Presentations

  • Invited Speaker “Inflammatory Cell Dynamics in the Stressed and Fibrotic Lung” NIEHS Seminar Series. Invited Talk/Keynote, Presented, 01/2023.
  • Invited Speaker “Spatial Investigation of Stress and Inflammation in the Healthy and Susceptible Lung” Cellular and Molecular Mechanisms of Toxicity Gordon Research Conference (2023) and SOT Mountain West Regional Chapter (2023). Invited Talk/Keynote, Presented, 01/2023.
  • Organizer and Chair, Symposium “Developmental Origins of Inflammatory and Immune Diseases: Identifying the Effects of In-Utero Stress on Immunological Competency” Society of Toxicology. Presentation, Presented, 01/2022.
  • “Air Pollution in the Aging Lung”. Geriatrics Division/GRECC Translational Research Grand Rounds, University of Utah. Presentation, Presented, 01/2022.
  • “The many faces of Environmental Exposure in the Health and Susceptible Lung”. Robert Wood Johnson Medical Hospital. Presentation, Presented, 01/2021.
  • Chair and Speaker, Block Symposium on Pathologies and Interventions “Role of CCR2+ Myeloid Cells in Pulmonary Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium”; American Association of Immunologists. Presentation, Presented, 01/2021.
  • "Modeling Environmental Exposure in the Healthy and Susceptible Lung". Center of Biomedical Research Excellence (COBRE) seminar series, Brown University. Presentation, Presented, 01/2021.
  • "Environmental and Genetic Drivers of Pulmonary Fibrosis”. University of California Davis. Presentation, Presented, 01/2020.
  • Organizer, Chair and Speaker, Continuing Education Symposium “Timing is Everything: Developmental Exposure Alters the Path of Immune Cell Maturation and Function”; Society of Toxicology. Presentation, Presented, 01/2020.
  • "Lung Epithelial Cell Stress Driven by Surfactant Protein-C Mutation Predisposes to Enhanced Susceptibility to Inhaled Toxicant Exposure”. Cellular and Molecular Mechanisms of Toxicity, Gordon Research Seminar. Presentation, Presented, 01/2019.
  • “Understanding Epithelial-Effector Cell Crosstalk in the Pathogenesis of Diffuse Parenchymal Lung Disease”. Symposium speaker and Chair, Society of Toxicology. Presentation, Presented, 01/2019.
  • Organizer, Chair and Speaker, Symposium “Immune-Epithelial Cell Crosstalk in Lung Toxicology and Disease”; Society of Toxicology. Presentation, Presented, 01/2019.
  • “Modulation of Myeloid Cell Recruitment and Activation by Alveolar Epithelial Type 2 Cells Drives Early Inflammation in a Murine Model of Mutant Surfactant Protein-C Pulmonary Fibrosis”. American Physiological Society - Experimental Biology. Presentation, Presented, 01/2018.
  • "Expression of a Pulmonary Fibrosis Associated Surfactant Protein C Mutant, SP-CI73T, in Alveolar type 2 Cells Induced Lung Inflammation and Aberrant Parenchymal Remodeling”. American Physiological Society - Experimental Biology. Presentation, Presented, 01/2017.
  • “Identification of Distinct Macrophage Subpopulations During Nitrogen Mustard-Induced. Presentation, Presented, 01/2016.
  • "Mechanisms of Macrophage Recruitment and Activation During Chemical-Induced Lung Injury and Fibrosis”. University of California San Francisco and University of Pennsylvania. Presentation, Presented, 01/2016.
  • "From the High School Classroom to the Laboratory Bench: Design of a One-Week Toxicology Summer Program”. Society of Toxicology Platform Session. Presentation, Presented, 01/2016.
  • Lung Injury and Fibrosis: Mechanisms of Recruitment and Activation”. University of North Carolina and East Carolina University. Presentation, Presented, 01/2016.
  • “Role of Macrophage Populations in Nitrogen Mustard-Induced Pulmonary Toxicity”. Universita’ degli studi di Urbino. Presentation, Presented, 01/2014.
  • “Regulation of Macrophage Activity by Histone Deacetylases during Nitrogen Mustard-Induced Lung Injury”. Joint Molecular Biosciences Graduate student association Annual Symposium. Presentation, Presented, 01/2014.

