Mahesh B Chandrasekharan portrait
  • Assistant Professor, Radiation Oncology Som

Research Keywords

  • Histone Modifications
  • Transcription
  • Genome Stability

Presentations

  • Chandrasekharan MB. Counteracting Enzymes Set1 and Jhd2 Co-Regulate H3k4 Methylation, Chromatin Dynamics, and Gene Expression 2017 Timothy C. Hall Memorial Symposium. Texas A&M University College Station, TX. , , 2017.
  • The 5th Annual World DNA & Genome Day 2014 Dalian, China (INVITATION DECLINED) Session A04: Chromatin Dynamics, Stability and Genome Integrity Network of Diseases. , , 2014.
  • Chandrasekharan MB. The Tail tells a Tale: Regulation of Histone H3 Methylation by Histone H2B Ubiquitination. Department of Biochemistry, Cell and Molecular Biology, University of Tennessee, Knoxville, TN. , , 2006.
  • Crowe AJ, Josefsson CA, Chandrasekharan MB, Hall TC. TATA box-directed transcription initiation and nucleosome positioning at the β -phaseolin promoter in vitro. Minisymposium on Transcriptional Regulation. Plant Biology 2002, Denver, CO. , , 2002.
  • Chandrasekharan MB, Hall TC. Role of DNA topology in phaseolin gene regulation. John Innes Centre, Norwich, UK. , , 1997.
  • Palani S, Bissell JE, Shukla PK, Chandrasekharan MB. Histone H2B monoubiquitination mediated regulation of nucleosome structure, function and dynamics. EpiCypher 2018. Biological & Clinical Frontiers in Epigenetics. Melia Nassau Beach Resort, Nassau, Bahamas. , , 2018.
  • Mahesh Chandrasekharan. Dynamic modulation of histone H3 lysine-4 post-translational modifications in regulating gene transcription and chromatin structure. Cold Spring Harbor Laboratory / Systems Biology: Global Regulation of Gene Expression. Cold Springs Harbor, NY. , , 2017.
  • Chandrasekharan MB, Huang F, Sun Z-W. Regulation of chromatin dynamics and nucleosome stability by histone H2B ubiquitination. Southeastern Regional Yeast Meeting, Nashville, TN. , , 2009.
  • Ng W-K, Chandrasekharan MB, Hall TC. Ordered histone modifications associated with phaseolin promoter potentiation and activation. Plant Biology, Seattle, WA. , , 2005.
  • Ng W-K, Chandrasekharan MB, Hall TC. Characterization of cis-regulatory regions involved in transcriptional regulation of the abscisic acid insensitive 3 locus in Arabidopsis thaliana. Plant Biology, Honolulu, HI. , , 2003.
  • Hall TC, Carranco R, Li G, Chandrasekharan MB. Replication inhibitor interference with phas promoter activation. Plant Biology, Honolulu, HI. , , 2003.
  • Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC. Isolation and characterization of a DNA (cytosine 5) methyltransferase gene from rice (Oryza sativa L.). Fourteenth annual meeting of the Thai Society for Biotechnology on Biotechnology for better living in the new economy. Sofitel Raja Orchid Khon Kaen, Khon Kaen Province, Thailand. , , 2002.
  • Hall TC, Li G, Chandrasekharan MB. Interaction of chromatin, transcription factors and negative regulators in spatial control of phaseolin expression. 16th FAOBMB (Fed. of Asian & Oceanian Biochemists & Mol. Biol.) Symposium, Academia Sinica, Taipei, Taiwan. , , 2002.
  • Chandrasekharan MB, Ng W-K, Bishop KJ, Hall TC. Module-specific expression from the phas promoter during embryogenesis in transgenic Arabidopsis. XIII International Conference on Arabidopsis Research. Poster session titled Reproductive Development. Seville, Spain. , , 2002.
