Alan Chuck Dorval portrait
  • Director of Graduate Studies, Biomedical Engineering
  • Associate Chair for Research, Biomedical Engineering
  • Associate Professor, Biomedical Engineering
801-587-7631

Publications

  • Craig J & Charlebois CM, Weaver KE, Brooks D, Ojemann J, Rampersad S, Dorval AD (2023). Creating patient-specific computational models for off-contact stimulation from stereo-electroencephalography leads. BioMedical Engineering Society. Published, 10/2023.
  • Charlebois CM & Anderson DN, Smith EH, Davis TS, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD, Butson CR (2023). Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation. International Neuromodulation Society. Published, 09/2023.
  • Rampersad S & Roig-Solvas B, Yarossi M, Dorval AD, Brooks DH (2023). Efficient optimization of transcranial temporal interference stimulation (tTIS). Brain Stimulation. Published, 02/2023.
  • Weaver KE & Paschall CJ, Ko A, Charlebois CM, Davis T, Brooks D, Rolston JD, Rampersad S, Dorval AD, Herron J, Ojemann J (2023). Validating multi-source current steering in stereotactic depth electrodes. Brain Stimulation. Published, 02/2023.
  • Caston RM & Wilson MG (2022). Stochastic Resonance Governs Memory Consolidation Accuracy in a Neural Network Model. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Vol. 2022, 225422572254-2257. Published, 09/01/2022.
  • Charlebois CM, Anderson DN, Johnson KA, Philip BJ & Davis TS (2022). Patient-specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy. Epilepsia. Vol. 63, 203720552037-2055. Published, 08/01/2022.
  • Rampersad S, Roig-Solvas B, Yarossi M, Dorval AD & Brooks D (2021). An efficient algorithm for electrode optimization of transcranial temporal interference. Brain Stimulation, annual conference. Published, 12/2021.
  • Charlesbois CM, Anderson DN, Johnson KA, Philip BJ, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD & Butson CR (2021). Cohort analysis of activation volumes and responsive neurostimulation parameters in patients with mesial temporal lobe epilepsy. Society for Neuroscience, annual conference. Published, 11/2021.
  • Charlesbois CM, Caldwell DJ, Rampersad S, Janson AP, Ojemann JG, Brooks DH, MacLeod RS, Butson CR & Dorval AD (2021). Validating patient-specific finite element models of direct electrocortical stimulation. Frontiers in Neuroscience. Vol. 15, 8365306. Published, 05/2021.
  • Anderson DN, Dorval AD, Rolston JD, Pulst SM & Anderson CJ (2021). Computational investigation of the impact of deep brain stimulation contact size and shape on neural selectivity. Journal of Neural Engineering. Vol. 18, 056004. Published, 05/2021.
  • Charlesbois CM, Anderson DN, Johnson KA, Philip BJ, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD & Butson CR (2020). Predictors of seizure reduction in patients with mesial temporal lobe eplilepsy treated with responsive neurostimulation. American Epilepsy Society, annual meeting. Published, 11/2020.
  • Heck B, Yarossi M, Roig-Solvas B, Rampersad S, Brooks D & Dorval AD (2020). Computational assessment of temporal interference stimulation’s capabilities in neuronal activation. Biomedical Engineering Society, annual meeting. Published, 10/2020.
  • Anderson CJ, Sheppard D & Dorval AD (2020). Parkinsonism and subthalamic deep brain stimulation dysregulate behavioral motivation in a rodent model. Brain Research. Vol. 1736, 146776. Published, 08/2020.
  • Anderson CJ, Anderson DN, Pulst SM, Butson CR & Dorval AD (2020). Neural selectivity, efficiency, and dose equivalence in deep brain stimulation through pulse width tuning and segmented electrodes. Brain Stimulation. Vol. 13, 1040-1050. Published, 07/2020.
  • Rampersad S, Roig-Solvas B, Yarossi M, Dorval AD & Brooks D (2020). Modeling and optimization of transcranial temporal interference stimulation. Neuromodec, annual meeting. Published, 04/2020.
  • Rampersad S, Roig-Solvas B, Yarossi M, Kulkarni PP, Santarnecchi E, Dorval AD & Brooks DH (2019). Prospects for transcranial temporal interference stimulation in humans: A computational study. NeuroImage. Vol. 202, 116124. Published, 11/2019.
  • Polar CA, Hoyer G & Dorval AD (2019). Cortico-subthalamic beta-coherence suppression during high-intensity, self-directed motion in a PD rat model. Biomedical Engineering Society, annual meeting. Published, 10/2019.
