JOHN STANSFIELD PARKINSON, JR portrait
  • Distinguished Professor, School Of Biological Sciences
801-581-7639

Publications

  • Uchida, Y. (2022). The Chemoreceptor Sensory Adaptation System Produces Coordinated Reversals of the Flagellar Motors on an Escherichia coli Cell. J Bacteriol. Published, 11/2022.
    https://journals.asm.org/doi/full/10.1128/jb.00278...
  • Flack, C.E. (2022). Structural signatures of Escherichia coli chemoreceptor signaling states revealed by cellular crosslinking. Proc. Natl. Acad. Sci. USA. Vol. 119. Published, 07/2022.
    https://www.pnas.org/doi/10.1073/pnas.2204161119
  • Piñas G.E. & DeSantis M.D., Cassidy C.K. and J.S. Parkinson (2022) Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity (2022). Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in Escherichia coli chemoreceptor arrays. Science Signaling. Vol. 15. Published, 01/2022.
    https://www.science.org/doi/10.1126/scisignal.abj1...
  • Nieto V. & Partridge J.D., Severin G., Lai R-Z., Waters C., Parkinson J.S. & R.M. Harshey (2020). Under elevated c-di-GMP in E. coli, YcgR alters flagellar motor bias and speed sequentially, with additional negative control of the flagellar regulon via the adaptor protein RssB. J Bacteriol. Published, 02/2020.
    https://jb.asm.org/content/202/1/e00578-19
  • Burt A. & Cassidy C.K., Ames, P., Bacla-Verloop M., Baulard M., Huard K., Luthey-Schulten Z., Desfosses A., Stansfield P.J., Margolin W., Parkinson J.S. & I. Gutsche (2020). Complete structure of the core signalling unit of the E. coli chemosensory array in an optimised minicell strain. Nature Communications. Published, 01/2020.
    https://www.nature.com/articles/s42003-019-0748-0
  • Cassidy C.K & Himes B.A., Sun D., Ma J., Zhao G., Parkinson J.S. Stansfield P.J. Luthey-Schulten Z. & P. Zhang (2020). Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations. Nature Commun. Biology. Published, 01/2020.
    https://www.nature.com/articles/s42003-019-0748-0#...
  • Nieto V., Partridge J.D., Severin G., Lai R-Z., Waters C., Parkinson J.S. & R.M. Harshey (2020) Under elevated c-di-GMP in E. coli, YcgR alters flagellar motor bias and speed sequentially, with additional negative control of the flagellar regulon via the adaptor protein RssB. J Bacteriol. 202:e00578-19.doi:10.1128/JB.00578-19. Published, 12/2019.
  • Piñas G.E. & J.S. Parkinson (2019) Identification of a kinase-active CheA conformation in Escherichia coli chemoreceptor signaling complexes. J Bacteriol. 201:e00543-19. doi:10.1128/JB.00543-19. Published, 09/2019.
  • Yang, W., C.K. Cassidy, P. Ames, C.A. Diebolder, K. Schulten, Z. Luthey-Schulten, J.S. Parkinson & A. Briegel (2019) In situ conformational changes of the Escherichia coli serine chemoreceptor in different signaling states. mBio, 10:e00973-19. doi: 10.1128/mBio.00973-19. Published, 07/2019.
  • Gao, Q., A. Cheng & J.S. Parkinson (2019) Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli. Proc. Natl. Acad. Sci. USA, 116:15651-15660. doi: 10.1073/pnas.1902521116. Published, 07/2019.
  • Flack, C.E. (2018). A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling. . Proc. Natl. Acad. Sci. USA, 115:. Vol. 115, E3519-E3528. Published, 03/26/2018.
  • Piñas, G.E. & Piñas, G.E., DeSantis, M.D. & J.S. Parkinson (2018). Noncritical signaling role of a kinase-receptor interaction surface in the Escherichia coli chemosensory core complex. J. Mol. Biol. Vol. 430, 1051-1064. Published, 02/14/2018.
  • Lai, R.Z. & Manson, M (ed) (2018). Monitoring two-component sensor kinases with a chemotaxis signal readout. In: Manson, M (ed) Bacterial Chemosensing, Methods in Molecular Biology. (pp. 127-135). Vol. 1729, Springer. Published, 02/11/2018.
  • Ames, P. & Manson, M (ed) (2018). All-codon mutagenesis for structure-function studies of chemotaxis signaling proteins. In: Manson, M (ed) Bacterial Chemosensing, Methods in Molecular Biology. (pp. 79-85). Vol. 1729, Springer. Published, 02/11/2018.
