Thomas E Lane portrait
  • Adjunct Professor, Pathology
  • Professor, Pathology
801-585-5554

Research Keywords

  • Multiple Sclerosis
  • Virology
  • Neural Stem Cells

Presentations

  • Single-cell RNA sequencing reveals distinct microglia subsets following CNS viral infection, Department of Neurosciences, University of Virginia, School of Medicine. , , 2019.
  • The immune molecule CD1d and it’s role in anti-viral immune responses, Department of Neurosciences, Case Western University, School of Medicine. , , 2019.
  • Microglia aid in host defense and restrict the severity of demyelination in response to infection with a neurotropic coronavirus. Dept. Neurology, Ohio State University, School of Medicine. , , 2019.
  • Single-cell RNA sequencing reveals how microglia shape the immunological landscape in response to CNS viral infection. 3iSymposium, University of Utah. , , 2019.
  • Innate immune response contribute to defense, disease and repair in a model of viral-induced neurologic disease, Dept. Neurobiology & Behavior, UC Irvine. , , 2019.
  • CXCR2 signaling regulates oligodendrocyte progenitor cell maturation. Immunology, Inflammation, and Infection Summer Retreat, Park City, UT. , , 2018.
  • Disrupted CXCR2 signaling in oligodendroglia lineage cells enhances myelin repair in a viral model of multiple sclerosis. FASEB Translational Neuroimmunology, Snowmass, CO. , , 2018.
  • The CXCL1:CXCR2 signaling axis contributes to neuroinflammation, demyelination and remyelination in a viral model of multiple sclerosis, Dept. Neurology, Cornell University. , , 2018.
  • Signaling through VCAM-1 on neural precursor cells mediates survival and differentiation. Stem Cell Affinity Group, University of Utah. , , 2017.
  • Host defense and disease following viral infection of the central nervous system, Dept. of Biology, San Diego State University. , , 2017.
  • Host defense and disease following viral infection of the central nervous system, Dept. of Biology, San Diego State University. , , 2016.
  • The CXCL1:CXCR2 signaling axis within the CNS affects neuroinflammation and demyelination following viral infection of the CNS. FASEB: Translational Neuroimmunology: From Mechanisms to Therapeutics, Big Sky MT. , , 2016.
  • Neuroscience and Philanthropy, University of Utah Health Sciences Planning & Strategy Retreat. , , 2015.
  • Stem Cells & Remyelination, UC Irvine, Stem Cells for the Injured Spinal Cord. , , 2015.
  • Audrey Steinman Gilden Lecture, International Society for Neurovirology, San Diego, CA. , , 2015.
  • Human neural precursor cells promote neurological recovery in a viral model of multiple sclerosis, Sanford-Burnham-Prebys Medical Discovery Institute, San Diego, CA. , , 2015.
  • Inducible expression of CXCL1 within the CNS amplifies neuroinflammation and demyelination in a viral model of multiple sclerosis, Snowbird Symposium, Snowbird Ski & Summer Resort, UT. , , 2015.
  • Surgical transplantation of neural progenitor cells promotes repair and remyelination in a viral model of multiple sclerosis, Department of Neurobiology and Anatomy, University of Utah. , , 2014.
  • Neural precursor cells and repair in a model of viral-induced demyelination, Washington University, Center for Neuroimmunology & Neuroinfectious Diseases, 2nd Annual Symposium. , , 2014.
  • Neural stem cells and treatment of viral-induced demyelinating diseases, Department of Neurobiology and Anatomy, University of Utah. , , 2014.
  • Neural stem cells and repair in a viral model of neurologic disease. Department of Mathematics, University of Utah. , , 2014.
  • Human neural precursors cells promote neurologic recovery in a viral model of multiple sclerosis. Department of Neurology, University of Utah School of Medicine, Brainstorm Retreat, Park City. , , 2014.
  • Human neural precursors cells promote neurologic recovery in a viral model of multiple sclerosis. Department of Biology, San Diego State University, CA. , , 2014.
  • Human neural precursors cells promote neurologic recovery in a viral model of multiple sclerosis. American Society for Neurochemistry. Long Beach, CA. , , 2014.
