2018, 13, 2577-2584. DOI: 10.1021/acschembio.8b00522. Published, 07/31/2018.
  • A. . M. Fleming, K. M. Stewart, G. M. Eyring, T. E. Ball, and C. J. Burrows, “Unraveling the 4n-1 rule for DNA i-motif stability: base pairs vs. loop lengths,” Org. Biomol. Chem. 2018, 16, 4537-4546. DOI: 10.1039/C8OB01198B. Published, 06/20/2018.
  • C. C. A. Omaga, A. M. Fleming, and C. J. Burrows, “The fifth domain in the G-quadruplex sequence motif of the human NEIL3 promoter locks DNA folding in response to oxidative damage,” Biochemistry, 2018, 57, 2958-2970. DOI: 10.1021/acs.biochem.8b00226. Published, 05/10/2018.
  • R. A. Rogers, A. M. Fleming and C. J. Burrows, “Unusual isothermal hysteresis in DNA i-motif pH transitions: A study of the RAD17 promoter sequence,” Biophys. J. 2018, 114, 1804-1814. DOI: 10.1016/j.bpj.2018.03.012. Published, 04/24/2018.
  • H. Ren, C. G. Cheyne, A. M. Fleming, C. J. Burrows, and H. S. White, “Single-Molecule Titration in a Protein Nanoreactor Reveals the Protonation/Deprotonation Mechanism of a C:C Mismatch in DNA,” J. Am. Chem. Soc. 2018, 140, 5153-5160. DOI: 10.1021/jacs.8b00593. Published, 03/21/2018.
  • T. Zeng, A. M. Fleming, Y. Ding, H. Ren, H. S. White, and C. J. Burrows, “Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA,” J. Org. Chem. 2018, 83, 3973-3978. DOI: 10.1021/acs.joc.8b00317. Published, 02/28/2018.
  • A. M. Fleming, J. Zhu, J. A. Visser, Y. Ding, J. Zhu, and C. J. Burrows, “Human DNA repair genes possess potential G-quadruplex sequences in their promoters and 5`-untranslated regions,” Biochemistry, 2018, 57, 991-1002. DOI: 10.1021/acs.biochem.7b01172. Published, 01/24/2018.
  • C. S. Tan, J. Riedl, A. M. Fleming, C. J. Burrows, H. S. White, “Kinetics of T3 DNA Ligase-Catalyzed Phosphodiester bond Formation Measured using the α-Hemolysin Nanopore,” ACS Nano 2016, 10, 11127–11135. DOI: 10.1021/acsnano.6b05995. Published, 11/28/2016.
  • A. M. Fleming, Y. Ding, and C. J. Burrows, “Zika virus genomic RNA possesses conserved G-quadruplexes characteristic of the Flaviviridae family,” ACS Infectious Disease, 2016, 2, 674-681. DOI: 10.1021/acsinfecdis.6b00109. Selected for “Editors’ Choice”. Cover art for October 2016 issue. Published, 08/07/2016.
  • B. Thapa, B. Munk, C. J. Burrows, and H. B. Schlegel, “Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5 and C4 Guanine-Lysine Adducts in Presence of the Benzophenone Photosensitizer," Chem. Res. Toxicol. 2016, 29, 1396-1409. DOI: 10.1021/acs.chemrestox.6b00057. Published, 08/01/2016.
  • Y. Zhang, X.-B. Li, A. M. Fleming, J. Dood, A. A. Beckstead, A. M. Orendt, C. J. Burrows, and B. Kohler, “UV-Induced Proton-Coupled Electron Transfer in Cyclic DNA Miniduplexes,” J. Am. Chem. Soc. 2016, 138, 7395–7401. DOI: 10.1021/jacs.6b03216. Highlighted in J. Am. Chem. Soc. 2016¸ 138, 7446. Published, 05/20/2016.
  • R. P. Johnson, R. Perrera, A. M. Fleming, C. J. Burrows, and H. S. White, “Energetics of Base Flipping at a DNA Mismatch Site Confined at the Latch Constriction of α-Hemolysin,” Faraday Disc. 2016, 193, 471-485. DOI: 10.1039/C6FD00058D. Published, 03/29/2016.
  • J. Riedl, A. M. Fleming and C. J. Burrows, “Sequencing of DNA lesions facilitated by site-specific excision via base excision repair DNA glycosylases yielding ligatable gaps,” J. Am. Chem. Soc. 2016, 138, 491-494. DOI: 10.1021/jacs.5b11563. Published, 01/07/2016.
  • Zhu J, Fleming AM, Orendt AM & Burrows CJ (2016). pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion. The Journal of organic chemistry. Vol. 81, 351-9. Published, 01/01/2016.
  • R. T. Perera, A. M. Fleming, A. M. Peterson, J. M. Heemstra, C. J. Burrows, and H. S. White, “Unzipping of A-form DNA-RNA or DNA-PNA duplexes and B-form DNA-DNA duplexes in the alpha-hemolysin nanopore,” Biophys. J. 2016, 110, 306-314. DOI:10.1016/j.bpj.2015.11.020. Published, 01/2016.