Grants, Contracts & Research Gifts

  • Epithelial-Immune Crosstalk During Acute Exacerbations of Pulmonary Fibrosis in the Aging Lung. PI: Venosa A. ALSAM Foundation Research Grant, 07/30/2021 - 05/31/2024. Total project budget to date: $0.00
  • Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis. PI: Venosa A. NIEHS, Outstanding New Environmental Scientist Award, 02/01/2021 - 11/30/2025. Total project budget to date: $0.00
  • Acute Inflammatory Exacerbations of Pulmonary Fibrosis in the Aging Lung. PI: Venosa A. University of Utah, Center on Aging Pilot Grant Program, 12/01/2020 - 11/30/2021. Total project budget to date: $0.00

Research Interests

Dr. Venosa is a pulmonary immunotoxicologist in the Department of Pharmacology and Toxicology. His research examines the effects of environmental air pollutants (ozone, particulate matter, cigarette smoke) on susceptible populations, with particular interest for genetic variants associated with pulmonary fibrosis. To address these research questions, his group utilizes clinically relevant and established models of lung susceptibility, including an in-house developed murine model of spontaneous pulmonary fibrosis driven by mutation on the surfactant protein C gene. By combining a wide variety of techniques (cell lineage tracing, bulk and single cell RNA-sequencing, metabolomics, lipidomics, etc..) his group is investigating signaling pathways involved in epithelial-immune cell crosstalk which could hold therapeutic value in pulmonary fibrosis.

