WASEEM ANANI portrait
  • Associate Professor (Clinical), Pathology

Research Statement

My research interests are focused on improving Transfusion Medicine through better understanding of the immune response to transfusion, the production of bench-to-bench side assays, and improved utilization of emerging technologies. My undergraduate work at the University of Michigan informs my current approach to scientific questions. I use a sound logic and a methodical approach to answering questions in Transfusion Medicine. As an attending at Versiti (formally BloodCenter of Wisconsin), my focus was to combine basic science knowledge to answer clinical conundrums as a translational physician scientist. Interesting clinical cases arrived to the Versiti Immunohematology Reference Laboratory from around the world, which could not be resolved with standard clinical techniques. Interweaving modern basic science methods from my lab often resulted in a clinically actionable answer. The most significant projects I worked on included modernization of the rare donor database by using machine learning and data visualization to predict the loci of rare donors in the population, identification of ABO subgroups with glycan microarrays, red blood cell glycan lesions in sickle cell disease, and glycan antibody formation in COVID-19 convalescent plasma. 

In my current role at CBS, I will collaborate with local clinicians to improve blood safety, efficacy, and utilization. This will come in the form of Quality Utilization Efficacy Safety Transfusion (QUEST) projects and collaborations with CBS members in publishing novel findings in the National Immunohematology Reference Laboratory.

Languages

  • English, Fluent.