  • Lai, R.Z. & Han, X.S., Dahlquist, F.W. & J.S. Parkinson (2017). Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme. Proc. Natl. Acad. Sci. USA. Vol. 114, E7583-E7591. Published, 09/2017.
  • Lai, R.Z. & K.K. Gosink & J.S. Parkinson (2017). Signaling consequences of structural lesions that alter the stability of chemoreceptor trimers of dimers. J. Mol. Biol. Vol. 429, 823-835. Published, 02/2017.
  • Networked chemoreceptors benefit bacterial chemotaxis performance. mBio doi:10.1128/mBio.01824-16. Published, 12/20/2016.
  • Classic spotlight: The discovery of bacterial transduction. J. Bacteriol. 198: 2899-2900. Published, 10/07/2016.
  • Classic spotlight: Look, Max – No math required!. J. Bacteriol. 198: 2281-2282. Published, 08/11/2016.
  • Classic spotlight: Dawn of the molecular era of bacterial chemotaxis. J. Bacteriol. 198: 1796. Published, 06/13/2016.
  • Evidence for a helix-clutch mechanism of transmembrane signaling in a bacterial chemoreceptor. J. Mol. Biol. 428: 3776-3788. Published, 03/24/2016.
  • The source of high signal cooperativity in bacterial chemosensory arrays. Proc. Natl. Acad. Sci. USA, 113: 3335-3340. Published, 03/06/2016.
  • Mowery P., P. Ames, R.H. Reiser and J.S. Parkinson (2015) Chemotactic signaling by single-chain chemoreceptors. PLoS One 10:e0145267. Published, 12/2015.
  • Kitanovic S., P. Ames and J.S. Parkinson (2015) A trigger residue for transmembrane signaling in the Escherichia coli serine chemoreceptor. J. Bacteriol. 197: 2568-2579. Published, 05/2015.
  • Parkinson, J. S., G. L. Hazelbauer and J.J. Falke (2015) Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol 23: 257-266. Published, 05/2015.
  • Lai, R.Z. and J.S. Parkinson (2014) Functional suppression of HAMP domain signaling defects in the E. coli serine chemoreceptor. J. Mol. Biol. 426: 3642-3655. Published, 08/15/2014.
  • Pedetta, A., J.S. Parkinson and C.A. Studdert, (2014) Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells. Mol. Microbiol. 93: 1144-1155. Published, 08/05/2014.
  • Nishiyama, S., A. Garzon and J.S. Parkinson (2014). Mutational analysis of the P1 phosphorylation domain in Escherichia coli CheA, the signaling kinase for chemotaxis. J Bacteriol 196(2): 257-264. Published, 01/07/2014.
  • Ames, P., Q. Zhou and J.S. Parkinson (2014). HAMP domain structural determinants for signalling and sensory adaptation in Tsr, the Escherichia coli serine chemoreceptor. Mol Microbiol 91(5): 875-886. Published, 01/07/2014.
  • Ortega, D.R., C. Yang, P. Ames, J. Baudry, J.S. Parkinson and I.B. Zhulin (2013). A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors. Nat Commun 4: 2881. Published, 12/03/2013.
  • Han, X.S. and J.S. Parkinson (2014). An unorthodox sensory adaptation site in the Escherichia coli serine chemoreceptor. J Bacteriol 196(3): 641-649. Published, 12/03/2013.
  • Briegel, A., Ames, P., Gumbart, J.C., Oikonomou, C.M., Parkinson, J.S. & G.T. Jensen (2013) The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state. Mol. Micribiol. 89: 831-841. Published, 07/12/2013.
  • Parkinson, J. S. (2013). “Bacterial chemotaxis,” in Brenner’s Encyclopedia of Genetics, 2nd Edn, eds S. Brenner and J. Miller . Elsevier. Published, 06/2013.
  • Pham, H.T & J. S. Parkinson, (2011) Phenol sensing by E. coli chemoreceptors: A non-classical mechanism. J. Bacteriol. 193: 6597-6604. Published, 06/2011.
  • Gosink, K. K., Y. Zhao & J. S. Parkinson, (2011) Mutational analysis of N381, a key trimer contact residue in Tsr, the E. coli serine chemoreceptor. J. Bacteriol., 193: 6452-6460. Published, 06/2011.
  • Kitanovic, S., P. Ames & J. S. Parkinson, (2011) Mutational analysis of the control cable that mediates transmembrane signaling in the E. coli serine chemoreceptor. J. Bacteriol. 193: 5062-5072. Published, 06/2011.
  • Zhou, Q., P. Ames & J. S. Parkinson, (2011) Biphasic control logic of HAMP domain signalling in the Escherichia coli serine chemoreceptor. Mol. Microbiol. 80: 596-611. Published, 01/2011.