  • Hall TC, Li G, Bishop KJ, Chandrasekharan MB. Chromatin and negative regulators contribute to spatial regulation of expression from the phaseolin promoter. American Society of Plant Biologists Annual Meeting. Poster session titled Regulation of Gene Expression. Providence, RI. , , 2001.
  • Crowe AJ, Chandrasekharan MB, Hall TC, Barton MC. Chromatin regulation of β-phaseolin gene expression in vitro. The Mechanisms of Eukaryotic Transcriptional Regulation Keystone Meeting, poster session titled chromatin structure and transcription. Santa Fe, NM. , , 2001.
  • Hall TC, Li G, Chandrasekharan MB, Zhou X, VandenBosch KA, Cook DR. Use of Medicago truncatula to probe seed protein gene activation processes. Conference on Molecular Genetics of Model Legumes. John Innes Centre, Norwich, UK. , , 2000.
  • Li G, Bishop KJ, Chandrasekharan MB, Hall TC. The β-phaseolin gene two-step. Penn State 18th Summer Symposium in Molecular Biology: Chromatin Structure and DNA Function. Penn State University, PA. , , 1999.
  • Hall TC, Li G, Chandrasekharan MB. The phaseolin two-step: chromatin potentiation and ABA-mediated activation. Molecular technology for plant improvement. North Carolina State University, Raleigh, NC. Ninth annual symposium. , , 1999.
  • Hall TC, Li G, Chandrasekharan MB, Zhang Y. Remodeling chromatin architecture of the phas promoter gives new room for expression. Juan March Symposium. Madrid, Spain. , , 1998.
  • Hall TC, Li G, Chandrasekharan MB. Participation of chromatin in the regulation of seed protein gene expression. 7th International Symposium on Seed Proteins of Plants. Gatersleben, Germany. , , 1997.
  • Chandrasekharan MB, Li G, Hall TC. A computer-derived model for factor interaction in phaseolin expression. Annual Meeting of the American Society of Plant Physiologists. San Antonio, Texas, USA. , , 1996.
  • Li G, Chandrasekharan MB, Hall TC. Use of in vivo footprinting to explore synergistic factor interaction in phaseolin expression. Annual Meeting of the American Society of Plant Physiologists. San Antonio, Texas, USA. , , 1996.
  • Jason Singer, Daniel Andrade, Diana Bareyan, David McClellan, Helena Lucente, Matthew Velinder, Luke Maese, Mahesh Chandrasekharan, Emily Theisen, Fang Liu, Sunil Sharma, Michael Engel. Lysine specific demethylase-1 inhibition as a therapeutic strategy that leverages the requirement for growth factor independence-1 in Notch-driven T-ALL. Poster session presented at AACR Special Conference: Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes, San Diego. Poster, Presented, 2013.
  • Michael Engel, Daniel Andrade, Luke Maese, Jason Singer, Diana Bareyan, David McClellan, Helena Lucente, Ryan Quinton, Mahesh Chandrasekharan, Fang Liu. Sumoylation regulates the half-life of growth factor independence (GFI)-1 to modulate transcriptional repression. Poster session presented at ASPHO Annual Meeting, Miami. Poster, Presented, 2013.
  • Daniel Andrade, Jason Singer, Diana Bareyan, David McClellan, Helena Lucente, Mahesh Chandrasekharan, Michael E. Engel. Notch and PIAS3 differentially regulate sumoylation of GFI1 to modulate transcriptional repression. Poster session presented at American Association for Cancer Research 104th Annual Meeting, Washington D.C. Poster, Presented, 2013.

