My lab (Vascular Access & Health Laboratory) integrates medicine, engineering, and bioscience to investigate the pathophysiology of hemodialysis vascular access dysfunction and the progression of cardiovascular disease (CVD) in individuals with chronic kidney disease (CKD). Employing a Bedside-to-Bench-to-Bedside approach, we begin with patient observations, translate our findings into animal and cell experiments for mechanistic studies, and develop targeted treatments. Our mission is to enhance patient outcomes, prolong access longevity, and improve vascular function through innovative experimental and computational research.

Our primary focus is on hemodialysis vascular access, where we analyze hemodynamics and mechanotransduction in vascular cells. We have established the world’s largest database of blood flow imaging and simulation data from arteriovenous access in dialysis patients and animal models, including pigs, rats, and mice. This unique resource not only deepens our understanding of hemodialysis access failure but also guides the development of new treatments. Given that cardiovascular disease is the leading cause of death in CKD patients, our research also aims to uncover the intricate mechanisms linking vascular dysfunction and CVD, ultimately striving to improve the quality of life for individuals affected by these interrelated conditions.