MONIKA FLECKENSTEIN portrait
  • Professor, Ophthalmology & Visual Science
801-581-2352

Research Statement

Degenerative retinal diseases

Characterization by innovative high-resolution imaging technology

Identification of prognostic biomarkers for disease progression

Validation of clinical endpoints for interventional trials

Scientific concept, design and principal investigator:

SIGHT-Study (Sparing of the Fovea in GA-Progression, NCT02332343)

DSGA-Study (Directional Spread of Geographic Atrophy, NCT0205199)

FOCUS OF CLINICAL ACTIVITIES

Degenerative retinal diseases

‘Medical Retina‘

Intravitreal drug delivery in exudative retinal diseases

Innovative medical therapy of retinal diseases in the context of interventional trials

Research Keywords

  • Age-related Macular Degeneration
  • Advanced Medical Imaging and Image Data Analysis
  • Clinical Trials
  • Retinal Degeneration

Languages

  • English, Fluent.

Publications

  • Holz FG, Sadda SR, Staurenghi G, Lindner M, Bird AC, Blodi BA, Bottoni F, Chakravarthy U, Chew EY, Csaky K, Curcio CA, Danis R, Fleckenstein M, Freund KB, Grunwald J, Guymer R, Hoyng CB, Jaffe GJ, Liakopoulos S, Mones JM, Oishi A, Pauleikhoff D, Rosenfeld PJ, Sarraf D, Spaide RF, Tadayoni R, Tufail A, Wolf S, Schmitz-Valckenberg S (date unknown). Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings. (pp. 464-478). Vol. 124. Accepted, .
  • Pfau M, Lindner M, Gliem M, Steinberg JS, Thiele S, Finger RP, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen. Vol. 32, 1819-1830. Accepted, .
  • Pfau M, Jolly JK, Wu Z, Denniss J, Lad EM, Guymer RH, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials. 100907. Accepted, .
  • Pfau M, von der Emde L, de Sisternes L, Hallak JA, Leng T, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Rubin DL (date unknown). Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration. Vol. 138, 1026-1034. Accepted, .
  • Pfau M, Walther G, von der Emde L, Berens P, Faes L, Fleckenstein M, Heeren TFC, Kortüm K, Künzel SH, Müller PL, Maloca PM, Waldstein SM, Wintergerst MWM, Schmitz-Valckenberg S, Finger RP, Holz FG (date unknown). [Artificial intelligence in ophthalmology : Guidelines for physicians for the critical evaluation of studies]. Vol. 117, 973-988. Accepted, .
  • Pfau M, von der Emde L, Dysli C, Thiele S, Möller PT, Lindner M, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (date unknown). Light Sensitivity Within Areas of Geographic Atrophy Secondary to Age-Related Macular Degeneration. Vol. 60, 3992-4001. Accepted, .
  • Pfau M, von der Emde L, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Determinants of Cone and Rod Functions in Geographic Atrophy: AI-Based Structure-Function Correlation. Vol. 217, 162-173. Accepted, .
  • Fleckenstein M, Thiele S, Pfau M, Schmitz-Valckenberg S, Holz FG (date unknown). [Dry Age-Related Macular Degeneration - Epidemiology and Classification]. Vol. 236, 1068-1075. Accepted, .
  • Böhringer D, Goos D, Ach T, Feltgen N, Fleckenstein M, Kohnen T, Lorenz K, Pielen A, Spital G, Wilhelm B, Böhringer S, Reinhard T, Arbeitsgemeinschaft DOG – Klinische Studienzentren. (date unknown). [Work sampling in ophthalmological clinical studies. A multicenter field study]. Vol. 116, 872-878. Accepted, .
  • Schmitz-Valckenberg S, Pfau M, Fleckenstein M, Staurenghi G, Sparrow JR, Bindewald-Wittich A, Spaide RF, Wolf S, Sadda SR, Holz FG (date unknown). Fundus autofluorescence imaging. 100893. Accepted, .
  • Sassmannshausen M, Pfau M, Thiele S, Fimmers R, Steinberg JS, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Longitudinal Analysis of Structural and Functional Changes in Presence of Reticular Pseudodrusen Associated With Age-Related Macular Degeneration. Vol. 61, 19. Accepted, .
  • Bax NM, Valkenburg D, Lambertus S, Klevering BJ, Boon CJF, Holz FG, Cremers FPM, Fleckenstein M, Hoyng CB, Lindner M, Foveal Sparing Atrophy Study Team (FAST). (date unknown). Foveal Sparing in Central Retinal Dystrophies. Vol. 60, 3456-3467. Accepted, .