  • R. P. Johnson, A. M. Fleming, L. R. Beuth, C. J. Burrows and H. S. White, “Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA,” J. Am. Chem. Soc. 2016, 138, 594-603. DOI: 10.1021/jacs.5b10710. Published, 12/24/2015.
  • N. An, A. M. Fleming, and C. J. Burrows, “Human telomere G-quadruplexes with five repeats accommodate 8-oxo-7,8-dihydroguanine by looping out the DNA damage,” ACS Chem. Biol. 2016, 11, 500–507. DOI: 10.1021/acschembio.5b00844. Published, 12/19/2015.
  • J. Zhu, A. M. Fleming, A. M. Orendt, and C. J. Burrows, “pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin affects Nucleotide Insertion Opposite the DNA Lesion,” J. Org. Chem. 2016, 81, 351–359. DOI: 10.1021/acs.joc.5b02180. (Featured Article; cover art for issue 2, 2016.). Published, 11/19/2015.
  • J. Riedl, Y. Ding, A. M. Fleming, and C. J. Burrows, “Identification of DNA Lesions Using a Third Base Pair for Amplification and Nanopore Sequencing,” Nature Comm. 2015, 6, 8807. DOI: 10.1038/ncomms9807. Published, 11/06/2015.
  • K. D. Karlin, S. J. Lippard, J. S. Valentine, and C. J. Burrows, “Solving 21st Century Problems in Biological Inorganic Chemistry Using Synthetic Models,” Acc. Chem. Res. 2015, 48, 2659-2660. Published, 11/2015.
  • Y. Ding, A. M. Fleming, H. S. White, and C. J. Burrows, “Differentiation of G:C vs. A:T and G:C vs. G:mC base pairs in the latch zone of alpha-hemolysin,” ACS Nano 2015, 9, 11325–11332. DOI: 10.1021/acsnano.5b05055. Published, 10/27/2015.
  • N. An, A. M. Fleming, H. S. White, and C. J. Burrows, “Nanopore Detection of 8-Oxoguanine in the Human Telomere Repeat Sequence,” ACS Nano 2015, 9, 4296–4307. DOI: 10.1021/acsnano.5b00722. Published, 10/13/2015.
  • Karlin KD, Lippard SJ, Valentine JS & Burrows CJ (2015). Editorial: Solving 21st Century Problems in Biological Inorganic Chemistry Using Synthetic Models. Accounts of chemical research. Vol. 48, 2659-60. Published, 10/01/2015.
  • A. M. Fleming, O. Alshykhly, A. M. Orendt, C. J. Burrows, “Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin,” Tetrahedron Lett. 2015, 56, 3191-3196. DOI: 10.1016/j.tetlet.2014.12.052. (Special issue in memory of Harry Wasserman). Published, 09/17/2015.
  • O. R. Alshykhly, A. M. Fleming, and C. J. Burrows, “Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair,” Chem. Res. Toxicol. 2015, 28, 1861-1871. DOI: 10.1021/acs.chemrestox.5b00302. Published, 08/27/2015.
  • J. Riedl and C. J. Burrows, “Site-specific labeling of DNA base modifications for amplification of DNA damage,” Coll. Czech Chem. Commun. 2015, 14, 91-92. Published, 07/06/2015.
  • A. M. Fleming, J. Zhou, S. S. Wallace, and C. J. Burrows, “A role for the fifth G-track in G-quadruplex forming oncogene promoter sequences during oxidative stress: Do these “spare tires” have an evolved function?” ACS Central Science 2015, 1, 226-233. DOI: 10.1021/acscentsci.5b00202. Published, 07/06/2015.
  • Y. Ding, A. M. Fleming, L. He, and C. J. Burrows, “Unfolding kinetics of the human telomere i-motif under a 10 pN force imposed by the alpha-hemolysin nanopore identify transient folded-state lifetimes at physiological pH,” J. Am. Chem. Soc. 2015, 137, 9053-9060. DOI: 10.1021/jacs.5b03912. Published, 06/25/2015.
  • O. R. Alshykhly, A. M. Fleming, and C. J. Burrows, “5-Carboxamido-5-formamido-2-iminohydantoin, in addition to 8-oxo-7,8-dihydroguanine, is the major product of the iron-Fenton or X-ray radiation-induced oxidation of guanine under aerobic reducing conditions in the nucleoside context,” J. Org. Chem. 2015, 80, 6996–7007. DOI: 10.1021/acs.joc.5b00689. Published, 06/19/2015.
  • Y. Ding, A. M. Fleming and C. J. Burrows, “Interactions between Biogenic Polyamines and DNA Hairpins Studied by the alpha-Hemolysin Nanopore,” Microchimica Acta, 2016, 183, 973-979. DOI: 10.1007/s00604-015-1516-6. Published, 05/10/2015.
  • Y. Ding, A. M. Fleming and C. J. Burrows, “Interactions between Biogenic Polyamines and DNA Hairpins Studied by the alpha-Hemolysin Nanopore,” Microchimica Acta, 2015, 10.1007/s00604-015-1516-6. Published, 05/2015.
