My research interest is in clinical exercise physiology and my work has focused on patients with chronic kidney disease. I have completed 3 NIH funded studies (RO1) in kidney and liver transplant and several privately funded studies on the effects of exercise training in patients treated with dialysis. My studies have included exercise training studies as well as a studies to determine physiologic limitations to exercise in patients with renal disease.
Through my studies and those of others it is clear that the severe physical limitations and many symptoms of fatigue and weakness experienced by patients with kidney disease can be improved with exercise training. The mechanisms of limitations have not been fully identified, but sarcopenia and resulting muscle dysfunction contribute, as well as abnormal cardiac responses to exercise may contribute. I am interested in the physiologic limitations to exercise in patients with kidney disease, but am also interested in how to best incorporate counselling and encouragement for increased physical activity within the health care setting of dialysis and after transplant.