Publications

  • Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D (date unknown). Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. eLife. Vol. 6. Accepted, .
  • Mageswaran, S.K. (date unknown). Mageswaran, S.K., M.G. Dixon, M. Curtiss, J.P. Keener, and M. Babst. 2013. Binding to any ESCRT can mediate ubiquitin-independent cargo sorting. Traffic, in press. Accepted, .
  • Moharir, A (date unknown). Eisosomes are metabolically regulated storage compartments for APC-type nutrient transporters. Mol. Biol. Vol. 29, 2113-27. Accepted, .
  • Babst, Markus (date unknown). Regulation of nutrient transporters by metabolic and environmental stresses. Current Opinion in Cell Biology. Vol. 65, 35-41. Accepted, .
  • Kim HJ, Jeong MY, Parnell TJ, Babst M, Phillips JD, Winge DR (date unknown). The Plasma Membrane Protein Nce102 Implicated in Eisosome Formation Rescues a Heme Defect in Mitochondria. The Journal of biological chemistry. Vol. 291, 17417-26. Accepted, .
  • Shestakova, A (date unknown). Shestakova, A., M. Curtiss, B.A. Davies, D.J. Katzmann, and M. Babst. 2013. The linker region plays a regulatory role in the assembly and activity of the Vps4 AAA ATPase. J. Biol. Chem. 288(37):26810-26819. Accepted, .
  • Babst, M. (date unknown). Babst, M., and G. Odorizzi. 2013. The balance of protein expression and degradation: an ESCRTs point of view. Curr. Opin. Cell Biol. 25(4): 489-494. Accepted, .
  • Davies, B.A. (date unknown). Davies, B.A., I.F. Azmi, J. Payne, A. Shestakova, B.F. Horazdovsky, M. Babst, and D.J. Katzmann. Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III dissociation. Mol. Biol. Cell 21(19):3396-3408. Accepted, .
  • Kim, H.J. (date unknown). The plasma membrane protein Nce102 implicated in eisosome formation rescues a heme defect in mitochondria. J. Biol Chem. Vol. 291, 17417-26. Accepted, .
  • Mageswaran, S.K. (date unknown). Constitutively active ESCRT-II suppresses the MVB sorting phenotype of ESCRT-0 or ESCRT-I mutants. Mol. Biol. Cell. Accepted, .
  • Babst, M (date unknown). Babst, M. 2014. Quality control at the plasma membrane: one mechanism does not fit all. J. Cell Biol. 205(1): 11-20. (PMCID24733583). Accepted, .
  • Babst, M. (date unknown). Eisosomes at the intersection of TORC1 and TORC2 regulation. Traffic. Vol. 20, 543– 551. Accepted, .
  • Jones, C.B. (date unknown). Jones, C.B., E.M. Ott, J.M. Keener, M. Curtiss, V. Sandrin, and M. Babst. 2012. Regulation of protein degradation by starvation-response pathways. Traffic 13:468-482. Accepted, .
  • Appadurai, D. (date unknown). Plasma membrane tension regulates eisosome structure and function. Molecular Biology of the Cell. Vol. 31, 287-303. Accepted, .
  • Moharir A (date unknown). Mitochondrial energy metabolism regulates the nutrient import activity and endocytosis of APC transporters. FEBS letters. Accepted, .
  • Mageswaran, S.K (date unknown). Mageswaran, S.K., M.G. Dixon, M. Curtiss, J.P. Keener, and M. Babst. 2014. Binding to any ESCRT can mediate ubiquitin-independent cargo sorting. Traffic 15(2): 212-229. (PMCID24148098). Accepted, .
  • Keener, J.M (date unknown). Keener, J.M., and M. Babst 2013. Quality control and substrate-dependent downregulation of the nutrient transporter Fur4. Traffic 14(4): 412-427. Accepted, .
  • Hill, C.P. (date unknown). Hill, C.P., and M. Babst. 2012. Structure and function of the membrane deformation AAA ATPase Vps4. Biochim. Biophys. Acta. 1823(1):172-181. Accepted, .
  • Babst, M. (date unknown). Babst, M. 2011. MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between. Curr. Opin. Cell Biol. 23(4):452-457. Accepted, .
  • Babst, M. (date unknown). Babst, M., B.A. Davies, and D.J. Katzmann. 2011. Regulation of Vps4 during MVB sorting and cytokinesis. Traffic 12(10):1298-1305. Accepted, .
  • Adell, M.A.Y. (date unknown). Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. eLife. Accepted, .
  • Mageswaran SK, Johnson NK, Odorizzi G, Babst M (date unknown). Constitutively active ESCRT-II suppresses the MVB-sorting phenotype of ESCRT-0 and ESCRT-I mutants. Molecular biology of the cell. Vol. 26, 554-68. Accepted, .
  • Shestakova, A. (date unknown). Shestakova, A., A. Hanono, S. Drosner, M. Curtiss, B.A. Davies, D.J. Katzmann, and M. Babst. 2010. Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol. Biol. Cell 21(6):1059-71. Accepted, .

Research Statement

In eukaryotes, the 'multivesicular body' (MVB) pathway delivers transmembrane proteins into the lumen of the lysosome for degradation. This degradation pathway is essential for regulating cell surface protein composition, nutrient uptake, cell communication and immune response. Disruption of the MVB sorting pathway can cause significant problems for the cell in responding to extracellular cues and results in pathogenic states such as uncontrolled cellular proliferation in cancers and neurodegenerative diseases. Several multiprotein complexes, called the ESCRTs, execute the sorting of proteins into the MVB pathway. Using yeast as a model system my laboratory combines genetics, cell biology and biochemistry to gain insight into the function of the ESCRT proteins.

Presentations

  • Yale University. Contributed Talk, Presented, 2014.
  • ETH Zurich Switzerland. Contributed Talk, Presented, 2012.
  • Yale University. Contributed Talk, Presented, 2012.
  • University of Bochum Germany. Contributed Talk, Presented, 2012.
  • University of Osnabrueck Germany. Contributed Talk, Presented, 2012.
  • University of Goettingen Germany. Contributed Talk, Presented, 2012.
  • The Children's Hospital of Philadelphia. Contributed Talk, Presented, 2011.
  • University of Pennsylvania. Contributed Talk, Presented, 2010.
  • University of Osnabrueck Germany. Contributed Talk, Presented, 2010.
  • Lysosome Gordon Conference, Conference: Biochemistry and Cell Biology of ESCRTs in Health and Disease. Contributed Talk, Presented, 2010.
  • University of Goettingen Germany. Contributed Talk, Presented, 2010.
  • Lysosome Gordon Conference, Conference: Biochemistry and Cell Biology of ESCRTs in Health and Disease, University of Goettingen Germany, University of Osnabrueck Germany, University of Pennsylvania. Contributed Talk, Presented, 2010.
  • Lysosomes and Endocytosis Gordon Conference. , Presented, 2019.
  • LMO 13 Conference (Switzerland). , Presented, 2018.
  • SMYTE 36 Conference (Italy). , Presented, 2018.

Research Equipment and Testing Expertise

  • Fluorescence microscope.

Languages

  • German, Fluent.

Geographical Regions of Interest

  • Europe