  • A. M. Fleming, O. Alshykhly, J. Zhu, J. G. Muller, and C. J. Burrows, “Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products,” Chem. Res. Toxicol. 2015, 28, 1292-1300. DOI: 10.1021/acs.chemrestox.5b00096. Published, 04/08/2015.
  • J. Zhou, A. M. Fleming, A. M. Averill, C. J. Burrows, and S. S. Wallace, “The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures,” Nucleic Acids Res. 2015, 43, 4039-4054. DOI: 10.1093/nar/gkv252. Published, 03/26/2015.
  • A. M. Fleming, E. I. Armentrout, J. Zhu, J. G. Muller, and C. J. Burrows, “Spirodi(iminohydantoin) Products from Oxidation of 2’-Deoxyguanosine in the Presence of NH4Cl in Nucleoside and Oligodeoxynucleotide Contexts,” J. Org. Chem. 2015, 80, 711-721 (Featured Article). DOI: 10.1021/jo502665p. Published, 02/24/2015.
  • R. T. Perera, A. M. Fleming, R. P. Johnson, C. J. Burrows, and H. S. White, “Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore,” Nanotechnology, 2015, 26, 074002. DOI:10.1088/0957-4484/26/7/074002. Published, 02/20/2015.
  • Y. Zhang, J. Dood, A. Beckstead, X.-B. Li, K. V. Nguyen, C. J. Burrows, R. Improta, and B. Kohler, “Photoinduced Electron Transfer in DNA: Charge Shift Dynamics between 8-Oxo-Guanine Anion and Adenine,” J. Phys. Chem. 2015, 119, 7491–7502. DOI: 10.1021/jp511220x. (Festschrift for Norman Sutin and John Miller.). Published, 02/08/2015.
  • Burrows C (2015). Editorial" Changes afoot!. Accounts of chemical research. Vol. 48, 153. Published, 02/01/2015.
  • A. H. Wolna, A. M. Fleming, and C. J. Burrows, “Single-molecule analysis of thymine-dimer containing G-quadruplexes formed from the human telomere sequence,” Biochemistry 2014, 53, 7484-7493. DOI: 10.1021/bi501072m. Published, 12/09/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/25407781
  • R. P. Johnson, A. M. Fleming, C. J. Burrows and H. S. White, “The Effect of Electrolyte Cation on Detecting DNA Damage with the Latch Constriction of α-Hemolysin,” J. Phys. Chem. Lett. 2014, 5, 3781–3786; DOI: 10.1021/jz502030e. Published, 11/06/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/25400876
  • Y. Ding, A. M. Fleming, H. S. White, and C. J. Burrows, “Internal and Terminal Hairpins: Unzipping Positions and Mechanisms in the α-Hemolysin Nanopore,” J. Phys. Chem. B, 2014, 118, 12873-12882. DOI: 10.1021/jp5101413. Published, 10/21/2014.
    http://pubs.acs.org/doi/abs/10.1021%2Fjp5101413
  • N. An, A. M. Fleming, E. G. Middleton, and C. J. Burrows, “Single-Molecule Investigation of G-Quadruplex Folds of the Human Telomere Sequence in a Protein Nanocavity,” Proc. Natl. Acad. Sci., U.S.A. 2014, 111, 14325–14331. DOI: 10.1073/pnas.1415944111. Published, 10/07/2014.
    http://www.pnas.org/content/111/40/14325.full.pdf+...
  • Y. Zhang, J. Dood, A. Beckstead, X.-B. Li, K. V. Nguyen, C. J. Burrows, R. Improta, and B. Kohler, “Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide,” Proc. Natl. Acad. Sci., U.S.A. 2014, 111, 11612-11617. DOI: 10.1073/pnas.1404411111. Published, 08/12/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/25071180
  • R. P, Johnson, A. M. Fleming, Q. Jin, C. J. Burrows, and H. S. White, “Temperature and Electrolyte Optimization of the α-Hemolysin Latch Sensing Zone for Detection of Base Modification in Double-Stranded DNA,” Biophys. J. 2014, 107, 924-931. DOI: 10.1016/j.bpj.2014.07.006. Published, 08/09/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/25140427
  • A. H. Wolna, A. M. Fleming, H. S. White, and C. J. Burrows, “Single-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recording,” J. Phys. Org. Chem. 2014, 27, 247-251; DOI: 10.1002/poc.3240. Published, 04/2014.