  • Charlebois CM, Philip BJ, Anderson DN, Butson CR & Dorval AD (2019). Differential response to anodic and cathodic cortical stimulation for seizure arrest. Biomedical Engineering Society, annual meeting. Published, 10/2019.
  • Weng G, Febinger HY & Dorval AD (2019). A rat model of parkinsonism with increasing dopaminergic degeneration & motor symptom progression biomedical engineering. Biomedical Engineering Society, annual meeting. Published, 10/2019.
  • Anderson CJ, Figueroa KP, Dorval AD & Pulst SM (2019). Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat. Annals of Neurology. Published, 03/2019.
  • Polar CA, Hoyer G & Dorval AD (2019). Cortico-subthalamic beta-coherence suppression during high-intensity, self-directed motion in a parkinsonian rat model. IEEE EMBS Conference on Neural Engineering Research. Published, 03/2019.
  • Anderson DN, Duffley G, Vorwerk J, Dorval AD & Butson CR (2019). Anodic stimulation misunderstood: preferential activation of fiber orientations with anodic waveforms in deep brain stimulation. Journal of neural engineering. Vol. 16, 016026. Published, 01/2019.
  • Taheri M, Dorval AD & White JA (2018). Modeling the variability of spontaneous astrocyte calcium activity and responses to repeated stimuli. Biomedical Engineering Society, annual meeting. Published, 10/2018.
  • Charlebois CM, Shayestehfard K, Anderson DN, Janson A, Cronin J, Dannhauer M, Caldwell D, Rampersad S, Sorensen L, Ojemann J, Brooks D, MacLeod R, Butson CR & Dorval AD (2018). Quantification of lead localization uncertainty in computational modeling of electrocorticography stimulation and recording. Biomedical Engineering Society, annual meeting. Published, 10/2018.
  • Polar CA, Gupta R, Lehmkuhle MJ & Dorval AD (2018). Correlation between cortical beta power and gait speed is suppressed in a parkinsonian model, but restored by therapeutic deep brain stimulation. Neurobiology of disease. Vol. 117, 137-148. Published, 07/2018.
  • Anderson CJ, Figueroa KP, Dorval AD & Pulst SM (2018). Low-frequency deep cerebellar stimulation improves gait ataxia, tremor, and falling in a rodent model of ataxia. Neural Interfaces Conference. Published, 06/2018.
  • Anderson DN, Duffley G, Vorwerk J, Dorval AD & Butson CR (2018). Anodic stimulation misunderstood: preferential activation of fiber orientations with anodic waveforms in deep brain stimulation. Neural Interfaces Conference. Published, 06/2018.
  • Febinger HY, Dorval AD & Rolston JD (2018). A sordid affair: spike sorting and data reproducibility. Neurosurgery. Published, 03/2018.
  • Anderson DN, Osting B, Vorwerk J, Dorval AD & Butson CR (2018). Optimized programming algorithm for cylindrical and directionally segmented deep brain stimulation electrodes. Journal of Neural Engineering. Published, 01/2018.
  • Moesinger R, Febinger HY & Dorval AD (2017). Continuous analysis of parkinsonian rodent gait via frustrated total internal reflection. Biomedical Engineering Society, annual meeting. Published, 10/2017.
  • Lambert KM, White JA, Dorval AD. “A rat model for isolating basal ganglia pathways for the study of information transmission.” Biomedical Engineering Society, annual meeting, Oct. 2016. Published, 10/2016.
  • Anderson DN, Osting B, Dorval AD, Butson CR. “Optimized programming algorithm for cylindrical and directionally segmented deep brain stimulation electrodes.” Biomedical Engineering Society, annual meeting, Oct. 2016. Published, 10/2016.
  • King NO, Anderson CJ, Dorval AD (2016) “Deep brain stimulation exacerbates hypokinetic dysarthria in a rat model of parkinsonism.” J Neurosci Res, 94(2):128-138, PMC4681650. Published, 02/01/2016.
  • Dorval AD. “Pallidal Neural Information Increases with Parkinsonian Severity in a Non-Human Primate Model.” Biomedical Engineering Society, annual meeting, Oct. 2015. Published, 10/01/2015.
  • Polar CA, Dorval AD. “Synchronization of EEG and behavioral recordings in healthy and hemi-parkinsonian rodents using a low power micro-recording embedded system.” Biomedical Engineering Society, annual meeting, Oct. 2015. Published, 10/01/2015.
  • Dorval AD, Muralidharan A, Jensen AL, Baker KJ, Vitek JL (2015) “Information in pallidal neurons increases with parkinsonian severity.” Parkinsonism Relat Disord, 21(11):1355-1361, PMID:26433544. Published, 08/01/2015.
