KELLY T. HUGHES portrait
  • Professor, School Of Biological Sciences
801-587-3367

Publications

  • Hendriksen JJ, Lee HJ & Bradshaw AJ (2022). Genetic Analysis of the Salmonella FliE Protein That Forms the Base of the Flagellar Axial Structure. mBio. Vol. 12, e0239221. Published, 02/01/2022.
  • Johnson S, Furlong EJ, Deme JC & Nord AL (2021). Molecular structure of the intact bacterial flagellar basal body. Nature microbiology. Vol. 6, 712-721. Published, 09/01/2021.
  • Akhade, A.S., S.M. Atif, B.S. Lakshmi, N. Dikshit, K.T. Hughes, A. Qadri & N. Subramanian (2020). Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. PNAS. Vol. 47, 29811-29822. Published, 11/2020.
  • Wozniak, C.E., J.J. Hendriksen, B.M. Olivera,, J.R. Roth & K.T. Hughes (2020). Integration of the pSLT plasmid into the Salmonella chromosome results in a temperature-sensitive growth defect due to aberrant DNA replication. Journal of Bacteriology. Published, 11/2020.
    https://doi.org/10.1128/JB.00380-20
  • Horstmann, J., M. Lunelli, H. Cazzola, J. Heidemann, C. Kühne, P. Steffen, S. Szefs, C. Rossi, R. Lokareddy, C. Wang, L. Lemaire, K. Hughes, C. Uetrecht, H. Schlüter, G. Grassl, T. Stradal, Y. Rossez, M. Kolbe & M. Erhardt (2020). Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion. Nature Communications. Published, 04/2020.
  • Horstmann, J.A., M. Lunelli, H. Cazzola, J. Heidemann, C. Kühne, P. Steffen, S. Szefs, C. Rossi, R.K. Lokareddy, C. Wang, K.T. Hughes, C. Uetrecht, H. Schlüter, G. A. Grassl, T.E.B. Stradal, Y. Rossez, M. Kolbe, and M. Erhardt. Flagella methylation promotes bacterial adhesion and host cell invasion. BioRxiv (2019), doi: https://doi.org/10.1101/774588. Published, 09/2019.
  • E. Ward & T.T. Renault, M. Erhardt, K.T. Hughes, and D.F. Blair (2018). Type-III Secretion Pore Formed by Flagellar Protein FliP. Molec. Microbiol. Vol. 107, 94-103. Published, 01/2018.
  • Hughes KT & Chevance FFV (2017). "Lost in translation: Seeing the forest by focusing on the trees". (pp. 182-185). Vol. 15. RNA biology. Published, 12/15/2017.
  • Chevance FFV & Hughes KT (2017). Case for the genetic code as a triplet of triplets. Proceedings of the National Academy of Sciences of the United States of America. Vol. 114, 4745-4750. Published, 11/01/2017.
  • Hughes KT (2017). Flagellum Length Control: How Long Is Long Enough?. (pp. R413-R415). Vol. 27. Current biology : CB. Published, 06/05/2017.
  • Chevance, F.F., & K.T. Hughes (2017). Coupling of flagellar gene expression with assembly in Salmonella enterica.. (pp. 47-71.). Vol. 1593, Methods Mol Biol. Published, 06/2017.
  • Cohen EJ, Ferreira JL, Ladinsky MS, Beeby M & Hughes KT (2017). Nanoscale-length control of the flagellar driveshaft requires hitting the tethered outer membrane. Science (New York, N.Y.). Vol. 356, 197-200. Published, 04/12/2017.
  • Erhardt M, Wheatley P, Kim EA, Hirano T, Zhang Y, Sarkar MK, Hughes KT & Blair DF (2017). Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical charged-residue cluster. Molecular microbiology. Vol. 104, 234-249. Published, 01/20/2017.
  • Maloy, S.M & K.T. Hughes, eds. (2017). “Brenner’s Encyclopedia of Genetics”. Elsevier Press. Published, 01/2017.
  • Hughes KT (2016). Mg2+-dependent translational speed bump acts to regulate gene transcription. Proceedings of the National Academy of Sciences of the United States of America. Vol. 113, 14881-14883. Published, 12/27/2016.
  • Wee DH & Hughes KT (2015). Molecular ruler determines needle length for the Salmonella Spi-1 injectisome. Proceedings of the National Academy of Sciences of the United States of America. Vol. 112, 4098-103. Published, 03/31/2015.
  • Erhardt, M., M.E. Mertens, F.D. Faniani, and K.T. Hughes. ATPase-independent type-III protein secretion in Salmonella enterica. PLoS Genetics (2014), 10: e1004800. Published, 11/13/2014.
  • Singer, H.M., M. Erhardt, and K.T. Hughes. Comparative analysis of the secretion capability of early and late flagellar type III secretion substrates. Molec. Microbiol. (2014), 93: 505-520. Published, 08/2014.
  • Guo, S., I. Alshamy, K.T. Hughes, and F.F.V. Chevance. Analysis of factors that affect FlgM-dependent type III secretion for protein purification with Salmonella Typhimurium. J. Bacteriol. (2014), 196: 2333-2347. Published, 07/2014.