  • Human neural progenitor cells and repair in a model of viral-induced demyelination. Neuroimmunology symposium: Inflammation-induced axonopathy: Insights into the neurodegenerative aspects of Multiple Sclerosis. University of Michigan. , , 2013.
  • CXCL1:CXCR2 signaling in host defense and disease in a model of viral-induced CNS disease. Chemokines and Chemokine Receptors in the Nervous System 3rd Edition. Rome, Italy. , , 2013.
  • Stem cells as tools for treating chronic demyelination. Dept. of Microbiology & Immunology, University of British Columbia. , , 2012.
  • Stems cells and Multiple Sclerosis. Allergan Lecture in Modern Biology, Irvine CA. , , 2012.
  • Neural progenitor cells and repair in a viral model of demyelination. Center for Virus Research, UCI. , , 2012.
  • Advances toward multiple sclerosis therapy using stem cells. California Institute for Regenerative Medicine, Los Angeles, CA. , , 2012.
  • MHC mismatch results in rejection of neural progenitor cells in a viral model of demyelination. Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics. FASEB, Carefree AZ. , , 2012.
  • Neural stem cells and repair in a viral model of demyelination. Mechanisms of Neurodegeneration in CNS Disease, Rocky Mountain Laboratories, Hamilton, MT. , , 2011.
  • Neural stem cells and repair in a viral model of demyelination. California MS Research Forum, San Francisco, CA. , , 2011.
  • Neural stem cells and repair in a viral model of demyelination. Center for Regenerative Medicine. Cedars-Sinai Medical Center, Los Angeles, CA. , , 2011.
  • Neural stem cells and repair in a viral model of demyelination. Dept. of Pathology, Albert Einstein College of Medicine. , , 2011.
  • Neural stem cells in promoting tissue repair in a viral model of demyelination. Judith Jaffee Multiple Sclerosis Center – Monthly MS Research Symposia, Dept. of Neurology, Cornell College of Medicine. , , 2011.
  • IP10/CXCL10 and inflammatory demyelination. Bristol-Myers Squibb. Princeton NJ. , , 2011.
  • Neural stem cells promote remyelination in a viral model of multiple sclerosis. Depts. Immunology and Neurology, Mayo Clinic. , , 2010.
  • Neural stem cells promote remyelination in a viral model of multiple sclerosis. Dept. Neurosciences, Cleveland Clinic and Research Foundation. , , 2010.
  • Mechanisms associated with CXCR2-mediated protection of oligodendrocytes in a viral model of multiple sclerosis. Dept. Pathology, U. Utah School of Medicine. , , 2010.
  • A protective role for ELR-positive chemokines during viral-induced encephalomyelitis. Dept. Microbiology, U. Iowa College of Medicine. , , 2010.
  • Chemokine receptors regulate positional migration of engrafted neural progenitor cells in a viral model of multiple sclerosis. California MS Research Forum. Newport Beach, CA. , , 2010.
  • CXCR2 signaling protects oligodendrocytes from cytokine-induced apoptosis. Chemokines and Chemokine Receptors in the Nervous System. Rome, Italy. , , 2009.
  • CXCR4 is required for positional migration of engrafted oligodendrocyte progenitor cells in a viral model of multiple sclerosis. Lymphoid Neogenesis, Grey Matter Pathology & Repair Pathways: Implications for Secondary Progressive Multiple Sclerosis. U. Michigan, Ann Arbor. , , 2009.
  • CXCR2 signaling and viral encephalomyelitis: A role for ELR+ chemokines in host defense. 12th International Symposium of Immunobiology. Santa Fe, New Mexico. , , 2009.
  • Methods for limiting neuroinflammation and promoting repair: Implications for Multiple Sclerosis. From Molecular Biology to Human Therapies: Strategies. Irvine, CA. , , 2009.
  • Spinal cord injury and immune response to viral infection. Roman Reed Research Symposium. Irvine, CA. , , 2009.
  • The role of chemokines in shaping host defense and disease following viral infection of the CNS. American Society for Neurochemistry. Charleston, SC. , , 2009.
