GLENN D PRESTWICH portrait
  • Presidential Professor of Medicinal Chemistry, Emeritus, Medicinal Chemistry
  • Research Professor, Emeritus, Department Of Biochemistry
  • Adjunct Professor, Emeritus - Otolaryngology, School Of Medicine-Operations
  • Adjunct Professor, Emeritus, Biomedical Engineering
801-585-9051

Research Keywords

  • Phosphoinositides
  • Lysophospholipids in Cell Signaling
  • Isoprenoid Signaling and Metabolism
  • Inositol Polyphosphates
  • Glycosaminoglycan Biomaterials for Wound Healing
  • Drug Delivery and Tissue Engineering

Presentations

  • Proteoglycans Gordon Conference, Session Chair. Panel, Presented, 07/10/2024.
  • Pharmaceutics Students, U Utah. Presentation, Presented, 08/25/2023.
  • 12th International Proteoglycan Conference, Horsley, UK (4-6 September). Invited Talk/Keynote, Presented, 08/2023.
  • HA 2023 Portland (3-9 June). Invited Talk/Keynote, Presented, 06/2023.
  • SC BioCraft, Clemson-MUSC. Presentation, Presented, 03/16/2023.
  • Proteoglycans Gordon Conference, Session Chair (13-17 July). Panel, Presented, 07/2022.
  • Southeastern University, College of Natural & Health Sciences. Invited Talk/Keynote, Presented, 03/17/2022.
  • Basement Membrane Extract Replacement Symposium/Webinar, online. Presentation, Presented, 10/21/2021.
  • Third Annual Drug Delivery West, online. Presentation, Presented, 05/08/2021.
  • Biologic Scaffolds Regenerative Medicine, Napa, CA (April 28-May 4). Invited Talk/Keynote, Presented, 05/2021.
  • Translate! Berlin, Invited Panelist, online. Panel, Presented, 01/26/2021.
  • Biomaterials WBC 2020, Keynote, HA Symposium (12-17 Dec). Invited Talk/Keynote, Presented, 12/2020.
  • Inland NW Students (AWIS/GRSA), WSU Spokane. Presentation, Presented, 02/13/2020.

Languages

  • English, fluent.