  • Cohen, E.J., and K.T. Hughes. Rod to hook transition for extracellular flagellum assembly is catalyzed by the L-ring-dependent rod-scaffold removal. J. Bacteriol. (2014), 196: 2387-2395. Published, 07/2014.
  • Chevance, F.F.V., S. Le Guyon, and K.T. Hughes. The effects of codon context on in vivo translation speed. PLoS Genetics (2014), 10: e1004392. Published, 06/05/2014.
  • Singer, H.M., C. Kühne, J.A. Deditius, K.T. Hughes, and M. Erhardt. The Salmonella Spi1 virulence regulatory protein protein HilD directly activates transcription of the flagellar master operon flhDC. J. Bacteriol. (2014), 196: 1448-1457. Published, 04/2014.
  • Mouslim, C., and K.T. Hughes. The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression. PLoS Pathog. (2014), 10: e1003987. Published, 03/06/2014.
  • Galeva, A., N. Moroz, Y.H. Yoon, K.T. Hughes, F.A. Samatey, and A.S. Kostyukova. Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgM. J. Bacteriol. (2014), 196: 1215-1221. Published, 03/2014.
  • Maloy, S.M. & K.T. Hughes, eds. “Brenner’s Encyclopedia of Genetics”, 2nd Edition (2013), Elsevier Press. Published, 06/2013.
  • Kawamoto, A., Y.V. Morimoto, T. Miyata, T. Minamino, K.T. Hughes, T. Kato, and K. Namba. Common and distinct structural features of Salmonella injectisome and flagellar basal body. Sci Rep. (2013), 3: 3369. Published, 04/2013.
  • Hughes, K.T. The LEE type III secretion-specificity switch: the devil’s in the data for a common mechanism. J. Bacteriol. (2012). Published, 09/2012.
  • Singer HM, Erhardt M, Steiner AM, Zhang MM, Yoshikami D, Bulaj G, Olivera BM, Hughes KT. Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system. MBio (2012), 3: 1-9. Published, 07/2012.
  • Takaya, A., M. Erhardt, K. Karata, K. Winterberg, T. Yamamoto, and K.T. Hughes. YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex. Molec. Microbiol. (2012), 83: 1268-1284. Published, 06/2012.
  • Hughes, K.T. Rebuttal: Mystery of FliK in length control of the flagellar hook. J. Bacteriol. (2012). Published, 06/2012.
  • Blair, D.F., and K.T. Hughes. Evolution of complex structures: the case of the bacterial flagellum. In "Microbes and the Origin of Species", R. Kolter and S.M. Maloy, eds., American Society for Microbiology Press, Washington, D.C. (2012). Published, 06/2012.
  • Hughes, K.T. Flagellar hook length is controlled by a secreted molecular ruler. J. Bacteriol. (2012). Published, 03/2012.
  • Griegel, A., X. Li, A.M. Bilwes, K.T. Hughes, G.J. Jensen, and B.R. Crane. Bacterial chemoreceptor arrays are hexagionally packed trimmers of receptor dimers networked by rings of kinase and coupling proteins. Proc. Natl. Acad. Sci. USA (2012), 109:3766-3771. Published, 03/2012.
  • Erhardt, M., H.M. Singer, D.H. Wee, J.P. Keener, and K.T. Hughes. An Infrequent MolecularRuler Controls Flagellar Hook Length in Salmonella enterica. EMBO J. (2011), 30: 2948-2961. Published, 02/2011.
  • Blair, D.F., and K.T. Hughes. Evolution of complex structures: the case of the bacterial flagellum. In "Microbes and the Origin of Species", R. Kolter and S.M. Maloy, eds., American Society for Microbiology Press, Washington, D.C. (2011). Published, 01/2011.
  • Hughes, K.T., and M. Erhardt. Bacterial Flagella. Online reference els, John Battista editor, Wiley-Blackwell publishers (2011). Published, 01/2011.
  • Blair, D.F., and K.T. Hughes. Evolution of complex structures: the case of the bacterial flagellum. In "Microbes and the Origin of Species", R. Kolter and S.M. Maloy, eds., American Society for Microbiology Press, Washington, D.C. (2011). Published, 01/2011.
  • Erhardt, M., T. Hirano, Y. Su, K. Paul, R., Wee, D.H., Mizuno, S.-I. Aizawa, and K.T. Hughes. The role of the FliK molecular ruler in hook-length control in Salmonella enterica. Molec. Microbiol. (2010), 75: 1272-1284. Published, 02/2010.
  • Erhardt, M., and K.T. Hughes. C-ring requirement in flagellar type III secretion is bypassed by FlhDC upregulation. Molec. Microbiol. (2010) 75: 376-393. Published, 01/2010.
  • Maloy, S.M., J. Casadesús and K.T. Hughes, eds. "Bacterial Genetics: A tribute to John Roth". (2010). American Society for Microbiology Press, Washington, D.C. Published, 01/2010.
  • Erhardt, M., K. Namba and K.T. Hughes. Bacterial nanomachines: the flagellum and type III injectisome. In "Prokaryote Cell Biology", L. Shapiro and R. Losick, eds. Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (2010). Published, 01/2010.

