• Associate Professor, Medicinal Chemistry


  • Lik Hang Yuen, Raphael M. Franzini. Stability of Oligonucleotide-Small MoleculeConjugates to DNA-deprotection Conditions. Poster session presented at Second Boston Symposium of Encoded Library Platforms, Boston, MA. Poster, Presented, 2017.
  • Raphael M. Franzini. “Cap-and-Catch” Purification of DNA-Encoded Chemical Libraries. Poster session presented at First Boston Symposium of Encoded Library Platforms, Boston, MA. Poster, Presented, 2015.


  • English, Fluent.


  • Xu M, Galindo-Murillo R, Cheatham TE, Franzini RM (date unknown). Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights. Vol. 15, 9855-9865. Accepted, .
  • Franzini RM, Randolph C (date unknown). Chemical Space of DNA-Encoded Libraries. Vol. 59, 6629-44. Accepted, .
  • Tu J, Xu M, Parvez S, Peterson RT, Franzini RM (date unknown). Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. Vol. 140, 8410-8414. Accepted, .
  • Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, Brown PJ, Näreoja K, Schüler H, Scheuermann J, Franzini R, Neri D (date unknown). A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition. Vol. 13, 1303-1307. Accepted, .
  • Tu J, Svatunek D, Parvez S, Liu AC, Levandowski BJ, Eckvahl HJ, Peterson RT, Houk KN, Franzini RM (date unknown). Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles. Vol. 58, 9043-9048. Accepted, .
  • Tu J, Xu M, Franzini RM (date unknown). Dissociative Bioorthogonal Reactions. Vol. 20, 1615-1627. Accepted, .
  • Xu M, Tu J, Franzini RM (date unknown). Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives. Vol. 53, 6271-6274. Accepted, .
  • Yuen LH, Franzini RM (date unknown). Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View. Vol. 18, 829-836. Accepted, .
  • Yuen LH, Franzini RM (date unknown). Stability of Oligonucleotide-Small Molecule Conjugates to DNA-Deprotection Conditions. Vol. 28, 1076-1083. Accepted, .
  • Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schüler H, Franzini RM (date unknown). A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes. Vol. 141, 5169-5181. Accepted, .