Anna R. Docherty, PhD portrait
  • Assistant Professor, Psychiatry
  • Assistant Professor, Interdisciplinary Program in Neuroscience
  • Affiliate Assistant Professor, Virginia Institute for Psychiatric & Behavioral Genetics

Research Keywords

  • Statistics
  • Statistical Genetics
  • Schizophrenia
  • Psychopathology
  • Psychiatric Genomics
  • Psychiatric Genetics
  • Molecular Genetics
  • Depression

Research Equipment and Testing Expertise

  • R, LDpred, GCTA, Plink, SAS, MPlus, OpenMx, Mx, Merlin.
  • Unix shell (bash), Perl, Python.

Languages

  • French, basic.

Geographical Regions of Interest

  • Asia
    Much of psychiatric genetics has been limited to populations of Northern European ancestry. Dr. Docherty particularly interested in how this research translates to genetic variation in populations with ancestry in Southeast Asia, Northern and Middle Africa, Latin America, South America, Indigenous North America, and India. She is also interested in how immigration and cultural displacement reflect distinct (and preventable) psychiatric sequelae.

Publications

  • Docherty, A. R., Moscati, A., Savage, J., Salvatore, J., Cooke, M., Aliev, F., Moore, A., Edwards, A. C., Adkins, D. E., Webb, B. T., Dick, D., Bacanu, S. A. & Kendler, K. S. (2017). Polygenic prediction of the phenome in emerging adulthood. In review, Psychological Science. Pending, 01/03/2017.
  • Merrill, A. M., Karcher, N. R., Cicero, D. C., Becker, T. M., Docherty, A. R., & Kerns, J. G. (2017). Evidence that communication impairment in schizophrenia is associated with generalized poor task performance. Psychiatry Research. In press, 01/03/2017.
  • Sawyers, C.,* Moore, A. A., Adkins, D. E, & Docherty, A. R. (2017). Opportunities for an enhanced integration of neuroimaging and genomics in psychiatry. *student. Submitted, 01/02/2017.
  • Docherty, A. R., Moscati, A., Adkins, D. E., Corvin, A., O'Neil, F. A., Riley, B. P., Kendler, K. S., Sullivan, P. F., Fanous, A. H. & Bacanu, S. A. (2017). Proof of concept: Genetic classification of schizophrenia risk using molecular pathways. In progress, 01/02/2017.
  • Docherty, A.R. (2017). Editorial: Genetic susceptibility to depression and obesity. British Journal of Psychiatry. In press, 01/01/2017.
  • Docherty, A. R., Lano, T., Adkins, D. E., Sponheim, S. R., & Kerns, J. G. (2017). Effort-based decision making and genetic liability for schizophrenia. Submitted, 01/01/2017.
  • Edwards, A. C., Docherty, A. R., Moscati, A., Bigdeli, T. B., Peterson, R., Hettema, J., Flint, J., & Kendler, K. S. (2017). Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in a Han Chinese sample. In review at Psychological Medicine. Submitted, 12/28/2016.
  • Eyler, L. T., Gough, S., Mischel, A. K., Elman, J. A., Hagler, D. J., Franz, C. E., Docherty, A. R., Dale, A. M. & Kremen, W. S. (2017). Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment? A Systematic Review. In review at Biological Psychiatry. Submitted, 12/21/2016.
  • Gillespie, N. A., Neale, M. C., Bates, T. C., Docherty, A. R., Eyler, L. T., Fennema-Notestine, C., Vassileva, J., Lyons, M. J., Prom-Wormley, E. C., Hickie, I. B., McGrath, J. J., Martin, N. G., Panizzon, M. S., Franz, C. E., Kremen, W. S., & Wright, M. J. (2017). Testing associations between cannabis use and subcortical volumes in two large population-based samples: Importance of accounting for co-occurring nicotine and multi-substance use. Submitted, 12/15/2016.
  • Docherty, A. R., Bigdeli, T. B., Yang, Z., Edwards, A. C., Peterson, R., Webb, B. T., Bacanu, S. A., Flint, J., Kendler, K. S., CONVERGE Consortium. (2017). Age at onset & family history of major depression: polygenic association with major depression? Depression and Anxiety. In press, 10/14/2016.
