DAVID W GRAINGER portrait
  • Distinguished Professor, Biomedical Engineering
  • Chair, Biomedical Engineering
  • Distinguished Professor, Pharmaceutical Chemistry
  • Adjunct Professor of Orthopedics, Orthopaedic Surgery Operations
  • Adjunct Professor, Chemistry

Research Statement

My research interests and group focus on the crossroads of materials and medicine. I am interested in the thematic as well as literal interfaces of biomaterials and living systems. This translates to study and innovation in medical diagnostic systems and bioassays, medical implant designs and improvement using innovative biomaterials and on-baord drug delivery, implant-related infections, surface analysis in biomedical systems, drug delivery systems for proteins and vaccines, and novel surface modification strategies.  I have substantial experience in technology transfer, industrial technology translation, consulting, expert witness and technical writing in diverse aspects of medical and drug delivery technology.   I have run numerous technical short courses for industrial and academic audiences upon request.   I am routinely invited to speak at government advisory, academic and industrial forums, panels, workshops, and working groups. 

Research Keywords

  • Pharmacotherapy
  • Biodiversity
  • Interleukins
  • Nucleic Acid Hybridization
  • Radiotherapy
  • Palliative Care
  • Plant Physiology or Morphology
  • Cancer Prevention
  • Handicapped Vocational Service
  • Plant Virology
  • Electronic Warfare

Presentations

  • Invited plenary speaker (virtual COVID-altered Zoom talk), “Tracing translational pathways in biomedical technology”, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain, April 5, 2021. , Presented, 2021.
  • “Responsible conduct, reproducibility and ethical issues in research”, School of Pharmacy, Queen’s University Belfast, Belfast, Northern Ireland, UK. , Presented, 2020.
  • “Point-Counterpoint: Wearable sensors will be more medically impacting than invasive sensors”, Surface in Biomaterials Foundation, Park City, UT. , Presented, 2019.
  • “Overview of Clinical Experiences with Nanoparticles”, Drug Delivery West, San Francisco, CA. , Presented, 2019.
  • “Delivery of biotech drugs from surgically placed implants - combination devices", Millennium Biotechnology Pan Arab Conference, Arabian Gulf University, Manama, Bahrain. , Presented, 2019.
  • “Barriers to translating biomedical technology,” 2018 Global Opportunities and Partnering Event for Innovative Medical Electronics and Medical Imaging. Ministry of Science and Technology, Taipei, Taiwan. , Presented, 2018.
  • “Comparing clinical and preclinical performance of nanomedicines: a disconnect?” European Society for Biomaterials, Maastricht, NL. , Presented, 2018.
  • “Antimicrobial Combination Medical Device Translation: Barriers in the University-Industry Translational Ecosystem”, National Materials and Manufacturing Board’s “Roundtable on Biomedical Engineering Materials and Applications”, National Academies, Washington D.C.,. , Presented, 2018.
  • “Strategies to immobilize and analyze biomolecules on surfaces”, Chemical Technology, RIKEN Institute, Saitama, Japan. , Presented, 2018.
  • “Comparing 2D and 3D kidney nephrotoxicity organoid models for drug screening,” TWIns, Tokyo Women’s Medical University, Tokyo, Japan. , Presented, 2018.

Research Groups

  • Eva Serio, . Biomedical Engineering. 2020 - 2021.
  • • Nicolas Metzler, . Bioengineering. 2017 - present.
  • Celia Dunn, . Biomedical Engineering. 2017 - present.
  • Sophia Bou-Ghannam, . Bioengineering. 2015 - 2021.
  • • Hallie Thorp, . Bioengineering. 2015 - 2021.

Research Equipment and Testing Expertise

  • Access to University Core Lab facilities as described on-line for the University, including the imaging, microscopy, histology, flow cytometry, and bioanalytical chemistry, and the Nano-Fab core facility with surface analysis tools, including imaging XPS and ellipsometry, SEM and TEM. Contact: David Grainger , , Bioengineering.