  • Willsie AC, Dorval AD (2015) “Computational field shaping for deep brain stimulation with thousands of contacts in a novel electrode geometry.” Neuromodulation 18(7):542-551, PMID:26245306. Published, 06/01/2015.
  • Anderson CJ, Sheppard DT, Huynh R, Anderson DN, Polar CA, Dorval AD (2015) “Subthalamic deep brain stimulation reduces pathological information transmission to the thalamus in a rat model of parkinsonism.” Front Neural Circuits, 9(31). PMC4491629. Published, 04/01/2015.
  • Willsie AC, Dorval AD (2015) “Fabrication and initial testing of the μDBS: a novel deep brain stimulation electrode with thousands of individually controllable contacts.” Biomed Microdevices 17(3):58, PMID:25981752. Published, 02/01/2015.
  • Anderson CJ, Dorval AD. “Information as theoretic metrics as biomarkers of parkinsonian symptom severity.” Biomedical Engineering Society, annual meeting, Oct. 2014. Published, 10/2014.
  • Polar CA, Gupta R, Dorval AD, Lehmkuhle MJ. “Motion-sensitive changes in cortical beta power, in a rat model of parkinsonism with DBS.” Neural Interfaces Conference, Jun. 2014. Published, 06/2014.
  • Ortega FA, Butera RJ, Christini DJ, White JA, Dorval AD. “Dynamic clamp in cardiac and neuronal systems using RTXI.” Methods in Molecular Biology: Patch Clamp, Humana Press, Totowa, NJ, 2014, 1183:327-354, PMID:25023319. Published, 06/2014.
  • Anderson CJ, Dorval AD. “Information-theoretic metrics as biomarkers of parkinsonian symptom severity.” Neural Interfaces Conference, Jun. 2014. Published, 06/2014.
  • Dorval AD, Grill WM. “Deep brain stimulation restores neuronal information transmission in the 6-OHDA rat model of parkinsonism.” J. Neurophysiol 111(10):1949-1959. PMC4044335. Published, 02/2014.
    http://www.ncbi.nlm.nih.gov/pubmed/24554786
  • Willsie AC, Dorval AD. “Charge steering in a novel DBS electrode may accommodate surgical targeting errors.” Proceedings of the 6th International IEEE EMBS Conference on Neural Engineering, 2013, 152-153, doi:10.1109/NER.2013.6695894. Published, 11/2013.
    http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumb...
  • Polar CA, Gupta R, Lehmkuhle MJ, Dorval AD. “Beta and low-gamma cortical waves during different states of motion in 6-OHDA hemi-parkinsonian rats.” IEEE EMBS Conference on Neural Engineering, biannual meeting, Oct. 2013. Published, 10/2013.
  • Willsie AC, Dorval AD. “Charge steering DBS accommodates non-optimal targeting.” Biomedical Engineering Society, annual meeting, Sept. 2013. Published, 09/2013.
  • Anderson CJ, Dorval AD. “Exploring the mechanisms of response time and action-suppression deficits correlated with Parkinson's disease and deep brain stimulation.” Biomedical Engineering Society, annual meeting, Sept. 2013. Published, 09/2013.
  • Dorval AD, Jensen AL, Baker KB, Vitek JL. “Neural information in globus pallidus degrades with increasing parkinsonian severity.” Biomedical Engineering Society, annual meeting, Sept. 2013. Published, 09/2013.
  • Polar CA, Dorval AD. “Cost-efficient animal tracking system used for the study of beta and gamma waves from primary motor cortex during movement in parkinsonian rats.” Biomedical Engineering Society, annual meeting, Sept. 2013. Published, 09/2013.
  • Broicher T, Malerba P, Dorval AD, Borisyuk A, Fernandez FR, White JA. “Spike phase locking in CA1 pyramidal neurons depends on background conductance and firing rate.” J Neurophysiol, 32(41):14374-14388, 2012, doi: 10.1523/JNEUROSCI.0842-12.2012. Published, 12/2012.
    http://www.jneurosci.org/content/32/41/14374.long
  • Polar CA, Dorval AD. “Active feedback system to record and stimulate simultaneously from a single electrode during deep brain stimulation.” Biomedical Engineering Society, annual meeting, Oct. 2012. Published, 10/2012.
  • Willsie AC, Dorval AD. “A novel, high-contact deep brain stimulating electrode for charge steering.” Biomedical Engineering Society, annual meeting, Oct. 2012. Published, 10/2012.
  • Dorval AD, Grill WM. “Deep brain stimulation restores information processing in a rodent model of parkinsonism.” Biomedical Engineering Society, annual meeting, Oct. 2012. Published, 10/2012.
  • Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE & Grill WM (2012). Stimulus features underlying reduced tremor suppression with temporally patterned DBS. Journal of Neurophysiology. Published, 01/2012.