  • Docherty, A. R., Moscati, A. A. & Fanous, A. H. (2016). Cross-disorder psychiatric genomics. Current Behavioral Neuroscience Reports.. Published, 08/02/2016.
  • Docherty, A. R., Moscati, A., Peterson, R., Edwards, A. C., Bigdeli, T. B., Adkins, D. E., Webb, B. T., Bacanu, S. A., Flint, J., Kendler, K. S. (2016). SNP-Based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: Findings from CONVERGE. Translational Psychiatry.. Published, 08/01/2016.
  • Edwards, A. C., Aggen, S. H., Cai, N., Bigdeli, T. B., Peterson, R. E., Docherty, A. R., Webb, B. T., Flint, J., & Kendler, K. S. (2016). Chronicity of depression and molecular markers in a large sample of Han Chinese women. Depression & Anxiety. Published, 08/01/2016.
  • Docherty, A. R. (2016). Genomic approaches to phenotype prediction. JAMA Psychiatry.. Published, 01/07/2016.
  • Docherty, A. R., Kremen, W., Panizzon, M., Franz, C., Lyons, M. J., Eaves, L., & Neale, M. C. (2015). Comparison of twin and extended pedigree designs for obtaining heritability estimates. Behavior Genetics. Published, 12/07/2015.
  • Docherty, A. R., Panizzon, M., Neale, M. C., Chen, C., Fiecas, M., Elyer, L. T., Fennema-Notestine, C., Hagler, D., Fischl, B., Franz, C., Jak, A., Lyons, M. J., Rinker, D., Thompson, W. K., Tsuang, M., Dale, A., & Kremen, W. (2015). Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? In press at NeuroImage.. Published, 10/08/2015.
  • Cicero, D. C., Docherty, A. R., Becker, T. M., Martin, E. A., & Kerns, J. K. (2015). Aberrant salience, self-concept clarity, and interview-rated psychotic-like experiences. Personality Disorders: Theory, Research, and Treatment. . Published, 08/07/2015.
  • Docherty, A. R., Panizzon, M., Sawyers, C. K., Neale, M. C., Elyer, L. T., Fennema-Notestine, C., Hagler, D., Fischl, B., Franz, C., Thompson, W. K., Tsuang, M., Dale, A., & Kremen, W. (2015). Genetic network properties of the human cortex based on regional thickness and surface area measures. Frontiers in Human Neuroscience. Published, 08/03/2015.
  • Docherty, A. R., Bigdeli, T. B., Edwards, A. C., Bacanu, S., Lee, D., Neale, M. C., M., Wormley, B. S., Walsh, D., O’Neill, F. A., Riley, B. P., Kendler, K. S. & Fanous, A. H. (2015). Gene-based and gene pathway analysis of symptom dimensions of psychotic illness based on schizophrenia-specific model of the OPCRIT. Schizophrenia Research. . Published, 08/03/2015.
  • Edwards, A. C., Bigdeli, T. B., Docherty, A. R., Bacanu, S., Lee, D., DeCandia, T., Moscati, A., Thiselton, D. M., Maher, B. S., Wormley, B. S., Walsh, D., O’Neill, F. A., Kendler, K. S., Riley, B. P. & H. Fanous, A. H. (2015). Meta-analysis of positive and negative symptoms reveals schizophrenia modifier genes. Schizophrenia Bulletin. Published, 08/03/2015.
  • Docherty, A. R. (2015). Regarding brain structural abnormalities in intellectually superior schizophrenia. Psychiatry Research: Neuroimaging.. Published, 08/03/2015.
  • Docherty, A. R., Sponheim, S. R., & Kerns, J. G. (2015) Self-reported affective traits and current affective experience in biological relatives of people with schizophrenia. Schizophrenia Research.. Published, 08/03/2015.
  • Panizzon, M., Neale, M. C., Docherty, A. R., Franz, C., Jacobson, K., Fiecas, M., Toomey, R., Xian, H., Vasilopoulos, T., Rana, B., McKenzie, R., Lyons, M. & Kremen, W. (2015). Genetic and environmental architecture of changes in episodic memory from middle to late middle age. Psychology and Aging.. Published, 01/02/2015.
  • Docherty, A. R. & Sponheim, S. R. (2014). Anhedonia as an Indicator of Genetic Liability to Schizophrenia. M. Ritsner (Ed.), Anhedonia: A Comprehensive Handbook. Dordrecht: Springer. Published, 08/01/2014.