Publications

  • Anani W, Schmidt A, Denomme G, Hoffmeister K (date unknown). Hemolytic anti ABO antibodies (hemolysins) in transplant patients have a broader IgM and restricted IgG glycan recognition repertoire. (pp. 886-994). Vol. 29. Accepted, .
  • Anani WQ, Gorlin J, Denomme GA (date unknown). Anti-D selection for D assignment among pregnant women and blood donors: impact of the Crawford antigen. Vol. 60, 1378-1380. Accepted, .
  • Anani W, Dobrozsi S, Punzalan R (date unknown). Identification of Peanut allergen in a transfused blood product causing transfusion associated anaphylaxis. (pp. 1108-1109). Vol. 60. Accepted, .
  • Jug R, Anani W, Callum J (date unknown). A possible case of recipient anti-neutrophil and anti-human leukocyte antigen antibody-mediated fatal reverse transfusion-related acute lung injury. Vol. 61, 1336-1340. Accepted, .
  • Anani WQ, Smith GP, Irani M, Puca KE (date unknown). A report of cerebral malaria treated with automated red blood cell exchange. (pp. 985-988). Vol. 57. Accepted, .
  • Anani W, Amin M, Pantanowitz L, Parwani AV (date unknown). A series of collision tumors in the genitourinary tract with a review of the literature. Vol. 210, 217-23. Accepted, .
  • Anani W, Fox C, Peck Palmer OM (date unknown). A 72-year-old woman with markedly increased ferritin. (pp. 561-2). Vol. 61. Accepted, .
  • Denomme GA, Anani WQ (date unknown). ABO titers: harmonization and identifying clinically relevant ABO antibodies. Vol. 60, 441-443. Accepted, .
  • Kalyani D, Dick A, Anani W, Sanford M (date unknown). Scope and Selectivity in Palladium-Catalyzed Directed C-H Bond Halogenation Reactions. Vol. 62, 11483-11498. Accepted, .
  • Anani W, Triulzi D, Yazer MH, Qu L (date unknown). Relative IgA-deficient recipients have an increased risk of severe allergic transfusion reactions. Vol. 107, 389-92. Accepted, .
  • Pandey P, Anani WQ, Gottschall JL, Denomme GA (date unknown). Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions. Vol. 1, 1977-1982. Accepted, .
  • Anani WQ, Zeevi A, Lunz JG (date unknown). EDTA Treatment of Serum Unmasks Complement-Mediated Prozone Inhibition in Human Leukocyte Antigen Antibody Testing. Vol. 146, 346-52. Accepted, .
  • Cancelas JA, Genthe JR, Stolla M, Rugg N, Bailey SL, Nestheide S, Shaz B, Mack S, Schroeder K, Anani W, Szczepiorkowski ZM, Dumont LJ, Yegneswaran S, Corash L, Mufti N, Benjamin RJ, Erickson AC (date unknown). Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage. Accepted, .
  • Anani W, Wucinski J, Baumann Kreuziger L, Gottschall J, Karafin M (date unknown). Therapeutic plasma exchange in refractory warm autoimmune hemolytic anemia. Vol. 57, 1336. Accepted, .
  • Anani WQ, Marchan MG, Bensing KM, Schanen M, Piefer C, Gottschall JL, Denomme GA (date unknown). Practical approaches and costs for provisioning safe transfusions during anti-CD38 therapy. Vol. 57, 1470-1479. Accepted, .
  • Anani WQ, Duffer K, Kaufman RM, Denomme GA (date unknown). How do I work up pretransfusion samples containing anti-CD38?. Vol. 57, 1337-1342. Accepted, .
  • Kron A, Del Giudice ME, Sholzberg M, Callum J, Cserti-Gazdewich C, Swarup V, Huang M, Distefano L, Anani W, Skeate R, Armali C, Lin Y (date unknown). Daily versus every other day oral iron supplementation in patients with iron deficiency anemia (DEODO): study protocol for a phase 3 multicentered, pragmatic, open-label, pilot randomized controlled trial. Vol. 8, 98. Accepted, .
  • Bercovitz RS, Drew CS, Bushee CL, Popovsky MA, Friedman KD, Anani WQ (date unknown). A microfluidic analysis of thrombus formation in reconstituted whole blood samples comparing spray-dried plasma versus fresh frozen plasma. Vol. 116, 540-546. Accepted, .
  • Anani WQ, Gottschall J, Denomme GA (date unknown). Red cell genotyping of rare blood donors: donation behaviour and data visualization. Vol. 116, 601-608. Accepted, .
  • Lapadat R, Anani WQ, Bensing KM, Aeschlimann J, Vege S, Lomas-Francis C, Westhoff CM, Fadeyi EA, Denomme GA (date unknown). A pair of S-silencing single nucleotide variants cis-linked on GYPB. Vol. 61, E34-E36. Accepted, .
  • Anani WQ, Yassai MB, Bensing KM, Denomme GA (date unknown). Molecular characterization of three novel weak D type alleles with additional haplotype data on weak D Types 1.2 and 18. Vol. 57, 1092-1093. Accepted, .
  • Knier M, Schanen M, Piefer C, Bensing KM, Marchan M, Anani WQ, Denomme GA (date unknown). How to use a cloud-based search engine of a centralized donor database to identify historical antigen-negative units in hospital inventories. Vol. 60, 414-416. Accepted, .
  • Zieger B, Boeckelmann D, Anani W, Falet H, Zhu J, Glonnegger H, Full H, Andresen F, Erlacher M, Lausch E, Fels S, Strahm B, Lang P, Hoffmeister KM (date unknown). Novel GNE Gene Variants Associated with Severe Congenital Thrombocytopenia and Platelet Sialylation Defect. Accepted, .
  • Yazer MH, Anani WQ, Denomme GA, Karafin MS, Sayers M, Shaz BH, Biomedical Excellence for Safer Transfusion (BEST) Collaborative. (date unknown). Trends in antigen-negative red blood cell distributions by racial or ethnic groups in the United States. Vol. 58, 145-150. Accepted, .
  • Anani WQ, Ojerholm E, Shurin MR (date unknown). Resolving Transferrin Isoforms via Agarose Gel Electrophoresis. Vol. 46, 26-33. Accepted, .
  • Anani W, Adams J, Berkey F (date unknown). Churg Strauss. PEPID Primary Care Plus. Accepted, .
  • Anani W, Chu, C, Oury T (date unknown). A 30-year-old Male with a Right Corneal Abrasion. University of Pittsburgh Clinical Pathology Case of the Month. Accepted, .
  • Anani W, Parwani A (date unknown). A 21-year-old Female with a Bladder Mass. University of Pittsburgh Anatomic Pathology Case of the Month. Accepted, .
  • Anani W, Hariri R (date unknown). Microbiology Webcase. University of Pittsburgh Clinical Pathology Case of the Month. Accepted, .
  • Anani W, Myers P (date unknown). Thylogale stigmatica. Animal Diversity Web, University of Michigan. Accepted, .
  • Anani WQ, Ashwood HE, Schmidt A, Burns RT, Denomme GA, Hoffmeister KM (date unknown). Predictive modeling of complex ABO glycan phenotypes by lectin microarrays. Vol. 4, 3960-3970. Accepted, .
  • Kalyani D, Dick AR, Anani WQ, Sanford MS (date unknown). A simple catalytic method for the regioselective halogenation of arenes. Vol. 8, 2523-6. Accepted, .
  • Hull KL, Anani WQ, Sanford MS (date unknown). Palladium-catalyzed fluorination of carbon-hydrogen bonds. Vol. 128, 7134-5. Accepted, .
  • Pandey P, Anani WQ, Pugh T, Gottschall JL, Denomme GA (date unknown). Complement activating ABO anti-A IgM/IgG act synergistically to cause erythrophagocytosis: implications among minor ABO incompatible transfusions. Vol. 18, 216. Accepted, .
  • Ashwood HE, Ashwood C, Schmidt AP, Gundry RL, Hoffmeister KM, Anani WQ (date unknown). Characterization and statistical modeling of glycosylation changes in sickle cell disease. Vol. 5, 1463-1473. Accepted, .
  • Denomme GA, Reinders S, Bensing KM, Piefer C, Schanen M, Curnes J, Treml A, Gottschall JL, Anani WQ (date unknown). Use of a cloud-based search engine of a centralized donor database to identify historical antigen-negative units in hospital inventories. Vol. 60, 417-423. Accepted, .
  • Anani W, Bruggeman R, Zander DS (date unknown). β-catenin expression in benign and malignant pleural disorders. Vol. 4, 742-7. Accepted, .
  • Denomme GA, Anani WQ, Avent ND, Bein G, Briggs LB, Lapadat RC, Montemayor C, Rios M, St-Louis M, Uhl L, Wendel S, Flegel WA (date unknown). Red cell genotyping precision medicine: a conference summary. (pp. 277-291). Vol. 8. Accepted, .
  • Denomme GA, Anani WQ (date unknown). Mass-scale red cell genotyping of blood donors: from data visualization to historical antigen labeling and donor recruitment. (pp. 2768-2770). Vol. 59. Accepted, .
  • Anani W, Shurin MR (date unknown). Targeting Myeloid-Derived Suppressor Cells in Cancer. (pp. 105-128). Vol. 1036. Accepted, .