Languages

  • German, Functional.

Geographical Regions of Interest

  • Germany
    Humboldt Foundation postdoctoral fellow, Mainz, 1989 Helmholtz Foundation programme reviewer, 2014 Brandenburg Center for Regenerative Medicine, Berlin, 2013-2016.
  • Japan
    frequent invited guest and JSPS Visiting Faculty Fellow, Tokyo Women's Medical University, 1998.
  • Switzerland
    advisor to the AO Foundation, EMPA, TEDD, and the CCMX Board Chair, Materials Science Initiative, Switzerland.
  • Netherlands
    regular visitor and consultant to the Institute of Biomedical Engineering, Royal University of Groningen.
  • Sweden
    Scientific Advisor to FORMAMP (EU FP7 R&D Centre on antimicrobial peptides) Umea, Sweden.
  • United Kingdom
    Scientific Advisor to EPSRC Next Generation Biomaterials Discovery Programme R&D Centre, University of Nottingham, U.K.

Publications

  • (date unknown). D.G. Castner, D.W. Grainger, Chapter 82: “Surface analytical methods: in situ and UHV techniques” in Comprehensive Biomaterials – an on-line compendium, Elsevier, Amsterdam, 2010, in press.. Accepted, .
  • (date unknown). F. Liu, D.W. Grainger, Chapter 40: “Fluorinated Biomaterials” in Comprehensive Biomaterials – an on-line compendium, Elsevier, Amsterdam, 2010, in press.. Accepted, .
  • (date unknown). G. Harbers, D.W. Grainger, “Chapter 3: Cell-Materials Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations”, in An Introduction to Biomaterials, 2nd ed. (J.O. Hollinger, S. Guelcher, eds), CRC Press, Boca Raton, FL, in press, 2009.. Accepted, .
  • M. Kondo, S. Kameishi, D.W. Grainger, T. Okano (date unknown). Novel Therapies Using Cell Sheets Engineered from Allogenic Mesenchymal Stem/Stromal Cells. Emerg. Top. Life Sci., ETLS20200151. 2020. Accepted, .
  • Busscher HJ, Alt V, van der Mei HC, Fagette PH, Zimmerli W, Moriarty TF, Parvizi J, Schmidmaier G, Raschke MJ, Gehrke T, Bayston R, Baddour LM, Winterton LC, Darouiche RO, Grainger DW (date unknown). A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant-Associated Infection. ACS biomaterials science & engineering. Vol. 5, 402-406. Accepted, .
  • Diekjürgen D, Grainger DW (date unknown). Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model. Pflugers Archiv : European journal of physiology. Vol. 470, 1311-1323. Accepted, .
  • Moriarty TF, Harris LG, Mooney RA, Wenke JC, Riool M, Zaat SAJ, Moter A, Schaer TP, Khanna N, Kuehl R, Alt V, Montali A, Liu J, Zeiter S, Busscher HJ, Grainger DW, Richards RG (date unknown). Recommendations for design and conduct of preclinical in vivo studies of orthopedic device-related infection. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. Vol. 37, 271-287. Accepted, .
  • Godek ML, Sampson JA, Duchsherer NL, McElwee Q, Grainger DW (date unknown). Rho GTPase protein expression and activation in murine monocytes/macrophages is not modulated by model biomaterial surfaces in serum-containing in vitro cultures. Vol. 17, 1141-1158. Accepted, .
  • J.D. Oliver, S. Jia, L.R. Halpern, E.M. Graham, E.C. Turner, J.S. Colombo, D.W. Grainger, R. D'Souza (date unknown). Innovative Molecular and Cellular Therapeutics in Cleft Palate Tissue Engineering. Tissue Eng. Part B Rev. Accepted, .
