VAHE BANDARIAN portrait
  • Associate Dean for Student Affairs, College Of Science-Dean
  • Professor, Chemistry
801-581-6366

Publications

  • Bommisetti P (2023). Insights into the Mechanism of Installation of 5-Carboxymethylaminomethyl Uridine Hypermodification by tRNA-Modifying Enzymes MnmE and MnmG. Journal of the American Chemical Society. Vol. 145, 269472696126947-26961. Published, 12/01/2023.
  • Fleming AM & Bommisetti P (2023). Direct Nanopore Sequencing for the 17 RNA Modification Types in 36 Locations in the E. coli Ribosome Enables Monitoring of Stress-Dependent Changes. ACS chemical biology. Vol. 18, 221122232211-2223. Published, 10/01/2023.
  • Eastman KAS (2023). Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation. The Journal of biological chemistry. Vol. 299, 105058105058. Published, 09/01/2023.
  • Rush KW & Eastman KAS (2023). Peptide Selenocysteine Substitutions Reveal Direct Substrate-Enzyme Interactions at Auxiliary Clusters in Radical S-Adenosyl-l-methionine Maturases. Journal of the American Chemical Society. Vol. 145, 101671017710167-10177. Published, 05/01/2023.
  • Greenhalgh ED & Kincannon W (2022). Spectroscopic and Computational Investigation of the Epoxyqueuosine Reductase QueG Reveals Intriguing Similarities with the Reductive Dehalogenase PceA. Biochemistry. Vol. 61, 195-205. Published, 02/01/2022.
  • Lewis JK, Jochimsen AS, Lefave SJ & Young AP (2021). New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products. Biochemistry. Vol. 60, 3347-3361. Published, 12/01/2021.
  • Young AP (2021). Eukaryotic TYW1 Is a Radical SAM Flavoenzyme. Biochemistry. Vol. 60, 2179-2185. Published, 11/01/2021.
  • Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP & van der Donk WA (2021). New developments in RiPP discovery, enzymology and engineering. Natural product reports. Vol. 38, 130-239. Published, 02/01/2021.
  • Miller SA & Bandarian V (2019). Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes. Journal of the American Chemical Society. Vol. 141, 11019-11026. Published, 07/01/2019.
  • Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V & Drennan CL (2019). Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein science : a publication of the Protein Society. Vol. 28, 202-215. Published, 01/2019.
  • Grell & Kincannon, Bruender, Blaesi, Krebs, Bandarian, Drennan (2018). Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase. Journal of Biological Chemistry. Vol. 293, 17349-17361. Published, 11/2018.
  • Walker & Kincannon, Bandarian, Elliott (2018). Deconvoluting the Reduction Potentials for the Three [4Fe-4S] Clusters in an AdoMet Radical SCIFF Maturase. Biochemistry. Vol. 57, 6050-6053. Published, 10/2018.
  • Kincannon & Bruender, Bandarian (2018). A Radical Clock Probe Uncouples H Atom Abstraction from Thioether Cross-Link Formation by the Radical S-Adenosyl-l-methionine Enzyme SkfB. Biochemistry. Vol. 57, 4816-4823. Published, 07/2018.
  • Bandarian (2018). Methods in Enzymology/Radical SAM Enzymes. Vol. 606. Elsevier. Published, 07/2018.
  • Bandarian (2018). Preface. Elsevier. Published, 07/2018.
