LAURIE Whittaker LECLAIR portrait
  • Professor (Clinical), Internal Medicine

Presentations

  • Invited presentation, Hudson Headwaters Health Network, Glens Falls, NY. , , 2017.
  • Invited Presentation for Education Grand Rounds, Norwalk Hospital, Western Connecticut Health Network. , Presented, 2017.
  • Invited Educational Grand Rounds Presentation, Danbury Hospital, Western Connecticut Health Network. , Presented, 2017.
  • Invited presentation on Cystic Fibrosis and associated research project discussions. , Presented, 2012.
  • Invited presentation and research discussion. , Accepted, 2009.
  • Leclair LW. Pathogens of the CF Lung: More than just Pseudomonas. Dartmouth-Hitchcock Medical Center, Hanover, NH. , , 2009.
  • Invited presentations and research discussions. , Presented, 2008.
  • Invited presentation. , Presented, 2007.
  • Leclair LW. Care in a Cystic Fibrosis Center: A Model for Quality Improvement. Stanford University School of Medicine, Palo Alto, CA. , , 2007.
  • Leclair LW. Bacterial Products Alter the Immune Response to Fungal Antigens. IDeA Networks of Biomedical Research Excellence (INBRE) Regional Meeting, University of Vermont, Burlington, VT. , , 2007.
  • Leclair LW. CD4 T Cells and their Role in CF Lung Disease Pathogenesis. Mount Desert Island Biological Laboratory, Salisbury, ME. , , 2005.
  • Invited presentation and research discussion. , Presented, 2005.
  • Leclair LW. Aspergillus fumigatus Airway Infection in a Murine Model of Cystic Fibrosis. Fred Hutchinson Cancer Research Center, Seattle, WA. , , 2005.
  • Co-Lead of Invited Workshop at the North American Cystic Fibrosis Conference. , Accepted, 2022.
  • Co-Lead of Workshop at the Western Group on Educational Affairs (WGEA) Meeting. , Accepted, 2022.
  • Co-Lead workshop at the University of Utah Health Core Educator Retreat. , Presented, 2020.
  • Lead workshop at the University of Utah Health Core Educator Retreat. , Presented, 2020.
  • Co-Lead workshop at the University of Utah Health Core Educator Retreat. , Presented, 2019.
  • Oral Presentation at the North American Cystic Fibrosis Conference. , Presented, 2018.
  • Leclair LW. Coping with a code: Providing an academic framework to help third year medical students prepare for the practical and emotional reactions to attempted resuscitation. International Association of Medical Science Educators Annual Meeting, Burlington, VT. , , 2017.
  • Leclair LW. Overview of a CF Center. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Anaheim, CA. , , 2011.
  • Leclair LW. Lung Disease in the Adult with CF. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Anaheim, CA. , , 2011.
  • Leclair LW. Nocardia and Pseudomonas: A Microbial Balancing Act? North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Baltimore, MD. , , 2010.
  • Leclair LW. The Relevance of Bacterial-Fungal Interaction to CF. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Orlando, FL. , , 2008.
  • Leclair LW. Fungal Airway Infection Leading to Progressive Respiratory Failure. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Anaheim, CA. , , 2007.
  • Leclair LW. Bone Density Screening at an Adult CF Program. Northern New England Cystic Fibrosis Consortium, Woodstock, VT. , , 2007.
  • Leclair LW. What Happens When CF Patients Grow Old? North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Denver, CO. , , 2006.
  • Leclair LW. Establishing an Adult CF Program: A Physicians Perspective. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Denver, CO. , , 2006.
  • Leclair LW. Osteoporosis Screening in Adults with Cystic Fibrosis: The Vermont Adult Centers Approach. Northern New England Cystic Fibrosis Consortium Spring Meeting, Durham, NH. , , 2006.
  • Leclair LW. CD4 T Cell Response to Aspergillus fumigatus Exposure in CF. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Baltimore, MD. , , 2005.
  • Leclair LW. Bench to Bedside: An Update in CF Research at UVM. Northern New England CF Consortium Spring Meeting, Durham, NH. , , 2003.
  • Leclair LW. ΔF508 Mice Have Persistent Airway Inflammation After Induction of Allergic Airway Disease. North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, New Orleans, LA. , , 2002.
  • Small group discussion leader at American Medical Association -Accelerating Change in Medical Education March thematic consortium meeting. Other, Presented, 2021.
  • Howe A, Leclair L. Exploring the Intent to Communicate in the Interprofessional Critical Care Setting. Poster session presented at Annual Meeting of the International Association of Medical Science Educators, Burlington, VT. Poster, Presented, 2017.
  • Leclair LW, Stapleton RD, Parsons PE, Irvin C, Suratt BT. Assessment of Junior Faculty Attitudes Toward Mentoring. Poster session presented at Career Flexibility for Biomedical Faculty of Today and Tomorrow, Boston University Medical Campus, Boston, MA. Poster, Presented, 2015.
  • Lee AC, Farkas J, Clouser R, Hamlin M, Bender P, Leclair LW. A Structured Training Program in Basic Critical Care Echocardiography Incorporating Didactic, Simulation and Bedside Teaching to Promote Clinical Competence. Poster session presented at American Thoracic Society International Conference, San Diego, CA. Poster, Presented, 2014.