  • Docherty, A. R., Cicero, D. C., Becker, T. M., & Kerns, J. G. (2014). Self-reported ambivalence in schizophrenia and associations with negative mood. Journal of Nervous and Mental Disease. Published, 08/01/2014.
  • Docherty, A. R., Sponheim, S. R., & Gizer, I. A. (2014). DISC1 loci not associated with anhedonia in individuals with genetic liability for schizophrenia. Psychiatric Genetics. . Published, 08/01/2014.
  • Cicero, D. C., Becker, T. M., Martin, E. A., Docherty, A. R., & Kerns, J. K. (2014). Correspondence between psychometric and clinical high risk for psychosis. Psychological Assessment. Published, 08/01/2014.
  • Docherty, A. R., Sponheim, S. R., & Kerns, J. G. (2014). Further examination of ambivalence in relation to the schizophrenia spectrum. Schizophrenia Research. Published, 08/01/2014.
  • Eaton, N. R., Krueger, R. F., Docherty, A. R. & Sponheim, S. R. (2014). Toward a Model-Based Approach to the Clinical Assessment of Personality Psychopathology. Journal of Personality Assessment.. Published, 08/01/2014.
  • January, A. M., Meyerson, D. A., Reddy, L. F., Docherty, A. R., & Klonoff, E. A. (2014). Impressions of misconduct: Clinical psychology doctoral students’ perceptions of faculty ethical violations. Training and Education in Professional Psychology.. Published, 08/01/2014.
  • Vrieze, S. I., Docherty, A. R., Arbisi, P., Thuras, P., Abecasis, C., Erbes, C. R., Siegel, W., Iacono, W., Sponheim, S. R., & Leskela, J. (2014). The electronic medical record is an invaluable clinical tool. Let’s start using it. Psychiatric Services. Published, 01/01/2014.
  • Cicero, D. C. Becker, T. M., Martin, E. A., Docherty, A. R., & Kerns, J. G. (2013). The role of aberrant salience and low self-concept clarity in psychotic-like experiences. Personality Disorders, 4, 33-42. Published, 08/01/2013.
  • Docherty, A. R., Coleman, M. J., Deutsch, C., Tu, X., Mendell, N. R., & Levy, D. L. (2012). Comparison of putative endophenotypes in schizophrenia patients with and without obsessive-compulsive disorder symptoms: Examining evidence for the schizo-obsessive subtype. Schizophrenia Research, 140, 83-86. Published, 08/01/2012.
  • Martin, E. A., Becker, T. M., Cicero, D. C., Docherty, A. R. & Kerns, J. G. (2011). Differential associations between schizotypy facets and aspects of attention to emotion. Psychiatry Research, 187, 94-99. Published, 08/01/2011.
  • Docherty, A. R., Berenbaum, H. & Kerns, J. G. (2011). Alogia and formal thought disorder: differential patterns of verbal fluency task performance. Journal of Psychiatric Research, 45, 1352-1357. Published, 08/01/2011.
  • Docherty, A. R. (2010). Society for International Research of Schizophrenia essay awards: A unifying hypothesis for the pathogenesis of schizotypal anhedonia. Schizophrenia Research Forum, www.schizophreniaforum.org/ images/ SRFSIRSEssaytop12.pdf. Accessed January 1, 2014. Published, 08/01/2010.
  • Grijalva, F. E., Ford, J. D., Docherty, A. R., Fricker-Elhai, A. E., & Elhai, J. D. (2008). Sociodemographic associations with mental health and residential care utilization among juvenile delinquents. Psychological Services, 5, 153-160. Published, 08/01/2008.
  • Kerns, J. G., Docherty, A. R. & Martin, E. A. (2008). Social and physical anhedonia and valence and arousal aspects of emotional experience. Journal of Abnormal Psychology, 117, 735-746. Published, 08/01/2008.
  • Docherty, A. R. & Sponheim, S. R. (2008). Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophrenia. Journal of Abnormal Psychology, 117, 788-798. Published, 08/01/2008.
  • Elhai, J. D., Gray, M. J., Docherty, A. R., Kashdan, T. B., & Kose, S. (2007). Structural validity of the posttraumatic stress disorder checklist among college students with a trauma history. Journal of Interpersonal Violence, 22, 1471-1478. Published, 08/01/2007.