Presentations

  • Receptor Fest (online); Gordon Research Conference on “Sensory Transduction in Microorganisms,” Ventura, CA; Bacterial Locomotion and Signal Transduction (Charleston, SC). Invited Talk/Keynote, Presented, 04/2023.
  • Bacterial Locomotion and Signal Transduction (Charleston, SC). Invited Talk/Keynote, Presented, 01/2023.
  • Gordon Research Conference on “Sensory Transduction in Microorganisms,” Ventura, CA. Invited Talk/Keynote, Presented, 10/2022.
  • Sichuan Agricultural University, Chengdu, China (online). Presentation, Presented, 06/2022.
  • Receptor Fest (online). Invited Talk/Keynote, Presented, 04/2022.
  • Bacterial Locomotion and Signal Transduction (online); Receptor Fest (online). Invited Talk/Keynote, Presented, 03/2022.
  • University of Wyoming. Presentation, Presented, 04/2021.
  • Sichuan Agricultural University, Chengdu, China / Yangzhou University, Yangzhou, China. Invited Talk/Keynote, Presented, 11/2019.
  • University of Oxford, Oxford, Great Britain / University of Leiden, Leiden, Netherlands . Invited Talk/Keynote, Presented, 10/2019.
  • ASM Intermountain Branch Regional Meeting (keynote speaker). Invited Talk/Keynote, Presented, 04/2019.
  • University of Osnabrück, Osnabrück, Germany / Max Planck Institute - Marburg, Germany / Ludwig Maximillian University, Martinsreid, Germany / University of Regensburg, Regensburg, Germany. Invited Talk/Keynote, Presented, 09/2018.
  • Weizmann Institute, Rehovot, Israel . Invited Talk/Keynote, Presented, 09/2018.
  • Oxford University, Oxford, Great Britain / Cambridge University, Cambridge, Great Britain. Invited Talk/Keynote, Presented, 08/2018.
  • Mini-symposium: Crossroads of bacterial moving and sensing”, Amsterdam, Netherlands. Invited Talk/Keynote, Presented, 08/2018.
  • Vietnam National University, Hanoi, Vietnam / Hosei University, Tokyo, Japan / Osaka University, Osake, Japan / Nagoya University, Nagoya, Japan. Invited Talk/Keynote, Presented, 03/2018.
  • Gordon Conference on “Sensory Transduction in Microorganisms,” Ventura, CA. Invited Talk/Keynote, Presented, 01/2018.
  • Vietnam National University, Hanoi, Vietnam. Invited Talk/Keynote, Presented, 12/2017.
  • JOHN STANSFIELD PARKINSON (2017) Weizmann Institute, Rehovot, Israel . Invited Talk/Keynote, Presented, 10/2017.
  • University of Osnabrück, Osnabrück, Germany . Invited Talk/Keynote, Presented, 09/15/2017.
  • "Mini-symposium: Crossroads of bacterial moving and sensing", Amsterdam, Netherlands. Invited Talk/Keynote, Presented, 09/2017.
  • JOHN STANSFIELD PARKINSON (2017) University of Regensburg, Regensburg, Germany. Invited Talk/Keynote, Presented, 09/2017.
  • Ludwig Maximillian University, Martinsreid, Germany . Invited Talk/Keynote, Presented, 09/2017.
  • JOHN STANSFIELD PARKINSON (2017) Max Planck Institute - Marburg, Germany . Invited Talk/Keynote, Presented, 09/2017.
  • JOHN STANSFIELD PARKINSON (2017) Cambridge University, Cambridge, Great Britain . Invited Talk/Keynote, Presented, 08/31/2017.
  • Oxford University, Oxford, Great Britain . Invited Talk/Keynote, Presented, 08/28/2017.
  • West Coast Bacterial Physiologists meeting, Asilomar, CA. Invited Talk/Keynote, Presented, 09/01/2016.
  • U. Missouri - Columbia. Invited Talk/Keynote, Presented, 07/30/2016.
  • Molecular Microbiology meeting, Vienna, Austria (speaker). Invited Talk/Keynote, Presented, 10/2015.
  • Bacterial Locomotion and Signal Transduction, Tucson, AZ Biophysical Society meeting, Baltimore, MD (speaker) . Invited Talk/Keynote, Presented, 08/2015.
  • UNAM - Mexico City . Presentation, Presented, 05/2012.
  • UNAM - Cuernavaca . Presentation, Presented, 05/2012.
  • Gordon Conference on “Sensory Transduction in Microorganisms,” Ventura, CA. Invited Talk/Keynote, Presented, 01/2012.
  • Princeton University . Presentation, Presented, 11/2011.

Research Groups

  • Khoosheh Gosink, Senior Associate. 12/2019 - present.
  • Germán Piñas, Research Professor. 07/2018 - present.
  • Caralyn Flack, Postdoc. 11/2014 - present.
  • Germán Piñas, Postdoc. 09/2011 - 07/2018.
  • Khoosheh Gosink, Senior Associate. 09/2003 - 08/2010.