MARIANA C BASERGA portrait
  • Professor (Clinical), Pediatrics
801-587-7491

Research Statement

Dr. Baserga is a member of the Division of Neonatology and her primary research interest focuses on interventional studies intended to improve neuroprotection of term and preterm infants at risk of poor neurodevelopmental outcomes. Dr. Baserga is a co-investigator in a multi center study designed to evaluate the long-term neuroprotective effects of erythropoietin given to extreme premature infants in the first few weeks of life. She is also co-investigator in a new proposal that investigates the safety of administering Darbepoetin as an adjunctive therapy to therapeutic hypothermia in term infants with hypoxic-ischemic encephalopathy.

Presentations

  • Update on NRN ongoing trials. Presented at Women and Newborn Annual Research Summit Conference, Intermountain Healthcare Employee Service Center, Salt Lake City, UT. , , 2017.
  • How near are we to using Darbepoetin or erythropoietin as neuroprotective agents for perinatal HIE? Presented at Frontiers in Pediatrics Research Lecture, University of Iowa. , , 2017.
  • Brain MRI Outcomes Following Darbepoetin Administration in Newborns Undergoing Hypothermia for Hypoxic-ischemic Encephalopathy. 9th International Conference on Brain Monitoring and Neuroprotection in the Newborn, Fota Island, Cork, Ireland (Ostrander B, McKinstry R, Beachy J, Ward R, DiGeronimo R, Ohls R, Walsh W, Mayock D, Juul S, Christensen R, Yoder B). , , 2016.
  • DIVENT: Decreasing Invasive Ventilator Time in Premature Neonates. A Quality Improvement Project.30th Conference on High Frequency Ventilation of Infants, Children and Adults, Snowbird, UT. , , 2013.
  • A Cool Way to Treat Hypoxic-Ischemic Encephalopathy. National Perinatal Association's 34th Annual Conference. , , 2013.
  • Neonatal Encephalopathy and Hypoxic Ischemic Encephalopathy: Advancing the Science and Improving Outcomes. National Institute of Child Health and Human Development, Bethesda, MD. , , 2013.
  • DIVENT: Decreasing Invasive Ventilator Time in Premature Neonates Conference on High-Frequency Ventilation of Infants, Children and Adults. Snowbird, UT. , , 2012.
  • University of Utah Research in Progress, Uteroplacental Insufficiency Affects Kidney Development and Leads to Adult Onset Hypertension. , , 2006.
  • Brain MRI outcomes following DANCE (Darbepoetin Administration in Newborns undergoing Hypothermia for Hypoxie-ischemic Encephalopathy). Platform presentation,9th International Conference on Brain Monitoring and Neuroprotection in the Newborn, Fota Island, Cork, Ireland. , , 2016.
  • DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy): Safety and Pharmacokinetic Trial. Platform presentation PAS-SPR Annual Conference, San Diego, CA. , , 2015.
  • Brain MRI Outcomes following DANCE (Darbepoetin Administration in Newborns Undergoing Hypothermia for Hypoxic-Ischemic Encephalopathy. Poster Symposium, AAP National Conference and Exhibition, San Diego, CA. , , 2015.
  • Splanchnic tissue oxygenation in preterm infants with significant anemia: Observations under near-infrared spectroscopy. Poster presentation, Society for Pediatric Research, Vancouver, Canada. , , 2014.
  • DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy): Safety and Pharmacoinetic Trial. Poster Symposium, International Conference on Brain Monitoring and Neuroprotection in the Newborn, Tampa, FL. , , 2014.
  • Splanchnic tissue oxygenation in preterm infants with significant anemia: observation under near-infrared spectroscopy. Platform presentation, WSPR, Carmel, CA. , , 2014.
  • University of Utah Research in Progress PENUT Trial Update. , , 2014.
  • DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy): Safety and Pharmacokinetic Trial. Platform presentation, WSPR, Carmel, CA. , , 2014.
  • DANCE - Darbe administration in newborns undergoing cooling for Encephalopathy: Safety and pharmacokinetic trial. Platform presentation, 2014 AAP National Conference and Exhibition, San Diego, CA (Joanna Beachy, Bradley Yoder, Robert Ward, Jessica Roberts, Catherine Sherwin, Michael Spigarelli, Robert DiGeronimo, Robin Ohls, William Walsh, Dennis Mayock, Sandra Juul, Robert Christensen). , , 2014.
  • PENUT Trial Update Research in Progress, University of Utah School of Medicine, Salt Lake City, UT. , , 2014.
  • DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy): Safety and Pharmacokinetic Trial. Platform presentation, AAP National Conference and Exhibition, San Diego, CA. , , 2014.
  • DANCE Trial Research in Progress, University of Utah School of Medicine, Salt Lake City, UT. , , 2013.
  • A Cool Way to Treat Hypoxic Ischemic Encephalopathy. Presented at National Perinatal Association's 34th Annual Conference, Salt Lake City, UT. , , 2013.
  • DIVENT: Decreasing Invasive Ventilator Time in Premature Neonates - Quality Improvement Project. Presented at 30th Conference on High Ventilation of Infants, Children and Adults. Snowbird, UT. , , 2013.
  • University of Utah Research in Progress DANCE Trial. , , 2013.
  • DIVENT: Decreasing invasive ventilator time in premature neonates. Advance Training Program (ATP) in Healthcare Delivery Improvement at the Intermountain Institute for Health Care Delivery Research Final QI Project, Salt Lake City, UT. , , 2012.