    http://www.ncbi.nlm.nih.gov/pubmed/21994263
  • Dorval AD (2011). "Logarithmic inter-spike interval distributions enable robust neuronal information estimates." Biomedical Engineering Society annual meeting. Published, 10/2011.
  • Dorval AD (2011) "Estimating Neuronal Information: Logarithmic Binning of Neuronal Inter-Spike Intervals." Entropy, 13(2), 485-501; doi:10.3390/e13020485. Published, 02/2011.
    http://www.mdpi.com/1099-4300/13/2/485/
  • Dorval AD, Kuncel AM, Birdno MJ, Turner DA, Grill WM (2010). Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity. J Neurophysiol 104(2):911-921, PMID20505125. Published, 07/2010.
    http://www.ncbi.nlm.nih.gov/pubmed/20505125
  • Dorval AD, Panjwani N, Qi RY, Grill WM. “Deep Brain Stimulation that Abolishes Parkinsonian Activity in Basal Ganglia Improves Thalamic Relay Fidelity in a Computational Circuit.” P IEEE EMBS 31:4230-4233, 2009. Published, 09/2009.
    http://www.ncbi.nlm.nih.gov/pubmed/19964346
  • Dorval AD, Russo GS, Hashimoto T, Xu W, Grill WM, Vitek JL (2008). Deep brain stimulation reduces neuronal entropy in the MPTP-primate model of Parkinson's disease. J Neurophysiol 100(5):2807-2818, PMC2585386. Published, 11/2008.
    http://www.ncbi.nlm.nih.gov/pubmed/18784271
  • Dorval AD (2008). Probability distributions of the logarithm of inter-spike intervals yield accurate entropy estimates from small datasets. J Neurosci Meth 173(1):129-139, PMC2610469. Published, 08/2008.
    http://www.ncbi.nlm.nih.gov/pubmed/18620755
  • Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Grill WM (2008). Tremor varies as a function of the temporal regularity of deep brain stimulation. NeuroReport 19(5):599-602, PMC2586391. Published, 01/2008.
    http://www.ncbi.nlm.nih.gov/pubmed/18388746
  • Dorval AD, Bettencourt JB, Netoff TI, White JA (2007). “Hybrid Neuronal Network Studies Under Dynamic Clamp.” Methods in Molecular Biology: Applied Patch Clamp, Humana Press, Totowa, NJ. Published, 07/01/2007.
    http://www.ncbi.nlm.nih.gov/pubmed/18827998
  • Haas JS, Dorval AD, White JA (2007). Contributions of Ih to feature selectivity in layer II stellate cells of the entorhinal cortex. J Comput Neurosci 22(2):161-171. Published, 04/2007.
    http://www.ncbi.nlm.nih.gov/pubmed/17053992
  • Dorval AD (2006). The rhythmic consequences of ion channel stochasticity. The Neuroscientist 12(5):442-448. Published, 07/01/2006.
    http://www.ncbi.nlm.nih.gov/pubmed/16957006
  • Dorval AD, White JA (2006). Synaptic input statistics tune the variability and reproducibility of neuronal responses. Chaos 16(2):26105. Published, 06/2006.
    http://www.ncbi.nlm.nih.gov/pubmed/16822037
  • Dorval AD, White JA (2005). Channel noise is essential for perithreshold oscillations in entorhinal stellate neurons. J Neurosci 25(43):10025-10028. Published, 10/2005.
    http://www.ncbi.nlm.nih.gov/pubmed/16251451
  • White JA, Dorval AD (2005). “Neuro-electric principles.” The Electrical Engineering Handbook, 3rd edition. Dorf RC (Ed.), CRC Press, Boca Raton. Published, 07/01/2005.
  • Netoff TI, Banks MI, Dorval AD, Acker CD, Haas JS, Kopell N, White JA (2005). Synchronization in hybrid neuronal networks of the hippocampal formation. J Neurophysiol 93(3):1197-1208. Published, 03/2005.
    http://www.ncbi.nlm.nih.gov/pubmed/15525802
  • White JA, Netoff TI, Dorval AD, Banks MI (2003). Assessing neuronal synchronization properties using spike time response methods. P IEEE EMBS, 25(3):2235-2238. Published, 2003.
  • Dorval AD, Netoff TI, White JA (2003). Real-time experimental control in cellular neurophysiology. P IEEE EMBS Neural Eng 1:71-74. Published, 2003.
    http://dorval.us/alan/Manuscripts/2003_Dorval_Neto...
  • White JA, Netoff TI, Acker CD, Dorval AD, Haas JS (2002). The biophysical bases of synchronous activity in the hippocampal formation. P IEEE EMBS, 24(3):1958-1959. Published, 2002.
  • Dorval AD, Christini DJ, White JA (2001). Real-time linux dynamic clamp: a fast and flexible way to construct virtual ion channels in living cells. Ann Biomed Eng 29(10):897-907. Published, 01/2001.
    http://www.ncbi.nlm.nih.gov/pubmed/11764320
  • White JA, Haas JS, Dorval AD (1999). Stochastic dynamic clamping as a method for studying the effects of biological noise sources. P IEEE EMBS 21(2):880. Published, 1999.

