ALLISON FITZGERALD CAREY portrait
  • Assistant Professor, Pathology
801-585-5872

Research Statement

My lab’s goal is to understand how bacterial genetic diversity impacts clinically relevant phenotypes such as antibiotic resistance and vaccine escape. Our focus is pathogenic mycobacteria, including Mycobacterium tuberculosis, the causative agent of tuberculosis, and atypical mycobacteria, which can cause chronic infections in the immunocompromised. We use a combination of experimental and computational approaches, including functional genomics, bacterial population genetics, and high-throughput phenotyping. Our long-term goal is to use this knowledge to inform the development of improved diagnostics, antibiotics, and vaccines.

Languages

  • English, Fluent.

Publications

  • Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Ménard R (date unknown). Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Vol. 20, 618-630. Accepted, .
  • Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL (date unknown). Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. Vol. 14, e1007305. Accepted, .
  • Carey AF, Carlson JR (date unknown). Insect olfaction from model systems to disease control. Vol. 108, 12987-95. Accepted, .
  • Carey AF, Singer M, Bargieri D, Thiberge S, Frischknecht F, Ménard R, Amino R (date unknown). Calcium dynamics of Plasmodium berghei sporozoite motility. Vol. 16, 768-83. Accepted, .
  • Carey AF, Wang X, Cicchetti N, Spaulding CN, Liu Q, Hopkins F, Brown J, Sixsmith J, Sutiwisesak R, Behar SM, Ioerger TR, Fortune SM (date unknown). Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes. e0011022. Accepted, .
  • Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM (date unknown). TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. Vol. 14, e1006939. Accepted, .
  • Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR (date unknown). Odorant reception in the malaria mosquito Anopheles gambiae. Vol. 464, 66-71. Accepted, .
  • Wang G, Carey AF, Carlson JR, Zwiebel LJ (date unknown). Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. Vol. 107, 4418-23. Accepted, .
  • Martin CJ, Carey AF, Fortune SM (date unknown). A bug's life in the granuloma. Vol. 38, 213-20. Accepted, .
  • Carey AF, Ménard R, Bargieri DY (date unknown). Scoring sporozoite motility. Vol. 923, 371-83. Accepted, .
  • Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM (date unknown). Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. (pp. e1007846). Vol. 15. Accepted, .