  • Pfau M, Lindner M, Goerdt L, Thiele S, Nadal J, Schmid M, Schmitz-Valckenberg S, Sadda SR, Holz FG, Fleckenstein M, Fundus Autofluorescence in Age-Related Macular Degeneration Study Group. (date unknown). PROGNOSTIC VALUE OF SHAPE-DESCRIPTIVE FACTORS FOR THE PROGRESSION OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION. Vol. 39, 1527-1540. Accepted, .
  • Pfau M, Lindner M, Steinberg JS, Thiele S, Brinkmann CK, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Visual field indices and patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry in macular diseases. Vol. 102, 1054-1059. Accepted, .
  • von der Emde L, Pfau M, Dysli C, Thiele S, Möller PT, Lindner M, Schmid M, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Artificial intelligence for morphology-based function prediction in neovascular age-related macular degeneration. Vol. 9, 11132. Accepted, .
  • Saßmannshausen M, Zhou J, Pfau M, Thiele S, Steinberg J, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Longitudinal Analysis of Retinal Thickness and Retinal Function in Eyes with Large Drusen Secondary to Intermediate Age-Related Macular Degeneration. Accepted, .
  • Steinberg JS, Saßmannshausen M, Pfau M, Fleckenstein M, Finger RP, Holz FG, Schmitz-Valckenberg S (date unknown). Evaluation of Two Systems for Fundus-Controlled Scotopic and Mesopic Perimetry in Eye with Age-Related Macular Degeneration. Vol. 6, 7. Accepted, .
  • Dieck S, Ibarra M, Moghul I, Yeung MW, Pantel JT, Thiele S, Pfau M, Fleckenstein M, Pontikos N, Krawitz PM (date unknown). Factors in Color Fundus Photographs That Can Be Used by Humans to Determine Sex of Individuals. Vol. 9, 8. Accepted, .
  • Oishi M, Oishi A, Lindner M, Pfau M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (date unknown). Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy. Vol. 58, 3303-3310. Accepted, .
  • Grassmann F, Harsch S, Brandl C, Kiel C, Nürnberg P, Toliat MR, Fleckenstein M, Pfau M, Schmitz-Valckenberg S, Holz FG, Chew EY, Swaroop A, Ratnapriya R, Klein ML, Mulyukov Z, Zamiri P, Weber BHF (date unknown). Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Accepted, .
  • Künzel SH, Möller PT, Lindner M, Goerdt L, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Pfau M (date unknown). Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Vol. 61, 63. Accepted, .
  • Pfau M, Goerdt L, Schmitz-Valckenberg S, Mauschitz MM, Mishra DK, Holz FG, Lindner M, Fleckenstein M (date unknown). Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Vol. 58, BIO121-BIO130. Accepted, .
  • Lindner M, Nadal J, Mauschitz MM, Luning A, Czauderna J, Pfau M, Schmitz-Valckenberg S, Holz FG, Schmid M, Fleckenstein M (date unknown). Combined Fundus Autofluorescence and Near Infrared Reflectance as Prognostic Biomarkers for Visual Acuity in Foveal-Sparing Geographic Atrophy. Vol. 58, BIO61-BIO67. Accepted, .
  • Pfau M, Lindner M, Muller PL, Birtel J, Finger RP, Harmening WM, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases. Vol. 58, BIO158-BIO167. Accepted, .
  • Thiele S, Nadal J, Pfau M, Saßmannshausen M, Fleckenstein M, Holz FG, Schmid M, Schmitz-Valckenberg S (date unknown). Prognostic value of intermediate age-related macular degeneration phenotypes for geographic atrophy progression. Accepted, .
  • Eter N, Pauleikhoff D, Agostini H, Fleckenstein M, Ziemssen F (date unknown). [Value and formats of quality assurance : Ophthalmology and intravitreal therapy between reality and wishful thinking]. Vol. 117, 298-306. Accepted, .
  • Sadda SR, Guymer R, Holz FG, Schmitz-Valckenberg S, Curcio CA, Bird AC, Blodi BA, Bottoni F, Chakravarthy U, Chew EY, Csaky K, Danis RP, Fleckenstein M, Freund KB, Grunwald J, Hoyng CB, Jaffe GJ, Liakopoulos S, Monés JM, Pauleikhoff D, Rosenfeld PJ, Sarraf D, Spaide RF, Tadayoni R, Tufail A, Wolf S, Staurenghi G (date unknown). Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT: Classification of Atrophy Report 3. (pp. 537-548). Vol. 125. Accepted, .