Research Statement

We apply the tools of engineering to study the nervous system and design ways to improve the health and quality of life for persons with neurological disorders. Our research activities include: engineering novel treatments to alleviate the symptoms of neurological disorders; quantifying information processing in the brain and interpreting informational changes induced by disease and treatment states; and elucidating the relationships between the structural elements of neurons and neural tissue, their physiological dynamics and their behavioral responses.  Pursuing these interests, wel performs experimental studies, recording and stimulating neurons and neural tissue while assessing symptom severity in computational systems, animal models and human participants with neurological disorders.

One recent focus has been to conduct neuroengineering research, oriented toward designing devices that will alleviate the symptoms of neurological disorders by modulating neuronal activity.  In most cases, intelligent construction of neuromodulatory devices requires a more complete understanding of how neuronal activity relates to behavior than exists currently.  Hence our specific goals are twofold: first, to better understand how neuronal activity corresponds to behavior and symptoms, and second to engineer interventions that will modify neuronal activity to improve function.

Research Keywords

  • Neuronal Information
  • Neuronal Semiotics
  • Neurophysiology
  • Translational Neuroscience
  • Parkinson's Disease
  • Neuropathophysioloy
  • Deep Brain Stimulation
  • Computational Neuroscience
  • Neuromodulation
  • Neurological Disorders
  • Neural Stimulation
  • Electrophysiology
  • Physiological Controls and Systems
  • Medical Devices