Languages

  • English, Fluent.

Publications

  • Hall TC, Chandrasekharan MB, Li G (date unknown). Phaseolin: its past, properties, regulation and future. (pp. 209-240). Kluwer, Dorderecht. Accepted, .
  • Huang F, Ramakrishnan S, Pokhrel S, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB (date unknown). Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination. Vol. 290, 28760-77. Accepted, .
  • Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW (date unknown). Hdac3 is essential for the maintenance of chromatin structure and genome stability. Vol. 18, 436-47. Accepted, .
  • Chandrasekharan MB, Li G, Bishop KJ, Hall TC (date unknown). S phase progression is required for transcriptional activation of the beta-phaseolin promoter. Vol. 278, 45397-405. Accepted, .
  • Yang G, Dong J, Chandrasekharan MB, Hall TC (date unknown). Kiddo, a new transposable element family closely associated with rice genes. Vol. 266, 417-24. Accepted, .
  • Tiburcio PDB, Locke MC, Bhaskara S, Chandrasekharan MB, Huang LE (date unknown). The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma. Vol. 13, 100819. Accepted, .
  • Bradley C, van der Meer R, Roodi N, Yan H, Chandrasekharan MB, Sun ZW, Mernaugh RL, Parl FF (date unknown). Carcinogen-induced histone alteration in normal human mammary epithelial cells. Vol. 28, 2184-92. Accepted, .
  • Chandrasekharan MB, Huang F, Sun ZW (date unknown). Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Vol. 106, 16686-91. Accepted, .
  • Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP (date unknown). A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Vol. 6. Accepted, .
  • Bhaskara S, Jacques V, Rusche JR, Olson EN, Cairns BR, Chandrasekharan MB (date unknown). Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression. Vol. 6, 27. Accepted, .
  • Nakanishi S, Lee JS, Gardner KE, Gardner JM, Takahashi YH, Chandrasekharan MB, Sun ZW, Osley MA, Strahl BD, Jaspersen SL, Shilatifard A (date unknown). Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. Vol. 186, 371-7. Accepted, .
  • Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW (date unknown). The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. Vol. 285, 24548-61. Accepted, .
  • Chandrasekharan MB, Huang F, Sun ZW (date unknown). Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors. Vol. 54, 304-14. Accepted, .
  • Chandrasekharan MB, Huang F, Chen YC, Sun ZW (date unknown). Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination. Vol. 30, 3216-32. Accepted, .
  • Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB (date unknown). Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription. Vol. 7, 11949. Accepted, .
  • Li G, Bishop KJ, Chandrasekharan MB, Hall TC (date unknown). beta-Phaseolin gene activation is a two-step process: PvALF- facilitated chromatin modification followed by abscisic acid-mediated gene activation. Vol. 96, 7104-9. Accepted, .
  • Bhaskara S, Chandrasekharan MB, Ganguly R (date unknown). Caffeine induction of Cyp6a2 and Cyp6a8 genes of Drosophila melanogaster is modulated by cAMP and D-JUN protein levels. Vol. 415, 49-59. Accepted, .
  • Meriesh HA, Lerner AM, Chandrasekharan MB, Strahl BD (date unknown). The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation. Vol. 295, 6561-6569. Accepted, .
  • Andrade D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, Chandrasekharan MB, Lucente H, McClellan D, Jones D, Sharma S, Liu F, Engel ME (date unknown). SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis. Vol. 36, 1438-50. Accepted, .
  • Carranco R, Chandrasekharan MB, Townsend JC, Hall TC (date unknown). Interaction of PvALF and VP1 B3 domains with the beta -phaseolin promoter. Vol. 55, 221-37. Accepted, .
  • Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S (date unknown). HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. Vol. 6, 4863-87. Accepted, .
  • Joo HY, Jones A, Yang C, Zhai L, Smith AD 4th, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H (date unknown). Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Vol. 286, 7190-201. Accepted, .
  • McCullough LL, Pham TH, Parnell TJ, Connell Z, Chandrasekharan MB, Stillman DJ, Formosa T (date unknown). Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae. Vol. 211, 877-892. Accepted, .
  • Chandrasekharan MB, Bishop KJ, Hall TC (date unknown). Module-specific regulation of the beta-phaseolin promoter during embryogenesis. Vol. 33, 853-66. Accepted, .
  • Grace ML, Chandrasekharan MB, Hall TC, Crowe AJ (date unknown). Sequence and spacing of TATA box elements are critical for accurate initiation from the beta-phaseolin promoter. Vol. 279, 8102-10. Accepted, .
  • Johnson DP, Chandrasekharan MB, Dutreix M, Bhaskara S (date unknown). Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy. Vol. 13. Accepted, .
  • Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S (date unknown). HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. Vol. 32, 49-60. Accepted, .
  • Ng DW, Chandrasekharan MB, Hall TC (date unknown). Ordered histone modifications are associated with transcriptional poising and activation of the phaseolin promoter. Vol. 18, 119-32. Accepted, .
  • Zhou X, Chandrasekharan MB, Hall TC (date unknown). High rooting frequency and functional analysis of GUS and GFP expression in transgenic Medicago truncatula A17. Vol. 162, 813-822. Accepted, .
  • Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC (date unknown). Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus. Vol. 218, 337-49. Accepted, .
  • Ng DW, Chandrasekharan MB, Hall TC (date unknown). The 5' UTR negatively regulates quantitative and spatial expression from the ABI3 promoter. Vol. 54, 25-38. Accepted, .
  • Hall TC, Li G, Chandrasekharan MB (date unknown). Participation of chromatin in the regulation of phaseolin gene expression. Vol. 152, 614-620. Accepted, .
  • Chandrasekharan MB, Huang F, Sun ZW (date unknown). Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. (pp. 460-8). Vol. 5. Accepted, .
  • Iyer LM, Kumpatla SP, Chandrasekharan MB, Hall TC (date unknown). Transgene silencing in monocots. (pp. 323-46). Vol. 43. Accepted, .
  • Ng DW, Wang T, Chandrasekharan MB, Aramayo R, Kertbundit S, Hall TC (date unknown). Plant SET domain-containing proteins: structure, function and regulation. (pp. 316-29). Vol. 1769. Accepted, .
  • Li G, Chandrasekharan MB, Wolffe AP, Hall TC (date unknown). Chromatin structure and phaseolin gene regulation. (pp. 121-9). Vol. 46. Accepted, .
  • Kumpatla SP, Chandrasekharan MB, Iyer LM, Li G, Hall TC (date unknown). Genome intruder scanning and modulation systems and transgene silencing. (pp. 97-104). Vol. 3. Accepted, .