  • B. E. Eckenroth, A. M. Fleming, J. B. Sweasy, C. J. Burrows, and S. Doublié, “Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in Templating Position,” Biochemistry 2014, 53, 2075–2077; DOI: 10.1021/bi500270e. Published, 03/26/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/24649945
  • Q. Jin, A. M. Fleming, R. Johnson, Y. Ding, C. J. Burrows and H. S. White, “Base-excision repair activity of uracil-DNA glycosylase monitored using the latch zone of α-hemolysin,” J. Am. Chem. Soc. 2013, 135, 19347–19353; DOI: 10.1021/ja410615d. Published, 12/26/2013.
    http://pubs.acs.org/doi/abs/10.1021/ja410615d
  • A. M. Fleming, A. M. Orendt, Y. He, J. Zhu, R. K. Dukor, and C. J. Burrows, “Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin,” J. Am. Chem. Soc. 2013, 135, 18191–18204; DOI: 10.1021/ja409254z. Published, 12/04/2013.
    http://pubs.acs.org/doi/abs/10.1021/ja409254z
  • S. Z. Krokeide, J. K. Laerdahl, M. Salah, L. Luna, F. H. Cederkvist, A. M. Fleming, C. J. Burrows, B. Dalhus and M. Bjørås, “Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroiminodihydantoin and guanidinohydantoin,” DNA Repair, 2013, 1159-1164; DOI: 10.1016/j.dnarep.2013.04.026. Published, 12/2013.
    http://www.sciencedirect.com/science/article/pii/S...
  • Q. Jin, A. M. Fleming, C. J. Burrows, and H. S. White, “Structural Destabilization of DNA Duplexes Containing Single Base Lesions Investigated by Nanopore Force Measurements,” Biochemistry, 2013, 52, 7870-7877. DOI: 10.1021/bi4009825. Published, 11/12/2013.
    http://pubs.acs.org/doi/abs/10.1021/bi4009825
  • Single-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recording. Published, 11/04/2013.
    http://onlinelibrary.wiley.com/doi/10.1002/poc.324...
  • A. H. Wolna, A. M. Fleming, H. S. White, and C. J. Burrows, “Single-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recording,” J. Phys. Org. Chem. 2014, 27, 247-251; DOI: 10.1002/poc.3240. Published, 11/04/2013.
  • X. Chen, A. M. Fleming, J. G. Muller, and C. J. Burrows, “Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry,” New J. Chem. 2013, 37, 3440–3449 (special issue in honor of Bernard Meunier). DOI:10.1039/C3NJ00418J. Published, 11/2013.
    http://pubs.rsc.org/en/content/articlelanding/2013...
  • J. Zhou, M. Liu, A. M. Fleming, C. J. Burrows, and S. S. Wallace, “Neil3 and NEIL1 DNA Glycosylases Remove Oxidative Damages from Quadruplex DNA and Exhibit Preferences for Lesions in the Telomeric Sequence Context*,” J. Biol. Chem. 2013, 288, 27263-27272. DOI: 10.1074/jbc.M113.479055. Published, 09/20/2013.
    http://www.jbc.org/content/288/38/27263.abstract
  • P. L. McKibbin, A. M. Fleming, M. A. Towheed, B. Van Houten, C. J. Burrows, and S. S. David, “Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair,” J. Am. Chem. Soc. 2013, 135, 13851-13861. DOI: 10.1021/ja4059469. Highlighted as a Spotlight in Chem. Res. Toxicol. 2013, 26, 1600−1601. Published, 09/18/2013.
    http://pubs.acs.org/doi/abs/10.1021/ja4059469
  • N. An, A. M. Fleming, and C. J. Burrows, “Interactions of the human telomere sequence with the α-hemolysin ion channel reveal structure-dependent signatures,” J. Am. Chem. Soc. 2013, 135, 8562–8570; DOI: 10.1021/ja400973m. Published, 06/12/2013.
    http://pubs.acs.org/doi/abs/10.1021/ja400973m
  • A. H. Wolna, A. M. Fleming, N. An, L. He, H. S. White, C. J. Burrows, “Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the alpha-Hemolysin Ion Channel,” Israel J. Chem. (special issue), 2013, 53, 417-430; DOI: 10.1002/ijch.201300022. Published, 06/2013.
    http://onlinelibrary.wiley.com/doi/10.1002/ijch.20...
  • A. M. Fleming and C. J. Burrows, “G-Quadruplex Folds of the Human Telomere Sequence Alter the Site Reactivity and Reaction Pathway of Guanine Oxidation Compared to Duplex DNA,” Chem. Res. Toxicol. 2013, 26, 593-607; DOI: 10.1021/tx400028y. (Cover art for the April 2013 issue is affiliated with this publication.). Published, 04/2013.
    http://pubs.acs.org/doi/abs/10.1021/tx400028y
  • K. V. Nguyen and C. J. Burrows, “Whence flavins? Redox-active Ribonucleotides Link Metabolism to the RNA World,” Acc. Chem. Res. 2012, 45, 2151–2159. Published, 12/2012.
    http://pubs.acs.org/doi/abs/10.1021/ar300222j
  • N. An, H. S. White, and C. J. Burrows, “Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel,” Chem. Commun. 2012, 48, 11410-11412. Published, 12/2012.
    http://pubs.rsc.org/en/content/articlelanding/2012...
