RYAN E LOOPER portrait
  • Professor, Chemistry
  • Associate Professor, Chemistry

Publications

  • Vaden, R. M (date unknown). A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine. ACS Publications. Accepted, .
  • Miller, Mariel (date unknown). Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms. PLOS ONE. Vol. 15. Accepted, .
  • Samuel K. McBrayer (date unknown). Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana Shi, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Ryan E. Looper, Keith L. Ligon, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, Jr. “Direct Inhibition of BCAT by 2HG Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma” 2016 submitted to Science... Accepted, .
  • Paladugu, Srinivas R (date unknown). A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid. ACS Organic Letters. Vol. 21, 7999–8002. Accepted, .
  • RYAN E LOOPER (date unknown). Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper* “Synthesis of naamidine A, related natural products and analogs: selective access to N2-acyl-2-aminoimidazoles.” 2015, Submitted to Org. Lett. Accepted, .
  • Laukka, T (date unknown). Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. Journal of Molecular Biology. Accepted, .
  • Philip, B. (date unknown). Mutant IDH1 Promotes Glioma Formation In Vivo. Cell Press. Vol. 430. Accepted, .
  • Tuomas Laukka (date unknown). “Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases. Journal of Molecular Biology. Vol. 430. Accepted, .
  • McBrayer SK (date unknown). Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. PubMed. Accepted, .
  • Justin M. Salvant (date unknown). Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons, Daniel Z. Kurek†, Ryan E. Looper “Regioselective base-mediated cyclizations of mono-N acylpropargylguanadines” 2016, submitted to J. Org. Chem. Accepted, .
  • RYAN E LOOPER (date unknown). Travis J. Haussener, Paul R. Sebahar, Ryan E. Looper* “Preparative synthesis of N-alkyl and N,N-dialkylplolyamines” manuscript in preparation for Tetrahedron Letters. Accepted, .
  • RYAN E LOOPER (date unknown). Ki-hyeok Kwon, Miao Yang and Ryan E. Looper* “Exploring hydroamination-cycloaddition-fragmentation sequences to access complex polycyclicguanidines and vinyl-2-aminoimidazoles” 2014, in preparation for Organic Letters. Accepted, .
  • RYAN E LOOPER (date unknown). Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons and Ryan E. Looper* “Regioselectiv synthesis of N2-acyl-2-aminoimidazoles via base catalyzed cyclizations of mono-N- acylpropargylguanidines” 2014, in preparation. Accepted, .
  • RYAN E LOOPER (date unknown). Jing Fan, Xin Teng, Ling Liu, Ryan E. Looper and Joshua D. Rabinowitz* “Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate” ACS Chemical Biology 2014, ASAP. Accepted, .
  • RYAN E LOOPER (date unknown). Travis Haussener, Hariprasada R. Kanna Reddy, Paul R. Sebahar, Ryan E. Looper* and Dustin L. Williams* “Polyamine-silicone coatings for reduced biofilm related infections in medical implants” 2014, in preparation. Accepted, .
  • RYAN E LOOPER (date unknown). Rachel M. Vaden, Celine B. Santiago, Joseph B. Gibbons, Justin M. Salvant, Matthew S. Sigman, Ryan E. Looper and Bryan E. Welm* “The novel small molecule Zinaamidole induces intracellular Zn2+ dyshomeostasis and cancer-selective cell death via a caspase independent mechanism” 2014, submitted. Accepted, .
  • RYAN E LOOPER (date unknown). Catherine M. Serrano, Harriprasada R. Kanna Reddy, Daniel M. Eiller, Michael Koch, Louis R. Barrows, Thomas A. Steitz and Ryan E. Looper* “Simplified Amicetin analogues as anti-tubercular agents and analysis of their interaction with the ribosome” 2014, in preparation for J. Am. Chem. Soc. Accepted, .
  • Willilams, D. L. (date unknown). In vivo efficacy of a unique first-in-class antibiofilm antibiotic for biofilm-related wound infections caused by Acinetobacter baumannii. Biofilm. Vol. 2. Accepted, .
  • Williams, DL (date unknown). In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection. Acta Biomater. Vol. 93, 36-49. Accepted, .
  • Ashton, NN (date unknown). In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating. Acta Biomater. Vol. 93, 25-35. Accepted, .
  • Nelli, Matthew R. (date unknown). Dissecting the Nucleoside Antibiotics as Universal Translation Inhibitors. Accounts of Chemical Research. Vol. 54(13), 2798-2811. Accepted, .
  • Looper, Ryan E. (date unknown). Small Molecular Weapons against Multi-Drug Resistance. Accounts of Chemical Research. Vol. 54(13), 2785-2787. Accepted, .
  • Banerjee, Aishwaryadev (date unknown). Batch-Fabricated α-Si Assisted Nanogap Tunneling Junctions. Nanomaterials. Vol. 9, 727. Accepted, .
  • Philip B (date unknown). Mutant IDH1 Promotes Glioma Formation In Vivo. PubMed. Accepted, .
  • Serrano, Catherine M. (date unknown). Unifying aminohexopyranose nucleoside antibiotics; implications for antibiotic design. Angewandte Chemie. Vol. 59, 11330-11333. Accepted, .
  • Banerjee, Aishwaryadev (date unknown). Molecular bridge-mediated ultralow-power gas sensing. Microsystems and Nanoengineering. Vol. 7. Accepted, .
  • Williams, Dustin L. (date unknown). Growth substrate may influence biofilm susceptibility to antibiotics. PLOS ONE. Accepted, .
  • Ki-Hyeok Kwon (date unknown). Ki-Hyeok Kwon, Miao Yang, Anne V. Edwards and Ryan E. Looper “Exploring hydroamination-cycloaddition-fragmentation sequences to access polycyclicguanidines and vinyl-2-aminoimidazoles” 2016, submitted Organic Letters. Accepted, .
  • RYAN E LOOPER (date unknown). Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm* “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor” Toxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378. Accepted, .
  • Divya Bharat (date unknown). Blueberry metabolites attenuate indices of lipotoxicity-induced endothelial dysfunction. PubMed. Accepted, .

