Mahesh B Chandrasekharan portrait
  • Assistant Professor, Radiation Oncology Som

Research Summary

Our overall goal is to study the role and regulation of protein modifications during transcription, replication and repair. Specifically, we plan to understand the mechanism of substrate recognition by histone modifying complexes and uncover signaling events within cells that regulate histone modifications. Our initial focus is to study the trans-histone crosstalk between H2B ubiquitination and H3-K4 and-K79 methylation during transcription in yeast and mammalian cells.


  • PhD, Biology, Texas A&M University