  • D. Lynn, C. Burrows, J. Goodwin, A. Mehta “Origins of Chemical Evolution,” (guest editorial) special issue of Accounts of Chemical Research, 2012, 45, 2023-2024. Published, 12/2012.
    http://pubs.acs.org/doi/abs/10.1021/ar300266q
  • U. Ghanty, E. Fostvedt, R. Valenzuela, P. A. Beal and C. J. Burrows, “Promiscuous 8-Alkyloxyadenosines in the Guide Strand of an SiRNA: Modulation of Silencing Efficacy and Off-Pathway Protein Binding,” J. Am. Chem. Soc. 2012, 134, 17643–17652. Published, 10/2012.
    http://pubs.acs.org/doi/abs/10.1021/ja307102g
  • A. M. Fleming, J. G. Muller, A. C. Dlouhy, and C. J. Burrows, “Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2’-deoxyguanosine to hydantoin products: Electrostatics, base stacking, and base pairing,” J. Am. Chem. Soc., 2012, 134, 15091–15102. Published, 09/2012.
    http://pubs.acs.org/doi/abs/10.1021/ja306077b
  • N. An, A. M. Fleming, H. S. White, and C. J. Burrows, “Crown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules,” Proc. Natl. Acad. Sci.(U.S.A.), 2012, 109, 11504-11509. Published, 07/2012.
    http://www.pnas.org/content/109/29/11504.abstract
  • Q. Jin, A. M. Fleming, C. J. Burrows, and H. S. White, “Unzipping Kinetics of Duplex DNA Containing Oxidized Lesions in an α-Hemolysin Nanopore,” J. Am. Chem. Soc. 2012, 134, 11006–11011. Published, 07/2012.
    http://pubs.acs.org/doi/abs/10.1021/ja304169n
  • K. V. Nguyen and C. J. Burrows, “Photorepair of cyclobutane pyrimidine dimers by 8-oxopurine nucleosides,” J. Phys. Org. Chem. 2012, 25, 574-577. Published, 07/2012.
    http://onlinelibrary.wiley.com/doi/10.1002/poc.291...
  • A. E. P. Schibel, N. An, Q. Jin, A. M. Fleming, C. J. Burrows, and H. S. White, “Nanopore detection of 8-oxo-7,8-dihydro-2’-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site,” J. Am. Chem. Soc. 2010, 132, 17992-17995. Published, 12/07/2010.
    http://pubs.acs.org/doi/pdf/10.1021/ja109501x
  • M. Liu, V. Bandaru, J. P. Bond, P. Jaruga, X. Zhao, P. P. Christov, C. J. Burrows, M. Dizdaroglu, C. J. Rizzo and S. S. Wallace, “The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo, Proc. Natl. Acad. Sci. (USA), 2010, 107, 4925-4930. Published, 03/16/2010.
    http://www.pnas.org/content/107/11/4925.full
  • P. Aller, Y. Ye, S. Wallace, C. J. Burrows, S. Doublié, “Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin,” Biochemistry, 2010, 49, 2502-2509. Published, 02/18/2010.
    http://pubs.acs.org/doi/pdf/10.1021/bi902195p
  • Y. Guo, V. Bandaru, P. Jaruga, X. Zhao, C. J. Burrows, S. Iwai, M. Dizdaroglu, J. P. Bond, and S. S. Wallace, “The DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate specificities from their Escherichia coli counterparts,” DNA Repair 2010, 9, 177-190. Published, 02/04/2010.
  • X. Zhao, N. Krishnamurthy, C. J. Burrows, and S. S. David, “Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble and duplex DNA contexts,” Biochemistry, 2010, 49, 1658-1666. Published, 01/25/2010.
    http://pubs.acs.org/doi/pdf/10.1021/bi901852q
  • N. An, A. M. Fleming, H. S. White, and C. J. Burrows, “Crown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules,” Proc. Natl. Acad. Sci.(U.S.A.), 2012, 109, 11504-11509. Published, 07/2007.

Research Statement

The heterocyclic bases of nucleic acids are rich targets for both toxins that damage DNA and drugs that interact with DNA and RNA. Our laboratory investigates several different aspects of nucleic acid chemistry ranging from base recognition by various probes to base reactions with oxidizing and alkylating agents. We are working to develop nanopore technology that would permit single molecule sequencing of DNA for damage.  In another area, we investigate DNA and RNA photophysical properties that are relevant to the RNA world and the origins of life.

Research Keywords

  • origins of life
  • DNA damage
  • DNA Sequencing Technology

Presentations

  • T.-Y. Shen lecture no. 2. Invited Talk/Keynote, Presented, 12/05/2023.
  • T.-Y. Shen Lecture no. 1. Invited Talk/Keynote, Presented, 12/04/2023.
  • Florida State University, Department of Biomedical Sciences, Tallahassee, FL. Invited Talk/Keynote, Presented, 11/15/2023.
  • University of Chicago, Department of Biochemistry and Molecular Biology, Chicago, IL. Invited Talk/Keynote, Presented, 11/01/2023.
  • Willamette University, Department of Chemistry, Salem, OR. Invited Talk/Keynote, Presented, 10/02/2023.