Publications

  • Duda GN & Grainger DW, Guldberg RE, Goldsobel, G, Prestwich, GD, Rauw, B, Volk H-D (2023). Measuring translational research impact requires reaching beyong current metrics. Sci. Transl. Med. Published, 12/2023.
  • Zhang W & Lanzoni G, Hani H, Yi X, Overi D, Shi L, Simpson S, Allen A, Suitt C, Ezzell JA, Alvaro D, Cardinale V, Gaudio E, Carpino G, Prestwich G, Dominguez-Bendala J, Gerber D, Mathews K, Piedrahita J, Wauthier E, He Z, Adin C, Sethupathy P, and Reid L.M (2022). Patch Grafting of Organoids of Stem/progenitors into Solid Organs Can Correct Genetic-Based Disease States. Biomaterials. Published, 12/2022.
  • Zhang W, Wang X, Lanzoni G, Wauthier E, Overi D, Wang Y, Oikawa T, Simpson S, Allen A, Suitt C, Jhirad A, Krollk J, Gerber D, Dominguez-Bendala J, Alvaro D, Cardinale V, Gaudio E, Carpino G, Prestwich G, Adin C, Mathews K, Piedrahita J, Sethupathy P, He Z & Reid L.M. (2022). The network of co-hepato/pancreatic stem/progenitors in postnatal pigs versus that in humans. Regenerative Medicine. Published, 12/2022.
  • G. N. Duda & D. W. Grainger, R. E. Guldberg, G. D. Prestwich, B. Rauw, H-D. Volk (2022). Measuring translational impact beyond common business or academic metrics. Science Translational Medicine. Published, 12/2022.
  • W. Zhang, G. Lanzoni, H. Hani, X. Yi, D. Overi, L. Shi, S. Simpson, A. Allen, C. Suitt, J. A. Ezzell, D. Alvaro, V. Cardinale, E. Gaudio, G. Carpino, G. Prestwich, J. Dominguez-Bendala, D. Gerber, P. Sethupathy, K. Mathews, J. Piedrahita, C. Adin, Z. He & E. Wauthier, L. Reid (2022). Patch grafting strategies of stem/progenitor organoids. Strategies for cell therapies for solid organs, and exemplified in liver and pancreas. Cell Stem Cell. Published, 12/2022.
  • V. Raja & Y. Gu, H-M. Lee, J. Deng, G. Prestwich, M. E. Ryan (2022). SAGE: Novel therapy to reduce inflammation in a naturally occurring dog model of periodontal disease. J. Exper. Pharmacol. Published, 12/2022.
  • D. Bhere, S. H. Choi, P. van de donk, D. Hope, K. GorXzak, A. Kunnumal, J. Khalsa, E. R. LechIch, C. Reinshagen, V. Leon, N. Nissar, W. Bi, C. Feng, H. Li, Y. S. Zhang, S. Liang, N. Vasdev, W. I. Essayd, P. Valdes, A. Golby, N. Banouni, A. Pallagina & R. Abdi, B. Fury, S. Smirnakis, A. Lowe, B. Reeve, A. Hiller, E. Chiocca, G. D. Prestwich, H. Wakimoto, G. Bauer, and K. Shah (2022). Target receptor idenIficaIon and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nature Commun. Published, 12/2022.
  • W. Zhang & E. Wauthier, G. Lanzoni, S. Simpson, W. Pitman, A. Allen, O. Lozoya, D. Gerber, G. Prestwich, X. Wang, J. Dominguez-Bendala, Z. He, P. Sethupathy, C. Adin, K. Matthews, J. Pedrahita, L. McAdams Reid (2021). Patch grafting. Strategies for transplantation of organoids into solid organs such as liver. Biomaterials. Published, 12/2021.
  • Y. Gu & V. Raja, H-M. Lee, H. Hong, G. Prestwich, M. E. Ryan (2021). Therapeutic potential of a novel semi-synthetic sulfated polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages. J. Inflammation. Published, 12/2021.
  • H. Kabra & T. Walimbe, K. Stuart, C. Indey, S. Jalgaonkar, E. Ikwa, T. Skurnac, J. Chen, A. Wooley, N. Snead, N. Bachtell, D. Leeming, M. Karsdal, G. Prestwich, A, Panitch, J. Paderi (2020). Localized inhibition of platelets and PDGF by a matrix targeted glycan mimetic significantly attenuates liver fibrosis. Biomaterials. Published, 12/2020.
  • M J. Velasquez-Hernandez & E. Astria, S. Winkler, W. Liang, H. Amenitsch, A. Poddar, R. Shukla, G. Prestwich, J. Paderi, C. J.Doonan, P. Falcaro (2020). Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans. Chem. Sci. Published, 12/2020.
  • B. K. Mann and G. D. Prestwich, Creating Commercial Value from Biomaterials, In, Translational Regenerative Medicine (A. Atala, A. Allickson, eds.), Elsevier (2014). Published, 12/2014.
  • G. D. Prestwich and S. Atzet, “I.2.7. Engineered Natural Materials” in Biomaterials Science: An Introduction to Materials in Medicine (Ratner, B.D., Hoffman, A.S., Lemmons, J.E., and Schoen, F.J., eds) pp. 195-209 (2013). Published, 12/2013.
  • G. D. Prestwich, T. Ghaly, P. Brudnicki, B. Ratliff, and M. S. Goligorsky, “Bioartificial Stem Cell Niches: Engineering a Regenerative Microenvironment,” Chapter 16, pp 245-256 in Regenerative Nephrology (M. S. Goligorsky, ed.), Elsevier Academic Press, London, San Diego (2011). Published, 12/2011.
  • R. C. Condie and G. D. Prestwich, “Designing Clinically Useful Substitutes for the Extracellular Matrix,” Chapter 1, B. Vernon, ed., Injectable Biomaterials: Science and Application, Woodhead Publishing, pp. 3-23 (2011). Published, 12/2011.
  • J. W. Kuo and G. D. Prestwich, “Chapter 73. Hyaluronic Acid” in Materials of Biological Origin – Materials Analysis and Implant Uses, Comprehensive Biomaterials, Vol. 2 (eds. P. Ducheyne, K. Healy, D. Hutmacher, J. Kirkpatrick), Elsevier pp. 239-259 (2011). Published, 12/2011.
  • D. Nguyen, O. Nguyen, H. Zhang, G. D. Prestwich, and M. M. Murph, “Reduction of Cell Proliferation and Viability in MeWo Melanoma Cells by a Bromophosponate Analog of Lysophosphatidic Acid,” Melanoma, ISBN:978-953-307-293-7. (March 8, 2011) https://www.intechopen.com/chapters/19958. Published, 03/08/2011.
  • N. V. Rao, G. D. Prestwich, J. R. Hoidal, and T. P. Kennedy, “Low Anti-Coagulant Heparins in the Treatment of Metastasis,” Melanoma, ISBN:978-953-307-293-7. (March 2011) https://www.intechopen.com/chapters/19093. Published, 03/2011.
  • Prestwich, G. (2008), "Visualizing and manipulating phosphoinositide and phospholipid signaling", in Austin, D. (ed.), Chemical Biology: The role of Chemistry in our fundamental understanding of Biology, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0331259-Prestwich). Published, 12/2008.
  • L. Feng and G.D. Prestwich & Taylor & Francis (2006). Functional Lipidomics. CRC Press. Published, 12/2006.