  • Lindner M, Kosanetzky S, Pfau M, Nadal J, Gordt LA, Schmitz-Valckenberg S, Schmid M, Holz FG, Fleckenstein M (date unknown). Local Progression Kinetics of Geographic Atrophy in Age-Related Macular Degeneration Are Associated With Atrophy Border Morphology. Vol. 59, AMD12-AMD18. Accepted, .
  • Müller PL, Pfau M, Möller PT, Nadal J, Schmid M, Lindner M, de Sisternes L, Stöhr H, Weber BHF, Neuhaus C, Herrmann P, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (date unknown). Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study. Vol. 59, AMD122-AMD131. Accepted, .
  • Thiele S, Pfau M, Larsen PP, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Multimodal Imaging Patterns for Development of Central Atrophy Secondary to Age-Related Macular Degeneration. Vol. 59, AMD1-AMD11. Accepted, .
  • Guymer RH, Rosenfeld PJ, Curcio CA, Holz FG, Staurenghi G, Freund KB, Schmitz-Valckenberg S, Sparrow J, Spaide RF, Tufail A, Chakravarthy U, Jaffe GJ, Csaky K, Sarraf D, Monés JM, Tadayoni R, Grunwald J, Bottoni F, Liakopoulos S, Pauleikhoff D, Pagliarini S, Chew EY, Viola F, Fleckenstein M, Blodi BA, Lim TH, Chong V, Lutty J, Bird AC, Sadda SR (date unknown). Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4. Vol. 127, 394-409. Accepted, .
  • Pfau M, Möller PT, Künzel SH, von der Emde L, Lindner M, Thiele S, Dysli C, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (date unknown). Type 1 Choroidal Neovascularization Is Associated with Reduced Localized Progression of Atrophy in Age-Related Macular Degeneration. Vol. 4, 238-248. Accepted, .
  • Lindner M, Pfau M, Czauderna J, Goerdt L, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (date unknown). Determinants of Reading Performance in Eyes with Foveal-Sparing Geographic Atrophy. Vol. 3, 201-210. Accepted, .
  • Birtel J, Lindner M, Mishra DK, Müller PL, Hendig D, Herrmann P, Holz FG, Fleckenstein M, Gliem M, Charbel Issa P (date unknown). Retinal imaging including optical coherence tomography angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum. Vol. 47, 240-249. Accepted, .
  • Sassmannshausen M, Steinberg JS, Fimmers R, Pfau M, Thiele S, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Structure-Function Analysis in Patients With Intermediate Age-Related Macular Degeneration. Vol. 59, 1599-1608. Accepted, .
  • von der Emde L, Pfau M, Thiele S, Möller PT, Hassenrik R, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Mesopic and Dark-Adapted Two-Color Fundus-Controlled Perimetry in Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Vol. 8, 7. Accepted, .
  • Müller PL, Pfau M, Schmitz-Valckenberg S, Fleckenstein M, Holz FG (date unknown). Optical Coherence Tomography-Angiography in Geographic Atrophy. Vol. 244, 42-50. Accepted, .
  • von der Emde L, Thiele S, Pfau M, Nadal J, Meyer J, Möller PT, Schmid M, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (date unknown). Assessment of Exudative Activity of Choroidal Neovascularization in Age-Related Macular Degeneration by OCT Angiography. Vol. 243, 120-128. Accepted, .
  • Thiele S, Nadal J, Pfau M, Saßmannshausen M, von der Emde L, Fleckenstein M, Holz FG, Schmid M, Schmitz-Valckenberg S, Molecular Diagnostic of Age-related Macular Degeneration Study Group. (date unknown). Prognostic Value of Retinal Layers in Comparison with Other Risk Factors for Conversion of Intermediate Age-related Macular Degeneration. Vol. 4, 31-40. Accepted, .
  • Thiele S, Nadal J, Fleckenstein M, Fang PP, Pfau M, Schmid M, Hua R, Holz FG, Schmitz-Valckenberg S (date unknown). Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns. Vol. 239, 110-120. Accepted, .
  • Fleckenstein M, Mitchell P, Freund KB, Sadda S, Holz FG, Brittain C, Henry EC, Ferrara D (date unknown). The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration. (pp. 369-390). Vol. 125. Accepted, .