  • Epitranscriptomics: Methods, Technologies, and Innovation Symposium; Cornell Weill. Invited Talk/Keynote, Presented, 07/25/2023.
  • Purdue University, Department of Medicinal Chemistry and Pharmacology, West Lafayette, IN. Invited Talk/Keynote, Presented, 04/06/2023.
  • Nucleic Acid Secondary Structures, G4s and Beyond, International Webinar. Invited Talk/Keynote, Presented, 03/16/2023.
  • Nanoscale Approaches to Biology Symp., Biophysical Society Meeting, San Diego, CA. Invited Talk/Keynote, Presented, 02/18/2023.
  • University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA. Invited Talk/Keynote, Presented, 02/14/2023.
  • University of Ottawa and Carleton University, Center for Toxicology. Invited Talk/Keynote, Presented, 01/25/2023.
  • University of Utah Science at Breakfast, College of Science. Invited Talk/Keynote, Presented, 11/17/2022.
  • 7th US-EU Conference on Repair of Endogenous DNA Damage, Stony Brook, NY. Invited Talk/Keynote, Presented, 11/06/2022.
  • Linus Pauling Award Symposium, Portland State U., Portland, OR. Invited Talk/Keynote, Presented, 10/29/2022.
  • Arrakis Therapeutics, Waltham, MA (online). Invited Talk/Keynote, Presented, 10/05/2022.
  • Institut des Sciences et d’Ingenierie Supramoleculaires, Strasbourg, France. Invited Talk/Keynote, Presented, 09/23/2022.
  • European DNA Repair Conference, Mainz, Germany. Invited Talk/Keynote, Presented, 09/20/2022.
  • International Conference on Environmental Mutagenesis, Keynote address, Ottawa, CA. Invited Talk/Keynote, Presented, 08/27/2022.
  • Founders’ Award Lecture, TOXI division, ACS Nat’l Meeting, Chicago, IL. Invited Talk/Keynote, Presented, 08/21/2022.
  • Workshop on Nucleic Acid Chemistry, Telluride, CO. Invited Talk/Keynote, Presented, 07/20/2022.
  • 38th Biennial Meeting of the Spanish Royal Society of Chemistry, Plenary lecture, Granada. Invited Talk/Keynote, Presented, 06/28/2022.
  • Nucleic Acid Chemistry and Biology, Canadian Chemical Society, Calgary, Alberta. Invited Talk/Keynote, Presented, 06/14/2022.
  • Nanopore Sequencing: From Genomes to Proteomes, Northeastern U., Boston, MA. Invited Talk/Keynote, Presented, 05/09/2022.
  • Indiana University, School of Medicine, Indianapolis, IN (online). Invited Talk/Keynote, Presented, 04/25/2022.
  • Washington University-St. Louis, Department of Chemistry, Weissman Lectures. Invited Talk/Keynote, Presented, 04/21/2022.
  • Huntsman Cancer Institute, Nuclear Control Program, University of Utah. Invited Talk/Keynote, Presented, 04/19/2022.
  • 3rd Symposium on Nucleic Acid Modification, Mosbach, Germany. Invited Talk/Keynote, Presented, 03/28/2022.
  • Breslow Award Symposium, ACS National Meeting, San Diego, CA. Invited Talk/Keynote, Presented, 03/20/2022.
  • University of Pennsylvania, Environmental Health Sciences Core Center, Philadelphia, PA (online). Invited Talk/Keynote, Presented, 02/17/2022.
  • Samuel I. Weissman Lectureship, Washington University-St. Louis, February 2022. Presentation, Presented, 02/2022.
  • Chemistry, Biology & Drug-Targeting of G- and C-Quadruplexes, Pacifichem, Honolulu, HI (online). Invited Talk/Keynote, Presented, 12/20/2021.
  • Free radical chemistry in biology & materials, Pacifichem, Honolulu, HI (online). Invited Talk/Keynote, Presented, 12/20/2021.
  • University of Nebraska, Department of Chemistry, Lincoln, NE (2 lectures, online). Invited Talk/Keynote, Presented, 11/12/2021.
  • University of Nebraska, Department of Chemistry, Lincoln, NE (2 lectures, online). Invited Talk/Keynote, Presented, 11/11/2021.
  • Nucleic Acids 2021—August Symposium, Plenary Lecture (online). Invited Talk/Keynote, Presented, 08/06/2021.
  • Institute of Cellular and Molecular Radiobiology, CEA, Fontenay-aux-Roses, Université Paris-Saclay, France (online). Invited Talk/Keynote, Presented, 05/27/2021.
  • Oregon State University, Phi Beta Kappa Lecture, Corvallis, OR (online). Invited Talk/Keynote, Presented, 05/26/2021.
  • SupraBio Symposium, Plenary lecture (online). Invited Talk/Keynote, Presented, 05/10/2021.
  • Biopolymers Symposium in honor of Eric Kool, ACS National Meeting (online). Invited Talk/Keynote, Presented, 04/06/2021.
  • Brown University, Leallyn Clapp Lecture & Colloquium (2 lectures), Department of Chemistry, Providence, RI (online). Invited Talk/Keynote, Presented, 03/18/2021.