Grants, Contracts & Research Gifts

  • Educational Scholarship Award "Longitudinal Integrated Clerkships: Do they Improve Patient Outcomes?". PI: - 2019. Total project budget to date:
  • Coordination of Mental Health Services for CF Patients and Caregivers. PI: - 2018. Total project budget to date:
  • Therapeutics and Development Network Award. PI: - 2017. Total project budget to date:
  • Frymoyer Scholars Award. PI: - 2014. Total project budget to date:
  • Adult Care Program Quality Improvement Award. PI: - 2012. Total project budget to date:
  • Therapeutics and Development network Award. PI: - 2014. Total project budget to date:
  • Research Grant. PI: Griswold. - 2012. Total project budget to date:
  • Cystic Fibrosis Research and Development Program Award “Phosphatidyalcholine Utilization in Pseudomonas Infections” (Project 1). PI: Stanton, Dartmouth College of Medicine. - 2009. Total project budget to date:
  • Cystic Fibrosis Research and Development Program Award “Cystic Fibrosis Transmembrane Conductance Regulator’s (CFTR) Role in CD4 Effector T Cell Development” (Project 2). PI: Stanton, Dartmouth College of Medicine. - 2009. Total project budget to date:
  • Research Project Grant (R01) "Nitrogen Dioxide in the Sensitization to Allergic Airway Disease". PI: ME Poynter. - 2012. Total project budget to date:
  • Clinical Research Facilitation Award. PI: - 2008. Total project budget to date:
  • COBRE Competitive Renewal (P20) “CD4 Cells in CF: Lessons Learned from Asthma” (Project 5). PI: Irvin. - 2010. Total project budget to date:
  • CF Clinical Center Grant: Adult Program. PI: - 2016. Total project budget to date:
  • Pilot and Feasibility Award “The Role of Th2 Inflammation in CF Airway Disease”. PI: - 2006. Total project budget to date:
  • Research Award “Measurement of Bacterial Shedding in Cystic Fibrosis Clinics”. PI: - 2006. Total project budget to date:
  • Trustees’ Research Development Fund Award “Inhaled Insulin for Cystic Fibrosis-Related Diabetes”. PI: - 2006. Total project budget to date:
  • Research Project Grant (R01) “Diabetes Therapy to Improve Lung Function and BMI in Patients with CF and Impaired Glucose Tolerance”. PI: - 2007. Total project budget to date:
  • Center of Biomedical Research Excellence (P20) “Th2 Mediated Airway Inflammation in the ΔF508 Mouse” (Project 5). PI: Irvin. - 2005. Total project budget to date:
  • Research Fellow Training Grant. PI: Jack Elias. - 2002. Total project budget to date:

Languages

  • English, Fluent.

