Thomas A. Zangle portrait
  • Associate Member, Cell Response and Regulation Program, Huntsman Cancer Institute
  • Assistant Professor, Chemical Engineering
(801) 587-9058

Publications

  • Mitchell S, Roy K, Zangle TA & Hoffmann A (2018). Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. Published, 03/07/2018.
    https://doi.org/10.1073/pnas.1715639115
  • Huang D, Leslie KA, Guest D, Yeshcheulova O, Roy IJ, Piva M, Moriceau G, Zangle TA, Lo RS, Teitell MA & Reed J (2018). High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity. Analytical chemistry. Published, 01/30/2018.
    https://pubs.acs.org/doi/abs/10.1021/acs.analchem....
  • Kim D. (2017). Soft lithography fabrication of index-matched microfluidic devices for reducing artifacts in fluorescence and quantitative phase imaging. Microfluidics and Nanofluidics. Vol. 22, 1-11. Published, 12/01/2017.
    https://link.springer.com/article/10.1007/s10404-0...

Research Statement

The Zangle Lab applies the principles of fluid mechanics and mass transport to study transport in single cells using both established and emerging microscopy techniques. Current work focuses on the use of quantitative phase microscopy (QPM) to quantify mass distributions within single cells and multicellular clusters. The resulting measurements can be used to assess the total mass of, or the transport of mass within, individual cells.

Research Keywords

  • Microscopy
  • Microfluidics
  • Fluid Mechanics
  • Cancer Biology
  • Breast Cancer

Research Equipment and Testing Expertise

  • My lab works with quantitative phase microscopy, a label free method to measure the mass of single, living cells.