  • Brown University, Leallyn Clapp Lecture & Colloquium (2 lectures), Department of Chemistry, Providence, RI (online). Invited Talk/Keynote, Presented, 03/17/2021.
  • University of Arkansas, Cancer Institute Forum, Little Rock, AR (online). Invited Talk/Keynote, Presented, 03/08/2021.
  • Ohio State University, Molecular, Cellular & Devel. Biology Program, Columbus, OH (online). Invited Talk/Keynote, Presented, 03/02/2021.
  • iNANO Symposium, Aarhus University, Aarhus, Denmark (online). Invited Talk/Keynote, Presented, 01/13/2021.
  • John Albert Southern Lectureship, Furman University. Presentation, Presented, 02/2020.
  • James and Jeanette Neckers Lectureship, Hope College. Presentation, Presented, 02/2020.
  • Distinguished Faculty Colloquium, University of Utah. Presentation, Presented, 02/2020.
  • Phi Beta Kappa Lectureships (6). Presentation, Presented, 02/2020.
  • 9 invited lectures at conferences; 7 invited lectures at institutions. Invited Talk/Keynote, Presented, 12/2019.
  • University of Missouri, Thomas Lectures, Department of Chemistry, Columbia, MO. Invited Talk/Keynote, Presented, 11/16/2017.
  • University of Illinois, Department of Chemistry, Urbana-Champaign, IL (canceled due to weather) . Invited Talk/Keynote, Other, 11/06/2017.
  • Swiss Chemical Society Lectureships: ETH, University of Zurich, University of Fribourg, University of Geneva, University of Basel. Invited Talk/Keynote, Presented, 10/16/2017.
  • Bioscience Symposium, University of Utah, Salt Lake City, UT. Invited Talk/Keynote, Presented, 09/12/2017.
  • Light and Dark Properties of DNA and Other Supramolecular Systems, JHU, Baltimore,MD. Invited Talk/Keynote, Presented, 08/18/2017.
  • Johns Hopkins University, Department of Chemistry, Baltimore, MD. Invited Talk/Keynote, Presented, 08/18/2017.
  • Science@theInterface, University of Chicago, Department of Chemistry, Chicago, IL. Invited Talk/Keynote, Presented, 06/16/2017.
  • University of Chicago, Department of Chemistry, Chicago, IL. Invited Talk/Keynote, Presented, 06/16/2017.
  • 15th Symposium on the Chemistry of Nucleic Acid Components, Cesky Krumlov, Czech Republic. Invited Talk/Keynote, Presented, 06/04/2017.
  • 6th International Symposium on Quadruplex Nucleic Acids, Prague, Czech Republic. Invited Talk/Keynote, Presented, 05/31/2017.
  • University of Texas, Department of Chemistry, Austin, TX. Invited Talk/Keynote, Presented, 05/12/2017.
  • University of San Diego, Department of Chemistry and Biochemistry, San Diego, CA. Invited Talk/Keynote, Presented, 05/02/2017.
  • Simon Fraser University, Department of Chemistry, Vancouver, BC. Invited Talk/Keynote, Presented, 04/27/2017.
  • University of Colorado, Department of Chemistry, Denver,CO. Invited Talk/Keynote, Presented, 04/14/2017.
  • Nucleic Acid Therapeutics: Mechanisms and Applications, 253rd National ACS Meeting, San Francisco, CA. Invited Talk/Keynote, Presented, 04/03/2017.
  • Zhang Dayu Lectureship, Dalian Institute, Dalian, China. Invited Talk/Keynote, Presented, 10/28/2016.
  • National Center for Nanoscience and Technology, Beijing, China. Invited Talk/Keynote, Presented, 10/27/2016.
  • ACS International Symposium on Innovations in Molecular Sciences, Beijing, China. Invited Talk/Keynote, Presented, 10/24/2016.
  • NAKAMA Program, University of Utah, Salt Lake City, UT. Invited Talk/Keynote, Presented, 10/07/2016.
  • Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Invited Talk/Keynote, Presented, 09/15/2016.
  • Radicals in the Rockies, Telluride, CO. Invited Talk/Keynote, Presented, 08/04/2016.
  • Telluride Workshop on Nucleic Acid Chemistry, Telluride, CO. Invited Talk/Keynote, Presented, 07/29/2016.
  • 36th Reaction Mechanisms Conference, St. Louis, MO. Invited Talk/Keynote, Presented, 06/28/2016.
  • National Cancer Institute, Frederick, MD. Invited Talk/Keynote, Presented, 05/02/2016.
  • Carnegie Mellon University, DNA Day Plenary Speaker, Pittsburg, PA. Invited Talk/Keynote, Presented, 04/25/2016.
  • Cornell University, Department of Chemistry and Chemical Biology, Ithaca, NY. Invited Talk/Keynote, Presented, 04/07/2016.
  • University of Toledo, Department of Chemistry, Toledo, OH. Invited Talk/Keynote, Presented, 03/21/2016.