  • Grell & Young, Drennan, Bandarian (2018). Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1. Journal of the American Chemical Society. Vol. 140, 6842-6852. Published, 05/2018.
  • Wilcoxen & Bruender, Bandarian, Britt (2018). A Radical Intermediate in Bacillus subtilis QueE during Turnover with the Substrate Analogue 6-Carboxypterin. Journal of the American Chemical Society. Vol. 140, 1753-1759. Published, 01/2018.
  • Nelp, MT, Young, AP, Stepanski, BM & Bandarian, V (2017). Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role. ACS. Vol. 56, 3874-3876. Published, 08/01/2017.
  • Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL & Bandarian V (2017). 7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies. Journal of the American Chemical Society. Vol. 139, 1912-1920. Published, 01/01/2017.
  • Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V & Drennan CL (2016). Molecular basis of cobalamin-dependent RNA modification. Nucleic acids research. Vol. 44, 9965-9976. Published, 09/01/2016.
  • Bruender NA & Bandarian V (2016). SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation. Biochemistry. Vol. 55, 4131-4. Published, 08/01/2016.
  • Bruender NA & Bandarian V (2016). The Radical S-Adenosyl-l-methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide. Biochemistry. Vol. 55, 2813-6. Published, 05/01/2016.
  • Nelp MT, Song Y, Wysocki VH & Bandarian V (2016). A Protein-derived Oxygen Is the Source of the Amide Oxygen of Nitrile Hydratases. The Journal of biological chemistry. Vol. 291, 7822-9. Published, 04/01/2016.
  • Bruender NA, Wilcoxen J, Britt RD & Bandarian V (2016). Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link. Biochemistry. Vol. 55, 2122-34. Published, 04/01/2016.
  • Bruender NA, Young AP & Bandarian V (2016). Correction to Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine Synthase. (pp. 1939). Vol. 55. Biochemistry. Published, 03/01/2016.
  • Song Y, Nelp MT, Bandarian V & Wysocki VH (2016). Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information. ACS central science. Vol. 1, 477-487. Published, 01/01/2016.
  • Bandarian V & Drennan CL (2015). Radical-mediated ring contraction in the biosynthesis of 7-deazapurines. Current opinion in structural biology. Vol. 35, 116-24. Published, 12/01/2015.
  • Nelp MT & Bandarian V (2015). A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate. Angewandte Chemie (International ed. in English). Vol. 54, 10627-9. Published, 09/01/2015.
  • Miles ZD, Myers WK, Kincannon WM, Britt RD & Bandarian V (2015). Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine. Biochemistry. Vol. 54, 4927-35. Published, 08/01/2015.
  • Young AP & Bandarian V (2015). Mechanistic Studies of the Radical S-Adenosyl-L-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction. Biochemistry. Vol. 54, 3569-72. Published, 06/01/2015.
  • Bruender NA, Young AP & Bandarian V (2015). Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase. Biochemistry. Vol. 54, 2903-10. Published, 05/01/2015.
  • Lajoie DM, Roberts SA, Zobel-Thropp PA, Delahaye JL, Bandarian V, Binford GJ & Cordes MH (2015). Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders. The Journal of biological chemistry. Vol. 290, 10994-1007. Published, 04/01/2015.