Presentations

  • "Lambda Lunch", Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, MD. Invited Talk/Keynote, Presented, 04/2021.
  • Gordon Conference: “Signal Transduction in Microorganisms”. Invited Talk/Keynote, Presented, 01/2020.
  • Department of Microbiology & Molecular Biology, BYU, Provo, UT. Contributed Talk, Presented, 09/2019.
  • Bacterial Locomotion and Signal Transduction (BLAST XV) Meeting, New Orleans, LA. Contributed Talk, Presented, 01/2019.
  • Department of Biological Sciences, University of Idaho, Moscow, ID. Contributed Talk, Presented, 10/2018.
  • Department of Microbiology, Trinity College, Dublin, Ireland. Contributed Talk, Presented, 07/2018.
  • ASM Microbe Annual meeting, Atlanta, GA. Contributed Talk, Presented, 06/2018.
  • ASM Microbe Annual meeting, Atlanta, GA. Contributed Talk, Presented, 06/2018.
  • Division of Bacterial, Parasitic, and Allergenic Products, FDA, Silver Springs, MD. Contributed Talk, Presented, 02/2018.
  • Gordon Research Conference: Signal Transduction in Microorganisms, Ventura, CA. Contributed Talk, Presented, 01/2018.
  • Department of Biological Sciences, Columbia University, New York, NY. Contributed Talk, Presented, 10/2017.
  • Department of Genetics, Universidad de Sevilla, Spain. Contributed Talk, Presented, 09/2017.
  • Department of Physics, University of Oxford, Oxford, United Kingdom. Contributed Talk, Presented, 07/2017.
  • "Lambda Lunch", Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, MD. Contributed Talk, Presented, 07/2017.
  • Bacterial Flagella & Type III Secretion Systems, Okinawa Institute of Science & Technology. Contributed Talk, Presented, 03/2017.
  • Gordon Research Conference on Microbial Stress Response. Contributed Talk, Presented, 07/2016.
  • Annual Meeting, American Society for Microbiology, Boston, MA. Contributed Talk, Presented, 06/2016.
  • Gordon Research Conference on Bacterial Cell Surfaces. Contributed Talk, Presented, 06/2016.
  • Advanced Bacterial Genetics course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Other, Presented, 06/2016.
  • Department of Biochemistry & Biophysics, University of California, San Francisco. Contributed Talk, Presented, 03/2016.
  • Helmholtz Institute for Infection Biology, Braunschweig, Germany. Contributed Talk, Presented, 09/2014.
  • Department of Biology, University of Namur, Mmamur, Belgium. Contributed Talk, Presented, 09/2014.
  • DNA Transactions Meeting, Oleron, France. Contributed Talk, Presented, 09/2014.
  • Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. Contributed Talk, Presented, 09/2014.
  • Okinawa Institute of Science & Technology, Japan. Contributed Talk, Presented, 03/2014.
  • Genetic Interest Group Seminar Series, University of Utah. Contributed Talk, Presented, 01/2014.
  • Science Night Live, College of Science, University of Utah. Invited Talk/Keynote, Presented, 01/2014.
  • Stan Maloy 60th Anniversary Symposium, San Diego State University. Contributed Talk, Presented, 09/2013.
  • Marine Science Institute, University of the Philippines. Contributed Talk, Presented, 06/2013.
  • Department of Pathology & Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX,. Contributed Talk, Presented, 04/2013.
  • Department of Microbiology, University of Washington, Seattle, WA. Contributed Talk, Presented, 10/2012.
  • Advanced Bacterial Genetics course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Contributed Talk, Presented, 06/2012.
  • Department of Molecular Biology & Microbiology, Case Western Reserve University, Cleveland, OH, October 2011. Contributed Talk, Presented, 10/2011.
  • International Union of Microbial Societies 2011 Congress, Sapporo, Japan, September 2011. Contributed Talk, Presented, 09/2011.
  • Molecular Microbiology Meeting, Institute for Molecular Infection Biology, University of Würtzburg, Germany, May 2011. Contributed Talk, Presented, 05/2011.
  • Institute of Microbiology, ETH, Zurich, Switzerland, April, 2011. Contributed Talk, Presented, 04/2011.
  • Global Health Institute, EPFL, Lausanne, Switzerland, April, 2011. Contributed Talk, Presented, 04/2011.

Research Groups

  • Craig Walker, Postdoc. 09/2011 - 06/30/2014.
  • Shukui Guo, Postdoc. 06/2009 - 12/31/2014.
  • Fabienne Chevance, Research Professor. 05/2009 - present.

Languages

  • French, fluent.