ANDREW G. ROBERTS portrait
  • Assistant Professor, Chemistry
  • Member, Biological Chemistry Program

Publications

  • Nwachukwu CI, McFadden TP & Roberts AG (2021). Ni-Catalyzed Iterative Alkyl Transfer from Nitrogen Enabled by the In Situ Methylation of Tertiary Amines. The Journal of organic chemistry. Vol. 85, 9979-9992. Published, 01/01/2021.
  • Ding H, Roberts AG & Harran PG (2020). Total Synthesis of Ageliferin via Acyl N-amidinyliminium Ion Rearrangement. Chemical science. Vol. 4, 303-306. Published, 09/01/2020.
  • Kirkeby EK & Roberts AG (2020). Design, synthesis and characterization of structurally dynamic cyclic N,S-acetals. Chemical communications (Cambridge, England). Vol. 56, 9118-9121. Published, 08/01/2020.
  • Ding H, Roberts AG, Chiang R & Harran PG (2019). Cascading Auto-oxidative Biproline Guanylations Form Optically Active Dispacamide Dimers and Permit an Eight-Step Synthesis of (-)-Ageliferin. The Journal of organic chemistry. Vol. 83, 7231-7238. Published, 11/01/2019.
  • Levinson AM, McGee JH, Roberts AG, Creech GS, Wang T, Peterson MT, Hendrickson RC, Verdine GL & Danishefsky SJ (2018). Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V). Journal of the American Chemical Society. Vol. 139, 7632-7639. Published, 12/01/2018.
  • Hui Ding, Andrew G. Roberts, Rocky Chiang & Patrick G. Harran (2018). Cascading Auto-oxidative Biproline Guanylations Form Optically Active Dispacamide Dimers and Permit an Eight-Step Synthesis of (−)-Ageliferin. Journal of Organic Chemistry. Vol. 83, 7231-7238. Published, 04/30/2018.
    https://pubs.acs.org/doi/10.1021/acs.joc.8b00631
  • Adam M. Levinson, John H. McGee, Andrew G. Roberts, Gardner G. Creech, Ting Wang, Michael T. Peterson, Ronald C. Hendrickson, Gregory L. Verdine & Samuel J. Danishefsky (2017). Total Chemical Synthesis and Folding of all-L and all-D Variants of Oncogenic KRas(G12V). Journal of the American Chemical Society. Vol. 139, 7632 - 7639. Published, 04/27/2017.
    https://pubs.acs.org/doi/abs/10.1021/jacs.7b02988
  • Roberts AG, Johnston EV, Shieh JH, Sondey JP, Hendrickson RC, Moore MA & Danishefsky SJ (2016). Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides. Journal of the American Chemical Society. Vol. 137, 13167-75. Published, 07/01/2016.
  • Andrew G. Roberts, Eric V. Johnston, Jae-Hung Shieh, Joseph P. Sondey, Ronald C. Hendrickson, Malcolm A. S. Moore & Samuel J. Danishefsky (2015). Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides. Journal of the American Chemical Society. Vol. 137, 13167 - 13175. Published, 09/24/2015.
    https://pubs.acs.org/doi/abs/10.1021/jacs.5b08754
  • Andrew G. Roberts (2013). Symmetry-Based Access to Polycyclic Bis-guanidines: Total Synthesis of (±)-Ageliferin and the Complete Axinellamine Ring System. ProQuest LLC. Published, 09/13/2013.
    https://escholarship.org/uc/item/7d94j8wz
  • Hui Ding, Andrew G. Roberts & Patrick G. Harran (2012). Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement. Chemical Science. Vol. 4, 303 - 306. Published, 10/24/2012.
    http://pubs.rsc.org/en/Content/ArticleLanding/2013...
  • Ding H, Roberts AG & Harran PG (2012). Synthetic (±)-axinellamines deficient in halogen. Angewandte Chemie (International ed. in English). Vol. 51, 4340-3. Published, 09/01/2012.
  • Hui Ding, Andrew G. Roberts & Patrick G. Harran (2012). Synthetic (±)-Axinellamines Deficient in Halogen. Angewandte Chemie Int. Ed. Vol. 51, 4340 - 4343. Published, 03/19/2012.
  • Qingyi Li, Paul Hurley, Hui Ding, Andrew G. Roberts, Radha Akella & Patrick G. Harran (2009). Exploring Symmetry-Based Logic for a Synthesis of Palau’amine. Journal of Organic Chemistry. Vol. 74, 5909 - 5919. Published, 07/16/2009.
    https://pubs.acs.org/doi/abs/10.1021/jo900755r

Research Statement

ORGANIC & BIOORGANIC CHEMISTRY - Reaction discovery, design and catalysis development for the chemical synthesis of small molecules and structurally unique peptide-based therapeutics. 

Presentations

  • Ghorai, A.; Roberts, A. G.* “Exploring Acyl Transfer Equilibration Strategies for the Chemical Synthesis of Lasso Peptides” (poster, July 31/Aug 1), Gordon Research Conference, Natural Products and Bioactive Compounds, Proctor Academy, Andover, NH. July 28 – August 2, 2019. Poster, Accepted, 07/2019.
  • Roberts, A. G. “Tools for Chemical Protein Synthesis” University of Utah, Department of Pharmaceutics & Pharmaceutical Chemistry, Salt Lake City, UT. November 26th, 2018. Contributed Talk, Presented, 11/26/2018.