  • Uteroplacental insufficiency down-regulates renal 11 B-Hydroxysteroid dehydrogenase type 2 (11HSD2) expression through epigenetic mechanisms. Platform presentation, Society for Pediatric Research. , , 2010.
  • Uteroplacental insufficiency down-regulates renal 11-B-Hydroxysteroid dehydrogenase type 2 (11HSD2) expression through epienetic mechanisms. Platform presentation, WSPR, Carmel, CA. , , 2010.
  • Prenatal Programming of Hypertension. Presented at Fetal Origins of Adult Diseases. Deer Valley, UT. , , 2009.
  • Uteroplacental Insufficiency Affects Kidney Development and Leads To Adult Onset Hypertension. , , 2008.
  • Uteroplacental insufficiency affects kidney vascular endothelial growth factor (VEGF) expression in a model of IUGR with compensatory glomerular hypertrophy. Platform presenttion, District VIII on Perinatal Pediatrics 33rd Annual Conference, Chateau Lake Louise, Alberta, Canada. , , 2008.
  • Uteroplacental insufficiency affects kidney vascular endothelial growth factor (VEGF) expression in a model of IUGR with compensatory glomerular hypertrophy. Platform presentation, District VIII 33rd Annual Conference, Chateau Lake Louise, Alberta, Canada. , , 2008.
  • IUGR Effects Upon Kidney Development. , , 2008.
  • Uteroplacental insufficiency down-regulates kidney vascular endothelial growth factor (VEGF). Platform presentation, WSPR, Carmel, CA. , , 2008.
  • Uteroplacental insufficiency affects kidney development and leads to adult onset hypertension. Research in Progress, University of Utah School of Medicine, Salt Lake City, UT. , , 2008.
  • Uteroplacental insufficiency alters kidney cyclooxygenase-2 (COX-2) expression and causes adult onset hypertension. Platform presentation, WSPR, Carmel, CA. , , 2006.
  • Uteroplacental insufficiency affects kidney development and leads to adult onset hypertension. Research in Progress, University of Utah School of Medicine, Salt Lake City, UT. , , 2006.
  • University of Utah Research in Progress Uteroplacental Insufficiency Affects Kidney Development and Leads To Adult Onset Hypertension. , , 2006.
  • IUGR Effects Upon The Rat Kidney Development. , , 2005.
  • Uteroplacental insufficiency induced stress alters glucocorticoid receptor expression and phosphorylation in neonatal IUGR rats. Platform presentation, Mead Johnson Western Conference on Perinatal Research, Palm Springs, CA. , , 2005.
  • IUGR effects upon the rat kidney development. Research in Progress, University of Utah School of Medicine, Salt Lake City, UT. , , 2005.
  • Uteroplacental insufficiency alters hepatic expression, phosphorylation and activity of the glucocorticoid receptor in fetal IUGR rats. Platform presentation, WSPR, Carmel, CA. , , 2005.
  • Vitamin A reduces p53 gene expression in a fetal lamb model of alveolar hypoplasia. Platform presentation, WSPR, Carmel, CA. , , 2004.
  • Uteroplacental insufficiency alters small intestine Bcl-2 and Bax expression in the term intrauterine growth retarded (IUGR) rat. Platform presentation, Society for Pediatric Research, Baltimore, MD. , , 2002.
  • Effects of four different doses of dopamine on cerebral hemodynamics in young rabbits as measured by near-infrared spectroscopy. Platform presentation, WSPR, Carmel, CA. , , 2002.
  • Uteroplacental insufficiency alters small intestine Bcl-w and Bax expression in the term intrauterine growth retarded (IUGR) rat. Platform, WSPR, Carmel, CA. , , 2002.
  • Uteroplacental insufficiency alters small intestine Bcl-w and Bax expression in the term intrauterine growth retarded (IUGR) rat. Platform, Mead Johnson's Western Conference on Perinatal Research, Rancho Mirage, CA. , , 2002.
  • Prolonged total parenteral nutrition and hepatobiliary dysfunction in extremely low birth weight infants. Platform presentation, WSPR, Carmel, CA. , , 2000.
  • Empirical antibiotic use in the neonatal ICU: which ones, for how long, for which bugs? Platform presentation, WSPR, Carmel, CA. , , 2000.
  • Nitric oxide in perinatal circulation during transition to extrauterine life. Society for Pediatric Research, San Francisco, CA. , , 1999.
  • Cerebral hemodynamics, oxygenation and metabolism in small preterm infants receiving bolus gavage feeding,. , , 1999.
  • Cerebral hemodynamics, oxygenation and metabolism in small preterm infants receiving bolus gavage feeding. WSPR, Platform presentation, Carmel, CA. , , 1999.
  • Braski K, Yost CC, Baserga MC. Splanchnic Tissue Oxygenation in Pretern Infants with Significant Anemia: Observations Under Near Infrared Spectroscopy,. Poster session presented at Pediatric Academic Society/ Society for Pediatric Research, Vancouver, BC, Canada. Poster, Presented, 2014.
  • Roberts J, Beachy JC, Yoder BA, Ward RM, Sherwin C, Spigarelli M, DiGeronimo RJ, Ohls R, Walsh W, Mayock D, Juul S, Christensen RD, Baserga MC. DANCE (Darbe Administration in Newborns Undergoing Cooling for Encephalopathy): Safety and Pharmacokinetic Trial. Poster session presented at 8th International Conference on Brain Monitoring and Neuroprotection in the Newborn, Tampa, FL. Poster, Presented, 2014.
  • Ostrander B, McKinstry R. Beachy J, Ward R, DiGeronimo R, Ohls R, Walsh W, Mayock D, Juul S, Christensen RD, Yoder BA, Baserga MC. Brain MRI Outcomes Following Darbepoetin Administration in Newborns Undergoing Hypothermia for Hypoxic-ischemic Encephalopathy. Poster session presented at 2014 AAP National Conference and Exhibition (NCE), San Diego, CA. Poster, Presented, 2014.