Presentations

  • Understanding and leveraging radical SAM enzyme reactivity towards novel scaffolds, Calvin University, Grand Rapids. Invited Talk/Keynote, Presented, 11/2023.
  • Understanding and leveraging radical SAM enzyme reactivity towards novel scaffolds, College of Wooster, Wooster . Invited Talk/Keynote, Presented, 11/2023.
  • Understanding and leveraging radical SAM enzyme reactivity towards novel scaffolds”, University of Michigan, Ann Arbor. Invited Talk/Keynote, Presented, 10/2023.
  • Mechanism and selectivity in peptide thioether crosslinks catalyzed by radical SAM enzymes, University of Wisconsin, Milwaukee. Invited Talk/Keynote, Presented, 04/2023.
  • Mechanism and selectivity in peptide thioether crosslinks catalyzed by radical SAM enzymes, University of Vermont. Invited Talk/Keynote, Presented, 03/2023.
  • Mechanism and selectivity in peptide thioether crosslinks catalyzed by radical SAM enzymes, Texas A & M. Invited Talk/Keynote, Presented, 02/2023.
  • Enzyme Mechanisms Conference. Invited Talk/Keynote, Presented, 01/2022.
  • Reconstitution of biosynthetic pathways one step at a time, University of Pennsylvania. Invited Talk/Keynote, Presented, 10/2019.
  • ASBMB Faculty Mentoring Workshop, Panelist and Mentor. Panel, Presented, 06/2019.
  • Studies on a radical SAM RiPP maturase, RiPP Conference, Granada, Spain. Contributed Talk, Presented, 04/2019.
  • Reconstructing the biosynthesis of natural products one step at a time, Syracuse University. Invited Talk/Keynote, Presented, 04/2019.
  • Enzymes, Coenzymes, and Metabolic Pathways GRC, Mechanistic studies of two radical SAM enzymes. Invited Talk/Keynote, Presented, 07/2018.
  • ASBMB Faculty Mentoring Workshop, Panelist and mentor. Panel, Presented, 06/2018.
  • Frontiers in Metallobiochemistry Symposium, Mechanistic studies of two radical SAM enzymes. Invited Talk/Keynote, Presented, 05/2018.
  • Carnegie Mellon University, Reconstructing the biosynthesis of natural products one step at a time. Invited Talk/Keynote, Presented, 04/12/2018.
  • ASBMB National Meeting, Reconstructing biosynthesis of hyper modified RNA bases one step at a time. Invited Talk/Keynote, Presented, 04/2018.
  • University of California, Irvine. Reconstructing biosynthetic pathways one step at a time. Invited Talk/Keynote, Presented, 10/13/2017.
  • ASBMB Faculty Mentoring Workshop . Panel, Presented, 07/22/2017.
  • New England Biolabs, Reconstructing biosynthesis of 7-deazapurines one step at a time. Invited Talk/Keynote, Presented, 06/06/2017.
  • ASBMB National Meeting, Attaining employment, tenure and promotion across the STEM academic landscape. Panel, Presented, 04/24/2017.
  • ACS National Meeting, Mechanistic studies on the radical SAM enzyme CDG synthase (invited). Conference Paper, Presented, 04/04/2017.
  • University of Maryland-Baltimore, Reconstructing the biosynthesis of 7-deazapurines one step at a time. Invited Talk/Keynote, Presented, 03/29/2017.
  • North Carolina State University. Invited Talk/Keynote, Presented, 02/20/2017.
  • California State University, Los Angeles. Invited Talk/Keynote, Presented, 10/11/2016.
  • California State University, San Bernardino Student recruiting trip. Invited Talk/Keynote, Other, 05/05/2016.
  • California State University, Los Angeles Student recruiting trip. Invited Talk/Keynote, Other, 05/04/2016.
  • ASBMB national meeting. Invited Talk/Keynote, Presented, 04/06/2016.
  • Metals in Biology, Gordon Research Conference. Conference Paper, Presented, 01/28/2016.
  • Nucleosides and Nucleotides Gordon Research Conference. Invited Talk/Keynote, Submitted, 07/02/2015.
  • Boston College. Invited Talk/Keynote, Submitted, 04/04/2015.
  • ACS meeting, Denver CO. Invited Talk/Keynote, Presented, 03/22/2015.
  • UC Davis, Department of Chemistry. Invited Talk/Keynote, Submitted, 02/17/2015.
  • University of Utah. Invited Talk/Keynote, Presented, 01/15/2015.

Research Groups

  • Jacob Pedigo, Graduate Student. 01/2023 - present.
  • Saswata Nayak, Graduate Student. 01/2021 - present.
  • Vlad Vinnik, Postdoc. 10/2019 - present.
  • Andrew Jochimson, Graduate Student. 01/2017 - present.
  • Dahvid Davda, Postdoc. 10/2016 - present.
  • Anthony Young, Postdoc. 09/2016 - present.
  • Sven Miller, Graduate Student. 08/2016 - 08/2019.
  • Will Kincannon, Graduate Student. 08/2014 - 08/2020.