Publications

  • Whittaker LA, Bisognano JD (date unknown). Right-Sided Heart Failure and Severe Tricuspid Regurgitation After Mediastinal Radiation. (pp. 23-5). Vol. 22. Accepted, .
  • Whittaker LA, Irvin CG (date unknown). Going to extremes of lung volume. Vol. 102, 831-3. Accepted, .
  • Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, Whittaker LA, Rincon M (date unknown). Fungal allergen beta-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells. Vol. 45, 1133-41. Accepted, .
  • Teneback CC, Scanlon TC, Wargo MJ, Bement JL, Griswold KE, Leclair LW (date unknown). Bioengineered lysozyme reduces bacterial burden and inflammation in a murine model of mucoid Pseudomonas aeruginosa lung infection. Vol. 57, 5559-64. Accepted, .
  • Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L (date unknown). Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Vol. 27, 593-602. Accepted, .
  • Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA (date unknown). Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. Vol. 177, 5186-94. Accepted, .
  • Scanlon TC, Teneback CC, Gill A, Bement JL, Weiner JA, Lamppa JW, Leclair LW, Griswold KE (date unknown). Enhanced antimicrobial activity of engineered human lysozyme. Vol. 5, 809-18. Accepted, .
  • Bevelander M, Mayette J, Whittaker LA, Paveglio SA, Jones CC, Robbins J, Hemenway D, Akira S, Uematsu S, Poynter ME (date unknown). Nitrogen dioxide promotes allergic sensitization to inhaled antigen. Vol. 179, 3680-8. Accepted, .
  • Wargo MJ, Gross MJ, Rajamani S, Allard JL, Lundblad LK, Allen GB, Vasil ML, Leclair LW, Hogan DA (date unknown). Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection. Vol. 184, 345-54. Accepted, .
  • Neveu WA, Allard JB, Dienz O, Wargo MJ, Ciliberto G, Whittaker LA, Rincon M (date unknown). IL-6 is required for airway mucus production induced by inhaled fungal allergens. Vol. 183, 1732-8. Accepted, .
  • Hodgkins SR, Ather JL, Paveglio SA, Allard JL, LeClair LA, Suratt BT, Boyson JE, Poynter ME (date unknown). NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization. Vol. 11, 102. Accepted, .
  • Goodwin M, Sueblinvong V, Eisenhauer P, Ziats NP, LeClair L, Poynter ME, Steele C, Rincon M, Weiss DJ (date unknown). Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice. Vol. 29, 1137-48. Accepted, .
  • Kostyk AG, Dahl KM, Wynes MW, Whittaker LA, Weiss DJ, Loi R, Riches DW (date unknown). Regulation of chemokine expression by NaCl occurs independently of cystic fibrosis transmembrane conductance regulator in macrophages. Vol. 169, 12-20. Accepted, .
  • Paveglio SA, Allard J, Mayette J, Whittaker LA, Juncadella I, Anguita J, Poynter ME (date unknown). The tick salivary protein, Salp15, inhibits the development of experimental asthma. Vol. 178, 7064-71. Accepted, .
  • Entezari M, Weiss DJ, Sitapara R, Whittaker L, Wargo MJ, Li J, Wang H, Yang H, Sharma L, Phan BD, Javdan M, Chavan SS, Miller EJ, Tracey KJ, Mantell LL (date unknown). Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Vol. 18, 477-85. Accepted, .
  • Leclair LW, Dawson M, Howe A, Hale S, Zelman E, Clouser R, Garrison G, Allen G (date unknown). A longitudinal interprofessional simulation curriculum for critical care teams: Exploring successes and challenges. Vol. 32, 386-390. Accepted, .
  • Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, Irvin CG, Janssen-Heininger YM (date unknown). Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness. Vol. 177, 959-69. Accepted, .
  • Whittaker LA, Cohn L (date unknown). Recent Concepts in the Pathogenesis and Treatment of Asthma. Vol. 9, 135-44. Accepted, .
