Education
- B.S., Materials Chemistry, Nankai University
- Postdoc, Biochemistry and Molecular Biology, University of Chicago
- Ph.D., Chemistry, University of California Davis
Research Interests
The Wang lab is deeply intrigued by the mechanisms underlying the regulatory installation, recognition, and functions of important chemical modifications on RNA, such as pseudo uridine and inosine. To unravel these mysteries, we are commi8ed to pioneering novel cell based assays and studying these modifications in specific biological contexts, such as during the innate immune response and in disease status. Armed with a deeper understanding of the regulatory mechanisms governing modification installation and their functional outcomes, we aspire to achieve precise, site-directed modulation of specific modifications at chosen locations, thereby fine-tuning properties of critical disease-related RNAs. Furthermore, our research endeavors extend to the development of cutting-edge molecular devices designed for the exploration of spatial and temporal dynamics of essential RNA modifications within living cells. This will contribute to the toolkit to facilitate unprecedent studies of RNA modifications. Our ultimate objectives are to advance the development of innovative RNA therapeutics and uncover novel drug targets to combat human diseases.