VAHE BANDARIAN portrait
  • Professor, Chemistry
801-581-6366

Publications

  • Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V & Drennan CL (2020). Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein science : a publication of the Protein Society. Vol. 28, 202-215. Published, 01/01/2020.
  • Miller SA & Bandarian V (2019). Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes. Journal of the American Chemical Society. Vol. 141, 11019-11026. Published, 07/01/2019.
  • Grell & Kincannon, Bruender, Blaesi, Krebs, Bandarian, Drennan (2018). Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase. Journal of Biological Chemistry. Vol. 293, 17349-17361. Published, 11/2018.
  • Walker & Kincannon, Bandarian, Elliott (2018). Deconvoluting the Reduction Potentials for the Three [4Fe-4S] Clusters in an AdoMet Radical SCIFF Maturase. Biochemistry. Vol. 57, 6050-6053. Published, 10/2018.
  • Kincannon & Bruender, Bandarian (2018). A Radical Clock Probe Uncouples H Atom Abstraction from Thioether Cross-Link Formation by the Radical S-Adenosyl-l-methionine Enzyme SkfB. Biochemistry. Vol. 57, 4816-4823. Published, 07/2018.
  • Bandarian (2018). Methods in Enzymology/Radical SAM Enzymes. Vol. 606. Elsevier. Published, 07/2018.
  • Lewis (2018). QueE: A Radical SAM Enzyme Involved in the Biosynthesis of 7-Deazapurine Containing Natural Products.. Vol. 606, Methods in Enzymology. Published, 07/2018.
  • Bandarian (2018). Preface. Elsevier. Published, 07/2018.
  • Young (2018). TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases.. Vol. 606, Methods in Enzymology. Published, 06/2018.
  • Grell & Young, Drennan, Bandarian (2018). Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1. Journal of the American Chemical Society. Vol. 140, 6842-6852. Published, 05/2018.
  • Wilcoxen & Bruender, Bandarian, Britt (2018). A Radical Intermediate in Bacillus subtilis QueE during Turnover with the Substrate Analogue 6-Carboxypterin. Journal of the American Chemical Society. Vol. 140, 1753-1759. Published, 01/2018.
  • Nelp, MT, Young, AP, Stepanski, BM & Bandarian, V (2017). Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role. ACS. Vol. 56, 3874-3876. Published, 08/01/2017.
  • Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL & Bandarian V (2017). 7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies. Journal of the American Chemical Society. Vol. 139, 1912-1920. Published, 01/01/2017.
  • Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V & Drennan CL (2016). Molecular basis of cobalamin-dependent RNA modification. Nucleic acids research. Vol. 44, 9965-9976. Published, 09/01/2016.
  • Bruender NA & Bandarian V (2016). SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation. Biochemistry. Vol. 55, 4131-4. Published, 08/01/2016.
  • Bruender NA & Bandarian V (2016). The Radical S-Adenosyl-l-methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide. Biochemistry. Vol. 55, 2813-6. Published, 05/01/2016.
  • Nelp MT, Song Y, Wysocki VH & Bandarian V (2016). A Protein-derived Oxygen Is the Source of the Amide Oxygen of Nitrile Hydratases. The Journal of biological chemistry. Vol. 291, 7822-9. Published, 04/01/2016.
  • Bruender NA, Wilcoxen J, Britt RD & Bandarian V (2016). Biochemical and Spectroscopic Characterization of a Radical S-Adenosyl-L-methionine Enzyme Involved in the Formation of a Peptide Thioether Cross-Link. Biochemistry. Vol. 55, 2122-34. Published, 04/01/2016.
  • Bruender NA, Young AP & Bandarian V (2016). Correction to Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine Synthase. (pp. 1939). Vol. 55. Biochemistry. Published, 03/01/2016.
  • Song Y, Nelp MT, Bandarian V & Wysocki VH (2016). Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information. ACS central science. Vol. 1, 477-487. Published, 01/01/2016.
  • Bandarian V & Drennan CL (2015). Radical-mediated ring contraction in the biosynthesis of 7-deazapurines. Current opinion in structural biology. Vol. 35, 116-24. Published, 12/01/2015.
  • Nelp MT & Bandarian V (2015). A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate. Angewandte Chemie (International ed. in English). Vol. 54, 10627-9. Published, 09/01/2015.
  • Miles ZD, Myers WK, Kincannon WM, Britt RD & Bandarian V (2015). Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine. Biochemistry. Vol. 54, 4927-35. Published, 08/01/2015.
  • Young AP & Bandarian V (2015). Mechanistic Studies of the Radical S-Adenosyl-L-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction. Biochemistry. Vol. 54, 3569-72. Published, 06/01/2015.
  • Bruender NA, Young AP & Bandarian V (2015). Chemical and Biological Reduction of the Radical SAM Enzyme CPH4 Synthase. Biochemistry. Vol. 54, 2903-10. Published, 05/01/2015.
  • Lajoie DM, Roberts SA, Zobel-Thropp PA, Delahaye JL, Bandarian V, Binford GJ & Cordes MH (2015). Variable Substrate Preference among Phospholipase D Toxins from Sicariid Spiders. The Journal of biological chemistry. Vol. 290, 10994-1007. Published, 04/01/2015.