  • Amarbir S Gill, Abigail Pulsipher, Jorgen S Sumsion, Gretchen M Oakley, Laurie W Leclair, Heather Howe, Richard R Orlandi, Jeremiah A Alt (date unknown). Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status. Vol. 14, 405-13. Accepted, .
  • Gill AS, Pulsipher A, Sumsion JS, Oakley GM, Leclair LW, Howe H, Orlandi RR, Alt JA (date unknown). Transcriptional Changes in Chronic Rhinosinusitis with Asthma Favor a Type 2 Molecular Endotype Independent of Polyp Status. Vol. 14, 405-413. Accepted, .
  • Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE (date unknown). Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury. Vol. 37, 1322-8. Accepted, .
  • Griswold KE, Bement JL, Teneback CC, Scanlon TC, Wargo MJ, Leclair LW (date unknown). Bioengineered lysozyme in combination therapies for Pseudomonas aeruginosa lung infections. Vol. 5, 143-7. Accepted, .
  • Zhu J, Bean HD, Wargo MJ, Leclair LW, Hill JE (date unknown). Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints. Vol. 7, 016003. Accepted, .
  • Wargo MJ, Ho TC, Gross MJ, Whittaker LA, Hogan DA (date unknown). GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites. Vol. 77, 1103-11. Accepted, .
  • Allard JB, Rinaldi L, Wargo MJ, Allen G, Akira S, Uematsu S, Poynter ME, Hogan DA, Rincon M, Whittaker LA (date unknown). Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Vol. 39, 776-88. Accepted, .
  • Anathy V, Aesif SW, Hoffman SM, Bement JL, Guala AS, Lahue KG, Leclair LW, Suratt BT, Cool CD, Wargo MJ, Janssen-Heininger YM (date unknown). Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia. Vol. 189, 463-74. Accepted, .
  • Cohn L, Whittaker L, Niu N, Homer RJ (date unknown). Cytokine regulation of mucus production in a model of allergic asthma. Vol. 248, 201-13; discussion 213-20, 277-82. Accepted, .
  • Gonzalez KD, Zuckerman JB, Sears EH, Prato BS, Guill M, Craig W, Milliard C, Parker E, Lever T, Griffin MM, Leclair LW (date unknown). Exploring probiotic use in a regional cystic fibrosis consortium. (pp. e20-e21). Vol. 17. Accepted, .
  • Zuckerman JB, Clock SA, Prato BS, McDevitt JJ, Zhou JJ, Leclair LW, Lucas FL, Saiman L (date unknown). Air contamination with bacteria in cystic fibrosis clinics: implications for prevention strategies. (pp. 598-601). Vol. 191. Accepted, .
  • Gill AS, Smith KA, Meeks H, Oakley GM, Curtin K, Leclair L, Howe H, Orlandi RR, Alt JA (date unknown). Asthma increases long-term revision rates of endoscopic sinus surgery in chronic rhinosinusitis with and without nasal polyposis. (pp. 1197-1206). Vol. 11. Accepted, .
  • Whittaker LA (date unknown). Recent Advances in Cystic Fibrosis. Vol. 19, Lesson 1. Accepted, .
  • Whittaker LA, Kaminsky D, Irvin C (date unknown). Respiratory System in Extreme Environments. Vol. 17, Lesson 23. Accepted, .
  • Leclair LW, Hogan DA (date unknown). Mixed bacterial-fungal infections in the CF respiratory tract. (pp. S125-32). Vol. 48 Suppl 1. Accepted, .
  • Whittaker LA, Teneback C (date unknown). Atypical mycobacterial and fungal infections in cystic fibrosis. (pp. 539-46). Vol. 30. Accepted, .
  • Sueblinvong V, Whittaker LA (date unknown). Fertility and pregnancy: common concerns of the aging cystic fibrosis population. (pp. 433-43). Vol. 28. Accepted, .
  • Whittaker LA, Kaminsky D (date unknown). Respiratory Physiology in Extreme Environments. (pp. 282-8). Vol. 13. Accepted, .
  • Sueblinvong V, Whittaker LA (date unknown). Management Issues in Women with Cystic Fibrosis. (pp. 24). Vol. 9. Accepted, .