  • IUPUI, Department of Chemistry and Chemical Biology, Indianapolis, IN. Invited Talk/Keynote, Presented, 11/11/2015.
  • Arizona State University, Eyring Lectures (2), Department of Chemistry & Biochemistry, Tempe, AZ. Invited Talk/Keynote, Presented, 11/05/2015.
  • University of Rochester, Biological Chemistry Cluster Featured Speaker, Rochester, NY. Invited Talk/Keynote, Presented, 05/28/2015.
  • Chemistry-Biology Interface Keynote Speaker, University of Rochester, Rochester, NY. Invited Talk/Keynote, Presented, 05/02/2015.
  • University of Iowa, Wawzonek Lecture, Department of Chemistry, Iowa City, IA. Invited Talk/Keynote, Presented, 04/30/2015.
  • Bürgenstock Conference on Stereochemistry, Bürgenstock, Switzerland. Invited Talk/Keynote, Presented, 04/26/2015.
  • Chemistry-Biology Interface Keynote Speaker, University of Rochester, Rochester, NY. Invited Talk/Keynote, Presented, 03/31/2015.
  • Award Symposium for Jaqueline Kiplinger, ACS National Meeting, Denver, CO. Invited Talk/Keynote, Presented, 03/22/2015.
  • 50th Anniversary of the Foote/Wexler Discovery: A Milestone for Singlet Oxygen Research, UCLA, Department of Chemistry, Los Angeles, CA. Invited Talk/Keynote, Presented, 03/12/2015.
  • EVONIK Symposium of Organic Chemistry, Ruhr-Universität Bochum, Germany. Invited Talk/Keynote, Presented, 02/12/2015.
  • Self-Assembly of Biomolecules, Balard Conference, Montpellier, France. Invited Talk/Keynote, Presented, 10/12/2014.
  • Frontiers in Genome Sciences, Institute of Chemical Biology & Drug Discovery, Stony Brook, NY. Invited Talk/Keynote, Presented, 10/09/2014.
  • Jerome A. Berson Lecturer, Yale University, Department of Chemistry, New Haven, CT. Invited Talk/Keynote, Presented, 09/25/2014.
  • Symposium on Chemical Approaches toward Understanding and Reprogramming RNA, ACS National Meeting, San Francisco, CA. Invited Talk/Keynote, Presented, 08/11/2014.
  • Telluride Workshop on Nucleic Acid Chemistry, Telluride, CO. Invited Talk/Keynote, Presented, 07/28/2014.
  • Pennsylvania State University, Department of Chemistry, University Park, PA. Invited Talk/Keynote, Presented, 04/24/2014.
  • Women in Science Symposium, Texas Woman’s University, Denton, TX. Invited Talk/Keynote, Presented, 03/28/2014.
  • University of Cincinnati, Department of Chemistry, Cincinnati, OH. Invited Talk/Keynote, Presented, 10/15/2010.
  • Symposium on Inflammation Biomarkers and Interventions, Division of Chemical Toxicology, ACS National Meeting, Boston, MA. Invited Talk/Keynote, Presented, 08/25/2010.
  • Symposium on Women at the Forefront of Preventing and Combating Disease, Women Chemists Committee, ACS National Meeting, Boston, MA. Invited Talk/Keynote, Presented, 08/22/2010.
  • Pinhead Town Talk, Telluride Science Research Center, Telluride, CO. Invited Talk/Keynote, Presented, 08/03/2010.
  • Contributed to 3 student posters/talks during 2010. Contributed Talk, Presented, 08/2010.
  • Workshop on Nucleic Acid Chemistry, Telluride, CO. Invited Talk/Keynote, Presented, 08/2010.
  • Radicals in the Rockies, Telluride, CO. Invited Talk/Keynote, Presented, 07/2010.
  • Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Prague, C. R. Invited Talk/Keynote, Presented, 06/16/2010.
  • EuChem Conference on Free Radicals, Bologna, Italy (plenary lecture). Invited Talk/Keynote, Presented, 06/2010.

Research Groups

  • Spencer S. Hoon, Undergraduate Student. Chemistry. 05/15/2023 - present.
  • Yizhou Wu, Undergraduate Student. Chemistry. 01/09/2023 - 12/15/2023.
  • Vilhelmina Done, Undergraduate Student. 01/2022 - 08/2023. Awards/Scholarships/Stipends: Beckman Scholar.
  • Paul Gaebler, Graduate Student. 01/2022 - present.
  • Hannah Farra, Undergraduate Student. 01/2022 - 08/2022.
  • Songjun Xiao, Postdoc. Chemistry. 07/15/2020 - 09/2022.
  • Tao Zeng, Postdoc. 05/2015 - 12/01/2017.
  • Fatjon Hannelli, Graduate Student. 09/2013 - 08/2016.

Research Equipment and Testing Expertise

  • Nanopore sequencing of DNA.

Languages

  • French, functional.

Geographical Regions of Interest

  • France
    On sabbatical at the Curie Institute, Paris and Orsay, 2019-2020.