Presentations

  • Charlebois CM, Anderson DN, Johnson KA, Phillip BJ, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD, Butson CR. “Predictors of seizure reduction in patients with mesial temporal lobe eplilepsy treated with responsive neurostimulation.”. Conference Paper, Refereed, Presented, 11/2020.
  • Dorval AD, Polar-Cabrera CA. “Parkinson’s Disease Suppresses Relationship Between Neural Beta Activity and Future Movement.”. Conference Paper, Refereed, Presented, 10/2020.
  • Rampersad S, Roig-Solvas B, Yarossi M, Dorval AD, Brooks D. “Modeling and optimization of transcranial temporal interference stimulation.” Neuromodec, annual meeting. Conference Paper, Refereed, Presented, 04/2020.
  • Rampersad S, Roig-Solvas B, Yarossi M, Santarnecchi E, Dorval AD, Brooks D. “Optimization of transcranial temporal interference stimulation of targets of interest using realistic human head models.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2019.
  • Charlebois CM, Philip BJ, Anderson DN, Butson CR, Dorval AD. “Patient-specific computational models of cortical activation for seizure improvement.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2019.
  • Charlebois CM, Philip BJ, Anderson DN, Dorval AD, Butson CR. “Patient-specific computational models of cortical activation for seizure improvement.” Park City Epilepsy Conference. Conference Paper, Refereed, Presented, 09/2019.
  • Anderson CJ, Anderson DN, Pulst SM, Butson CR, Dorval AD.“Neural selectivity, efficiency, and dose equivalence in deep brain stimulation through pulse width tuning and segmented electrodes.” Minnesota Neuromodulation Symposium. Conference Paper, Refereed, Presented, 04/2019.
  • Duffley G, Anderson DN, Vorwerk J, Dorval AD, Butson CR. “The activating function based volume of tissue activated (VTA): an axon orientation and projection independent method for predicting neural activation by deep brain stimulation (DBS).” Society for Neuroscience, annual meeting, Nov. 2018. Conference Paper, Refereed, Presented, 11/2018.
  • Charlebois CM, Shayestehfard K, Anderson DN, Janson A, Cronin J, Dannhauer M, Caldwell D, Rampersad S, Sorensen L, Ojemann J, Brooks D, MacLeod R, Butson CR, Dorval AD. “Validating cortical surface electrode localization uncertainty with stimulation and clinical stimulation.” Society for Neuroscience, annual meeting, Nov. 2018. Conference Paper, Refereed, Presented, 11/2018.
  • Taheri M, Dorval AD, White JA. “Modeling the variability of spontaneous astrocyte calcium activity and responses to repeated stimuli.” Society for Neuroscience, annual meeting, Nov. 2018. Conference Paper, Refereed, Presented, 11/2018.
  • Anderson DN, Duffley G, Vorwerk J, Dorval AD, Butson CR. “Anodic stimulation misunderstood: preferential activation of fiber orientations with anodic waveforms in deep brain stimulation.” Society for Neuroscience, annual meeting, Nov. 2018. Conference Paper, Refereed, Presented, 11/2018.
  • Rampersad S, Yarossi M, Shayestehfard K, Roig-Solvas B, Dorval AD, Brooks D. “Simulations of temporal interference tCS in a realistic head model.” Neuromodulation Conference, Aug. 2018. Conference Paper, Refereed, Presented, 08/2018.
  • Taheri M, Dorval AD, White JA. “Modeling the variability of spontaneous astrocyte calcium activity and responses to repeated stimuli.” Computational NeuroScience, annual meeting, Jul. 2018. Conference Paper, Refereed, Presented, 07/2018.
  • Caldwell D, Cronin J, Charlesbois C, Gkogkidis CA, Shayestehfard K, Guler S, Dannhauer M, Ko AL, MacLeod RS, Ball T, Dorval AD, Brooks DH, Ojemann JG, Sorenson LB. “OPTISTIM — Combining computational neuroscience and electrophysiology for optimal cortical electric stimulation.” Collaborative Research in Computational Neuroscience, annual meeting, Jun. 2018. Conference Paper, Refereed, Presented, 06/2018.
  • Febinger HY, Henry C, Dorval AD. “A model of gradual dopamine depletion in the rat.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2017.
  • Anderson CJ, Dorval AD, Pulst SM. “Dentate nucleus deep cerebellar stimulation reduces motor symptoms of degenerate cerebellar ataxias.” Minnesota Neuromodulation Symposium. Conference Paper, Refereed, Presented, 04/2017.
  • Henry C, Febinger HY, Dorval AD. “A model of gradual dopamine depletion in the rat.” Biomedical Engineering West Regional Conference, Jan 2017. Conference Paper, Refereed, Presented, 01/2017.
  • Lambert KM, White JA, Dorval AD. “Development of an in vivo model of basal ganglia pathway isolation for study of information transmission.” Society for Neuroscience, annual meeting, Nov. 2016. Conference Paper, Refereed, Presented, 11/2016.
  • Anderson CJ, Dorval AD. “DBS of the STN creates impulse control disorders and fails to restore parkinsonian apathy and action selection deficits.” Society for Neuroscience, annual meeting, Nov. 2016. Conference Paper, Refereed, Presented, 11/2016.
  • Anderson DN, Osting B, Dorval AD, Butson CR. “Optimized programming algorithm for cylindrical and directionally segmented deep brain stimulation electrodes.” Society for Neuroscience, annual meeting, Nov. 2016. Conference Paper, Refereed, Presented, 11/2016.
  • Dorval AD, King NO, Anderson CJ. “Stimulation of the subthalamic nucleus exacerbates dysarthria in a rat model of parkinsonism.” Society for Neuroscience, annual meeting, Nov. 2016. Conference Paper, Refereed, Presented, 11/2016.
  • Anderson CJ, Shepherd D, Dorval AD. “STN-DBS creates impulse disorders and fails to restore parkinsonian apathy and action selection deficits.” North American Neuromodulation Society , annual meeting, Jun. 2016. Conference Paper, Refereed, Presented, 06/2016.
  • Anderson DN, Osting B, Vorwerk J, Dorval AD, Butson CR. “Optimized programming algorithm for cylindrical and directionally segmented deep brain stimulation electrodes.” North American Neuromodulation Society , annual meeting, Jun. 2016. Conference Paper, Refereed, Presented, 06/2016.
  • Anderson CJ, Shepherd D, Huynh R, Anderson D, Polar-Cabrera C, Dorval AD. “Subthalamic DBS reduces pathological information transmission to the thalamus in a rat mode of parkinsonism.” Society for Neuroscience, annual meeting, Oct. 2015. Conference Paper, Refereed, Presented, 10/01/2015.
