RYAN E LOOPER

RYAN E LOOPER portrait
  • Associate Professor, Chemistry

Publications

Publications

  • Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana Shi, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Ryan E. Looper, Keith L. Ligon, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, Jr. “Direct Inhibition of BCAT by 2HG Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma” 2016 submitted to Science. Released, 10/2016.
  • Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons, Daniel Z. Kurek, Ryan E. Looper “Regioselective base-mediated cyclizations of mono-N acylpropargylguanadines” 2016, submitted to J. Org. Chem. Submitted, 08/2016.
  • Travis J. Haussener, Paul R. Sebahar, Hariprasada K. Reddy, Dustin L. Williams and Ryan E. Looper “A Practical Synthesis of N-alkyl- and N’,N’-dialkyl polyamines”, Tetrahedron Letters. 2016, 57, 2845-2848. Published, 06/29/2016.
  • Ki-Hyeok Kwon, Miao Yang, Anne V. Edwards and Ryan E. Looper “Exploring hydroamination-cycloaddition-fragmentation sequences to access polycyclicguanidines and vinyl-2-aminoimidazoles” 2016, submitted Organic Letters. Submitted, 01/2016.
  • Srinivas R. Paladugu and Ryan E. Looper “Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.” Tetrahedron Lett. 2015, 56, 6332-6334. Published, 11/2015.
    http://www.pubfacts.com/detail/26594065/Preparatio...
  • Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper* “Synthesis of naamidine A, related natural products and analogs: selective access to N2-acyl-2-aminoimidazoles.” 2015, Submitted to Org. Lett. . Published, 09/11/2015.
    http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b0170...
  • Kihyeok Kwon, Travis J. Haissener and Ryan E. Looper "Preparation of mono-Cbz protected guanidines (Potassium carbobenzyloxycyanamide, carbbezyloxycyanamide potassium salt)" Org. Synth. 2015, 92, 91-102. Published, 03/25/2015.
    http://www.orgsyn.org/Content/pdfs/procedures/v92p...
  • Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm* “Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor” Toxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378. Published, 01/2015.
    http://www.ncbi.nlm.nih.gov/pubmed/25265996
  • Ki-hyeok Kwon, Catherine M. Serrano, Michael Koch, Louis R. Barrows and Ryan E. Looper* “Synthesis of bicyclic guanidines via cascade hydroamination /Michael additions of mono-N-acylpropargylguanidines” Organic Letters, 2014, 16, 6048-6051. Published, 11/13/2014.
    http://pubs.acs.org/doi/abs/10.1021/ol502691w?jour...
  • Justin M. Salvant, Anne V. Edwards, Joseph B. Gibbons and Ryan E. Looper* “Regioselectiv synthesis of N2-acyl-2-aminoimidazoles via base catalyzed cyclizations of mono-N- acylpropargylguanidines” 2014, in preparation.. In progress, 08/2014.
  • Rachel M. Vaden, Celine B. Santiago, Joseph B. Gibbons, Justin M. Salvant, Matthew S. Sigman, Ryan E. Looper and Bryan E. Welm* “The novel small molecule Zinaamidole induces intracellular Zn2+ dyshomeostasis and cancer-selective cell death via a caspase independent mechanism” 2014, submitted. Revise/resubmit(1), 08/2014.
  • Jing Fan, Xin Teng, Ling Liu, Ryan E. Looper and Joshua D. Rabinowitz* “Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate” ACS Chemical Biology 2014, ASAP. In progress, 08/2014.
  • Travis J. Haussener, Paul R. Sebahar, Ryan E. Looper* “Preparative synthesis of N-alkyl and N,N-dialkylplolyamines” manuscript in preparation for Tetrahedron Letters . In progress, 08/2014.
  • Catherine M. Serrano, Harriprasada R. Kanna Reddy, Daniel M. Eiller, Michael Koch, Louis R. Barrows, Thomas A. Steitz and Ryan E. Looper* “Simplified Amicetin analogues as anti-tubercular agents and analysis of their interaction with the ribosome” 2014, in preparation for J. Am. Chem. Soc.. In progress, 08/2014.
  • Ki-hyeok Kwon, Miao Yang and Ryan E. Looper* “Exploring hydroamination-cycloaddition-fragmentation sequences to access complex polycyclicguanidines and vinyl-2-aminoimidazoles” 2014, in preparation for Organic Letters.. In progress, 08/2014.
  • Travis Haussener, Hariprasada R. Kanna Reddy, Paul R. Sebahar, Ryan E. Looper* and Dustin L. Williams* “Polyamine-silicone coatings for reduced biofilm related infections in medical implants” 2014, in preparation. In progress, 08/2014.