Languages

  • Italian, Fluent.
  • Spanish, Fluent.
  • French, Fluent.
  • English, Fluent.

Publications

  • Baserga M, Hale MA, McKnight RA, Yu X, Callaway CW, Lane RH (date unknown). Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats. Vol. 289, R1348-53. Accepted, .
  • Baserga M, Hale MA, Ke X, Wang ZM, Yu X, Callaway CW, McKnight RA, Lane RH (date unknown). Uteroplacental insufficiency increases p53 phosphorylation without triggering the p53-MDM2 functional circuit response in the IUGR rat kidney. Vol. 291, R412-8. Accepted, .
  • Baserga M, Kaur R, Hale MA, Bares A, Yu X, Callaway CW, McKnight RA, Lane RH (date unknown). Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. Vol. 299, R334-42. Accepted, .
  • Baserga M, Bares AL, Hale MA, Callaway CW, McKnight RA, Lane PH, Lane RH (date unknown). Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension. Vol. 85, 361-7. Accepted, .
  • Braski K, Weaver-Lewis K, Loertscher M, Ding Q, Sheng X, Baserga M (date unknown). Splanchnic-Cerebral Oxygenation Ratio Decreases during Enteral Feedings in Anemic Preterm Infants: Observations under Near-Infrared Spectroscopy. Vol. 113, 75-80. Accepted, .
  • Baserga M, Chan B (date unknown). Hematochezia and thrombocytopenia in a 3-day-old infant: Congenital adenoviral infection. Vol. 11, 335-338. Accepted, .
  • Sandra E. Juul1, Bryan A. Comstock1, Rajan Wadhawan2; Dennis E. Mayock1, Sherry E. Courtney3, Tonya Robinson4, Kaashif A. Ahmad5, Ellen Bendel-Stenzel6, Mariana Baserga7, Edmund F. LaGamma8, L. Corbin Downey9, Raghavendra Rao10, Nancy Fahim10, Andrea Lampland11, Ivan D. Frantz, III12, Janine Y. Khan13, Michael Weiss14, Maureen M. Gilmore15, Robin K. Ohls16, Nishant Srinivasan17, Jorge E. Perez18, Victor McKay19, Phuong T. Vu1, Jean Lowe16, Karl Kuban20; Michael O’Shea21, Adam L. Hartman22, Patrick J. Heagerty1, and the PENUT Trial Consortium (date unknown). Safety and Efficacy of High Dose Erythropoietin Administered Prophylactically to Extremely Low Gestational Age Neonates in the Preterm Epo Neuroprotection (PENUT) Trial. Accepted, .
  • Bahr TM, Kerry BB, Baserga MC, Christensen RD (date unknown). Improving thermoregulation in transported preterm infants. Accepted, .