  • Novel Treatments for MS. Southern California Chapter of the National Multiple Sclerosis Society. , , 2009.
  • CXCR2 signaling protects oligodendrocytes in a model of viral-induced demyelination. Symposium on Glial-Neuronal Interactions in Health and Disease. UC Riverside. , , 2008.
  • ELR+ chemokines in host defense and disease following viral infection of the CNS. 34th La Jolla Immunology Conference. , , 2008.
  • Progenitor cell-mediated remyelination following viral-induced demyelination – FASEB Neural-Immune Interactions: Pathology and Molecular Mechanisms of Repair. Carefree, AZ. , , 2008.
  • MHV infection of the CNS: A model of defense, disease, and repair - Department of Pathology, University of Michigan, Ann Arbor. , , 2008.
  • Cell Replacement Strategies for Promoting Remyelination – Department of Neurology, Johns Hopkins School of Medicine, Baltimore MD. , , 2008.
  • CXCR2 and Spinal Cord Injury – Roman Reed Research Meeting: California Spinal Cord Injury and Neural Regeneration Consortium. , , 2008.
  • The Chemokine Receptor CXCR2: Roles in Host Defense and Disease following Viral Infection of the CNS. Plenary Speech at 8th International Symposium on NeuroVirology. , , 2007.
  • Innate Immune Responses to Viral Infection of the CNS: A Little Goes a Long Way - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories – Hamilton, MT. , , 2007.
  • Chemokine Signaling and Viral Infection of the CNS: Pathways to Defense, Disease, and Regeneration – Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories – Hamilton, MT. , , 2007.
  • Cell Replacement Strategies for Promoting Remyelination – Department of Pathology, University of Utah. , , 2007.
  • Cell Replacement Strategies for Promoting Remyelination – Department of Pathology, Children’s Hospital – Los Angeles. , , 2007.
  • Cell Replacement Strategies for Promoting Remyelination – Department of Neurology, Oregon Health & Science University. , , 2006.
  • Progenitor Cell-Induced Remyelination in a Viral Model of Demyelination – Department of Microbiology and Immunology, Brown School of Medicine. , , 2006.
  • Progenitor Cell-Induced Remyelination in a Viral Model of Demyelination – Department of Pathology, University of Michigan, School of Medicine. , , 2006.
  • Progenitor Cell-Induced Remyelination in a Viral Model of Demyelination – FASEB Summer Research Conference: Neural-Immune Interactions: Pathological Mechanisms and Repair. Tucson, AZ. , , 2006.
  • Innate Immune Responses to Viral Infection of the CNS - American Society for Microbiology,. Positive-strand RNA virus session. Orlando, FL. , , 2006.
  • Neuroimmunology and Inflammation, Guest Lecturer, UCSD for Lecture Series entitled “Neurosciences at the Boundaries of Neurology and Psychiatry”. , , 2006.
  • Chemokines and Viral Infection of the CNS, Invited Session Chair – American Society of Neurochemistry Meeting, Portland Oregon March 2006. , , 2006.
  • Targeting chemokines for the treatment of inflammatory disease. Collaborative Research Center SFB 571 "Autoimmune reactions: from manifestation and mechanisms to therapy” Munich, Germany. , , 2005.
  • Novel methods for treating neuroinflammatory disease. Louisiana State University. , , 2005.
  • NKG2D signaling and host defense following mouse hepatitis virus infection of the central nervous system. Nidovirus Conference, Colorado Springs. , , 2005.
  • Chemokines and host defense following viral infection of the CNS. Texas A&M. , , 2005.
  • Chemokine expression in response to viral infection of the CNS: Linking innate and adaptive immunity, International Society of Neuroimmunology Symposium (Session Chair); 2005 AAI Annual Meeting. , , 2005.
  • The chemokine CXCL10 and it’s role in immune-mediated demyelinating diseases. Killam Lecture Series, McGill University. , , 2004.
  • Targeting chemokines for prevention and treatment of neuroinflammatory diseases. International Society for Interferon and Cytokine Research. Cairns, Australia. , , 2003.