  • Keith M. Gligorich, Rachel M. Vaden, Dawne N. Shelton, Guoying Wang, Cindy B. Matsen, Ryan E. Looper, Matthew S. Sigman, and Bryan E. Welm “Development of a Screen To Identify Selective Small Molecules Active Against Patient-Derived Metastatic and Chemoresistant Breast Cancer Cells” Breast Cancer Research, 2013 15(4), R58. PMID: 23879992. PMC4028696. Published, 07/23/2014.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC402869...
  • Kaitlin J. Basham, Vasudev R. Bhonde, Collin Keiffer, James B. C. Mack, Matthew Hess, Bryan E. Welm and Ryan E. Looper* “ Bis-aryloxadiazoles as effective activators of the aromatic hydrocarbon receptor” Bioorg. Med. Chem. Lett. 2014, 24, 2473-2476. DOI: 10.1016/j.bmcl.2014.04.013. Published, 06/01/2014.
    http://stephenson.pure.elsevier.com/en/publication...
  • Miao Yang, Shannon Odelberg, Dean Li and Ryan E. Looper* “Cationic-Rh(II) complexes for the synthesis of dihydropyrimidines from propargylureas” 2013, Tetrahedron, 69, 5744-5750. DOI:10.1016/j.tet.2013.04.071. Published, 07/08/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23807819
  • Vasudev R. Bhonde and Ryan E. Looper* “Carbamic acid, N-[[[(1,1 dimethylethoxy)carbonyl] amino](methylthio)methylene]-,1,1-dimethylethyl ester” Encyclopedia of Reagents for Organic Synthesis (eROS), 2013, in press. DOI: 10.1002/047084289X.rn01529. Published, 04/22/2013.
    http://onlinelibrary.wiley.com/doi/10.1002/0470842...
  • Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K. Schneider, Christine McMahon, Glenn Cowley, David Root, Benjamin L. Ebert, and William G. Kaelin Jr. “(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible” Science, 2013, 339, 1621-1625. DOI:10.1126/science.1231677. Published, 03/29/2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23393090
  • Kaitlin J. Basham, Collin Keiffer, Dawne N. Shelton, Chris J. Leonard, Vasudev R. Bhonde, Hariprasad Vankayalapati, Brett Milash, David J. Bearss , Ryan E. Looper and Bryan E. Welm “Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.” J. Biol. Chem. 2013, 288(4), 2261-2270. Published, 01/25/2013.
    http://www.jbc.org/content/288/4/2261.abstract
  • Joseph B. Gibbons, Keith M. Gligorich, Bryan E. Welm and Ryan E. Looper* “Synthesis of the reported structures for kealiinines B and C” Organic Letters 2012, 14, 4734-4737. Published, 09/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol3019242
  • Travis J. Haussener and Ryan E. Looper* “An epoxide opening cascade to access the pactamycin core” Organic Letters 2012, 14, 3632–3635. . Published, 07/2012.
    http://pubs.acs.org/doi/abs/10.1021/ol301461e
  • Gregory P. Tochtrop and Ryan E. Looper "Target-oriented synthesis/ Strategies for building focused libraries and their uses." In Chemical Genomics, Cambridge University Press, 2012. Published, 05/2012.
  • Peppi Koivunen*, Sungwoo Lee, Chris G Duncan, Giselle Lopez, Shakti Ramkissoon, Julie Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Gross, Ryan Looper, Keith Ligon, Roeland Verhaak, Hai Yan, and William G. Kaelin, Jr*. “Transformation by the (R) Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation” Nature, 2012 483, 484-488. Published, 03/2012.
    http://www.nature.com/nature/journal/v483/n7390/fu...
  • Ryan E. Looper and Robert M. Williams “Efficient Asymmetric Synthesis of N-tert- Butoxycarbonyl-a-Aminoacids using 4-tert-Butoxycarbonyl-5,6-Diphenylmorpholin-2-one: (R)-(N-tert-Butoxycarbonyl)allylglycine” Organic Synthesis 2012, 89, 394-403. Published, 03/2012.
    http://www.orgsyn.org/orgsyn/pdfs/v89p0394.pdf
  • Vasudev R. Bhonde and Ryan E. Looper* “A stereocontrolled synthesis of (+)-saxitoxin” J. Am. Chem. Soc. 2011, 133 20172–20174. Published, 11/12/2011.
  • Ryan E. Looper*, Travis J. Haussener and James B. C. Mack† “Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines” J. Org. Chem, 2011, 76 (16), 6967-6971. Published, 06/08/2011.
  • Catherine M. Serrano and Ryan E. Looper* “Rapid assembly of cytimidine through tandem Cu-catalyzed N-aryl amidation reactions” Organic Letters, 2011, 13, 5000-5003. Published, 05/07/2011.