  • Anderson DN, Willsie AC, Butson CR, Dorval AD. “Toward the implementation of a novel DBS electrode for targeted neural activation.” Society for Neuroscience, annual meeting, Oct. 2015. Conference Paper, Refereed, Presented, 10/01/2015.
  • Featured Seminar, Real-Time eXperimental Interface Conference, Atlanta, GA. “Closed-Loop Neuromodulation – exposing pitfall and promise with preclinical trials via RTXI.” May 2015. Invited Talk/Keynote, Presented, 05/08/2015.
  • Keynote Seminar, Rocky Mountain Bioengineering Symposium, Salt Lake City, UT. “Improving Deep Brain Stimulation Therapy by Understanding Parkinsonian Neurophysiology.” Apr. 2015. Invited Talk/Keynote, Presented, 04/10/2015.
  • Anderson CJ, Shepherd D, Huynh R, Nesterovich D, Polar-Cabrera C, Dorval AD. “Subthalamic DBS reduces pathological information transmission to the thalamus in a rat mode of parkinsonism.” Minnesota Neuromodulation Symposium, Apr. 2015. Conference Paper, Refereed, Presented, 04/01/2015.
  • Lambert KM, White JA, Dorval AD. “An acute pharmacological approach for the study of information transmission through basal ganglia.” Society for Neuroscience, annual meeting, Nov. 2014. Conference Paper, Refereed, Presented, 11/01/2014.
  • George A, Patel Y, Ortega F, White JA, Christini D, Dorval AD, Butera R. “The real-time eXperiment interface: a closed-loop data acquistion system with sub-millisecond latencies for electrophysiology.” Society for Neuroscience, annual meeting, Nov. 2014. Conference Paper, Refereed, Presented, 11/01/2014.
  • Anderson CJ, Dorval AD. “Information as theoretic metrics as biomarkers of parkinsonian symptom severity.” Society for Neuroscience, annual meeting, Nov. 2014. Conference Paper, Refereed, Presented, 11/01/2014.
  • National Science Foundation Workshop, BioMedical Engineering Society Conference, San Antonio TX. “Neuromodulation for Neural Prostheses Control.” Oct. 2014. Invited Talk/Keynote, Presented, 10/2014.
  • Neuroscience Chalk Talks, Program in Neuroscience, Boston University, Boston MA. “Understanding and Improving Deep Brain Stimulation.” Oct. 2014. Invited Talk/Keynote, Presented, 10/2014.
  • Polar CA, Gupta R, Dorval AD, Lehmkuhle MJ. “Motion-sensitive changes in cortical beta power, in a rat model of parkinsonism with DBS.” Neural Interfaces Conference, Jun. 2014. Conference Paper, Refereed, Presented, 06/01/2014.
  • Anderson CJ, Dorval AD. “Information-theoretic metrics as biomarkers of parkinsonian symptom severity.” Neural Interfaces Conference, Jun. 2014. Conference Paper, Refereed, Presented, 06/01/2014.
  • Anderson CJ, Dorval AD. “Information theoretic metrics as biomarkers of Parkinson’s disease symptom severity.” Minnesota Neuromodulation Symposium, Apr. 2014. Conference Paper, Refereed, Presented, 04/01/2014.
  • Willsie AC, Dorval AD. “Charge steering in a novel DBS electrode may accommodate surgical targeting errors.” Society for Neuroscience, annual meeting, Oct. 2013. Conference Paper, Refereed, Presented, 10/01/2013.
  • Lehmkuhle MJ, Rossi CA, Dorval AD. “The evolution of cortical oscillations in a rate model of Parkinson's disease.” Society for Neuroscience, annual meeting, Oct. 2012. Conference Paper, Refereed, Presented, 10/01/2012.
  • Broicher T, Malbera P, Dorval AD, Borisyuk A, Fernandez FR, White JA. “Spike phase locking in CA1 pyramidal neurons depends on background conductance and firing rate.” Society for Neuroscience, annual meeting, Oct. 2012. Conference Paper, Refereed, Presented, 10/01/2012.
  • Dorval AD, Jensen AL, Baker KB, Vitek JL. “Directed information in globus pallidus neurons decreases with increasing parkinsonian severity.” Society for Neuroscience, annual meeting, Oct. 2012. Conference Paper, Refereed, Presented, 10/01/2012.
  • Parkinson's Disease Circuit Mechanisms Nanosymposium, Society for Neuroscience Conference, New Orleans LA. “Directed information in globus pallidus neurons decreases with increasing parkinsonian severity.” Oct. 2012. Invited Talk/Keynote, Presented, 10/2012.
  • Design of Medical Devices Conference, Minneapolis MN. “Closed-Loop Deep Brain Stimulation to Suppress Beta Activity in Parkinson's Disease.”. Invited Talk/Keynote, Accepted, 04/2012.
  • King Z, Lehmkuhle MJ, Dorval AD, Hendricks JL, Arps J, Richardson-Burns SM. “Conducting polymer electrode coatings improve the in vivo performance of microECoG arrays for neural applications.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2011.
  • Polar CA, Frerck MJ, Dorval AD, Lehmkuhle MJ. “Real-time feedback control of cortical beta activity via subthalamic nucleus stimulation in a parkinsonian rat model.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2011.
  • Physiology, Biophysics and Systems Biology Seminar Series, Weill Cornell Medical College, New York NY.“Quantifying and harnessing the electrophysiological mechanisms of deep-brain-stimulation-induced parkinsonian symptom relief.”. Invited Talk/Keynote, Presented, 10/2011.
  • Tathireddy P, Bamberg E, Lee S, Sharma R, Rieth L, Martinez JJ, Dorval AD, White JA, Slozbacher F. “High aspect ratio Utah microelectrode array for neural interface applications.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 11/2010.
  • Qi RY, Dorval AD, Grill WM (2009). “Deep brain stimulation regularizes patterns of neuronal firing in a rat model of Parkinson's disease.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 10/2009.
    http://www.abstractsonline.com/Plan/ViewAbstract.a...
  • Dorval AD, Grill WM (2009). “High frequency stimulation reduces disordered neuronal activity and alleviates parkinsonian symptoms in the 6-OHDA rat model.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 10/2009.
    http://www.abstractsonline.com/Plan/ViewAbstract.a...
  • Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2009). “Stimulus features underlying reduced tremor suppression during deep brain stimulation (DBS) with temporally irregular patterns.” Society for Neuroscience, annual meeting. Conference Paper, Refereed, Presented, 10/2009.
    http://www.abstractsonline.com/Plan/ViewAbstract.a...