Presentations

  • Reconstitution of biosynthetic pathways one step at a time, University of Pennsylvania. Invited Talk/Keynote, Presented, 10/2019.
  • Studies on a radical SAM RiPP maturase, RiPP Conference, Granada, Spain. Contributed Talk, Presented, 04/2019.
  • Reconstructing the biosynthesis of natural products one step at a time, Syracuse University. Invited Talk/Keynote, Presented, 04/2019.
  • Enzymes, Coenzymes, and Metabolic Pathways GRC, Mechanistic studies of two radical SAM enzymes. Invited Talk/Keynote, Presented, 07/2018.
  • ASBMB Faculty Mentoring Workshop, Panelist and mentor. Panel, Presented, 06/2018.
  • Frontiers in Metallobiochemistry Symposium, Mechanistic studies of two radical SAM enzymes. Invited Talk/Keynote, Presented, 05/2018.
  • Carnegie Mellon University, Reconstructing the biosynthesis of natural products one step at a time. Invited Talk/Keynote, Presented, 04/12/2018.
  • ASBMB National Meeting, Reconstructing biosynthesis of hyper modified RNA bases one step at a time. Invited Talk/Keynote, Presented, 04/2018.
  • University of California, Irvine. Reconstructing biosynthetic pathways one step at a time. Invited Talk/Keynote, Presented, 10/13/2017.
  • ASBMB Faculty Mentoring Workshop . Panel, Presented, 07/22/2017.
  • New England Biolabs, Reconstructing biosynthesis of 7-deazapurines one step at a time. Invited Talk/Keynote, Presented, 06/06/2017.
  • ASBMB National Meeting, Attaining employment, tenure and promotion across the STEM academic landscape. Panel, Presented, 04/24/2017.
  • ACS National Meeting, Mechanistic studies on the radical SAM enzyme CDG synthase (invited). Conference Paper, Presented, 04/04/2017.
  • University of Maryland-Baltimore, Reconstructing the biosynthesis of 7-deazapurines one step at a time. Invited Talk/Keynote, Presented, 03/29/2017.
  • North Carolina State University. Invited Talk/Keynote, Presented, 02/20/2017.
  • California State University, Los Angeles. Invited Talk/Keynote, Presented, 10/11/2016.
  • California State University, San Bernardino Student recruiting trip. Invited Talk/Keynote, Other, 05/05/2016.
  • California State University, Los Angeles Student recruiting trip. Invited Talk/Keynote, Other, 05/04/2016.
  • ASBMB national meeting. Invited Talk/Keynote, Presented, 04/06/2016.
  • Metals in Biology, Gordon Research Conference. Conference Paper, Presented, 01/28/2016.
  • Nucleosides and Nucleotides Gordon Research Conference. Invited Talk/Keynote, Submitted, 07/02/2015.
  • Boston College. Invited Talk/Keynote, Submitted, 04/04/2015.
  • ACS meeting, Denver CO. Invited Talk/Keynote, Presented, 03/22/2015.
  • UC Davis, Department of Chemistry. Invited Talk/Keynote, Submitted, 02/17/2015.
  • University of Utah. Invited Talk/Keynote, Presented, 01/15/2015.

Research Groups

  • Andrew Jochimson, Graduate Student. 01/2017 - present.
  • Dahvid Davda, Postdoc. 10/2016 - present.
  • Anthony Young, Postdoc. 09/2016 - present.
  • Sven Miller, Graduate Student. 08/2016 - present.
  • Will Kincannon, Graduate Student. 08/2013 - present.