  • Kim K, Thorp H, Bou-Ghannam S, Grainger DW, Okano T (date unknown). Stable cell adhesion affects mesenchymal stem cell sheet fabrication: Effects of fetal bovine serum and human platelet lysate. Journal of tissue engineering and regenerative medicine. Vol. 14, 741-753. Accepted, .
  • Abou-El-Enein M, Duda GN, Gruskin EA, Grainger DW (date unknown). Strategies for Derisking Translational Processes for Biomedical Technologies. Trends in biotechnology. Vol. 35, 100-108. Accepted, .
  • Lee CY, Harbers GM, Grainger DW, Gamble LJ, Castner DG (date unknown). Fluorescence, XPS, and TOF-SIMS surface chemical state image analysis of DNA microarrays. Vol. 129, 9429-38. Accepted, .
  • J. Falconer (date unknown). J. Falconer, S. Lu, C. Jones, D.W Grainger, “Carbon Nanomaterials Rescue Polyaromatic Hydrocarbon Toxicity in Zebrafish Embryo Cultures”, Environ. Sci. Nano, 2015, 2, 645 – 652; DOI: 10.1039/C5EN00111K. Accepted, .
  • Grainger DW (date unknown). Cell-based drug testing; this world is not flat. Advanced drug delivery reviews. Vol. 69-70, vii-xi. Accepted, .
  • Gong P, Harbers GM, Grainger DW (date unknown). Multi-technique comparison of immobilized and hybridized oligonucleotide surface density on commercial amine-reactive microarray slides. Vol. 78, 2342-51. Accepted, .
  • Falconer JL, Alt JA, Grainger DW (date unknown). Comparing ex vivo and in vitro translocation of silver nanoparticles and ions through human nasal epithelium. Biomaterials. Vol. 171, 97-106. Accepted, .
  • Aamodt JM, Grainger DW (date unknown). Extracellular matrix-based biomaterial scaffolds and the host response. Biomaterials. Vol. 86, 68-82. Accepted, .
  • Brooks BD, Sinclair KD, Grainger DW, Brooks AE (date unknown). A resorbable antibiotic-eluting polymer composite bone void filler for perioperative infection prevention in a rabbit radial defect model. PloS one. Vol. 10, e0118696. Accepted, .
  • DAVID W GRAINGER (date unknown). H. Herd Gustafson, D. Holt-Casper, D.W. Grainger, H. Ghandehari,, “Nanoparticle Uptake: The Phagocyte Problem“, NanoToday, 2015 Aug; 10(4): 487-510. doi: 10.1016/j.nantod.2015.06.006; PMCID: PMC4666556; NIHMSID: NIHMS707252. Accepted, .
  • Christie RJ, Findley DJ, Dunfee M, Hansen RD, Olsen SC, Grainger DW (date unknown). Photopolymerized hydrogel carriers for live vaccine ballistic delivery. Vol. 24, 1462-9. Accepted, .
  • 169. B. Brooks (date unknown). “A 3-D organoid in vitro kidney model for in vivo nanomaterials toxicity assessment,” Biomaterials, 10.1016/j.biomaterials.2014.04.060, 2014. Accepted, .
  • A. Rao (date unknown). “Biophysical aspects of nucleic acids on surfaces relevant to microarray performance, Biomaterials. Sci., (2014) 2(4), 436-471. DOI:10.1039/C3BM60181A. Accepted, .
  • DAVID W GRAINGER (date unknown). M. Avula, D. Jones; A. Rao, D. McClain, L.D. McGill, D.W. Grainger; F. Solzbacher, “Local release of masitinib alters in vivo implantable continuous glucose sensor performance”, Biosensors Bioelectron. (2016) 77 149–156;DOI 10.1016/j.bios.2015.08.059. Accepted, .
  • Wu P, Grainger DW (date unknown). Drug/device combinations for local drug therapies and infection prophylaxis. (pp. 2450-67). Vol. 27. Accepted, .