Copyrights

  • Methods for Preventing a Serious Health Consequence and/or Tissue Damage After Exposure to Ionizing Radiation and/or Chemotherapy, U. S. Patent 11,642,366. Won Yon Lee, Abigail Pulsipher, Justin P. Savage, Thomas P. Kennedy, Glenn D. Prestwich, 05/09/2023.
  • Deuterium-Enriched Hyaluronan, Canadian Patent CA 2,931,726. G. D. Prestwich, 03/15/2022.
  • Novel Multi-Well 3D Organoid Plates and High Throughput Methods for Preparing the 3D Organoids, U. S. Provisional Application 63/201,717. A. Skardal, G. D. Prestwich, 05/11/2021.
  • Deuterium-Enriched Hyaluronan, EP 3074427 B1. G. D. Prestwich, 02/02/2021.
  • Opioid independent surgical anesthetic, PCT No. TBA, Docket 6300.446.1a. B. Davis, A. Simpson, J. Agarwal, S. Wojtalewicz, J. Shea, H. Sant, B. Gale, G. D. Prestwich, 09/12/2020.
  • Methods and Compositions for Treating Chronic Rhinosinusitis, PCT US20/056419. Glenn D. Prestwich, Abigail Pulsipher , Thomas P. Kennedy, and Jeremiah Alt, 07/07/2020.
  • Deuterium-Enriched Hyaluronan, Israel Patent 245,741. G. D. Prestwich, 07/01/2020.
  • Deuterium-Enriched Hyaluronan, Hong Kong Patent HK 1,227,907. G. D. Prestwich, 04/24/2020.
  • Deuterium-Enriched Hyaluronan, Continuation 2, U. S. Patent 10,398,636. G. D. Prestwich, 09/03/2019.
  • Pharmaceutical Compositions Composed of Low Molecular Weight Sulfated Hyaluronanan, U. S. Patent 10,226,481. Glenn D. Prestwich, Siam Oottamasathien, Wanjian Jia, Lindsi McCoard, and Won Yong Lee, 04/12/2019.
  • Deuterium-Enriched Hyaluronan, Continuation, Australian Patent 2014352672. G. D. Prestwich, 03/14/2019.
  • Applications of Partially and Fully Sulfated Hyaluronans, U. S. Patent 10,179,147. Glenn D. Prestwich, Siam Oottamasathien and Thomas P. Kennedy, 01/15/2019.
  • Methods for Treating or Preventing Urological Inflammation, European Patent EP 2688402. Glenn D. Prestwich, Siam Oottamasathien, Wanjian Jia, Lindsi McCoard, and Won Yong Lee, 11/28/2018.
  • Methods for Potentiating Cancer Treatment using Ionizing Radiation, US Patent application Ser. No. 62/760,134. Won Yong Lee, Thomas P. Kennedy, and Glenn D Prestwich, 11/13/2018.
  • Deuterium-Enriched Hyaluronan, Continuation, U. S. Patent 9,849,073. G. D. Prestwich, 12/26/2017.
  • Applications of Partially and Fully Sulfated Hyaluronans, Japanese Patent No. 6230909. Glenn D. Prestwich, Siam Oottamasathien and Thomas P. Kennedy, 10/27/2017.
  • Methods and Compositions for Treating Chronic Rhinosinusitis, US Patent Application 62/573,903. Glenn D. Prestwich, Abigail Pulsipher , Thomas P. Kennedy, and Jeremiah Alt, 10/18/2017.
  • Bioconjugates with Chemically Modified Backbones, App. 62530056. John E. Paderi, Glenn D. Prestwich, Katherine A. Stuart, Harsha Kabra, Elvis Ikwa, 07/07/2017.
  • The Use of Alkylated Semi-synthetic Glycosaminoglycan Ethers for the Treatment of Inflammation, U. S. Patent 9,549,945. Glenn D. Prestwich, Jianxing Zhang , Thomas P. Kennedy, and Narayanam Rao, 01/24/2017.
  • Methods for Treating or Preventing Urological Inflammation, U. S. Patent 9,522,162. Glenn D. Prestwich, Siam Oottamasathien, Wanjian Jia, Lindsi McCoard, and Won Yong Lee, 12/20/2016.
  • Alkylated Semi-synthetic Glycosaminoglycan Ethers, and Methods of Making and of Use Thereof, Canadian Patent 2,719,666. Glenn D. Prestwich, Jianxing Zhang , N. Rao, X. Xu, and Thomas Kennedy, 08/16/2016.
  • a-Chloro and a-Bromo Phosphonate Analogs of Lysophosphatidic Acid and Methods of Making and Using Thereof, Canadian Patent 2,690,762. Glenn D. Prestwich, Gabor Tigyi, Guangui Zhang, Guowei Jiang, Joanna Gajewiak, and Honglu Zhang, 06/14/2016.
  • Bioconjugates and Uses Thereof, U. S. Patent Application 62/276,194. Glenn D. Prestwich, John E. Paderi, Julia Chen, and Rush L. Bartlett II, 04/15/2016.
  • Alkylated Semi-synthetic Glycosaminoglycan Ethers, and Methods of Making and of Use Thereof, Korean Patent 10-1594552. Glenn D. Prestwich, Jianxing Zhang , N. Rao, X. Xu, and Thomas Kennedy, 02/05/2016.
  • Deuterium-Enriched Hyaluronan, U. S. Patent 9,187,576. G. D. Prestwich, 11/17/2015.
  • The Use of Alkylated Semi-synthetic Glycosaminoglycan Ethers for the Treatment of Dental Disorders, U. S. Patent 8,951,990. Glenn D. Prestwich, Thomas Kennedy, Jianxing Zhang, and N. V. Rao, 02/10/2015.