Publications

  • Golden TN & Venosa A, Gow AJ (2022). Cell Origin and iNOS Function Are Critical to Macrophage Activation Following Acute Lung Injury. Front Pharmacol. Published, 01/2022.
  • Nguyen J & Armstrong BS, Tomer Y, Cowman S, Rayavara Veerabhadraiah S, Beers MF, and Venosa A (2022). Immunophenotyping of Acute Inflammatory Exacerbations of Lung Injury Driven by Mutant Surfactant Protein-C: A Role for Inflammatory Eosinophils. Front Pharmacol. Published, 01/2022.
  • Venosa A & Cowman S, Katzen J, Tomer Y, Armstrong BS, Mulugeta S and Beers MF (2021). Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium. Front. Immunol. Published, 01/2021.
  • Venosa A & Smith LC, Gow AJ, Zarbl H, Laskin JD, and Laskin DL (2021). Macrophage Activation in the Lung during the Progression of Injury Induced by Nitrogen Mustard is Associated with Histone Modifications and Altered miRNA Expression. Toxicol. Appl. Pharmacol. Published, 01/2021.
  • Golden T & Murray A, Venosa A, Gow AJ (2021). A comprehensive dataset to assess morphological changes subsequent to bleomycin exposure. Data Brief. Published, 01/2021.
  • Tomer Y & Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S (2021). The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling. Am J Physiol Lung Cell Mol Physiol. Published, 01/2021.
  • Murphy S & Kokkinaki D, Lam M, Venosa A, Sherrill-Mix S, Casu C, Rivella S, Weiner A, Park J, Shin S, Vaughan A, Hahn B, Meyer NJ, Hunter C, Worthen SG, Mangalmurti NS (2021). DNA binding to TLR9 expressed by Red Blood Cells promotes innate immune activation and anemia. Sci. Transl. Med. Published, 01/2021.
  • Venosa A & Gow JG, Taylor S, Golden TN, Murray A, Abramova E, Malaviya R, Laskin DL, Gow AJ (2021). Myeloid cell dynamics in bleomycin-induced pulmonary injury in mice; effects of anti-TNFα antibody. Toxicol Appl Pharmacol. Published, 01/2021.
  • Chen P & Zhang X, Venosa A, Lee IH, Myers D, Holloway JA, Prud'homme RK, Gao D, Szekely Z, Laskin JD, Laskin DL, Sinko PJ (2020). A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages. Pharmaceutics. Published, 01/2020.
  • Venosa A (2020). Senescence in Pulmonary Fibrosis: Between Aging and Exposure. Front Med (Lausanne). Published, 01/2020.
  • Sunil VR & Vayas KN, Abramova EV, Rancourt R, Cervelli JA, Malaviya R, Goedken M, Venosa A, Gow AJ, Laskin JD, Laskin DL (2020). Lung Injury, Oxidative Stress and Ffibrosis in Mice Following Exposure to Nitrogen Mustard. Toxicol Appl Pharmacol. Published, 01/2020.
  • Murray A & Gow AJ, Venosa A, Andres J, Malaviya R, Adler D, Yurkow E, Laskin JD, Laskin DL (2020). Assessment of Mustard Vesicant Lung Injury and Anti-TNF-α Efficacy in Rodents Using Live-Animal Imaging. Ann N Y Acad Sci. Published, 01/2020.
  • Smith LC & Venosa A, Gow AJ, Laskin JD, Laskin DL (2020). Transcriptional Profiling of Lung Macrophages During Pulmonary Injury Induced by Nitrogen Mustard. Ann N Y Acad Sci. Published, 01/2020.
  • Katzen J & Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF (2019). An SFTPC BRICHOS Mutant Links Epithelial ER Stress and Spontaneous Lung Fibrosis. JCI Insight. Published, 01/2019.
  • Venosa A & Smith LC, Murray A, Banota T, Gow AJ, Laskin JD, Laskin DL (2019). Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids. Toxicol Sci. Published, 01/2019.
  • Venosa A & Katzen J, Tomer Y, Kopp M, Jamil S, Russo SJ, Mulugeta S, Beers MF (2019). Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice. J Immunol. Published, 01/2019.
  • Nureki SI & Tomer Y, Venosa A, Katzen J, Russo SJ, Jamil S, Barrett M, Nguyen V, Kopp M, Mulugeta S, Beers MF (2018). Expression of Mutant Sftpc in Murine Alveolar Epithelia Drives Spontaneous Lung Fibrosis. J Clin Invest. Published, 01/2018.
  • Venosa A & Gow JG, Hall L, Malaviya R, Gow AJ, Laskin JD, Laskin DL (2017). Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol Sci. Published, 01/2017.
  • Malaviya R & Sunil VR, Venosa A, Vayas KN, Businaro R, Heck DE, Laskin JD, Laskin DL (2016). Macrophages and Inflammatory mediators in Pulmonary Injury Induced by Mustard Vesicants. Ann N Y Acad Sci. Published, 01/2016.
  • Weinberger B & Malaviya R, Sunil VR, Venosa A, Heck DE, Laskin JD, Laskin DL (2016). Mustard Vesicant-Induced Lung Injury: Advances in Therapy. Toxicol Appl Pharmacol. Published, 01/2016.
  • Venosa A & Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL (2016). Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis. Am J Respir Cell Mol Biol. Published, 01/2016.
  • Malaviya R & Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD, Laskin DL (2016). Inflammatory Mechanisms of Pulmonary Injury Induced by Mustards. Toxicol Lett. Published, 01/2016.
  • Venosa A & Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL (2015). Protective role of spleen - Derived Macrophages in Lung Inflammation, Injury, and Fibrosis Induced by Nitrogen Mustard. Am J Physiol Lung Cell Mol Physiol. Published, 01/2015.
  • Malaviya R & Sunil VR, Venosa A, Verissimo VL, Cervelli JA, Vayas KN, Hall L, Laskin JD, Laskin DL (2015). Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor-α Antibody. Toxicol Sci. Published, 01/2015.
  • Malaviya R & Venosa A, Hall L, Gow AJ, Sinko PJ, Laskin JD, Laskin DL (2012). Attenuation of Acute Nitrogen Mustard-Induced Lung Injury, Inflammation and Fibrogenesis by a Nitric Oxide Synthase Inhibitor. Toxicol Appl Pharmacol. Published, 01/2012.