  • Chemokines and the regulation of innate and adaptive immune responses following coronavirus infection of the central nervous system. La Jolla Immunology Symposium. La Jolla, CA. , , 2003.
  • The chemokine CXCL10/IP-10: A role in host defense and disease following viral infection of the central nervous system. La Jolla Institute for Allergy and Immunology. , , 2003.
  • Targeting chemokines for prevention and treatment of neuroinflammatory diseases. Amgen, Seattle, WA. , , 2003.
  • The chemokine CXCL10/IP-10: A role in host defense and disease following viral infection of the central nervous system. City of Hope, Childrens Hospital. , , 2003.
  • Mechanisms of remyelination following spinal cord damage and demyelination. California Spinal Cord Injury/Neuronal Regeneration. , , 2003.
  • Chemokines as Targets for Treatment of Neuorinflammatory Disease. Keynote Speaker for Drug and Discovery Session. BioFuture 2002 Conference. Vancouver, British Columbia. , , 2002.
  • The chemokine CXCL10/IP-10: A Role in Host Defense and Disease Following Viral Infection of the Central Nervous System. Dept. of Microbiology and Immunology, University of Oklahoma School of Medicine. , , 2002.
  • The chemokine CXCL10/IP-10: A Role in Host Defense and Disease Following Viral Infection of the Central Nervous System. FASEB Summer Research Conference. Microbial Pathogenesis: Mechanisms of Infectious Diseases. , , 2002.
  • New strategies for the treatment of human paralysis. UCI Chief Executive Round Table Retreat, Maui, Hawaii. , , 2002.
  • Balancing host defense and neuropathology: CXCL10 and viral infection of the central nervous system. Dept. of Pharmacology, UCI. , , 2002.
  • New strategies for the treatment of Multiple Sclerosis. Orange County Chapter of the National Multiple Sclerosis Society. , , 2002.
  • Chemokines and chemokine receptors as regulators of neuroinflammation and disease following viral infection of the CNS. Pathogenesis Seminar Series, The Scripps Research Institute. , , 2001.
  • Balancing host defense and neuropathology: CXCL10 and viral infection of the central nervous system: Dept. of Neurosciences, The Lerner Research Institute, The Cleveland Clinic and Research Foundation. , , 2001.
  • Chemokines and viral-induced neurologic disease: Balancing host defense and neuropathology. Dept. of Neurology, University of Southern California. , , 2001.
  • Chemokines and viral-induced neurologic disease: Balancing host defense and neuropathology. Tularik, Inc., Division of Biology, San Francisco, CA. , , 2000.
  • Chemokines and viral-induced neurologic disease: Balancing host defense and pathology. Division of Virology, Fox Chase Cancer Center, Philadelphia, PA. , , 2000.
  • Chemokines and viral-induced neurologic disease: Balancing host defense and pathology. Dept. of Biological Chemistry, UC Irvine. , , 2000.
  • Chemokine function during viral-induced neurologic disease. Irvine Research Unit in Animal Virology, UC Irvine. , , 1999.
  • Functional significance of chemokine expression during viral-induced demyelination. Dept. Microbiology and Molecular Genetics, UC Irvine. , , 1999.
  • Coronavirus-induced central nervous system disease: understanding the role of chemokines in inflammation and demyelination. Institute for Aging and Dementia, UC Irvine. , , 1999.
  • Audrey Steinman Gilden Lecture, International Society for NeuroVirology. , , 2015.
  • Stem cells and Multiple Sclerosis. Keynote Address, 12th Annual MS Research Symposium, UCSD. San Diego, CA. , , 2012.
  • Neural stem cells as a therapeutic approach for treating MS. Keynote speaker for Discovery Science Center – The Innovators, Newport Beach, CA. , , 2010.
  • Neural stem cell therapies for promoting remyelination. NSM ICC 7th Annual Science Symposium – Biomedical Advances in Stem Cells. Keynote Speaker. , , 2010.
  • Frontiers in Neurology: Stem Cells and Beyond – Keynote speaker, Sierra Nevada Hospital Fundraising Event. , , 2006.

Languages

  • English, Fluent.