Research Groups

  • Jeremi Godbout, Graduate Student. Biomedical Engineering. 08/15/2023 - present.
  • Diego Perez, Graduate Student. Biomedical Engineering. 08/15/2023 - present.
  • James Craig, Graduate Student. Biomedical Engineering. 08/15/2021 - present.
  • Chantel Charlebois, Graduate Student. 08/15/2017 - 05/15/2023.
  • Robert Moesinger, Graduate Student. Bioengineering. 05/15/2016 - 05/15/2018.
  • Nikhita Lanka, Graduate Student. Electrical & Computer Engineering. 01/01/2016 - 05/15/2017.
  • Heidi Febinger, Graduate Student. Neuroscience. 03/01/2015 - 08/31/2019.
  • Daria Anderson, Graduate Student. Bioengineering. 08/15/2014 - 08/15/2019.
  • Katherine Lambert, Graduate Student. Bioengineering. 08/15/2013 - 12/31/2018.
  • Eric Melonakos, Graduate Student. Bioengineering. 08/15/2012 - 08/15/2017.
  • Sanjay Devnani, Graduate Student. Electrical Engineering. 08/15/2009 - 05/15/2011.

Research Equipment and Testing Expertise

  • All the equipment and expertise to perform to all the experiments and testing we need.

Software Titles

  • RTXI 2.0. Hard real time control software for electrophysiological experiments. Release Date: 07/01/2015. Inventors: David Christini, Robert Butera, John A White, Alan D Dorval.

Laboratory Wiki

http://www.bioen.utah.edu/faculty/ADD/wiki/