Presentations

  • Denver University, Engineering the Aminohexose-Cytosine Antibiotics as Selective P-site Inhibitors. , Presented, 2021.
  • Pfizer, Inc. Groton CT, Discovery and Development of the first selective ribosomal P-site inhibitors. , Presented, 2020.
  • Gordon Research Conference on Natural Products. , Presented, 2019.
  • Nucleosides and Nucleotides GRC, Engineering the Aminohexose-Cytosine Antibiotics as Selective P-site Inhibitors. , Presented, 2017.
  • Montana State University, Synthetic Studies on the Paralytic Shellfish Toxins. , Presented, 2017.
  • Dartmouth, Synthetic Studies on the Paralytic Shellfish Toxins. , Presented, 2016.
  • Utah Valley University, Synthetic Studies on the Paralytic Shellfish Toxins. , Presented, 2016.
  • Colorado State University, Synthetic Studies on the Paralytic Shellfish Toxins. , Presented, 2016.
  • Utah High School Summer Science Enrichment Program (U of U, July 2nd , 2015) “Antimicrobial resistance: a problem, a solution and a challenge for you”. , Presented, 2015.
  • Northwest Regional ACS Meeting (Pocatello, ID , June 25th , 2015) “Synthetic and biological investigations of natural product inspired 2-aminoimidazole scaffolds”. , Presented, 2015.
  • College of Science’s “Science at Breakfast” (Zion’s Bank, Salt Lake City, UT , January 15th, 2015) “Big Pharma, Little U”. , Presented, 2015.
  • College of Pharmacy (University of Utah; November 5th, 2014) “New strategies to target chronic biofilm impaired wounds”. , Presented, 2014.
  • Biointerface 2014 (San Francisco, CA; October 8th, 2014) “Medical Device Technologies: Potential to Treat and Prevent Biofilm Implant-Related Infections”. , Presented, 2014.
  • Eli Lilly and Co. (Indianapolis, IN; March 9th , 2014) 16th Biennial Lilly Grantee Symposium “New Methods to Access Guanidinium Ion Natural Products”. , Presented, 2014.
  • Amgen Inc., Young Investigators Award Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • Merck and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • Michigan State University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • 244th ACS National Meeting, Invited contribution to the Young Investigators Symposium “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • Eli Lilly and Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • NSF Workshop, Endicott House, MIT “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • Colorado State University. , Presented, 2012.
  • Case Western Reserve University “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • University of Wisconsin-Madison “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • Sigma-Aldrich Co. “Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds”. , Presented, 2012.
  • University of Copenhagen "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • Constellation Pharmaceuticals "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • Amgen Inc. "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • Boston University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • University of Pennsylvania "Propargylguanidine hydroaminations and their application to important heterocyclic scaffolds". , Presented, 2012.
  • Emory University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • Vanderbilt university "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • University of Alabama "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • Texas A&M University "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • UC Santa Barbara "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2012.
  • University of Texas southwestern medical center, Dallas "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2011.
  • UC Irvine "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2011.
  • "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2011.
  • University of Notre Dame "Propargylguanidine hydroaminations and their application to important heterocyclic systems". , Presented, 2011.

Research Groups

  • Kyle Nogales, . 2016 - present.
  • Ben Tresco, . 2016 - present.
  • Matt Nelli, . 2016 - present.
  • Melisa Rollins, . 2015 - present.
  • Cody Bender, . 2015 - present.
  • Emily Kirkeby, . Chemistry. 2015 - 2017.
  • Daniel Kurek , . Chemistry. 2015 - 2016.
  • Samuel Broadbent, . Chemistry. 2015 - 2020.
  • Scott Eldridge, . Chemistry. 2015 - 2016.
  • Toni Guo, . 2012 - present.